Alkaline Phosphatase

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  Subject Areas on Research

  • 1,25-Dihydroxycholecalciferol deficiency: the probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. 
  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • A GWAS Study on Liver Function Test Using eMERGE Network Participants. 
  • A comparison of the extents of methylation of vesicular stomatitis virus messenger RNA. 
  • A fixative for use in muscle histochemistry. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis. 
  • A single infusion of zoledronic acid produces sustained remissions in Paget disease: data to 6.5 years. 
  • A time-dependent statistical model which relates current clinical status to prognosis: application to advanced prostatic cancer. 
  • Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase. 
  • Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. 
  • Active specific immunotherapy of Dukes B2 and C colorectal carcinoma: comparison of two doses of the vaccine. 
  • Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. 
  • Acute, subacute, and residual effects of polychlorinated biphenyl (pcb) in rats. II. Pathology and electron microscopy of liver and serum enzyme study. 
  • Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery. 
  • Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events. 
  • Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. 
  • Amoxicillin-Clavulanate-Induced Liver Injury. 
  • An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. 
  • Analysis and isolation of renal tubular cells by flow cytometry. 
  • Analysis of injury in complex organ preservation. 
  • Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. 
  • Antiresorptive effect of a single infusion of microgram quantities of zoledronate in Paget's disease of bone. 
  • Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers. 
  • Bioactive surface modification of metal oxides via catechol-bearing modular peptides: multivalent-binding, surface retention, and peptide bioactivity. 
  • Burden of Illness in Adults With Hypophosphatasia: Data From the Global Hypophosphatasia Patient Registry. 
  • Calcitonin stimulates growth and maturation of embryonic chick pelvic cartilage in vitro. 
  • Calcitonin stimulates maturation of mammalian growth plate cartilage. 
  • Capromab Pendetide imaging of prostate cancer. 
  • Casein kinase I in the mammalian circadian clock. 
  • Centrifugal migration of mesenchymal cells in embryonic lung. 
  • Change in surface roughness by dynamic shape-memory acrylate networks enhances osteoblast differentiation. 
  • Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study. 
  • Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chains, and binding to microtubules. 
  • Chemokines have diverse abilities to form solid phase gradients. 
  • Children's liver chemistries vary with age and gender and require customized pediatric reference ranges. 
  • Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium. 
  • Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis. 
  • Clinical profiles of treated and untreated adults with hypophosphatasia in the Global HPP Registry. 
  • Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults. 
  • Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U). 
  • Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone. 
  • Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease. 
  • Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells. 
  • Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5. 
  • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. 
  • Detection of phosphorylation by enzymatic techniques. 
  • Diagnosis and management of myeloproliferative disorders. 
  • Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry. 
  • Differentiation of human embryonic stem cells along a hepatic lineage. 
  • Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. 
  • Distinction between alkaline phosphatase and Mg2+-ATPase of the human polymorphonuclear leukocyte. 
  • Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease. 
  • Ectopic Ocular Surface Calcification in Patients With Hypophosphatasia Treated With Asfotase Alfa. 
  • Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial. 
  • Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells. 
  • Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: results of the Comparative HDL Efficacy and Safety Study (CHESS). 
  • Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. 
  • Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI. 
  • Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis. 
  • Enterotoxigenic Escherichia coli secretes active heat-labile enterotoxin via outer membrane vesicles. 
  • Evaluation of human milk fortification from the time of the first feeding: effects on infants of less than 31 weeks gestational age. 
  • Extracellular secretion of pectate lyase by the Erwinia chrysanthemi out pathway is dependent upon Sec-mediated export across the inner membrane. 
  • Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia. 
  • Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism. 
  • Functional and mobility impairments associated with Paget's disease of bone. 
  • Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. 
  • Genetic analysis of regulatory mutants of alkaline phosphatase of E. coli. 
  • Glycogen debranching enzyme deficiency: long-term study of serum enzyme activities and clinical features. 
  • Glycogenic Hepatopathy Causing Elevated Lactic Acid and Liver Enzymes. 
  • Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3. 
  • Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. 
  • Guanine nucleotide regulatory proteins in receptor-mediated polyphosphoinositide hydrolysis in human leukocytes. 
  • Hepatotoxic effects of CCl4 on English sole (Parophrys vetulus): possible indicators of liver dysfunction. 
  • Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification. 
  • Hypercalcemia following acute renal failure. 
  • Hypoparathyroidism: a possible cause of osteomalacia . 
  • Hypotensive effects of clonidine and chlorthalidone. Controlled clinical trial of drugs administered singly and in combination. 
  • Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. 
  • Immunohistochemical expression of monoclonal antibody 43-9F in testicular germ cell tumours. 
  • Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. 
  • Impact of liver tumour burden, alkaline phosphatase elevation, and target lesion size on treatment outcomes with 177Lu-Dotatate: an analysis of the NETTER-1 study. 
  • Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury. 
  • In vitro stimulation of alkaline phosphatase activity in immature embryonic chick pelvic cartilage by adenosine 3'5'-monophosphate. 
  • Increasing use of positron emission tomography among medicare beneficiaries undergoing radical cystectomy. 
  • Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. 
  • Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. 
  • Influence of lead on mineralization during bone growth. 
  • Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice. 
  • Inter- and Intra-individual Variation, and Limited Prognostic Utility, of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis. 
  • Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice. 
  • Intestinal alkaline phosphatase decreases intraperitoneal adhesion formation. 
  • Intestinal alkaline phosphatase prevents metabolic syndrome in mice. 
  • Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. 
  • Investigation of ALPL variant states and clinical outcomes: An analysis of adults and adolescents with hypophosphatasia treated with asfotase alfa. 
  • Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program. 
  • Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate. 
  • Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. 
  • Marrow cell transplantation for infantile hypophosphatasia. 
  • Metabolic and functional characterization of human adipose-derived stem cells in tissue engineering. 
  • Micromere descendants at the blastula stage are involved in normal archenteron formation in sea urchin embryos. 
  • Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells. 
  • Modulation of O6-alkylguanine-DNA alkyltransferase-mediated carmustine resistance using streptozotocin: a phase I trial. 
  • Molecular and clinical analysis of ALPL in a cohort of patients with suspicion of Hypophosphatasia. 
  • Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Mouse primordial germ cells: isolation and in vitro culture. 
  • Normal serum activities of some diagnostic enzymes in dromedary camel in Sudan. 
  • Nucleotide pool in pho regulon mutants and alkaline phosphatase synthesis in Escherichia coli. 
  • Outcomes after esophagectomy: a ten-year prospective cohort. 
  • Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury. 
  • Peyronie's disease is associated with Paget's disease of bone. 
  • Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer. 
  • Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia. 
  • Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme. 
  • Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage. 
  • Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient. 
  • Predictors of successful clinical and laboratory outcomes in patients with primary sclerosing cholangitis undergoing endoscopic retrograde cholangiopancreatography. 
  • Pretransplant status and patient survival following liver transplantation. 
  • Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase. 
  • Prognostic impact of the neutrophil-to-lymphocyte ratio in men with metastatic castration-resistant prostate cancer. 
  • Prognostic model predicting metastatic castration-resistant prostate cancer survival in men treated with second-line chemotherapy. 
  • Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer. 
  • Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis. 
  • Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice. 
  • Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models. 
  • Risk Factors for and Effects of Persistent and Severe Hypophosphatemia Following Ferric Carboxymaltose. 
  • Risk of secondary hyperparathyroidism after laparoscopic gastric bypass surgery in obese women. 
  • Role of mitogen-activated protein kinase in osteoblast differentiation. 
  • Separation of ectoderm and endoderm from sea urchin pluteus larvae and demonstration of germ layer-specific antigens. 
  • Serum alkaline phosphatase changes predict survival independent of PSA changes in men with castration-resistant prostate cancer and bone metastasis receiving chemotherapy. 
  • Serum hepatic enzyme and bilirubin elevations during parenteral nutrition. 
  • Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure. 
  • Side effects suspected to be related to doxycycline use in cats. 
  • Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease. 
  • Single infusion of zoledronate in Paget's disease of bone: a placebo-controlled, dose-ranging study. 
  • Solubilization of tricalcium phosphate by P(3HB) accumulating Azotobacter chroococcum MAL-201. 
  • Spectrum of statin hepatotoxicity: experience of the drug-induced liver injury network. 
  • Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy. 
  • Teratocarcinoma differentiation: plasminogen activator activity associated with embryoid body formation. 
  • The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis. 
  • The effect of membrane filtration upon protein conformation. 
  • The effects of hepatic cryosurgery on tumor growth in the liver. 
  • The impact of PSA on prostate cancer management. Can we abandon routine staging pelvic lymphadenectomy? 
  • The relationship between hepatitis B surface antigen and antibody and continued drug use in narcotic dependency: a randomized controlled study. 
  • The relationship of body mass index and serum testosterone with disease outcomes in men with castration-resistant metastatic prostate cancer. 
  • The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine. 
  • The structure of a molybdopterin precursor. Characterization of a stable, oxidized derivative. 
  • Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity. 
  • Topical calcipotriene has no short-term effect on calcium and bone metabolism of patients with psoriasis. 
  • Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. 
  • Transplantation of multipotent progenitors from the adult olfactory epithelium. 
  • Treating primary liver cancer with hepatic arterial infusion of floxuridine and dexamethasone: does the addition of systemic bevacizumab improve results? 
  • Treatment of metastatic endocrine-unresponsive carcinoma of the prostate gland with multiagent chemotherapy: indicators of response to therapy. 
  • Triiodothyronine stimulates maturation of porcine growth-plate cartilage in vitro. 
  • Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. 
  • Uncoupling of bone turnover following hip replacement. 
  • Urine and serum lactic dehydrogenase, lactic dehydrogenase isoenzymes, and alkaline phosphatase in the nephrotic syndrome. 
  • Use of human gametes obtained from anonymous donors for the production of human embryonic stem cell lines. 
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. 
  • Whole body hyperthermia and heat-sensitizing drugs: a pilot study in canine lymphoproliferative disease. 
  • Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Halabi, Susan, Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology