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Subject Areas on Research
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase.
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Acute difluoromethylornithine treatment increases skin flap survival in rats.
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Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine showing correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels.
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Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine.
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Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
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Autoradiographic localization of ornithine decarboxylase in cerebellar cortex of the developing rat with [3H]alpha-difluoromethylornithine.
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Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
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Critical development periods for inhibition of ornithine decarboxylase by alpha-difluoromethylornithine: effects on ontogeny of sensorimotor behavior.
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Dendritic development of Purkinje and granule cells in the cerebellar cortex of rats treated postnatally with alpha-difluoromethylornithine.
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Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.
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Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition.
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Effect of epidermal growth factor on ornithine decarboxylase activity in A431 cells.
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Effect of intravenous alpha-difluoromethylornithine on the polyamine levels of normal tissue and a transplantable fibrosarcoma.
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Effects of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity.
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Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma.
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Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
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Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine.
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Impaired morphological development of the dorsal cochlear nucleus in hamsters treated postnatally with alpha-difluoromethylornithine.
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In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry.
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Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth.
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Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.
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Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth.
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Ontogenetic changes in laminar distribution of ornithine decarboxylase during development of cerebellar cortex: autoradiographic localization with [3H]alpha-difluoromethylornithine.
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Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
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Polyamine-directed preferential nutritional repletion of normal tissues in tumor-bearing hosts.
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Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block.
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Polyamines as intermediates in developmental neurotoxic events.
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Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase.
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Postnatal development of brain alpha 1-adrenergic receptors: in vitro autoradiography with [125I]HEAT in normal rats and rats treated with alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
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Prenatal alpha-difluoromethylornithine treatment: effects on postnatal renal growth and function in the rat.
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Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion.
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Reduced cell death in skin flaps in rats treated with difluoromethylornithine.
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Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity.
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Role of ornithine decarboxylase and the polyamines in nervous system development: a review.
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Role of ornithine decarboxylase in cardiac growth and hypertrophy.
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Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
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Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine.
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Whole body hyperthermia and heat-sensitizing drugs: a pilot study in canine lymphoproliferative disease.
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