Alpha-Globulins

• 

  Subject Areas on Research

  • Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. 
  • Antifibrinolytic agents make alpha1- and beta2-microglobulinuria poor markers of postcardiac surgery renal dysfunction. 
  • Association of interleukin-6 and other biologic variables with depression in older people living in the community. 
  • Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers. 
  • Biosynthesis of bikunin proteins in the human carcinoma cell line HepG2 and in primary human hepatocytes. Polypeptide assembly by glycosaminoglycan. 
  • Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes. 
  • Evolutionary conservation of heavy chain protein transfer between glycosaminoglycans. 
  • Formation of the alpha 1-microglobulin chromophore in mammalian and insect cells: a novel post-translational mechanism? 
  • Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase. 
  • Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. 
  • In vivo metabolism of inter-alpha-trypsin inhibitor and its proteinase complexes: evidence for proteinase transfer to alpha 2-macroglobulin and alpha 1-proteinase inhibitor. 
  • Incorporation of pentraxin 3 into hyaluronan matrices is tightly regulated and promotes matrix cross-linking. 
  • Inflammatory cells degrade inter-alpha inhibitor to liberate urinary proteinase inhibitors. 
  • Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury. 
  • Inter-α-inhibitor impairs TSG-6-induced hyaluronan cross-linking. 
  • Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma. 
  • Mechanism of action of inter-alpha-trypsin inhibitor. 
  • Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II). 
  • Organization of the inter-alpha-inhibitor heavy chains on the chondroitin sulfate originating from Ser(10) of bikunin: posttranslational modification of IalphaI-derived bikunin. 
  • Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. 
  • Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. 
  • Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma. 
  • Reactivity of anti-human C-reactive protein (CRP) and serum amyloid P component (SAP) monoclonal antibodies with limulin and pentraxins of other species. 
  • Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury. 
  • Steroid hormone regulation of specific gene expression. 
  • Structure of inter-alpha-inhibitor (inter-alpha-trypsin inhibitor) and pre-alpha-inhibitor: current state and proposition of a new terminology. 
  • The TSG-6 and I alpha I interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link. 
  • The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans. 
  • The role of inter-alpha-trypsin inhibitor and other proteinase inhibitors in the plasma clearance of neutrophil elastase and plasmin. 
  • The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2. 
  • Transfer of inter-alpha-inhibitor heavy chains to hyaluronan by surface-linked hyaluronan-TSG-6 complexes. 
  • alpha 1-Microglobulin destroys the proteinase inhibitory activity of alpha 1-inhibitor-3 by complex formation. 
  • alpha 2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats.