Eflornithine

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  Subject Areas on Research

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase. 
  • Acute difluoromethylornithine treatment increases skin flap survival in rats. 
  • Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine showing correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels. 
  • Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine. 
  • Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. 
  • Autoradiographic localization of ornithine decarboxylase in cerebellar cortex of the developing rat with [3H]alpha-difluoromethylornithine. 
  • Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. 
  • Critical development periods for inhibition of ornithine decarboxylase by alpha-difluoromethylornithine: effects on ontogeny of sensorimotor behavior. 
  • Dendritic development of Purkinje and granule cells in the cerebellar cortex of rats treated postnatally with alpha-difluoromethylornithine. 
  • Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. 
  • Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition. 
  • Effect of epidermal growth factor on ornithine decarboxylase activity in A431 cells. 
  • Effect of intravenous alpha-difluoromethylornithine on the polyamine levels of normal tissue and a transplantable fibrosarcoma. 
  • Effects of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity. 
  • Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma. 
  • Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase. 
  • Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine. 
  • Impaired morphological development of the dorsal cochlear nucleus in hamsters treated postnatally with alpha-difluoromethylornithine. 
  • In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry. 
  • Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth. 
  • Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. 
  • Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. 
  • Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth. 
  • Ontogenetic changes in laminar distribution of ornithine decarboxylase during development of cerebellar cortex: autoradiographic localization with [3H]alpha-difluoromethylornithine. 
  • Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. 
  • Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair. 
  • Polyamine metabolism in different pathological states of the brain. 
  • Polyamine metabolism in reversible cerebral ischemia: effect of alpha-difluoromethylornithine. 
  • Polyamine-directed preferential nutritional repletion of normal tissues in tumor-bearing hosts. 
  • Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block. 
  • Polyamines as intermediates in developmental neurotoxic events. 
  • Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase. 
  • Postnatal development of brain alpha 1-adrenergic receptors: in vitro autoradiography with [125I]HEAT in normal rats and rats treated with alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. 
  • Prenatal alpha-difluoromethylornithine treatment: effects on postnatal renal growth and function in the rat. 
  • Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion. 
  • Reduced cell death in skin flaps in rats treated with difluoromethylornithine. 
  • Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity. 
  • Role of ornithine decarboxylase and the polyamines in nervous system development: a review. 
  • Role of ornithine decarboxylase in cardiac growth and hypertrophy. 
  • Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. 
  • Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine. 
  • Whole body hyperthermia and heat-sensitizing drugs: a pilot study in canine lymphoproliferative disease. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology