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Subject Areas on Research
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2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.
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A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation.
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A decade of caspases.
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ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells.
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Allosteric Inhibition of ABL Kinases: Therapeutic Potential in Cancer.
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Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.
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Allosteric cooperation in a de novo-designed two-domain protein.
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Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins.
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Allosteric inhibition of kinesin-5 modulates its processive directional motility.
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Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer.
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Allosteric interactions in non-alpha chains isolated from normal human hemoglobin, fetal hemoglobin, and hemoglobin Abruzzo (beta143 (H21) His replaced by Arg).
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Allosteric intermediates indicate R2 is the liganded hemoglobin end state.
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Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.
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Allosteric modulation of Callinectes sapidus hemocyanin by binding of L-lactate.
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Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions.
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Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis.
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Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
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Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.
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Allosteric regulation of type I hexokinase: A site-directed mutational study indicating location of the functional glucose 6-phosphate binding site in the N-terminal half of the enzyme.
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Allosteric transition intermediates modelled by crosslinked haemoglobins.
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Allostery in Callinectes sapidus hemocyanin: cooperative oxygen binding and interactions with L-lactate, calcium, and protons.
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An engineered liver glycogen phosphorylase with AMP allosteric activation.
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An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.
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An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate.
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An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation.
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Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator.
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Beta-arrestin-biased ligands at seven-transmembrane receptors.
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Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.
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Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.
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Biased signalling: from simple switches to allosteric microprocessors.
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
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Characterization of nucleotide binding sites on chloroplast coupling factor 1.
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Characterization of the ionizable groups interacting with anionic allosteric effectors of human hemoglobin.
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Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes.
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Chloride and pH dependence of cooperative interactions in Limulus polyphemus hemocyanin.
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Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.
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Co-operative interactions between troponin-tropomyosin units extend the length of the thin filament in skeletal muscle.
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Coarse-grained modeling of allosteric regulation in protein receptors.
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Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.
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Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.
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Conversion of a maltose receptor into a zinc biosensor by computational design.
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Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation.
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Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
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Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences.
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Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins.
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Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor.
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Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
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Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.
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Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).
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Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways.
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Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.
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Effect of oxygen and allosteric effects on structural stability of oligomeric hemocyanins of the arthropod, Limulus polyphemus, and the mollusc, Helix pomatia.
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Effects of S-nitrosation on oxygen binding by normal and sickle cell hemoglobin.
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Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat.
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Efficiency, selectivity, and robustness of nucleocytoplasmic transport.
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Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein.
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Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling.
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Functional coupling of oxygen binding and vasoactivity in S-nitrosohemoglobin.
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G protein-coupled receptor kinases.
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Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts.
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Glutathione activates virulence gene expression of an intracellular pathogen.
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Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes.
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How Gsalpha activates adenylyl cyclase.
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How the EcoRI endonuclease recognizes and cleaves DNA.
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Identification and characterization of the sodium-binding site of activated protein C.
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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
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Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.
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Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors.
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Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.
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Interaction of aspartate transcarbamylase with 5-bromocytidine 5'-tri-, di-, and monophosphates.
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K channel subconductance levels result from heteromeric pore conformations.
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Kinetics of allosteric enzymes.
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L-glutamine D-fructose-6-P aminotransferase regulation by glucose-6-P and UDP-N-acetylglucosamine.
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Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding.
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Lipid molecules induce p38α activation via a novel molecular switch.
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Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate
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ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
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Manipulation of ligand binding affinity by exploitation of conformational coupling.
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Mechanism of corepressor-mediated specific DNA binding by the purine repressor.
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Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.
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Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
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Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.
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Multiple conformational changes in enzyme catalysis.
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Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
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Nucleotide regulation of soluble guanylate cyclase substrate specificity.
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Oxygen binding by Limulus polyphemus hemocyanin: allosteric modulation by chloride ions.
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Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands.
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RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system.
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Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.
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Receptor biophysics and biochemistry. Enzymes.
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Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner.
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Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.
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Regulation of the deleterious effects of binge-like exposure to alcohol during adolescence by α7 nicotinic acetylcholine receptor agents: prevention by pretreatment with a α7 negative allosteric modulator and emulation by a α7 agonist in alcohol-preferring (P) male and female rats.
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Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog.
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Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate.
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S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function.
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S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control.
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S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action.
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Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.
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Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.
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Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.
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Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.
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Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate.
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Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.
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Structural basis for the root effect in haemoglobin.
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Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.
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Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy.
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Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin.
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Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
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The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis.
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The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino terminus.
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The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor.
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The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
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The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors.
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The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?
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The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat.
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Three-dimensional structure of calmodulin.
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Thrombomodulin increases the rate of thrombin inhibition by BPTI.
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Tropomyosin. Does resolution lead to reconciliation?
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Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor.
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gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia.
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β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.
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β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
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