Amino Acid Sequence

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  Subject Areas on Research

  • (1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein. 
  • (i, i + 4) Ion pairs stabilize helical peptides derived from smooth muscle caldesmon. 
  • 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts. 
  • 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1. 
  • 15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus. 
  • 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. 
  • 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. 
  • 4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. 
  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species. 
  • A 3.8 Å resolution cryo-EM structure of a small protein bound to an imaging scaffold. 
  • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. 
  • A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 
  • A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data. 
  • A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. 
  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. 
  • A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. 
  • A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13. 
  • A Hausdorff-based NOE assignment algorithm using protein backbone determined from residual dipolar couplings and rotamer patterns. 
  • A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency. 
  • A Lysine Residue Essential for Geminivirus Replication Also Controls Nuclear Localization of the Tomato Yellow Leaf Curl Virus Rep Protein. 
  • A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination. 
  • A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 
  • A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. 
  • A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. 
  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. 
  • A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin. 
  • A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries. 
  • A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. 
  • A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division. 
  • A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A candidate taste receptor gene near a sweet taste locus. 
  • A carcinoembryonic antigen (CEA) binding protein from ascites influences CEA uptake by macrophages. 
  • A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells. 
  • A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility. 
  • A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. 
  • A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques. 
  • A comparison of regulatory features in primate lentiviruses. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A comparison of the structure of hamster pancreatic insulin and insulin extracted from a transplantable hamster islet-cell carcinoma. 
  • A comprehensive panel of near-full-length clones and reference sequences for non-subtype B isolates of human immunodeficiency virus type 1. 
  • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. 
  • A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. 
  • A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. 
  • A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. 
  • A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. 
  • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. 
  • A conserved family of enzymes that phosphorylate inositol hexakisphosphate. 
  • A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope. 
  • A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor. 
  • A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. 
  • A critical role of STAYGREEN/Mendel's I locus in controlling disease symptom development during Pseudomonas syringae pv tomato infection of Arabidopsis. 
  • A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. 
  • A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. 
  • A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection. 
  • A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. 
  • A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago. 
  • A family of candidate taste receptors in human and mouse. 
  • A family of receptors coupled to guanine nucleotide regulatory proteins. 
  • A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. 
  • A functional proteomics approach to signal transduction. 
  • A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1. 
  • A gain-of-function mutation in IAA16 confers reduced responses to auxin and abscisic acid and impedes plant growth and fertility. 
  • A gain-of-function mutation in a plant disease resistance gene leads to constitutive activation of downstream signal transduction pathways in the snc1 mutant 
  • A gain-of-function polymorphism controlling complex traits and fitness in nature. 
  • A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. 
  • A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic. 
  • A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus. 
  • A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function. 
  • A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome). 
  • A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors. 
  • A human protein related to yeast Cdc6p. 
  • A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). 
  • A kinesin motor in a force-producing conformation. 
  • A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. 
  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
  • A member of a family of sulfate-activating enzymes causes murine brachymorphism. 
  • A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. 
  • A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. 
  • A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. 
  • A model for alignment of Env V1 and V2 hypervariable domains from human and simian immunodeficiency viruses. 
  • A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels. 
  • A molecular analysis of hyalin--a substrate for cell adhesion in the hyaline layer of the sea urchin embryo. 
  • A molecular basis for MHC class II--associated autoimmunity. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3. 
  • A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. 
  • A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. 
  • A multigene family encoding a diverse array of putative pheromone receptors in mammals. 
  • A multimember kinesin gene family in Drosophila. 
  • A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. 
  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. 
  • A negative coregulator for the human ER. 
  • A neural survival factor is a candidate oncogene in breast cancer. 
  • A neutralizing epitope of the superantigen SEA has agonist activity on T cells. 
  • A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice. 
  • A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. 
  • A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins. 
  • A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. 
  • A new kinesin tree. 
  • A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. 
  • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. 
  • A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. 
  • A novel alternative splice domain in zebrafish tenascin-C. 
  • A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation. 
  • A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype. 
  • A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. 
  • A novel dwarfing mutation in a green revolution gene from Brassica rapa. 
  • A novel human endogenous retroviral protein inhibits cell-cell fusion. 
  • A novel leptin receptor isoform in rat. 
  • A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. 
  • A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. 
  • A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. 
  • A novel polypeptide secreted by activated human T lymphocytes. 
  • A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. 
  • A novel relaxase homologue is involved in chromosomal DNA processing for type IV secretion in Neisseria gonorrhoeae. 
  • A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs. 
  • A novel thermostable branching enzyme from an extremely thermophilic bacterial species, Rhodothermus obamensis. 
  • A novel two-component hybrid molecule regulates vascular morphogenesis of the Arabidopsis root. 
  • A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. 
  • A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae. 
  • A patient with Ehlers-Danlos syndrome type VI is a compound heterozygote for mutations in the lysyl hydroxylase gene. 
  • A peptide sequence on carcinoembryonic antigen binds to a 80kD protein on Kupffer cells. 
  • A phase II study of two HIV type 1 envelope vaccines, comparing their immunogenicity in populations at risk for acquiring HIV type 1 infection. AIDS Vaccine Evaluation Group. 
  • A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. 
  • A positive addition to a negative tail's tale. 
  • A potential therapeutic application of SET/I2PP2A inhibitor OP449 for canine T-cell lymphoma. 
  • A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides. 
  • A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii. 
  • A proteogenomic survey of the Medicago truncatula genome. 
  • A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. 
  • A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity. 
  • A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. 
  • A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. 
  • A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. 
  • A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. 
  • A self-adjuvanting supramolecular vaccine carrying a folded protein antigen. 
  • A self-assembling peptide acting as an immune adjuvant. 
  • A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. 
  • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. 
  • A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. 
  • A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells. 
  • A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. 
  • A single amino acid defines cross-species reactivity of tree shrew (Tupaia belangeri) CD1d to human invariant natural killer T (iNKT) cells. 
  • A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. 
  • A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability. 
  • A solid sample preparation method that reduces signal suppression effects in the MALDI analysis of peptides. 
  • A stochastic evolutionary model for protein structure alignment and phylogeny. 
  • A strategy for the rapid identification of phosphorylation sites in the phosphoproteome. 
  • A structure-based mechanism for drug binding by multidrug transporters. 
  • A synthetic peptide homologous to retroviral envelope protein down-regulates TNF-alpha and IFN-gamma mRNA expression. 
  • A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression. 
  • A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition. 
  • A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. 
  • A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. 
  • A third distinct tumor necrosis factor receptor of orthopoxviruses. 
  • A threshold for central T cell tolerance to an inducible serum protein 
  • A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. 
  • A unified model for de novo design of elastin-like polypeptides with tunable inverse transition temperatures. 
  • A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patient. 
  • A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents. 
  • A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251. 
  • A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. 
  • A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. 
  • A yeast cyclophilin gene essential for lactate metabolism at high temperature. 
  • A zebrafish model for the Shwachman-Diamond syndrome (SDS). 
  • ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. 
  • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. 
  • ATP-regulated activity of the plasmin-streptokinase complex: a novel mechanism involving phosphorylation of streptokinase. 
  • Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants. 
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. 
  • Absence of mitochondrial progesterone receptor polymorphisms in women with spontaneous preterm birth. 
  • Absence of mutation in the beta-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer's disease. 
  • Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor. 
  • Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling. 
  • Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes. 
  • Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis. 
  • Act globally, think locally: systems biology addresses the PDZ domain. 
  • Activation of MAP kinase by a dual specificity Tyr/Thr kinase. 
  • Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. 
  • Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. 
  • Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. 
  • Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide. 
  • Activation of interleukin 4- and interleukin 6-secreting cells by HIV-specific synthetic peptides. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Activation of tat-defective human immunodeficiency virus by ultraviolet light. 
  • Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. 
  • Activation-dependent conformational changes in {beta}-arrestin 2. 
  • Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase. 
  • Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. 
  • Adaptive evolution drives the diversification of zinc-finger binding domains. 
  • Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Adducin: structure, function and regulation. 
  • Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. 
  • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. 
  • Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. 
  • Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. 
  • Adrenergic receptors. 
  • Adrenergic receptors. Models for regulation of signal transduction processes. 
  • Adrenergic receptors: recent insights into their mechanism of activation and desensitization. 
  • AepG is a glucuronosyltransferase involved in acidic exopolysaccharide synthesis and contributes to environmental adaptation of Haloarcula hispanica. 
  • Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41. 
  • Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas. 
  • AglR is required for addition of the final mannose residue of the N-linked glycan decorating the Haloferax volcanii S-layer glycoprotein. 
  • Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin. 
  • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. 
  • Algorithm for backrub motions in protein design. 
  • All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. 
  • Allelic and locus heterogeneity in inherited venous malformations. 
  • Allelic diversity and gene genealogy at the self-incompatibility locus in the Solanaceae. 
  • Allosteric interactions in non-alpha chains isolated from normal human hemoglobin, fetal hemoglobin, and hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). 
  • Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. 
  • Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. 
  • Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor. 
  • Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers. 
  • Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. 
  • Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. 
  • Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • Alternative splicing of the BSC1 gene generates tissue-specific isoforms in the German cockroach. 
  • Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. 
  • Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. 
  • Amino acid alterations in fibronectin binding protein A (FnBPA) and bacterial genotype are associated with cardiac device related infection in Staphylococcus aureus bacteraemia. 
  • Amino acid preferences for specific locations at the ends of alpha helices. 
  • Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients. 
  • Amino acid residues in thrombin-sensitive region and first epidermal growth factor domain of vitamin K-dependent protein S determining specificity of the activated protein C cofactor function. 
  • Amino acid sequence of a major apoprotein from hen plasma very low density lipoproteins. 
  • Amino acid sequence of the nucleotide binding region of chloroplast coupling factor 1. 
  • Amino acid sequence of the signal peptide of apoVLDL-II, a major apoprotein in avian very low density lipoproteins. 
  • Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death. 
  • Amino acid sequences of pyridoxal 5'-phosphate binding sites and fluorescence resonance energy transfer in chicken liver fatty acid synthase. 
  • Amino acid sequences of substrate-binding sites in chicken liver fatty acid synthase. 
  • Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C. 
  • Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. 
  • Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. 
  • Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface. 
  • Amplification of a complete simian immunodeficiency virus genome from fecal RNA of a wild chimpanzee. 
  • Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. 
  • An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate. 
  • An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission. 
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. 
  • An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. 
  • An N-terminal truncation of the ncd motor protein supports diffusional movement of microtubules in motility assays. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor. 
  • An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. 
  • An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. 
  • An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. 
  • An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. 
  • An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow. 
  • An effector site that stimulates G-protein GTPase in photoreceptors. 
  • An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies. 
  • An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. 
  • An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. 
  • An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with alpha 2-antiplasmin. 
  • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. 
  • An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. 
  • Analysis of HIV-1 subtype B third variable region peptide motifs for induction of neutralizing antibodies against HIV-1 primary isolates. 
  • Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial. 
  • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. 
  • Analysis of erythropoietin and erythropoietin receptor genes expression in cattle during acute infection with Trypanosoma congolense. 
  • Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. 
  • Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals. 
  • Analysis of partial pol and env sequences indicates a high prevalence of HIV type 1 recombinant strains circulating in Gabon. 
  • Analysis of phenylthiohydantoin amino acid mixtures for sequencing by thermospray liquid chromatography/mass spectrometry. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat. 
  • Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase. 
  • Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila. 
  • Analysis of the glycoproteome of Toxoplasma gondii using lectin affinity chromatography and tandem mass spectrometry. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. 
  • Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. 
  • Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB. 
  • Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. 
  • Ancestral and consensus envelope immunogens for HIV-1 subtype C. 
  • Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. 
  • Angiotensin mediates stimulation of ventilation after vasopressin V1 receptor blockade. 
  • AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide. 
  • Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. 
  • Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia. 
  • Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain. 
  • Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. 
  • Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm. 
  • Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. 
  • Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline. 
  • Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. 
  • Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120. 
  • Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. 
  • Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved. 
  • Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins. 
  • Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein. 
  • Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel. 
  • Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. 
  • Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection. 
  • Antithrombin III, a serpin family protease inhibitor, is a major heparin binding protein in porcine aqueous humor. 
  • ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. 
  • Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. 
  • Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. 
  • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. 
  • Aquaporin 6 binds calmodulin in a calcium-dependent manner. 
  • Aquaporin in Candida: characterization of a functional water channel protein. 
  • Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains. 
  • Aquaporins in Saccharomyces: Characterization of a second functional water channel protein. 
  • Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses. 
  • Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. 
  • Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response. 
  • Arabidopsis Small Rubber Particle Protein Homolog SRPs Play Dual Roles as Positive Factors for Tissue Growth and Development and in Drought Stress Responses. 
  • Arabidopsis iba response5 suppressors separate responses to various hormones. 
  • Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity. 
  • Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. 
  • Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 
  • Arsenic trioxide uptake by human and rat aquaglyceroporins. 
  • Arterial response to shear stress critically depends on endothelial TRPV4 expression. 
  • Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. 
  • Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope. 
  • Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches. 
  • Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240. 
  • Assignment of aliphatic side-chain 1HN/15N resonances in perdeuterated proteins. 
  • Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia. 
  • Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. 
  • Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells. 
  • Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. 
  • Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore. 
  • Atomic structures of tubulin and FtsZ. 
  • Augmentation of human immunodeficiency virus type 1 neutralizing antibody by priming with gp160 recombinant vaccinia and boosting with rgp160 in vaccinia-naive adults. The NIAID AIDS Vaccine Clinical Trials Network. 
  • Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys. 
  • Autism and developmental disability caused by KCNQ3 gain-of-function variants. 
  • Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry. 
  • Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition. 
  • Autoimmunity to munc-18 in Rasmussen's encephalitis. 
  • Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by 'autoantigen complementarity'. 
  • Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. 
  • Autosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3. 
  • Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. 
  • Avid binding of beta A amyloid peptide to its own precursor. 
  • Axl2 integrates polarity establishment, maintenance, and environmental stress response in the filamentous fungus Ashbya gossypii. 
  • B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. 
  • BBK* (Branch and Bound Over K*): A Provable and Efficient Ensemble-Based Protein Design Algorithm to Optimize Stability and Binding Affinity Over Large Sequence Spaces. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. 
  • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. 
  • BW2258U89: a GRP receptor antagonist which inhibits small cell lung cancer growth. 
  • Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin. 
  • Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene. 
  • Bacteriophage T4 mutants hypersensitive to an antitumor agent that induces topoisomerase-DNA cleavage complexes. 
  • Barnacle cement: a polymerization model based on evolutionary concepts. 
  • Basic fibroblast growth factor regulates the conversion of pro-luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons. 
  • Basic residues in the nucleocapsid domain of Gag are critical for late events of HIV-1 budding. 
  • Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels. 
  • Bayesian segmentation of protein secondary structure. 
  • Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. 
  • Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. 
  • Beta-adrenergic receptor kinase: primary structure delineates a multigene family. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. 
  • Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. 
  • Betadoublet: de novo design, synthesis, and characterization of a beta-sandwich protein. 
  • Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens. 
  • BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics. 
  • Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. 
  • Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis. 
  • Bimodal activation of SMC ATPase by intra- and inter-molecular interactions. 
  • Binding of G protein beta gamma-subunits to pleckstrin homology domains. 
  • Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro. 
  • Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain. 
  • Binding site on human immunoglobulin G for the affinity ligand HWRGWV. 
  • Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles. 
  • Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases. 
  • Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells. 
  • Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. 
  • Biochemistry of protein prenylation. 
  • Biogenesis, cellular localization, and functional activation of the heat-stable enterotoxin receptor (guanylyl cyclase C). 
  • Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. 
  • Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus. 
  • Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. 
  • Biophysical highlights from 54 years of macromolecular crystallography. 
  • Biosensor system for continuous monitoring of organophosphate aerosols. 
  • Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773. 
  • Biosynthesis of renin: multiplicity of active and intermediate forms. 
  • Bivalent peptides as PDZ domain ligands. 
  • Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. 
  • Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation. 
  • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. 
  • Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones. 
  • Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs. 
  • Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. 
  • Bridged peptide macrocycles as ligands for PDZ domain proteins. 
  • Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection. 
  • Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1. 
  • Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. 
  • C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways. 
  • C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats. 
  • C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation. 
  • CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. 
  • CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. 
  • CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. 
  • CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. 
  • CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity. 
  • CD20: a regulator of cell-cycle progression of B lymphocytes. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. 
  • CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CD6-ligand interactions: a paradigm for SRCR domain function? 
  • CD6. 
  • CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef. 
  • CFTR: development of high- affinity antibodies and localization in sweat gland. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. 
  • CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches. 
  • CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels. 
  • CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90. 
  • COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis. 
  • COMMD proteins, a novel family of structural and functional homologs of MURR1. 
  • CSGALNACT1-congenital disorder of glycosylation: A mild skeletal dysplasia with advanced bone age. 
  • CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. 
  • CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. 
  • Ca(2+)-dependent interaction of recoverin with rhodopsin kinase. 
  • Ca(2+)-regulated serine protease associated with the nuclear scaffold. 
  • Ca(2+)/CaM-dependent kinases: from activation to function. 
  • Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. 
  • Ca2+/calmodulin-dependent protein kinase IV and calcium signaling. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. 
  • Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. 
  • Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. 
  • Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy. 
  • Calcineurin is required for virulence of Cryptococcus neoformans. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. 
  • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. 
  • Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. 
  • Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues. 
  • Calcium binding is required for calmodulin function in Aspergillus nidulans. 
  • Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. 
  • Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells. 
  • Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. 
  • Calmodulin activation of target enzymes. Consequences of deletions in the central helix. 
  • Calmodulin binds to caldesmon in an antiparallel manner. 
  • Calmodulin mediates Ca2+ sensitivity of sodium channels. 
  • Calmodulin supports both inactivation and facilitation of L-type calcium channels. 
  • Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation. 
  • Calmodulin: a prototypical calcium sensor. 
  • Calspermin is a testis specific calmodulin-binding protein closely related to Ca2+/calmodulin-dependent protein kinases. 
  • Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM. 
  • Capric acid and hydroxypropylmethylcellulose increase the immunogenicity of nasally administered peptide vaccines. 
  • Carcinoembryonic antigen binding to Kupffer cells is via a peptide located at the junction of the N-terminal and first loop domains. 
  • Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. 
  • Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. 
  • Casein kinase I: another cog in the circadian clockworks. 
  • Casein kinase II copurifies with yeast DNA topoisomerase II and re-activates the dephosphorylated enzyme. 
  • Catecholamine receptors: structure, function, and regulation. 
  • Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption. 
  • Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. 
  • Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. 
  • Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Cellular and molecular biology of the aquaporin water channels. 
  • Cellular functions of metallo-endoproteinases. 
  • Cellular immune response to cryptic epitopes during therapeutic gene transfer. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Cellular mechanisms of wingless/Wnt signal transduction. 
  • Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. 
  • Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. 
  • Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. 
  • Characterization and expression of a rice RAD23 gene. 
  • Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. 
  • Characterization and expression of the unique calmodulin gene of Aspergillus nidulans. 
  • Characterization and partial amino acid sequence of human plasma glutathione peroxidase. 
  • Characterization and structure of the manganese-responsive transcriptional regulator ScaR. 
  • Characterization of COMMD protein-protein interactions in NF-kappaB signalling. 
  • Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor. 
  • Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain. 
  • Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes. 
  • Characterization of RanBP2-associated molecular components in neuroretina. 
  • Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop. 
  • Characterization of a UBC13 kinase in Plasmodium falciparum. 
  • Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21. 
  • Characterization of a cDNA for the unexpressed form of cytochrome P-450g from the (-g) rat and differentiation of its mRNA from that of the (+g) phenotype using specific oligoprobes. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. 
  • Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. 
  • Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. 
  • Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope. 
  • Characterization of a trimeric MPER containing HIV-1 gp41 antigen. 
  • Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings. 
  • Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. 
  • Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe. 
  • Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli. 
  • Characterization of canine intestinal cholecystokinin-58 lacking its carboxyl-terminal nonapeptide. Evidence for similar post-translational processing in brain and gut. 
  • Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice. 
  • Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. 
  • Characterization of fragment E from fibrinogen and cross-linked fibrin. 
  • Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. 
  • Characterization of gelatinases linked to extracellular matrix invasion in ovarian adenocarcinoma: purification of matrix metalloproteinase 2. 
  • Characterization of glycosylation profiles of HIV-1 transmitted/founder envelopes by mass spectrometry. 
  • Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins. 
  • Characterization of human brain cDNA encoding the general isoform of beta-spectrin. 
  • Characterization of human immunodeficiency virus type 1 in saliva and blood plasma by V3-specific heteroduplex tracking assay and genotype analyses. 
  • Characterization of immunophilins in the silkmoth Bombyx mori. 
  • Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. 
  • Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B. 
  • Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. 
  • Characterization of primary isolate-like variants of simian-human immunodeficiency virus. 
  • Characterization of prorenin activation using a synthetic peptide substrate. 
  • Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. 
  • Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. 
  • Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion. 
  • Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. 
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. 
  • Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the siroheme-Fe4S4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase. 
  • Characterization of the cystic fibrosis transmembrane conductance regulator in a colonocyte cell line. 
  • Characterization of the flavoprotein moieties of NADPH-sulfite reductase from Salmonella typhimurium and Escherichia coli. Physicochemical and catalytic properties, amino acid sequence deduced from DNA sequence of cysJ, and comparison with NADPH-cytochrome P-450 reductase. 
  • Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region. 
  • Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. 
  • Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. 
  • Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia. 
  • Characterization of the rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila. 
  • Characterization of the role of cadherin in regulating cell adhesion during sea urchin development. 
  • Characterization of the secondary structure of calmodulin in complex with a calmodulin-binding domain peptide. 
  • Characterization of the statin-like S1 and rat elongation factor 1 alpha as two distinctly expressed messages in rat. 
  • Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. 
  • Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase. 
  • Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. 
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. 
  • Characterization of vps33+, a gene required for vacuolar biogenesis and protein sorting in Schizosaccharomyces pombe. 
  • Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. 
  • Chemistry and biology of the ramoplanin family of peptide antibiotics. 
  • Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone. 
  • Chicken perinatal troponin Ts are generated by a combination of novel and phylogenetically conserved alternative splicing pathways. 
  • Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. 
  • Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. 
  • Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes. 
  • Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor. 
  • Chordin is required for neural but not axial development in sea urchin embryos. 
  • Chromosomal localization of gene for human glutamate receptor subunit-7. 
  • Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. 
  • Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. 
  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. 
  • Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. 
  • Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. 
  • Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro. 
  • Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant. 
  • Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer. 
  • Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients. 
  • Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. 
  • Cloned Erwinia chrysanthemi out genes enable Escherichia coli to selectively secrete a diverse family of heterologous proteins to its milieu. 
  • Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor. 
  • Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. 
  • Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons. 
  • Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. 
  • Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. 
  • Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. 
  • Cloning and characterization of a mammalian prenyl protein-specific protease. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Cloning and characterization of two splice variants of human phosphodiesterase 11A. 
  • Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. 
  • Cloning and developmental expression of the chick type II and type III TGF beta receptors. 
  • Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. 
  • Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. 
  • Cloning and expression of full-length cDNA encoding human vitamin D receptor. 
  • Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. 
  • Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling. 
  • Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues. 
  • Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19. 
  • Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65. 
  • Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder. 
  • Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. 
  • Cloning of human androgen receptor complementary DNA and localization to the X chromosome. 
  • Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. 
  • Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog 
  • Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. 
  • Cloning of the cDNA for the human beta 1-adrenergic receptor. 
  • Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. 
  • Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapy. 
  • Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. 
  • Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae. 
  • Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. 
  • Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. 
  • Cloning, expression, and cellular localization of a human prenylcysteine lyase. 
  • Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. 
  • Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. 
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. 
  • Cloning, overexpression, purification, and immunobiology of an 85-kilodalton outer membrane protein from Haemophilus ducreyi. 
  • Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. 
  • Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. 
  • Clostridium taeniosporum spore ribbon-like appendage structure, composition and genes. 
  • Clustered Arg–Gly–Asp peptides enhances tumor targeting of nonviral vectors 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. 
  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 
  • Coat proteins and selective protein packaging into transport vesicles. 
  • Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. 
  • Collision-induced dissociative chemical cross-linking reagents and methodology: Applications to protein structural characterization using tandem mass spectrometry analysis. 
  • Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. 
  • Combinatorial mutagenesis of the reactive site region in plasminogen activator inhibitor I. 
  • Combined antibody-high-performance liquid chromatography approach to assess prohormone processing. 
  • Combining MALDI-FTMS and bioinformatics for rapid peptidomic comparisons. 
  • Combining expression and comparative evolutionary analysis. The COBRA gene family. 
  • Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data. 
  • Common promoter elements in odorant and vomeronasal receptor genes. 
  • Compact organization of rRNA genes in the filamentous fungus Ashbya gossypii. 
  • Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. 
  • Comparative chemical properties of avian oncornavirus polypeptides. 
  • Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes. II. Variant DK1: evidence for a discrete CTL recognition region. 
  • Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes: variants M7 and DR1. 
  • Comparison of HIV Type 1 ADA gp120 monomers versus gp140 trimers as immunogens for the induction of neutralizing antibodies. 
  • Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein. 
  • Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans. 
  • Comparison of plasminogen binding and activation on extracellular matrices produced by vascular smooth muscle and endothelial cells. 
  • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. 
  • Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. 
  • Complete and N-terminal amino-acid sequences of CNBr-peptides CB5 and CB3 from diphteria toxin fragment B [proceedings]. 
  • Complete sequence of the Drosophila nonmuscle myosin heavy-chain transcript: conserved sequences in the myosin tail and differential splicing in the 5' untranslated sequence. 
  • Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophages. 
  • Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation. 
  • Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. 
  • Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. 
  • Comprehensive analysis of commercially available mouse antichicken monoclonal antibodies for cross-reactivity with peripheral blood leukocytes from commercial turkeys. 
  • Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy. 
  • Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals. 
  • Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease. 
  • Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. 
  • Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. 
  • Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. 
  • Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore. 
  • Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore. 
  • Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope. 
  • Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5. 
  • Computational design of receptor and sensor proteins with novel functions. 
  • Concentration-dependent behavior of nisin interaction with supported bilayer lipid membrane. 
  • Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. 
  • Conformational preferences of a chimeric peptide HIV-1 immunogen from the C4-V3 domains of gp120 envelope protein of HIV-1 CAN0A based on solution NMR: comparison to a related immunogenic peptide from HIV-1 RF. 
  • Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions. 
  • Consensus Coexpression Network Analysis Identifies Key Regulators of Flower and Fruit Development in Wild Strawberry. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Conservation of structure and location of Rhizobium meliloti and Klebsiella pneumoniae nifB genes. 
  • Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. 
  • Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors. 
  • Conserved Structural Motif Identified in Peptides That Bind to Geminivirus Replication Protein Rep. 
  • Conserved cAMP signaling cascades regulate fungal development and virulence. 
  • Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells. 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. 
  • Conserved motifs II to VI of DNA helicase II from Escherichia coli are all required for biological activity. 
  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant. 
  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant: corrections and clarifications. 
  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant: further clarifications. 
  • Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold. 
  • Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. 
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. 
  • Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. 
  • Constitutive expression of CaSRP1, a hot pepper small rubber particle protein homolog, resulted in fast growth and improved drought tolerance in transgenic Arabidopsis plants. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms. 
  • Construction and phenotypic characterization of HIV type 1 functional envelope clones of subtypes G and F. 
  • Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design. 
  • Construction of a fluorescent biosensor family. 
  • Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center. 
  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. 
  • Contractile proteins in Drosophila development. 
  • Contribution of a 28-kilodalton membrane protein to the virulence of Haemophilus influenzae. 
  • Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae. 
  • Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding. 
  • Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. 
  • Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0. 
  • Control of morphology and virulence by ADP-ribosylation factors (Arf) in Mucor circinelloides. 
  • Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I. 
  • Control of the orientational order and nonlinear optical response of the "push-pull" chromophore RuPZn via specific incorporation into densely packed monolayer ensembles of an amphiphilic four-helix bundle peptide: characterization of the peptide-chromophore complexes. 
  • Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. 
  • Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake. 
  • Controlled release of biologics for the treatment of type 2 diabetes. 
  • Convergent evolution of escape from hepaciviral antagonism in primates. 
  • Conversion of an immunogenic human immunodeficiency virus (HIV) envelope synthetic peptide to a tolerogen in chimpanzees by the fusogenic domain of HIV gp41 envelope protein. 
  • Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. 
  • Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. 
  • Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1. 
  • Cordon-bleu is a conserved gene involved in neural tube formation. 
  • Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 
  • Correlation between env V1/V2 region diversification and neutralizing antibodies during primary infection by simian immunodeficiency virus sm in rhesus macaques. 
  • Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. 
  • Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel. 
  • Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. 
  • Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Creativity comes from interactions: modules of protein interactions in plants. 
  • Crk is required for apoptosis in Xenopus egg extracts. 
  • Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. 
  • Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. 
  • Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. 
  • Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae. 
  • Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. 
  • Crystal structure of MtaN, a global multidrug transporter gene activator. 
  • Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region. 
  • Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. 
  • Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. 
  • Crystal structure of an activated response regulator bound to its target. 
  • Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. 
  • Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution. 
  • Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation. 
  • Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. 
  • Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW. 
  • Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. 
  • Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. 
  • Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. 
  • Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. 
  • Crystal structures of the membrane-binding C2 domain of human coagulation factor V. 
  • Crystallization and preliminary x-ray studies of NADPH-cytochrome P450 reductase. 
  • Crystallization of a Complex Between MYC and Jas Motif. 
  • Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine. 
  • Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. 
  • Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cyclin-binding motifs are essential for the function of p21CIP1. 
  • Cysteine-rich regions of pig gastric mucin contain von willebrand factor and cystine knot domains at the carboxyl terminal(1). 
  • Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses. 
  • Cytoplasmic domain truncation enhances fusion activity by the exterior glycoprotein complex of human immunodeficiency virus type 2 in selected cell types. 
  • Cytoskeletal actin gene families of Xenopus borealis and Xenopus laevis. 
  • DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. 
  • DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3. 
  • DNA bending near the replication origin of IncFII plasmid NR1. 
  • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. 
  • DNA polymerase delta is required for human mismatch repair in vitro. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • DNA sequence analysis of X-ray induced Adh null mutations in Drosophila melanogaster. 
  • DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy. 
  • De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas. 
  • De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. 
  • De novo design of a single-chain diphenylporphyrin metalloprotein. 
  • De novo design, expression, and characterization of Felix: a four-helix bundle protein of native-like sequence. 
  • De novo engineering of intracellular condensates using artificial disordered proteins. 
  • De novo heterozygous missense and loss-of-function variants in CDC42BPB are associated with a neurodevelopmental phenotype. 
  • De novo variants in the alternative exon 5 of SCN8A cause epileptic encephalopathy. 
  • Defensins: natural anti-HIV peptides. 
  • Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. 
  • Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria. 
  • Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA. 
  • Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. 
  • Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. 
  • Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. 
  • Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. 
  • Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. 
  • Deletion of carboxy-terminal residues of murine granulocyte-macrophage colony-stimulating factor results in a loss of biologic activity and altered glycosylation. 
  • Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. 
  • Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function. 
  • Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. 
  • Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. 
  • Dependence of germinal center B cells on expression of CD21/CD35 for survival. 
  • Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4. 
  • Derivation of a biologically contained replication system for human immunodeficiency virus type 1. 
  • Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks). 
  • Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet. 
  • Design of a novel small peptide targeted against a tumor-specific receptor. 
  • Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies. 
  • Design of experimental synthetic peptide immunogens for prevention of HIV-1 and HTLV-I retroviral infections. 
  • Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus. 
  • Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Design, selection, and development of cyclic peptide ligands for human erythropoietin. 
  • Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease. 
  • Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1. 
  • Designing an extracellular matrix protein with enhanced mechanical stability. 
  • Detection and characterization of methionine oxidation in peptides by collision-induced dissociation and electron capture dissociation. 
  • Detection of amino-terminal extracellular domain of somatostatin receptor 2 by specific monoclonal antibodies and quantification of receptor density in medulloblastoma. 
  • Detection of mucosal antibodies in HIV type 1-infected individuals. 
  • Detection of murine cytomegalovirus immediate early 1 transcripts in the spleens of latently infected mice. 
  • Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity. 
  • Determinants of Tenascin-C and HIV-1 envelope binding and neutralization. 
  • Determinants of kinesin motor polarity. 
  • Determinants of molecular motor directionality. 
  • Determination of bioactive peptides using capillary zone electrophoresis/mass spectrometry. 
  • Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling. 
  • Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly. 
  • Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization. 
  • Development of a vaccine for the prevention of AIDS, a critical appraisal. 
  • Development of an on-line preconcentration method for the analysis of pathogenic lipopolysaccharides using capillary electrophoresis-electrospray mass spectrometry. Application to small colony isolates. 
  • Development of mammalian serum albumin affinity purification media by peptide phage display. 
  • Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. 
  • Development of peptide antagonists that target estrogen receptor-cofactor interactions. 
  • Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8. 
  • Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. 
  • Developmentally regulated expression of two members of the Nrarp family in zebrafish. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Diagnostic protein discovery using liquid chromatography/mass spectrometry for proteolytic peptide targeting. 
  • Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis. 
  • Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. 
  • Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia. 
  • Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. 
  • Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras. 
  • Differential adhesion of rat colon carcinoma cells to fibronectin in relation to their tumorigenicity. 
  • Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes. 
  • Differential expression of S1 and elongation factor-1 alpha during rat development. 
  • Differential expression of gamma-aminobutyric acidA receptor subunits. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates. 
  • Differential gene expression from a single transcription unit during spermatogenesis. 
  • Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack. 
  • Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. 
  • Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. 
  • Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. 
  • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. 
  • Differentiation of strains in Mycobacterium tuberculosis complex by DNA sequence polymorphisms, including rapid identification of M. bovis BCG. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. 
  • Diminished class II-associated Ii peptide binding to the juvenile dermatomyositis HLA-DQ alpha 1*0501/DQ beta 1*0301 molecule. 
  • Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B. 
  • Direct sequencing of the activation peptide and the catalytic domain of the factor IX gene in six species. 
  • Directed evolution of recombinase specificity by split gene reassembly. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. 
  • Disarming the mustard oil bomb. 
  • Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A. 
  • Discovery of Thermostable, Fluorescently Responsive Glucose Biosensors by Structure-Assisted Function Extrapolation. 
  • Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. 
  • Discovery of prosimian and afrotherian foamy viruses and potential cross species transmissions amidst stable and ancient mammalian co-evolution. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. 
  • Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. 
  • Disruption of the toxic conformation of the expanded polyglutamine stretch leads to suppression of aggregate formation and cytotoxicity. 
  • Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. 
  • Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs. 
  • Distinct CD4+ helper T cells involved in primary and secondary responses to infection. 
  • Distinct Regions of the Haloferax volcanii Dolichol Phosphate-Mannose Synthase AglD Mediate the Assembly and Subsequent Processing of the Lipid-Linked Mannose. 
  • Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. 
  • Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens. 
  • Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection. 
  • Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila. 
  • Distribution of immunoreactive androgen-binding protein/sex hormone-binding globulin in tissues of the fetal rat. 
  • Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. 
  • Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. 
  • Disulfide bond requirements for active Wnt ligands. 
  • Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain. 
  • Diverse proteins homologous to inositol monophosphatase. 
  • Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. 
  • Diversity and organization of human T cell receptor delta variable gene segments. 
  • Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid. 
  • Diversity of full-length subtype E HIV type 1 env sequences in early seroconvertors from northern Thailand. 
  • Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA. 
  • Domain structure and DNA binding regions of beta protein from bacteriophage lambda. 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. 
  • Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases. 
  • Dr(a-) polymorphism of decay accelerating factor. Biochemical, functional, and molecular characterization and production of allele-specific transfectants. 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. 
  • Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. 
  • Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. 
  • Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. 
  • Drug-associated changes in amino acid residues in Gag p2, p7(NC), and p6(Gag)/p6(Pol) in human immunodeficiency virus type 1 (HIV-1) display a dominant effect on replicative fitness and drug response. 
  • Dual kinase-mediated regulation of PITK by CaMKII and GSK3. 
  • Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site. 
  • Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G. 
  • Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein. 
  • E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. 
  • E3 Ligase AtAIRP5/GARU Regulates Drought Stress Response by Stimulating SERINE CARBOXYPEPTIDASE-LIKE1 Turnover 
  • EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. 
  • ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. 
  • ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. 
  • Early elicitor induction in members of a novel multigene family coding for highly related RING-H2 proteins in Arabidopsis thaliana 
  • Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. 
  • Ectopic expression of mucins in colorectal cancer metastasis. 
  • Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide. 
  • Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission. 
  • Effect of bilirubin UDP glucuronosyltransferase 1 gene TATA box genotypes on serum bilirubin concentrations in chronic liver injuries. 
  • Effect of desialylation on the biological properties of human plasminogen. 
  • Effect of heterologous factor V heavy chain sequences on the secretion of recombinant human factor VIII. 
  • Effect of pH and anions on functional properties of hemoglobin from Lemur fulvus fulvus. 
  • Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity? 
  • Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. 
  • Effects of mutant Ran/TC4 proteins on cell cycle progression. 
  • Elastin-like polypeptides as models of intrinsically disordered proteins. 
  • Elastin-like polypeptides: biomedical applications of tunable biopolymers. 
  • Electron capture dissociation mass spectrometry in characterization of peptides and proteins. 
  • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. 
  • Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. 
  • Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec. 
  • Emergence of SARS-CoV-2 through recombination and strong purifying selection. 
  • Endo16 is required for gastrulation in the sea urchin Lytechinus variegatus. 
  • Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. 
  • Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. 
  • Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB. 
  • Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. 
  • Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells. 
  • Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. 
  • Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. 
  • Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA. 
  • Enhanced HIV-1 neutralization by a CD4-VH3-IgG1 fusion protein. 
  • Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. 
  • Enhanced binding and inertness to dehalogenation of alpha-melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate. 
  • Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology. 
  • Envelope V3 amino acid sequence predicts HIV-1 phenotype (co-receptor usage and tropism for macrophages). 
  • Envelope diversity, coreceptor usage and syncytium-inducing phenotype of HIV-1 variants in saliva and blood during primary infection. 
  • Enzymatic generation of the amino terminus of the beta-amyloid peptide. 
  • Enzymatic modification of proteins with a geranylgeranyl isoprenoid. 
  • Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. 
  • Epithelial cell adherence mediated by the enterotoxigenic Escherichia coli tia protein. 
  • Epitope insertion into variable loops of HIV-1 gp120 as a potential means to improve immunogenicity of viral envelope protein. 
  • Epitope tagging for tracking elastin-like polypeptides. 
  • Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. 
  • Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythropoietin receptor contains both growth-promoting activity and differentiation-promoting activity. 
  • Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure. 
  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. 
  • Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. 
  • Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. 
  • Estrogen receptor-cofactor interactions as targets for novel drug discovery. 
  • Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation. 
  • Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. 
  • Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain. 
  • Evaluation of ligand-dependent changes in AR structure using peptide probes. 
  • Evidence against posttranslational glycosylation of rat glucocorticoid receptors. 
  • Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. 
  • Evidence for a disease-resistance pathway in rice similar to the NPR1-mediated signaling pathway in Arabidopsis. 
  • Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. 
  • Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2. 
  • Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. 
  • Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. 
  • Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. 
  • Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport. 
  • Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas. 
  • Evidence that CCK-58 has structure that influences its biological activity. 
  • Evidence that calpains and elastase do not produce the von Willebrand factor fragments present in normal plasma and IIA von Willebrand disease. 
  • Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. 
  • Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. 
  • Evidence that structural variants within the human delta-globin protein may reflect genetic interactions between the delta- and beta-globin genes. 
  • Evolution and diversity in human herpes simplex virus genomes. 
  • Evolution of budding yeast prion-determinant sequences across diverse fungi. 
  • Evolution of graded refractive index in squid lenses. 
  • Evolution of regeneration and fission in annelids: insights from engrailed- and orthodenticle-class gene expression. 
  • Evolution of the 12 kDa FK506-binding protein gene. 
  • Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. 
  • Evolution of the cytoskeleton. 
  • Evolution of the sex-related locus and genomic features shared in microsporidia and fungi. 
  • Evolutionary implications of primate endogenous retroviruses. 
  • Evolutionary mechanisms for eucaryotic genes. 
  • Excitation-contraction coupling in airway smooth muscle. 
  • Exon skipping in purine nucleoside phosphorylase mRNA processing leading to severe immunodeficiency. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus. 
  • Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 
  • Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. 
  • Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies. 
  • Expression and function of the uvsW gene of bacteriophage T4. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression and functional characterization of chimeras between human and bovine vitamin-K-dependent protein-S-defining modules important for the species specificity of the activated protein C cofactor activity. 
  • Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase. 
  • Expression cloning and characterization of the TGF-beta type III receptor. 
  • Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. 
  • Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. 
  • Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. 
  • Expression of Sry, the mouse sex determining gene. 
  • Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. 
  • Expression of a copper-containing amine oxidase by human ciliary body. 
  • Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL). 
  • Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. 
  • Expression of an EF-1 alpha-like rat cDNA, S1, in E. coli and production of a rabbit polyclonal antiserum to the recombinant protein. 
  • Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line. 
  • Expression of cyp26b1 during zebrafish early development. 
  • Expression of erythropoietin receptor splice variants in human cancer. 
  • Expression of human protein phosphatase-1 in Saccharomyces cerevisiae highlights the role of phosphatase isoforms in regulating eukaryotic functions. 
  • Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. 
  • Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells. 
  • Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae. 
  • Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans. 
  • Expression of the vaccinia virus A2.5L redox protein is required for virion morphogenesis. 
  • Expression of transforming growth factor-beta type II receptor in rat lung is regulated during development. 
  • Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. 
  • Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. 
  • Extensive junctional diversity of rearranged human T cell receptor delta genes. 
  • Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Extracellular secretion of pectate lyase by the Erwinia chrysanthemi out pathway is dependent upon Sec-mediated export across the inner membrane. 
  • Extrinsic pathway proteolytic activity. 
  • FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG). 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. 
  • FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. 
  • FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. 
  • FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis 
  • FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans. 
  • FOXP2 variation in great ape populations offers insight into the evolution of communication skills. 
  • Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. 
  • Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. 
  • Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. 
  • Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation. 
  • Fibrin specific peptides derived by phage display: characterization of peptides and conjugates for imaging. 
  • Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. 
  • FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria. 
  • Fine mapping of the Pc locus of Sorghum bicolor, a gene controlling the reaction to a fungal pathogen and its host-selective toxin. 
  • Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. 
  • Finishing the euchromatic sequence of the human genome. 
  • Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells. 
  • Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA. 
  • Fluorescent probes as indicators of conformation changes in transducin on activation. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. 
  • Folding mechanism of a multiple independently-folding domain protein: double B domain of protein A. 
  • Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. 
  • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 
  • From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. 
  • Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. I. In vitro studies. 
  • Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. II. In vivo studies. 
  • Functional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same Gene. 
  • Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques. 
  • Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. 
  • Functional analysis of SPINDLY in gibberellin signaling in Arabidopsis. 
  • Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling. 
  • Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II. 
  • Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain. 
  • Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors. 
  • Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation. 
  • Functional characterization of medaka CYP3A38 and CYP3A40: kinetics and catalysis by expression in a recombinant baculovirus system. 
  • Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene. 
  • Functional development of the T cell receptor for antigen. 
  • Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes. 
  • Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. 
  • Functional domains of the ubiquitous chromatin protein DEK. 
  • Functional equivalence of an evolutionarily conserved RNA binding module. 
  • Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia. 
  • Functional expression of a MAP kinase kinase in COS cells and recognition by an anti-STE7/byr1 antibody. 
  • Functional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels. 
  • Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. 
  • Functional interrogation and mining of natively paired human VH:VL antibody repertoires. 
  • Functional properties of carboxypeptidase-digested hemoglobins. 
  • Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue. 
  • Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. 
  • Functional reconstitution of purified human Hv1 H+ channels. 
  • Functional selection of protease inhibitory antibodies. 
  • Functional significance of the central helix in calmodulin. 
  • Functionalized micellar assemblies prepared via block copolymers synthesized by living free radical polymerization upon peptide-loaded resins. 
  • Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. 
  • Functionally important regions of the factor IX gene have a low rate of polymorphism and a high rate of mutation in the dinucleotide CpG. 
  • Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. 
  • Fungal and algal gene expression in early developmental stages of lichen-symbiosis. 
  • Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation. 
  • Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. 
  • G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. 
  • G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. 
  • G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. 
  • G-protein-linked signal transduction systems control development in Dictyostelium. 
  • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. 
  • GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. 
  • GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. 
  • GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity. 
  • Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae. 
  • Gamma-phosphate-linked ATP-sepharose for the affinity purification of protein kinases. Rapid purification to homogeneity of skeletal muscle mitogen-activated protein kinase kinase. 
  • Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease. 
  • Gastrulation. 
  • Gating currents from a delayed rectifier K+ channel with altered pore structure and function. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene up-regulation in heart during mammalian hibernation. 
  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics. 
  • Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples. 
  • Generation of high curvature membranes mediated by direct endophilin bilayer interactions. 
  • Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzees. 
  • Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD. 
  • Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent. 
  • Genetic and phenotypic changes accompanying the emergence of epizootic subtype IC Venezuelan equine encephalitis viruses from an enzootic subtype ID progenitor. 
  • Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. 
  • Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. 
  • Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells. 
  • Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology. 
  • Genetic engineering of a single-chain antibody fragment for surface immobilization in an optical biosensor. 
  • Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain. 
  • Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies. 
  • Genetic structure and DNA sequences at junctions involved in the rearrangements of Bacillus subtilis strains carrying the trpE26 mutation. 
  • Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. 
  • Genetic variation in yellow fever virus: duplication in the 3' noncoding region of strains from Africa. 
  • Genetic variation of HIV type 1 in four World Health Organization-sponsored vaccine evaluation sites: generation of functional envelope (glycoprotein 160) clones representative of sequence subtypes A, B, C, and E. WHO Network for HIV Isolation and Characterization. 
  • Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria. 
  • Genetically Encoded Elastin-Like Polypeptides for Drug Delivery. 
  • Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages. 
  • Genetically divergent strains of human immunodeficiency virus type 2 use multiple coreceptors for viral entry. 
  • Genetically encoded elastin-like polypeptide nanoparticles for drug delivery. 
  • Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system. 
  • Genetically engineered calmodulins differentially activate target enzymes. 
  • Genome maps 7. The human transcript map. Wall chart. 
  • Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects. 
  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genome-wide survey and expression analysis of the OSCA gene family in rice. 
  • Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements. 
  • Genomic organization and cloning of the human homologue of murine Sipa-1. 
  • Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape. 
  • Genomic structure and amino acid sequence domains of the human La autoantigen. 
  • Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). 
  • Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio). 
  • Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development. 
  • Genotype is an important determinant of phenotype in adenosine deaminase deficiency. 
  • Getting a grip on the CTD of Pol II. 
  • Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences. 
  • Gill-specific transcriptional regulation of Na+/K+ -ATPase alpha-subunit in the euryhaline shore crab Pachygrapsus marmoratus: sequence variants and promoter structure. 
  • Glioblastoma multiforme and the epidermal growth factor receptor. 
  • Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration. 
  • Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodies. 
  • Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). 
  • Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport. 
  • Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis. 
  • Glyceraldehyde-3-phosphate dehydrogenase is regulated on a daily basis by the circadian clock. 
  • Glycogen storage disease type IV: novel mutations and molecular characterization of a heterogeneous disorder. 
  • Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help. 
  • Glycosyl phosphatidylinositol-linked blood group antigens and paroxysmal nocturnal hemoglobinuria. 
  • Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers. 
  • Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility. 
  • Glycosylation site-specific analysis of clade C HIV-1 envelope proteins. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT). 
  • Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. 
  • Gz, a guanine nucleotide-binding protein with unique biochemical properties. 
  • HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins. 
  • HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172. 
  • HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. 
  • HIV type 1 V3 region primer-induced antibody suppression is overcome by administration of C4-V3 peptides as a polyvalent immunogen. 
  • HIV type 1 subtypes in Malaysia, determined with serologic assays: 1992-1996. 
  • HIV vaccine development at Duke University Medical Center. 
  • HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. 
  • HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection. 
  • HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. 
  • HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression. 
  • HIV-1 intrapatient sequence diversity in the immunogenic V3 region. 
  • HIV-1 neutralizing antibody and approaches to the envelope diversity problem. 
  • HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide. 
  • HIV-1 sequence subtype D in the United States. 
  • HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. 
  • HLA-A2 mutants immunoselected in vitro. Definition of residues contributing to an HLA-A2-specific serological determinant. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HNF-3 beta as a regulator of floor plate development. 
  • Halobacterium salinarum NRC-1 PeptideAtlas: toward strategies for targeted proteomics and improved proteome coverage. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Harpin, elicitor of the hypersensitive response produced by the plant pathogen Erwinia amylovora. 
  • Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? 
  • Helix lap-joints as ion-binding sites: DNA-binding motifs and Ca-binding "EF hands" are related by charge and sequence reversal. 
  • Hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site. 
  • Hemoglobins from trout: structural and functional properties. 
  • Hemoglobins of two terebellid polychaetes: Enoplobranchus sanguineus and Amphitrite ornata. 
  • Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. 
  • Heparin oligosaccharides enhance tissue-type plasminogen activator: a correlation between oligosaccharide length and stimulation of plasminogen activation. 
  • Hepatic HKDC1 Expression Contributes to Liver Metabolism. 
  • Heterogeneity of angiotensin synthetic pathways and receptor subtypes: physiological and pharmacological implications. 
  • Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. 
  • Heterologous neutralizing antibody induction in a simian-human immunodeficiency virus primate model: lack of original antigenic sin. 
  • Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling. 
  • Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. 
  • Hierarchical Bayesian mixture modelling for antigen-specific T-cell subtyping in combinatorially encoded flow cytometry studies. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. 
  • High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. 
  • High resolution AFM topographs of the Escherichia coli water channel aquaporin Z. 
  • High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccination. 
  • High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. 
  • High-level expression of Escherichia coli NADPH-sulfite reductase: requirement for a cloned cysG plasmid to overcome limiting siroheme cofactor. 
  • High-level misincorporation of lysine for arginine at AGA codons in a fusion protein expressed in Escherichia coli. 
  • Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India. 
  • Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. 
  • Homology analysis of the protein sequences of fatty acid synthases from chicken liver, rat mammary gland, and yeast. 
  • How cations change peptide structure. 
  • How the EcoRI endonuclease recognizes and cleaves DNA. 
  • Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. 
  • Human G(alpha q): cDNA and tissue distribution. 
  • Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. 
  • Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. 
  • Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. 
  • Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. 
  • Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. 
  • Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. 
  • Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. 
  • Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. 
  • Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. 
  • Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. 
  • Human factor IXLincoln Park: a molecular characterization. 
  • Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. 
  • Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies. 
  • Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen. 
  • Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelope. 
  • Human immunodeficiency virus vaccines. 
  • Human infection by genetically diverse SIVSM-related HIV-2 in west Africa. 
  • Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strain. 
  • Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. 
  • Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae. 
  • Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation. 
  • Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o). 
  • Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize. 
  • Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro. 
  • Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. 
  • Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets. 
  • Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. 
  • Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. 
  • Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation 
  • Hybridoma SLE autoantibodies: insights for the pathogenesis of autoimmune disease. 
  • Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC-NPC Culture 
  • Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity. 
  • Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain. 
  • IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. 
  • Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1 
  • Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. 
  • Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. 
  • Identification and characterization of a cDNA encoding cytochrome P450 3A from the fresh water teleost medaka (Oryzias latipes). 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. 
  • Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. 
  • Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody. 
  • Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. 
  • Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae. 
  • Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. 
  • Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Identification and developmental expression of two activin receptors in baboon lung. 
  • Identification and expression of the ecdysone receptor in the harpacticoid copepod, Amphiascus tenuiremis, in response to fipronil. 
  • Identification and localization of a possible rhodopsin in the echinoderms Asterias forbesi (Asteroidea) and Ophioderma brevispinum (Ophiuroidea). 
  • Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation. 
  • Identification and localization of the fatty acid modification in ghrelin by electron capture dissociation. 
  • Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. 
  • Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. 
  • Identification of MeCP2 mutations in a series of females with autistic disorder. 
  • Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. 
  • Identification of a 41 kDa protein embedded in the biosilica of scales and bristles isolated from Mallomonas splendens (Synurophyceae) 
  • Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. 
  • Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene. 
  • Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. 
  • Identification of a chloroform-soluble membrane miniprotein in Escherichia coli and its homolog in Salmonella typhimurium. 
  • Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor. 
  • Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting. 
  • Identification of a fetal exon in the human fast troponin T gene. 
  • Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-1alpha. 
  • Identification of a homogentisate-1,2-dioxygenase gene in the fungus Exophiala lecanii-corni: analysis and implications. 
  • Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. 
  • Identification of a mutant DNA polymerase delta in Saccharomyces cerevisiae with an antimutator phenotype for frameshift mutations. 
  • Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. 
  • Identification of a new family of protein phosphatase 2A regulatory subunits. 
  • Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. 
  • Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. 
  • Identification of a nonsense mutation at codon 128 of the Norrie's disease gene in a male infant. 
  • Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. 
  • Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer. 
  • Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. 
  • Identification of a novel gene linked to parkin via a bi-directional promoter. 
  • Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins. 
  • Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. 
  • Identification of a p28 gene in Ehrlichia ewingii: evaluation of gene for use as a target for a species-specific PCR diagnostic assay. 
  • Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis. 
  • Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits. 
  • Identification of a region of genetic variability among Bacillus anthracis strains and related species. 
  • Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma. 
  • Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. 
  • Identification of a synthetic peptide that mimics an HIV glycoprotein 120 envelope conformational determinant exposed following ligation of glycoprotein 120 by CD4. 
  • Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus. 
  • Identification of additional members of human G-protein-coupled receptor kinase multigene family. 
  • Identification of amino acid residues involved in structural and ubiquinone-binding functions of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides. 
  • Identification of amino acid sequences in fibrinogen gamma -chain and tenascin C C-terminal domains critical for binding to integrin alpha vbeta 3. 
  • Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase. 
  • Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. 
  • Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function. 
  • Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. 
  • Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8. 
  • Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1. 
  • Identification of five hemoglobins in B6C3F1 mice by mass spectrometry and sequence analysis. 
  • Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. 
  • Identification of gemin5 as a novel 7-methylguanosine cap-binding protein. 
  • Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. 
  • Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. 
  • Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. 
  • Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of monomeric alpha-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric alpha-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbeiana. 
  • Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA. 
  • Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase. 
  • Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. 
  • Identification of putative human T cell receptor delta complementary DNA clones. 
  • Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor. 
  • Identification of sites within gp41 that serve as targets for antibody-dependent cellular cytotoxicity by using human monoclonal antibodies. 
  • Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. 
  • Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. 
  • Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. 
  • Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets. 
  • Identification of the TBX5 transactivating domain and the nuclear localization signal. 
  • Identification of the breast cancer susceptibility gene BRCA2. 
  • Identification of the components controlling inactivation of voltage-gated Ca2+ channels. 
  • Identification of the endogenous smooth muscle myosin phosphatase-associated kinase. 
  • Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. 
  • Identification of the functionally relevant calmodulin binding site in smooth muscle caldesmon. 
  • Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. 
  • Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions. 
  • Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets. 
  • Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection. 
  • Identification of the sex genes in an early diverged fungus. 
  • Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. 
  • Identification of troponin C antagonists from a phage-displayed random peptide library. 
  • Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. 
  • Identification, characterization, and evolution of a primate beta-defensin gene cluster. 
  • Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes). 
  • Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta. 
  • Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. 
  • Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA. 
  • Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. 
  • IgG antibodies from patients with bullous pemphigoid bind to localized epitopes on synthetic peptides encoded by bullous pemphigoid antigen cDNA. 
  • IgG autoantibodies to "switch peptide" determinants of TCR alpha/beta in human pregnancy. 
  • Immune responses to coiled coil supramolecular biomaterials. 
  • Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. 
  • Immunization with recombinant canarypox vectors expressing membrane-anchored glycoprotein 120 followed by glycoprotein 160 boosting fails to generate antibodies that neutralize R5 primary isolates of human immunodeficiency virus type 1. 
  • Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity. 
  • Immunobiology of the human immunodeficiency virus envelope and its relationship to vaccine strategies. 
  • Immunochemical and molecular analysis of antigen binding to lipid anchored and soluble forms of an MHC independent human alpha/beta T cell receptor. 
  • Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state. 
  • Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system. 
  • Immunoinformatics approaches to explore Helicobacter Pylori proteome (Virulence Factors) to design B and T cell multi-epitope subunit vaccine. 
  • Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. 
  • Immunolocalization of PKC zeta in rat photoreceptor inner segments. 
  • Immunologic and virologic analyses of an acutely HIV type 1-infected patient with extremely rapid disease progression. 
  • Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccines. 
  • Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. 
  • Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia. 
  • Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. 
  • Immunoreaction at 43 kDa with anti-ubiquitin antibody in breast neoplasms. 
  • Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. 
  • Immunosuppressive retroviral peptides: immunopathological implications for immunosuppressive influences of retroviral infections. 
  • Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display. 
  • Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8. 
  • Importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators. 
  • Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. 
  • Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. 
  • Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. 
  • Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens. 
  • Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1. 
  • Improved datasets and evaluation methods for the automatic prediction of DNA-binding proteins. 
  • Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. 
  • In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: comparison with its murine parent. 
  • In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains. 
  • In vitro motility of AtKCBP, a calmodulin-binding kinesin protein of Arabidopsis. 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • In vitro selection and characterization of human immunodeficiency virus type 2 with decreased susceptibility to lopinavir. 
  • In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. 
  • In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail. 
  • In vivo genetic variability of the human immunodeficiency virus type 2 V3 region. 
  • In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth. 
  • In vivo post-translational processing and subunit reconstitution of cephalosporin acylase from Pseudomonas sp. 130. 
  • In-vivo studies on the cis-acting replication initiator protein of IncFII plasmid NR1. 
  • Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. 
  • Incongruence between primary sequence data and the distribution of a mitochondrial atp1 group II intron among ferns and horsetails 
  • Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. 
  • Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. 
  • Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv. 
  • Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. 
  • Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF. 
  • Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling. 
  • Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. 
  • Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo. 
  • Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences. 
  • Induced plant defense responses against chewing insects. Ethylene signaling reduces resistance of Arabidopsis against Egyptian cotton worm but not diamondback moth. 
  • Induction of HIVMN neutralizing antibodies in primates using a prime-boost regimen of hybrid synthetic gp120 envelope peptides. 
  • Induction of a human carbonyl reductase gene located on chromosome 21. 
  • Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains. 
  • Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. 
  • Induction of primary, human antigen-specific cytotoxic T lymphocytes in vitro using dendritic cells pulsed with peptides. 
  • Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. 
  • Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1. 
  • Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. 
  • Influence of HLA-C expression level on HIV control. 
  • Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses. 
  • Infrequent RAS oncogene mutations in human prostate cancer. 
  • Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families. 
  • Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. 
  • Inhibition of Factor Xa : a potential target for the development of new anticoagulants. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch. 
  • Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. 
  • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 
  • Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. 
  • Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. 
  • Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E. 
  • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. 
  • Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics. 
  • Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. 
  • Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. 
  • Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. 
  • Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth. 
  • Initiating a structural study of 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. 
  • Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis. 
  • Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype B. 
  • Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone. 
  • Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C. 
  • Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. 
  • Interaction between transcriptional activator protein LAC9 and negative regulatory protein GAL80. 
  • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. 
  • Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. 
  • Interaction of synthetic HA2 influenza fusion peptide analog with model membranes. 
  • Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. 
  • Interaction sites of the COOH-terminal region of the gamma subunit of cGMP phosphodiesterase with the GTP-bound alpha subunit of transducin. 
  • Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. 
  • Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression. 
  • Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein. 
  • Internal triplication in the structure of human ceruloplasmin. 
  • Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence. 
  • Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery. 
  • Intra- and inter-subunit disulfide bond formation is nonessential in adeno-associated viral capsids. 
  • Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. 
  • Intraclonal generation of antibody mutants in germinal centres. 
  • Intragenic duplication and divergence in the spectrin superfamily of proteins. 
  • Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses. 
  • Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site. 
  • Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. 
  • Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity. 
  • Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis. 
  • Investigating the Role of Class I Adenylate-Forming Enzymes in Natural Product Biosynthesis. 
  • Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas. 
  • Investigation of phosphoprotein signatures of archived prostate cancer tissue specimens via proteomic analysis. 
  • Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. 
  • Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. 
  • Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. 
  • Involvement of two putative alternative sigma factors in stress response of the radioresistant bacterium Deinococcus radiodurans. 
  • Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 
  • Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells. 
  • Is renin a factor in the etiology of essential hypertension? 
  • Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40. 
  • Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association. 
  • Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. 
  • Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin. 
  • Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. 
  • Isolation and characterization of a human pro alpha 2(I) collagen gene segment. 
  • Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. 
  • Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1. 
  • Isolation and characterization of cDNA clones encoding pig gastric mucin. 
  • Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes. 
  • Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana. 
  • Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. 
  • Isolation and characterization of the gene encoding rat glucose-dependent insulinotropic peptide. 
  • Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. 
  • Isolation and characterization of the major apolipoprotein from chicken high density lipoproteins. 
  • Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin. 
  • Isolation and characterization of the replicon of a Thiobacillus intermedius plasmid. 
  • Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. 
  • Isolation and expression of multiple forms of beta amyloid protein precursor cDNAs. 
  • Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase. 
  • Isolation and nucleotide sequence of canine glucose-6-phosphatase mRNA: identification of mutation in puppies with glycogen storage disease type Ia. 
  • Isolation and nucleotide sequence of human liver glycogen debranching enzyme mRNA: identification of multiple tissue-specific isoforms. 
  • Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. 
  • Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. 
  • Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. 
  • Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor. 
  • Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. 
  • Isolation of a functional human gene for brain creatine kinase. 
  • Isolation of a rat parvalbumin gene and full length cDNA. 
  • Isolation of an active fragment of protein phosphatase inhibitor-I from rabbit skeletal muscle. 
  • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. 
  • Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. 
  • Isolation of novel EGFR-specific VHH domains. 
  • Isolation of protein prenyltransferases from bovine brain and baculovirus expression system. 
  • Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. 
  • Isolation of the structural gene for calmodulin. 
  • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. 
  • Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator. 
  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 
  • Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. 
  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. 
  • JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling. 
  • Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. 
  • Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. 
  • Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. 
  • Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage. 
  • Keyhole limpet hemocyanin: structural and functional characterization of two different subunits and multimers. 
  • Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. 
  • Kinesin: switch I & II and the motor mechanism. 
  • Kinetic scheme for intermolecular RNA cleavage by a ribozyme derived from hepatitis delta virus RNA. 
  • Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). 
  • L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. 
  • L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. 
  • LAB: a new membrane-associated adaptor molecule in B cell activation. 
  • LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids. 
  • LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. 
  • LRRK2 autophosphorylation enhances its GTPase activity. 
  • La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. 
  • Lanthanide-binding tags as versatile protein coexpression probes. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX. 
  • Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles. 
  • Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling. 
  • Lefty proteins exhibit unique processing and activate the MAPK pathway. 
  • Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. 
  • Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions. 
  • Leukocyte chemoattractant peptides from the serpin heparin cofactor II. 
  • Levels of p53 protein increase with maturation in human hematopoietic cells. 
  • Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. 
  • Lewy body and Alzheimer pathology in a family with the amyloid-beta precursor protein APP717 gene mutation. 
  • Ligand-induced conformational changes in a thermophilic ribose-binding protein. 
  • Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes. 
  • Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. 
  • Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes 
  • Limited breadth of the protective immunity elicited by simian immunodeficiency virus SIVmne gp160 vaccines in a combination immunization regimen. 
  • Limited proteolysis of the alpha-macroglobulin rat alpha 1-inhibitor-3. Implications for a domain structure. 
  • Linkage of kdr-type resistance and the para-homologous sodium channel gene in German cockroaches (Blattella germanica). 
  • Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. 
  • Lipid modifications of G proteins. 
  • Lipid molecules induce p38α activation via a novel molecular switch. 
  • Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation. 
  • Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis. 
  • Lipoprotein (a): purification and kinetic analysis. 
  • Lipoprotein(a) and its role in atherothrombotic disease. 
  • Lithographic patterning of photoreactive cell-adhesive proteins. 
  • Local encoding of computationally designed enzyme activity. 
  • Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. 
  • Localization of a baculovirus-induced chitinase in the insect cell endoplasmic reticulum. 
  • Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. 
  • Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neurons. 
  • Localization of substance P NK-1 receptors in rat tongue. 
  • Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. 
  • Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor. 
  • Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins. 
  • Locus-specific somatic hypermutation in germinal centre T cells. 
  • Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. 
  • Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery. 
  • Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. 
  • Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase. 
  • Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992. 
  • Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 
  • Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo. 
  • LvTbx2/3, a T-box Family Transcription Factor Involved in Formation of the Oral/Aboral Axis of the Sea Urchin Embryo 
  • Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis. 
  • M6P/IGF2 receptor: a candidate breast tumor suppressor gene. 
  • MAGE-1-specific precursor cytotoxic T-lymphocytes present among tumor-infiltrating lymphocytes from a patient with breast cancer: characterization and antigen-specific activation. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2. 
  • Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. 
  • Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses. 
  • Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants. 
  • Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. 
  • Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. 
  • Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes. 
  • Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. 
  • Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain. 
  • Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras. 
  • Mapping of homologous, amino-terminal neutralizing regions of human T-cell lymphotropic virus type I and II gp46 envelope glycoproteins. 
  • Mapping of immunogenic regions of human T cell leukemia virus type I (HTLV-I) gp46 and gp21 envelope glycoproteins with env-encoded synthetic peptides and a monoclonal antibody to gp46. 
  • Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells. 
  • Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. 
  • Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. 
  • Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production. 
  • Mass Spectrometry and Ion Mobility Characterization of Bioactive Peptide-Synthetic Polymer Conjugates. 
  • Mass spectrometry as a readout of protein structure and function. 
  • Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions. 
  • Mass spectrometry-based thermal shift assay for protein-ligand binding analysis. 
  • Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. 
  • Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes. 
  • Matching isotopic distributions from metabolically labeled samples. 
  • Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. 
  • Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. 
  • Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. 
  • Mechanical Stability of a Small, Highly-Luminescent Engineered Protein NanoLuc. 
  • Mechanical anisotropy of ankyrin repeats. 
  • Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. 
  • Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. 
  • Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286. 
  • Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. 
  • Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma. 
  • Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency. 
  • Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. 
  • Megalin mediates renal uptake of heavy metal metallothionein complexes. 
  • Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor. 
  • Membrane topology and biogenesis of eukaryotic signal peptidase. 
  • Messenger RNAs of a strongly-expressed late gene of cowpox virus contain 5'-terminal poly(A) sequences. 
  • Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I). 
  • Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases. 
  • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. 
  • Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. 
  • Microsomal membranes contain a high affinity binding site for prenylated peptides. 
  • Microsporidian methionine aminopeptidase type 2. 
  • Microtubule-associated protein 1B (MAP1B) is present in glial cells phosphorylated different than in neurones. 
  • Mimosine targets serine hydroxymethyltransferase. 
  • Minimal PAM specificity of a highly similar SpCas9 ortholog. 
  • Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer. 
  • Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. 
  • Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. 
  • Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability. 
  • Missense mutation in a von Willebrand factor type A domain of the alpha 3(VI) collagen gene (COL6A3) in a family with Bethlem myopathy. 
  • Mitochondrial gene rearrangements confirm the parallel evolution of the crab-like form. 
  • Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. 
  • Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. 
  • Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. 
  • Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region. 
  • Mixed peptide sequencing and the FASTF/FASTS algorithms. 
  • Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans. 
  • Modeling and superposition of multiple protein structures using affine transformations: analysis of the globins. 
  • Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors. 
  • Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. 
  • Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia. 
  • Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations. 
  • Modification of polyurethaneurea with PEG and YIGSR peptide to enhance endothelialization without platelet adhesion. 
  • Modulating adaptive immune responses to peptide self-assemblies. 
  • Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine. 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ. 
  • Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain. 
  • Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • Modulation of the binding of signal peptides to lipid bilayers by dipoles near the hydrocarbon-water interface. 
  • Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin. 
  • Molecular analyses of the Arabidopsis TUBBY-like protein gene family. 
  • Molecular analysis of HLA-B35 alleles and their relationship to HLA-B15 alleles. 
  • Molecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiency. 
  • Molecular analysis of proteins associated with the synaptic vesicle membrane. 
  • Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse. 
  • Molecular analysis of the 60-kDa human Ro ribonucleoprotein. 
  • Molecular analysis of the AGL gene: identification of 25 novel mutations and evidence of genetic heterogeneity in patients with Glycogen Storage Disease Type III. 
  • Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. 
  • Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems. 
  • Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33. 
  • Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. 
  • Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C. 
  • Molecular and genetic evidence for a tetrapolar mating system in the basidiomycetous yeast Kwoniella mangrovensis and two novel sibling species. 
  • Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies. 
  • Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression. 
  • Molecular basis for elliptocytosis associated with glycophorin C and D deficiency in the Leach phenotype. 
  • Molecular basis for species-specific sensitivity to "hot" chili peppers. 
  • Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae. 
  • Molecular basis of adenosine deaminase deficiency. 
  • Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. 
  • Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. 
  • Molecular biologist's guide to proteomics. 
  • Molecular biology of adrenergic receptors. 
  • Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships. 
  • Molecular biology of the vitamin D hormone. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Molecular characterization of CLPT1, a SEC4-like Rab/GTPase of the phytopathogenic fungus Colletotrichum lindemuthianum which is regulated by the carbon source. 
  • Molecular characterization of DSC1 orthologs in invertebrate species. 
  • Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. 
  • Molecular characterization of TRP1, a gene coding for tryptophan synthetase in the basidiomycete Coprinus cinereus. 
  • Molecular characterization of a sodium channel gene from the Silkworm Bombyx mori. 
  • Molecular characterization of an arachnid sodium channel gene from the varroa mite (Varroa destructor). 
  • Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines. 
  • Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization. 
  • Molecular cloning and characterization of Aspergillus nidulans cyclophilin B. 
  • Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. 
  • Molecular cloning and characterization of a novel histone deacetylase HDAC10. 
  • Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. 
  • Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. 
  • Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. 
  • Molecular cloning and functional expression of a recombinant 72.5 kDa fragment of the 110 kDa regulatory subunit of smooth muscle protein phosphatase 1M. 
  • Molecular cloning and nucleotide sequence of a cDNA clone coding for the cell attachment domain in human fibronectin. 
  • Molecular cloning and nucleotide sequence of cDNA encoding human muscle glycogen debranching enzyme. 
  • Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. 
  • Molecular cloning and sequence analysis of a cDNA coding for the mouse alpha-like embryonic globin chain x. 
  • Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA. 
  • Molecular cloning and sequencing of chicken liver fatty acid synthase cDNA. 
  • Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney. 
  • Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. 
  • Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. 
  • Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families. 
  • Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. 
  • Molecular cloning of a novel human GTP-binding protein and its potential role in chemoattractant stimulus-response coupling. 
  • Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. 
  • Molecular cloning of acid alpha-glucosidase cDNA of Japanese quail (Coturnix coturnix japonica) and the lack of its mRNA in acid maltase deficient quails. 
  • Molecular cloning of aldolases for synthetic applications. 
  • Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. 
  • Molecular cloning of dimethyl sulfoxide reductase from Rhodobacter sphaeroides. 
  • Molecular cloning of human liver sulfite oxidase. 
  • Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues. 
  • Molecular cloning of rainbow trout (Oncorhynchus mykiss) eggshell zona radiata protein complementary DNA: mRNA expression in 17beta-estradiol- and nonylphenol-treated fish. 
  • Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP). 
  • Molecular cloning of rat liver sulfite oxidase. Expression of a eukaryotic Mo-pterin-containing enzyme in Escherichia coli. 
  • Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. 
  • Molecular cloning of the cDNA for androgen-dependent sperm-coating glycoproteins secreted by the rat epididymis. 
  • Molecular cloning of the cDNA for ligatin. 
  • Molecular cloning of the cDNA for two major androgen-dependent secretory proteins of 18.5 kilodaltons synthesized by the rat epididymis. 
  • Molecular cloning of the first metazoan beta-1,3 glucanase from eggs of the sea urchin Strongylocentrotus purpuratus. 
  • Molecular cloning of the structural gene for exopolygalacturonate lyase from Erwinia chrysanthemi EC16 and characterization of the enzyme product. 
  • Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein. 
  • Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. 
  • Molecular cloning, expression and functional characterization of rabbit anticoagulant vitamin-K-dependent protein S. 
  • Molecular cloning, nucleotide sequence, and marker exchange mutagenesis of the exo-poly-alpha-D-galacturonosidase-encoding pehX gene of Erwinia chrysanthemi EC16. 
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. 
  • Molecular defects underlying the Kell null phenotype. 
  • Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. 
  • Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. 
  • Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions. 
  • Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. 
  • Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. 
  • Molecular dissection of gating in the ClC-2 chloride channel. 
  • Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. 
  • Molecular evolution of human immunodeficiency virus env in humans and monkeys: similar patterns occur during natural disease progression or rapid virus passage. 
  • Molecular evolution of the junctophilin gene family. 
  • Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates. 
  • Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. 
  • Molecular mechanics simulation of the interaction of estrogen receptor with estrogen regulatory element. 
  • Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase. 
  • Molecular mechanisms of action of calmodulin. 
  • Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. 
  • Molecular phylogeny of naidid worms (Annelida: Clitellata) based on cytochrome oxidase I. 
  • Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA. 
  • Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. 
  • Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. 
  • Molecular surveillance of HIV-1 field strains in Nigeria in preparation for vaccine trials. 
  • Molybdopterin from molybdenum and tungsten enzymes. 
  • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. 
  • Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration. 
  • Motif module map reveals enforcement of aging by continual NF-kappaB activity. 
  • Motor proteins. 1: kinesins. 
  • Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. 
  • Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. 
  • Mouse small eye results from mutations in a paired-like homeobox-containing gene. 
  • Mouse/human chimeric Me1-14 antibody: genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization. 
  • Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. 
  • Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A). 
  • Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. 
  • Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ. 
  • Multifunctional thermally transitioning oligopeptides prepared by ring-opening metathesis polymerization. 
  • Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence. 
  • Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. 
  • Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. 
  • Multiple cell-type-specific elements regulate Myc protein stability. 
  • Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome. 
  • Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. 
  • Multiple red cell ferritin mRNAs, which code for an abundant protein in the embryonic cell type, analyzed by cDNA sequence and by primer extension of the 5'-untranslated regions. 
  • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. 
  • Multiplex-PCR-based recombination as a novel high-fidelity method for directed evolution. 
  • Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis. 
  • Murine CD7 shares antigenic cross-reactivity with HSP-60. 
  • Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. 
  • MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. 
  • Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function. 
  • Mutagenic analysis of functional domains of the mos proto-oncogene and identification of the sites important for MAPK activation and DNA binding. 
  • Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 
  • Mutation analysis of the TSC2 gene in an African-American family. 
  • Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. 
  • Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. 
  • Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. 
  • Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome. 
  • Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels. 
  • Mutational analysis of the TrkA gene in prostate cancer. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein. 
  • Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. 
  • Mutational spectrum of the oral-facial-digital type I syndrome: a study on a large collection of patients. 
  • Mutations causing hemophilia B: direct estimate of the underlying rates of spontaneous germ-line transitions, transversions, and deletions in a human gene. 
  • Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. 
  • Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. 
  • Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss. 
  • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. 
  • Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. 
  • Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. 
  • Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. 
  • Mutations in the TSGA14 gene in families with autism spectrum disorders. 
  • Mutations in the active site of Escherichia coli phosphofructokinase. 
  • Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. 
  • Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. 
  • Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. 
  • Mutations in the glucose-6-phosphatase gene are associated with glycogen storage disease types 1a and 1aSP but not 1b and 1c. 
  • Mutations in the medium chain acyl-CoA dehydrogenase (MCAD) gene. 
  • Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • Mutations of the BRAF gene in human cancer. 
  • Mutations of the bacteriophage T4 type II DNA topoisomerase that alter sensitivity to antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide and an antibacterial quinolone. 
  • Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly. 
  • Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration. 
  • Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. 
  • Mutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase. 
  • Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae. 
  • Myeloma light chains are ligands for cubilin (gp280). 
  • Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain. 
  • Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. 
  • Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. 
  • Myotilin is mutated in limb girdle muscular dystrophy 1A. 
  • Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. 
  • N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin. 
  • N-terminal amino acid sequences of three functionally different troponin T isoforms from rabbit fast skeletal muscle. 
  • N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding. 
  • N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins. 
  • NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC. 
  • NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A. 
  • NMR structural characterization of the CDK inhibitor p19INK4d. 
  • NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. 
  • NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins. 
  • NMR structure of activated CheY. 
  • NMR-derived solution conformations of a hybrid synthetic peptide containing multiple epitopes of envelope protein gp120 from the RF strain of human immunodeficiency virus. 
  • Na+ channel function, regulation, structure, trafficking and sequestration. 
  • Nanoscale separations combined with tandem mass spectrometry. 
  • Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. 
  • Native like helices in a specially designed β peptide in the gas phase. 
  • Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster. 
  • Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology. 
  • Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. 
  • Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1. 
  • Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease. 
  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. 
  • Neck-linker length dependence of processive Kinesin-5 motility. 
  • Negative regulation of Armadillo, a Wingless effector in Drosophila. 
  • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. 
  • Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. 
  • Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif. 
  • Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. 
  • Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. 
  • Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II. 
  • Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. 
  • Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. 
  • Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart. 
  • Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. 
  • Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea. 
  • Neutralization epitopes of the HIV-1 primary isolate DH012. 
  • New insights into the phylogenetic distribution and evolutionary origins of the septins. 
  • New insights into the proton-dependent oxygen affinity of Root effect haemoglobins. 
  • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. 
  • New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. 
  • New nitrogen-fixing microorganisms detected in oligotrophic oceans by amplification of Nitrogenase (nifH) genes. 
  • New simian immunodeficiency virus infecting De Brazza's monkeys (Cercopithecus neglectus): evidence for a cercopithecus monkey virus clade. 
  • Next-generation genotyping of hypervariable loci in many individuals of a non-model species: technical and theoretical implications. 
  • Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs. 
  • Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. 
  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 
  • Noncanonical self-assembly of highly asymmetric genetically encoded polypeptide amphiphiles into cylindrical micelles. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1. 
  • Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. 
  • Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. 
  • Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication. 
  • Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences. 
  • Novel circular DNA viruses in stool samples of wild-living chimpanzees. 
  • Novel compound heterozygous mutations in MYO7A in a Chinese family with Usher syndrome type 1. 
  • Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function. 
  • Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. 
  • Novel peptide inhibitors of angiotensin-converting enzyme 2. 
  • Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides. 
  • Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker. 
  • Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype. 
  • Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Nuclear RNA-binding proteins. 
  • Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. 
  • Nuclear export of mammalian PERIOD proteins. 
  • Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. 
  • Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies. 
  • Nuclear protein localization. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains. 
  • Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase. 
  • Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family. 
  • Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli. 
  • Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1. 
  • Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. 
  • O-glycosylation as a sorting determinant for cell surface delivery in yeast. 
  • Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. 
  • On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. 
  • Oncogenes and anti-oncogenes in human central nervous system tumors. 
  • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. 
  • Optimal sequence selection in proteins of known structure by simulated evolution. 
  • Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model. 
  • Optogenetic photochemical control of designer K+ channels in mammalian neurons. 
  • Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene. 
  • Organization of carboxysome genes in the thiobacilli. 
  • Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). 
  • Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data. 
  • Origin of fetal troponin T: developmentally regulated splicing of a new exon in the fast troponin T gene. 
  • Outer dense fiber proteins are dominant postobstruction autoantigens in adult Lewis rats. 
  • Overexpression and mutation of p53 in epithelial ovarian cancer. 
  • Overexpression of CaDSR6 increases tolerance to drought and salt stresses in transgenic Arabidopsis plants. 
  • Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction. 
  • Overexpression of a Brassica rapa NGATHA gene in Arabidopsis thaliana negatively affects cell proliferation during lateral organ and root growth. 
  • Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. 
  • Overexpression of the apple MpNPR1 gene confers increased disease resistance in Malus x domestica. 
  • Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster. 
  • Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers. 
  • PACES: Protein sequential assignment by computer-assisted exhaustive search. 
  • PAS is a dimerization domain common to Drosophila period and several transcription factors. 
  • PER protein interactions and temperature compensation of a circadian clock in Drosophila. 
  • PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation. 
  • PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. 
  • PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. 
  • PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex. 
  • PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. 
  • PSORS2 is due to mutations in CARD14. 
  • Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. 
  • Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules. 
  • Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript. 
  • Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. 
  • Paralogous VDRs in teleosts:transition of nuclear receptor function 
  • Parc-ing p53 in the cytoplasm. 
  • Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. 
  • Partial NH2- and cooh-terminal sequence analyses of Eco RI DNA restriction and modification enzymes. 
  • Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. 
  • Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection. 
  • Pathway analysis of protein electron-transfer reactions. 
  • Patterns of somatic mutation in human cancer genomes. 
  • Patterns of variation within self-incompatibility loci. 
  • Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 
  • Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans. 
  • Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices. 
  • Peptide YY inhibits meal-stimulated pancreatic and gastric secretion. 
  • Peptide antagonists of the human estrogen receptor. 
  • Peptide array X-linking (PAX): a new peptide-protein identification approach. 
  • Peptide specificity determinants at P-7 and P-6 enhance the catalytic efficiency of Ca2+/calmodulin-dependent protein kinase I in the absence of activation loop phosphorylation. 
  • Peptide-PEG amphiphiles as cytophobic coatings for mammalian and bacterial cells. 
  • Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells. 
  • Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. 
  • Peptide-mediated targeting of the islets of Langerhans. 
  • Peptide-polymer bioconjugates: hybrid block copolymers generated via living radical polymerizations from resin-supported peptides. 
  • Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. 
  • Peripheral blood mononuclear cells from patients with bullous pemphigoid have an increased frequency of response to synthetic peptides encoded by BPAG1. 
  • Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission. 
  • Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. 
  • Phage display screening for peptides that inhibit polyglutamine aggregation. 
  • Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. 
  • Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand. 
  • Phenylalanine 30 plays an important role in receptor binding of verotoxin-1. 
  • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. 
  • Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. 
  • Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. 
  • Phosphoproteomic analysis of human mesenchymal stromal cells during osteogenic differentiation. 
  • Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. 
  • Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. 
  • Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle. 
  • Phosphorylation of Gz in human platelets. Selectivity and site of modification. 
  • Phosphorylation of Nox1 regulates association with NoxA1 activation domain. 
  • Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay. 
  • Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. 
  • Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes. 
  • Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation. 
  • Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. 
  • Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding. 
  • Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK. 
  • Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. 
  • Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis. 
  • Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. 
  • Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx. 
  • Phosphorylation of the cystic fibrosis transmembrane conductance regulator. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. 
  • Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. 
  • Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. 
  • Phosphorylation-dependent control of ZIPK nuclear import is species specific. 
  • Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments. 
  • Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O. 
  • Phylogenetic footprint analysis of IGF2 in extant mammals. 
  • Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus. 
  • Physiological and molecular basis of thyroid hormone action. 
  • Physiologically regulated alternative splicing patterns of fast troponin T RNA are conserved in mammals. 
  • Physiopathologic role of cubilin and megalin. 
  • Phytochrome regulation and differential expression of gibberellin 3b-hydroxylase genes in germinating Arabidopsis seeds 
  • Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. 
  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. 
  • Polyglutamine domain proteins with expanded repeats bind neurofilament, altering the neurofilament network. 
  • Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? 
  • Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemic cells, and breast cancer. 
  • Polymorphisms in Fibronectin Binding Proteins A and B among Staphylococcus aureus Bloodstream Isolates Are Not Associated with Arthroplasty Infection. 
  • Polymorphisms in fibronectin binding protein A of Staphylococcus aureus are associated with infection of cardiovascular devices. 
  • Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. 
  • Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. 
  • Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. 
  • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. 
  • Positive patches and negative noodles: linking RNA processing to transcription? 
  • Positive selection driving diversification in plant secondary metabolism. 
  • Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. 
  • Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy. 
  • Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain. 
  • Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers. 
  • Potential pathogenicity of deglycosylated IgG cross reactive with streptokinase and fibronectin in the serum of patients with rheumatoid arthritis. 
  • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. 
  • Potential sources of the 1995 Venezuelan equine encephalitis subtype IC epidemic. 
  • Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. 
  • Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. 
  • Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. 
  • Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. 
  • Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases. 
  • Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features. 
  • Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition. 
  • Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. 
  • Prenylated peptides in identification of specific binding proteins. 
  • Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. 
  • Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. 
  • Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. 
  • Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. 
  • Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. 
  • Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules. 
  • Primary structure and domain organization of human alpha and beta adducin. 
  • Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation. 
  • Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides. 
  • Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. 
  • Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration. 
  • Pro-GnRH processing. 
  • Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. 
  • Probing the renin active site by collisional quenching of endogenous fluorescence. 
  • Probing the stability of native and activated forms of alpha2-macroglobulin. 
  • Processing of the luteinizing hormone-releasing hormone precursor in the preoptic area and hypothalamus of the rat. 
  • Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. 
  • Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase. 
  • Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. 
  • Prognosis in familial amyotrophic lateral sclerosis: progression and survival in patients with glu100gly and ala4val mutations in Cu,Zn superoxide dismutase. 
  • Prolonged clinical latency and survival of macaques given a whole inactivated simian immunodeficiency virus vaccine. 
  • Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. 
  • Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex. 
  • Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult. 
  • Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. 
  • Properties of chimeric prostacyclin/prostaglandin D2 receptors: site-directed mutagenesis reveals the significance of the isoleucine residue at position 323. 
  • Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody. 
  • Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. 
  • Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. 
  • Proteases of Dermatophagoides pteronyssinus. 
  • Protection from nitrosative stress: a central role for microbial flavohemoglobin. 
  • Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures. 
  • Protein S-nitrosylation: purview and parameters. 
  • Protein design and folding: template trapping of self-assembled helical bundles. 
  • Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer. 
  • Protein farnesyltransferase. 
  • Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. 
  • Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. 
  • Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. 
  • Protein kinase C beta II specifically binds to and is activated by F-actin. 
  • Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies. 
  • Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. 
  • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. 
  • Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. 
  • Protein kinases that phosphorylate activated G protein-coupled receptors. 
  • Protein lipidation in cell signaling. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Protein phosphatases: recent progress. 
  • Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. 
  • Protein prenyltransferases. 
  • Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. 
  • Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. 
  • Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments. 
  • Proteome analyses using accurate mass and elution time peptide tags with capillary LC time-of-flight mass spectrometry. 
  • Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. 
  • Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. 
  • Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits. 
  • Proteomic analysis of the NOS2 interactome in human airway epithelial cells. 
  • Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration. 
  • Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction. 
  • Protonation of the neutral repeats of the RNA polymerase II CTD. 
  • Prox 1, a prospero-related homeobox gene expressed during mouse development. 
  • Pseudomonas syringae pv. syringae harpinPss: a protein that is secreted via the Hrp pathway and elicits the hypersensitive response in plants. 
  • Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion. 
  • Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris. 
  • Purification and characterization of the Cu,Zn SOD from Escherichia coli. 
  • Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. 
  • Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. 
  • Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. 
  • Purification of glycopeptides of human plasma proteins by high-performance liquid chromatography. 
  • Purification of kinesin-related protein complexes from eggs and embryos. 
  • Purification of recombinant proteins by fusion with thermally-responsive polypeptides. 
  • Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. 
  • Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. 
  • Purification, characterization, and immunogenicity of a soluble trimeric envelope protein containing a partial deletion of the V2 loop derived from SF162, an R5-tropic human immunodeficiency virus type 1 isolate. 
  • Purification, cloning, and expression of a peripheral-type benzodiazepine receptor. 
  • Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. 
  • Puzzle pieces defined: locating common packing units in tertiary protein contacts. 
  • Quantification of in vitro endothelial cell adhesion to vascular graft material. 
  • Quantification of the binding affinity of a specific hydroxyapatite binding peptide. 
  • Quantitative and selective fluorophore labeling of phosphoserine on peptides and proteins: characterization at the attomole level by capillary electrophoresis and laser-induced fluorescence. 
  • Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. 
  • Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa. 
  • R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. 
  • RAMP like proteins : RTP and REEP family of proteins. 
  • RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. 
  • RGS10 is a selective activator of G alpha i GTPase activity. 
  • RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. 
  • RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. 
  • RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. 
  • RNA editing generates tissue-specific sodium channels with distinct gating properties. 
  • RNA recognition: towards identifying determinants of specificity. 
  • RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. 
  • RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease cluster. 
  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. 
  • RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis. 
  • RTK and TGF-beta signaling pathways genes in the sea urchin genome. 
  • Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties. 
  • Radical changes in beta-amyloid form and function. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. 
  • Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells. 
  • Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV. 
  • Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. 
  • Rapid assignment of protein side chain resonances using projection-reconstruction of (4,3)D HC(CCO)NH and intra-HC(C)NH experiments. 
  • Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution. 
  • Rapid evolution of a pollen-specific oleosin-like gene family from Arabidopsis thaliana and closely related species. 
  • Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1. 
  • Rapid optimization of enzyme substrates using defined substrate mixtures. 
  • Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations. 
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 
  • Rat amylin: cloning and tissue-specific expression in pancreatic islets. 
  • Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis. 
  • Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme. 
  • Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis. 
  • Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. 
  • Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle. 
  • Reaper is regulated by IAP-mediated ubiquitination. 
  • Reaper-induced apoptosis in a vertebrate system. 
  • Receptors for the TGF-beta ligand family. 
  • Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder. 
  • Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY. 
  • Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis. 
  • Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial. 
  • Recognition molecules and immunoglobulin domains in invertebrates. 
  • Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein. 
  • Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. 
  • Recognition of single-stranded DNA by the bacteriophage T4-induced type II topoisomerase. 
  • Recombinant human interleukin 1 alpha: purification and biological characterization. 
  • Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation. 
  • Recombinant single-chain variable fragment antibodies against extracellular epitopes of human multidrug resistance protein MRP3 for targeting malignant gliomas. 
  • Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli. 
  • Reconstitution of mitochondrial processing peptidase from the core proteins (subunits I and II) of bovine heart mitochondrial cytochrome bc(1) complex. 
  • Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models. 
  • Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. 
  • Reduced levels of human apoE4 protein in an animal model of cognitive impairment. 
  • Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. 
  • Regional clustering of shared neutralization determinants on primary isolates of clade C human immunodeficiency virus type 1 from South Africa. 
  • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. 
  • Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. 
  • Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. 
  • Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. 
  • Regulation of G protein-coupled receptors by agonist-dependent phosphorylation. 
  • Regulation of HIF-1alpha stability through S-nitrosylation. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. 
  • Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. 
  • Regulation of alpha1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. 
  • Regulation of arrestin-3 phosphorylation by casein kinase II. 
  • Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. 
  • Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. 
  • Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization. 
  • Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. 
  • Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase. 
  • Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin. 
  • Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. 
  • Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation. 
  • Regulation of plant arginase by wounding, jasmonate, and the phytotoxin coronatine. 
  • Regulation of protein kinases by pseudosubstrate prototopes. 
  • Regulation of smooth muscle myosin light chain kinase by calmodulin. 
  • Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. 
  • Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. 
  • Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. 
  • Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2. 
  • Regulation of transcription factor NFAT by ADP-ribosylation. 
  • Regulation of type II adenylyl cyclase mRNA in rabbit skeletal muscle by chronic motor nerve pacing. 
  • Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation. 
  • Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. 
  • Regulatory and structural motifs of chicken gizzard myosin light chain kinase. 
  • Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. 
  • Relationship of the glyoxylate pathway to the pathogenesis of Cryptococcus neoformans. 
  • Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. 
  • Reliable genotypic tropism tests for the major HIV-1 subtypes. 
  • Remarkable conservation of structure among intermediate filament genes. 
  • Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. 
  • Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle. 
  • Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. 
  • Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. 
  • Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. 
  • Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. 
  • Resistance of Zwitterionic Peptide Monolayers to Biofouling. 
  • Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. 
  • Response of blood leukocytes to thrombin receptor peptides. 
  • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. 
  • Retina-specifically expressed novel subtypes of bovine cyclophilin. 
  • Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. 
  • Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. 
  • Rheological properties of cysteine-containing elastin-like polypeptide solutions and hydrogels. 
  • Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding. 
  • RoBo-1, a novel member of the urokinase plasminogen activator receptor/CD59/Ly-6/snake toxin family selectively expressed in rat bone and growth plate cartilage. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress. 
  • Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. 
  • Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase. 
  • Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase. 
  • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. 
  • Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors. 
  • Role of chaperones in antigen processing. 
  • Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. 
  • Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase. 
  • Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein. 
  • Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans. 
  • Role of septins in the orientation of forespore membrane extension during sporulation in fission yeast. 
  • Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. 
  • Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. 
  • Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation. 
  • Role of vasoactive mediators in the pathogenesis of Chagas' disease. 
  • Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. 
  • Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis. 
  • S-allele diversity in a natural population of Physalis crassifolia (Solanaceae) (ground cherry) assessed by RT-PCR. 
  • S-allele sequence diversity in natural populations of Solanum carolinense (Horsenettle). 
  • SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. 
  • SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. 
  • SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. 
  • SP75 is encoded by the DP87 gene and belongs to a family of modular Dictyostelium discoideum outer layer spore coat proteins. 
  • SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. 
  • Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. 
  • Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. 
  • Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial. 
  • Safety and immunogenicity of a live recombinant canarypox virus expressing HIV type 1 gp120 MN MN tm/gag/protease LAI (ALVAC-HIV, vCP205) followed by a p24E-V3 MN synthetic peptide (CLTB-36) administered in healthy volunteers at low risk for HIV infection. AGIS Group and L'Agence Nationale de Recherches sur Le Sida. 
  • Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen. DATRI 010 Study Group. Division of AIDS Treatment Research Initiative. 
  • Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants. 
  • Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization. 
  • Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. 
  • Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation. 
  • Sculpting proteins interactively: continual energy minimization embedded in a graphical modeling system. 
  • Scythe: a novel reaper-binding apoptotic regulator. 
  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. 
  • Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway. 
  • Secretion of extracellular superoxide dismutase in neonatal lungs. 
  • Selected contribution: a three-dimensional model for assessment of in vitro toxicity in balaena mysticetus renal tissue. 
  • Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA. 
  • Selection of novel affinity-matured human chondroitin sulfate proteoglycan 4 antibody fragments by yeast display. 
  • Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. 
  • Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells. 
  • Selective expression of insulin-like growth factor II in the songbird brain. 
  • Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor. 
  • Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. 
  • Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE. 
  • Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope. 
  • Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. 
  • Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation. 
  • Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. 
  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. 
  • Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. 
  • Separation of meiotic and mitotic effects of claret non-disjunctional on chromosome segregation in Drosophila. 
  • Sequence analysis and insertional inactivation of a gene encoding Moraxella sp. CK-1 cell wall hydrolase. 
  • Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. 
  • Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. 
  • Sequence coevolution and structure stabilization modulate olfactory receptor expression. 
  • Sequence context of indel mutations and their effect on protein evolution in a bacterial endosymbiont. 
  • Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins. 
  • Sequence homology of the Ca2+-dependent regulator of cyclic nucleotide phosphodiesterase from rat testis with other Ca2+-binding proteins. 
  • Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase. 
  • Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. 
  • Sequence variation in the transforming growth factor-beta1 (TGFB1) gene and multiple sclerosis susceptibility. 
  • Sequence variation outside the "active" region of dog and rabbit cholecystokinin-58 results in bioactivity differences. 
  • Sequences and phylogenetic analysis of the nef gene from Thai subjects harboring subtype E HIV-1. 
  • Sequencing of laminin B chain cDNAs reveals C-terminal regions of coiled-coil alpha-helix. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Sex in the 90s: SRY and the switch to the male pathway. 
  • Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. 
  • Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies. 
  • Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque. 
  • Similar T-cell immune responses induced by group M consensus env immunogens with wild-type or minimum consensus variable regions. 
  • Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV. 
  • Simple assay for proteases based on aggregation of stimulus-responsive polypeptides. 
  • Simultaneous comparison of three protein sequences. 
  • Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry. 
  • Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations. 
  • Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule. 
  • Single-headed myosin II acts as a dominant negative mutation in Dictyostelium. 
  • Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor. 
  • Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. 
  • Site-directed mutagenesis of the inhibitory subunit of retinal rod cyclic GMP phosphodiesterase. 
  • Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. 
  • Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. 
  • Sites of interaction between kinase-related protein and smooth muscle myosin. 
  • Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism. 
  • Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function. 
  • Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus. 
  • Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics. 
  • Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. 
  • Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry. 
  • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. 
  • Smads bind directly to the Jun family of AP-1 transcription factors. 
  • Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition. 
  • Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands. 
  • Solution NMR structure of the N-terminal domain of the human DEK protein. 
  • Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. 
  • Solution NMR studies of the plant peptide hormone CEP inform function. 
  • Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. 
  • Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations. 
  • Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. 
  • Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1. 
  • Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. 
  • Solution structure of the core NFATC1/DNA complex. 
  • Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage. 
  • Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. 
  • Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe. 
  • Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. 
  • SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis. 
  • Sparsely sampled high-resolution 4-D experiments for efficient backbone resonance assignment of disordered proteins. 
  • Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. 
  • Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks. 
  • Species specificity of antibodies to regulatory subunits of cyclic AMP-dependent protein kinases. 
  • Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species. 
  • Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger. 
  • Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells. 
  • Specific peptide probes for G-protein interaction with effectors. 
  • Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation. 
  • Specificity and regulation of a synaptic vesicle docking complex. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Specificity of human bactericidal antibodies against PorA P1.7,16 induced with a hexavalent meningococcal outer membrane vesicle vaccine. 
  • Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. 
  • Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer. 
  • Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. 
  • Spot hemoglobin. Studies on the Root effect hemoglobin of a marine teleost. 
  • Springs and hinges: dynamic coiled coils and discontinuities. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. 
  • Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures. 
  • Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. 
  • Stage-specific expression of B cell translocation gene 1 in rat testis. 
  • Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation. 
  • Streptokinase and human fibronectin share a common epitope: implications for regulation of fibrinolysis and rheumatoid arthritis. 
  • Stretching single protein molecules: titin is a weird spring. 
  • Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. 
  • Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. 
  • Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. 
  • Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. 
  • Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins. 
  • Structural alterations of the epidermal growth factor receptor gene in human gliomas. 
  • Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. 
  • Structural analysis of HLA-A2 antigen from immunoselected mutant 8.6.1: further definition of an HLA-A2-specific serological determinant. 
  • Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes. 
  • Structural analysis of the functional sites of class I HLA antigens. 
  • Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein. 
  • Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee. 
  • Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA). 
  • Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. 
  • Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA. 
  • Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin. 
  • Structural and functional domains of the Drosophila ncd microtubule motor protein. 
  • Structural and functional features of the HIV envelope glycoprotein and considerations for vaccine development. 
  • Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA. 
  • Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. 
  • Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: a component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon. 
  • Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. 
  • Structural basis for ADP-mediated transcriptional regulation by P1 and P7 ParA. 
  • Structural basis for SH2D1A mutations in X-linked lymphoproliferative disease. 
  • Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. 
  • Structural basis for an unexpected mode of SERM-mediated ER antagonism. 
  • Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. 
  • Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. 
  • Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism. 
  • Structural basis for the root effect in haemoglobin. 
  • Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. 
  • Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. 
  • Structural basis of diverse membrane target recognitions by ankyrins. 
  • Structural basis of pilus subunit recognition by the PapD chaperone. 
  • Structural basis of the intrasteric regulation of myosin light chain kinases. 
  • Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry. 
  • Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter. 
  • Structural features of nephritogenic lupus autoantibodies. 
  • Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin. 
  • Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. 
  • Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation. 
  • Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR. 
  • Structural model of human ceruloplasmin based on internal triplication, hydrophilic/hydrophobic character, and secondary structure of domains. 
  • Structural organization and chromosomal assignment of the parvalbumin gene. 
  • Structural organization of the human MS4A gene cluster on Chromosome 11q12. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structural properties of a subset of nephritogenic anti-DNA antibodies. 
  • Structural relationships in glycogen phosphorylases. 
  • Structural requirements for association of neurofascin with ankyrin. 
  • Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. 
  • Structural studies of Klenow fragment: an enzyme with two active sites. 
  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. 
  • Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes. 
  • Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. 
  • Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. 
  • Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum. 
  • Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea. 
  • Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. 
  • Structure and function of the adrenergic receptor family. 
  • Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin. 
  • Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant. 
  • Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex. 
  • Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues. 
  • Structure and immune recognition of trimeric pre-fusion HIV-1 Env. 
  • Structure and mechanism of the G protein-coupled receptor kinases. 
  • Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. 
  • Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. 
  • Structure and stability of monomeric lambda repressor: NMR evidence for two-state folding. 
  • Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. 
  • Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. 
  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. 
  • Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. 
  • Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri. 
  • Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer. 
  • Structure of human Niemann-Pick C1 protein. 
  • Structure of mammalian protein geranylgeranyltransferase type-I. 
  • Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. 
  • Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. 
  • Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. 
  • Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. 
  • Structure of the adrenergic and related receptors. 
  • Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. 
  • Structure of the endonuclease domain of MutL: unlicensed to cut. 
  • Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II. 
  • Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1). 
  • Structure of the genes encoding transcription factor IIB and TATA box-binding protein from Drosophila melanogaster. 
  • Structure of the human MutSalpha DNA lesion recognition complex. 
  • Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. 
  • Structure of the manganese-bound manganese transport regulator of Bacillus subtilis. 
  • Structure of the molybdenum site of Rhodobacter sphaeroides biotin sulfoxide reductase. 
  • Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. 
  • Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin. 
  • Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. 
  • Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K). 
  • Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. 
  • Structure, function, and biosynthesis of the major human histocompatibility antigens (HLA-A and HLA-B). 
  • Structure-based classification of 45 FK506-binding proteins. 
  • Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion. 
  • Structure-guided reprogramming of serine recombinase DNA sequence specificity. 
  • Structures and mechanisms of DNA restriction and modification enzymes. 
  • Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. 
  • Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. 
  • Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. 
  • Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. 
  • Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. 
  • Structures of yeast vesicle trafficking proteins. 
  • Studies of high doses of a human immunodeficiency virus type 1 recombinant glycoprotein 160 candidate vaccine in HIV type 1-seronegative humans. The AIDS Vaccine Clinical Trials Network. 
  • Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein. 
  • Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiography. 
  • Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity. 
  • Substrate promiscuity: AglB, the archaeal oligosaccharyltransferase, can process a variety of lipid-linked glycans. 
  • Substrate recognition by the EcoRI endonuclease. 
  • Substrate specificities and identification of putative substrates of ATM kinase family members. 
  • Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains. 
  • Subunit IV of cytochrome bc1 complex from Rhodobacter sphaeroides. Localization of regions essential for interaction with the three-subunit core complex. 
  • Successful herbivore attack due to metabolic diversion of a plant chemical defense. 
  • Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection. 
  • Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. 
  • Superpotent synthetic tripeptide mimics of the mud-crab pumping pheromone. 
  • Suppression of conformational heterogeneity at a protein-protein interface. 
  • Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes. 
  • Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses. 
  • Surface loop dynamics in adeno-associated virus capsid assembly. 
  • Surface structure of human mucin using X-ray photoelectron spectroscopy. 
  • Surface-and hydrogel-mediated delivery of nucleic acid nanoparticles 
  • Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis. 
  • Sustained release of antibiotics from injectable and thermally responsive polypeptide depots. 
  • SymROP: ROP protein with identical helices redesigned by all-atom contact analysis and molecular dynamics. 
  • Synaptic, transcriptional and chromatin genes disrupted in autism. 
  • Syncoilin isoform organization and differential expression in murine striated muscle. 
  • Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. 
  • Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. 
  • Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients. 
  • Synergy and duality in peptide antibiotic mechanisms. 
  • Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. 
  • Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. 
  • Synthesis and characterization of fluoropolymeric substrata with immobilized minimal peptide sequences for cell adhesion studies. I. 
  • Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery 
  • Synthesis of DNA coding for human proinsulin. 
  • Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. 
  • Synthesis of human CCK26-33 and CCK-33 related analogues on 2,4-DMBHA and TMBHA. 
  • Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition. 
  • Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity. 
  • Synthetic peptide in mineral oil adjuvant elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes in rhesus monkeys. 
  • Synthetic peptides containing T and B cell epitopes from human immunodeficiency virus envelope gp120 induce anti-HIV proliferative responses and high titers of neutralizing antibodies in rhesus monkeys. 
  • Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. 
  • T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children. 
  • T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • T-cell-receptor affinity and thymocyte positive selection. 
  • TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. 
  • TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877. 
  • TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death. 
  • TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis. 
  • TGF beta signals through a heteromeric protein kinase receptor complex. 
  • TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. 
  • TRPV1b, a functional human vanilloid receptor splice variant. 
  • Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides. 
  • Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents. 
  • Target domain definition and classification in CASP8. 
  • Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. 
  • Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. 
  • Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. 
  • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 
  • Targeting Pim Kinases and DAPK3 to Control Hypertension. 
  • Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. 
  • Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking. 
  • Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. 
  • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. 
  • Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. 
  • Technology evaluation: BLP-25, Biomira Inc. 
  • Temperature sensitive peptides: engineering hyperthermia-directed therapeutics. 
  • Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. 
  • Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita. 
  • Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. 
  • Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. 
  • Testis ecdysiotropin, an insect gonadotropin that induces synthesis of ecdysteroid. 
  • Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. 
  • Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins. 
  • The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. 
  • The 2.0 A crystal structure of a heterotrimeric G protein. 
  • The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX). 
  • The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies. 
  • The 70-kDa heat shock cognate protein (Hsc73) gene is enhanced by ovarian hormones in the ventromedial hypothalamus. 
  • The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger. 
  • The ATP binding site of the yeast plasma membrane proton-translocating ATPase. 
  • The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure. 
  • The Alacoil: a very tight, antiparallel coiled-coil of helices. 
  • The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. 
  • The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. 
  • The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. 
  • The Arabidopsis PLEIOTROPIC DRUG RESISTANCE8/ABCG36 ATP binding cassette transporter modulates sensitivity to the auxin precursor indole-3-butyric acid. 
  • The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway. 
  • The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. 
  • The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. 
  • The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. 
  • The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase. 
  • The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF. 
  • The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules. 
  • The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro. 
  • The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line. 
  • The CD19/CD21 signal transduction complex of B lymphocytes. 
  • The COBRA family of putative GPI-anchored proteins in Arabidopsis. A new fellowship in expansion. 
  • The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. 
  • The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling. 
  • The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complex. 
  • The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. 
  • The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. 
  • The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Drosophila Tis11 protein and its effects on mRNA expression in flies. 
  • The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells. 
  • The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. 
  • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. 
  • The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana. 
  • The Ehlers-Danlos syndromes. 
  • The Erwinia amylovora avrRpt2EA gene contributes to virulence on pear and AvrRpt2EA is recognized by Arabidopsis RPS2 when expressed in pseudomonas syringae. 
  • The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. 
  • The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke. 
  • The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. 
  • The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. 
  • The GA2 locus of Arabidopsis thaliana encodes ent-kaurene synthase of gibberellin biosynthesis. 
  • The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. 
  • The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes. 
  • The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. 
  • The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. 
  • The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. 
  • The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis. 
  • The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. 
  • The HDAC complex and cytoskeleton. 
  • The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain. 
  • The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. 
  • The HrpZ proteins of Pseudomonas syringae pvs. syringae, glycinea, and tomato are encoded by an operon containing Yersinia ysc homologs and elicit the hypersensitive response in tomato but not soybean. 
  • The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters. 
  • The LOV domain family: photoresponsive signaling modules coupled to diverse output domains. 
  • The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A. 
  • The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. 
  • The Lutheran glycoprotein: a multifunctional adhesion receptor. 
  • The Maf transcription factors: regulators of differentiation. 
  • The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. 
  • The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. 
  • The Pseudomonas syringae Hrp regulation and secretion system controls the production and secretion of multiple extracellular proteins. 
  • The Pseudomonas syringae pv. syringae 61 hrpH product, an envelope protein required for elicitation of the hypersensitive response in plants. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. 
  • The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. 
  • The Role of Brachyruy (T) During Gastrulations Movement in the Sea Urchin, Lytechinus variegatus 
  • The RosR transcription factor is required for gene expression dynamics in response to extreme oxidative stress in a hypersaline-adapted archaeon. 
  • The SABRE gene is required for normal cell expansion in Arabidopsis. 
  • The SAF-box domain of chromatin protein DEK. 
  • The SARS-CoV-2 Spike variant D614G favors an open conformational state. 
  • The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root. 
  • The SHORT-ROOT gene controls radial patterning of the Arabidopsis root through radial signaling. 
  • The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. 
  • The Snail repressor is required for PMC ingression in the sea urchin embryo. 
  • The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. 
  • The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The TetR family of transcriptional repressors. 
  • The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120. 
  • The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain. 
  • The V3 domain of SIVmac251 gp120 contains a linear neutralizing epitope. 
  • The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. 
  • The acceptor substrate specificity of porcine submaxillary UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is dependent on the amino acid sequences adjacent to serine and threonine residues. 
  • The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein. 
  • The activation domain of the MotA transcription factor from bacteriophage T4. 
  • The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. 
  • The adrenergic receptors. 
  • The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family. 
  • The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. 
  • The amino acid sequence of the delta subunit (calmodulin) of rabbit skeletal muscle phosphorylase kinase. 
  • The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. 
  • The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. 
  • The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. 
  • The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. 
  • The anatomy and taxonomy of protein structure. 
  • The androgen-binding protein gene is expressed in CD1 mouse testis. 
  • The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. 
  • The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage. 
  • The aromatase enzyme: from cloning to cancer. 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription. 
  • The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription. 
  • The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog. 
  • The basic helix-loop-helix domain of the aryl hydrocarbon receptor nuclear transporter (ARNT) can oligomerize and bind E-box DNA specifically. 
  • The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. 
  • The beta bulge: a common small unit of nonrepetitive protein structure. 
  • The beta sliding clamp binds to multiple sites within MutL and MutS. 
  • The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. 
  • The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. 
  • The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. 
  • The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency. 
  • The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor. 
  • The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin. 
  • The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. 
  • The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. 
  • The catalytic subunit of yeast telomerase. 
  • The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. 
  • The chromosomal region containing pab-1, mip, and the A mating type locus of the secondarily homothallic homobasidiomycete Coprinus bilanatus. 
  • The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target. 
  • The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. 
  • The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. 
  • The complete genome sequence of Roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism. 
  • The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. 
  • The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin. 
  • The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. 
  • The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. 
  • The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. 
  • The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor. 
  • The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding. 
  • The crystal structure of the UvsW helicase from bacteriophage T4. 
  • The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease. A study of 50 patients. 
  • The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome. 
  • The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding. 
  • The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control. 
  • The disulfide bonding pattern in ficolin multimers. 
  • The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera. 
  • The effect of substituted laminin A chain-derived peptides on the conformation and activation kinetics of plasminogen. 
  • The emerging kinesin family of microtubule motor proteins. 
  • The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant. 
  • The energetics of binding of a signal peptide to lipid bilayers: the role of bilayer properties. 
  • The essential sequence elements required for RNAP II carboxyl-terminal domain function in yeast and their evolutionary conservation. 
  • The evolution of a complex eucaryotic gene. 
  • The evolution of homing endonuclease genes and group I introns in nuclear rDNA. 
  • The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system. 
  • The extent of amino-terminal heterogeneity in rabbit fast skeletal muscle troponin T. 
  • The extra fragment of the iron-sulfur protein (residues 96-107) of Rhodobacter sphaeroides cytochrome bc1 complex is required for protein stability. 
  • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. 
  • The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. 
  • The family of glycogen phosphorylases: structure and function. 
  • The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. 
  • The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen. 
  • The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The gamma delta T cell receptor. 
  • The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung. 
  • The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. 
  • The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. 
  • The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. 
  • The genetic structure and diversity of the A and B mating-type genes from the tropical oyster mushroom, Pleurotus djamor. 
  • The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The helix-turn-helix DNA binding motif. 
  • The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. 
  • The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. 
  • The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. 
  • The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. 
  • The human cytokine I-309 is a monocyte chemoattractant. 
  • The human keratin genes and their differential expression. 
  • The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity. 
  • The identification of a second actin-binding region in spinophilin/neurabin II. 
  • The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. 
  • The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition. 
  • The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation. 
  • The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. 
  • The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. 
  • The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors. 
  • The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces. 
  • The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies. 
  • The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. 
  • The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. 
  • The insecticidal potential of scorpion beta-toxins. 
  • The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. 
  • The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. 
  • The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. 
  • The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. 
  • The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase. 
  • The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. 
  • The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies. 
  • The loss of a polymorphic glycosylation site caused by Thr-927-->Ile is linked to a second polymorphic Val-816-->Ile substitution in lysosomal alpha-glucosidase of American blacks. 
  • The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. 
  • The mammalian beta-adrenergic receptors. 
  • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. 
  • The many substrates and functions of ATM. 
  • The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. 
  • The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. 
  • The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. 
  • The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. 
  • The modulation of MSC integrin expression by RGD presentation 
  • The molecular epidemiology of HIV-1 among male sex workers in northern Thailand. 
  • The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. 
  • The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters. 
  • The mouse Cd83 gene: structure, domain organization, and chromosome localization. 
  • The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms. 
  • The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. 
  • The multisubunit IkappaB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IkappaB alpha. 
  • The nature and significance of differential keratin gene expression. 
  • The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. 
  • The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx mori. 
  • The nontranscribed chicken calmodulin pseudogene cross-hybridizes with mRNA from the slow-muscle troponin C gene. 
  • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. 
  • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. 
  • The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. 
  • The nucleolar localization domain of the catalytic subunit of human telomerase. 
  • The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. 
  • The origin and evolution of animal appendages. 
  • The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. 
  • The phosphoCTD-interacting domain of Topoisomerase I. 
  • The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. 
  • The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. 
  • The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds. 
  • The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis. 
  • The products of gene I and the overlapping in-frame gene XI are required for filamentous phage assembly. 
  • The rRNA-encoding DNA array has an altered structure in topoisomerase I mutants of Saccharomyces cerevisiae. 
  • The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. 
  • The regulation of DNA topoisomerase II by casein kinase II. 
  • The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila. 
  • The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment. 
  • The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. 
  • The role of Sry in cellular events underlying mammalian sex determination. 
  • The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes. 
  • The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. 
  • The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. 
  • The role of the supernumerary subunit of Rhodobacter sphaeroides cytochrome bc1 complex. 
  • The roles of 14-3-3 proteins in signal transduction. 
  • The second-largest subunit of the poxvirus RNA polymerase is similar to the corresponding subunits of procaryotic and eucaryotic RNA polymerases. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • The sequence of the reovirus serotype 3 L3 genome segment which encodes the major core protein lambda 1. 
  • The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively. 
  • The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. 
  • The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. 
  • The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain. 
  • The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II. 
  • The statistical conformation of a highly flexible protein: small-angle X-ray scattering of S. aureus protein A. 
  • The structural basis of repertoire shift in an immune response to phosphocholine. 
  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. 
  • The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus. 
  • The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus. 
  • The substrate specificity of cyclic AMP-dependent protein kinase: amino acid sequences at the phosphorylation sites of herring protamine (clupeine). 
  • The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth. 
  • The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. 
  • The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. 
  • The thyroid hormone receptor recruits NCoR via widely spaced receptor-interacting domains. 
  • The type 1 angiotensin II receptor tail affects receptor targeting, internalization, and membrane fusion properties. 
  • The type I and type II bovine scavenger receptors expressed in Chinese hamster ovary cells are trimeric proteins with collagenous triple helical domains comprising noncovalently associated monomers and Cys83-disulfide-linked dimers. 
  • The tyrosine corner: a feature of most Greek key beta-barrel proteins. 
  • The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. 
  • The vitamin D receptor: a primitive steroid receptor related to thyroid hormone receptor. 
  • The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells. 
  • The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. 
  • The winged-helix DNA-binding motif: another helix-turn-helix takeoff. 
  • The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. 
  • The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. 
  • Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol. 
  • Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Thirteen Mhc-DQA1 alleles from two populations of baboons. 
  • This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts. 
  • Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. 
  • Three-dimensional biomimetic patterning in hydrogels to guide cellular organization. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Thrombin-catalyzed activation of recombinant human factor V. 
  • Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. 
  • Tissue-specific expression of Ran isoforms in the mouse. 
  • Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences. 
  • Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure. 
  • Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target. 
  • Topology of an amiloride-binding protein. 
  • Topology of the yeast plasma membrane proton-translocating ATPase. 
  • Total chemical synthesis of the B1 domain of protein L from Peptostreptococcus magnus. 
  • Total synthesis, purification, and characterization of human [Phe(p-CH2SO 3Na)52, Nle32,53,56, Nal55]-CCK20-58, [Tyr52, Nle32,53,56, Nal55]-CCK-58, and [Phe(p-CH2SO3Na)52, Nle32,53,56, Nal55]-CCK-58. 
  • Toxicity of expanded polyglutamine-domain proteins in Escherichia coli. 
  • Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Transcription of a poxvirus early gene is regulated both by a short promoter element and by a transcriptional termination signal controlling transcriptional interference. 
  • Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. 
  • Transcriptional regulation of the mouse presenilin-1 gene. 
  • Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis. 
  • Transcytosis-blocking abs elicited by an oligomeric immunogen based on the membrane proximal region of HIV-1 gp41 target non-neutralizing epitopes. 
  • Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules. 
  • Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. 
  • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. 
  • Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. 
  • Transient expression of a winged-helix protein, MNF-beta, during myogenesis. 
  • Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration. 
  • Translating antibody-binding peptides into peptoid ligands with improved affinity and stability. 
  • Translocator proteins in the two-partner secretion family have multiple domains. 
  • Transthyretin sequesters amyloid beta protein and prevents amyloid formation. 
  • Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. 
  • Tunable molecular tension sensors reveal extension-based control of vinculin loading. 
  • Turning off the signal: desensitization of beta-adrenergic receptor function. 
  • Turnip yellow mosaic virus as a chemoaddressable bionanoparticle. 
  • Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. 
  • Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I. 
  • Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. 
  • Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII. 
  • Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. 
  • Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. 
  • Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro. 
  • Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae. 
  • Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency. 
  • Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella. 
  • Two proteins of the Dictyostelium spore coat bind to cellulose in vitro. 
  • Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. 
  • Two tRNA gene clusters associated with rRNA operons rrnD and rrnE in Bacillus subtilis. 
  • Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon. 
  • Two types of recombination hotspots in bacteriophage T4: one requires DNA damage and a replication origin and the other does not. 
  • Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. 
  • Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex. 
  • Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
  • Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions. 
  • Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. 
  • Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry. 
  • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. 
  • Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. 
  • Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin. 
  • Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
  • Unusual RNA splicing generates a secreted form of HLA-A2 in a mutagenized B lymphoblastoid cell line. 
  • Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. 
  • Use of artificial neural networks for the accurate prediction of peptide liquid chromatography elution times in proteome analyses. 
  • Use of dominant-negative HrpA mutants to dissect Hrp pilus assembly and type III secretion in Pseudomonas syringae pv. tomato. 
  • Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol. 
  • Use of synthetic peptides in primates to induce high-titered neutralizing antibodies and MHC class I-restricted cytotoxic T cells against acquired immunodeficiency syndrome retroviruses: an HLA-based vaccine strategy. 
  • Using N-Terminal Coordination of Cu(II) and Ni(II) to Isolate the Coordination Environment of Cu(I) and Cu(II) Bound to His13 and His14 in Amyloid-β(4-16). 
  • Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays. 
  • Using context to improve protein domain identification. 
  • Using fluorine nuclear magnetic resonance to probe changes in the structure and dynamics of membrane-active peptides interacting with lipid bilayers. 
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. 
  • Utilization of immunoglobulin G Fc receptors by human immunodeficiency virus type 1: a specific role for antibodies against the membrane-proximal external region of gp41. 
  • V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice. 
  • V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144. 
  • V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion. 
  • Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. 
  • Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates. 
  • Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models. 
  • Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. 
  • Vaccine-elicited V3 loop-specific antibodies in rhesus monkeys and control of a simian-human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate envelope. 
  • Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection. 
  • Vaccine-induced neutralizing antibodies directed in part to the simian immunodeficiency virus (SIV) V2 domain were unable to protect rhesus monkeys from SIV experimental challenge. 
  • Valency-dependent affinity of bioactive hydroxyapatite-binding dendrons. 
  • Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. 
  • Variable region sequence analysis of anti-DNA antibodies: evidence for a family of closely related germ-line VH genes encoding lupus autoantibodies. 
  • Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility. 
  • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. 
  • Verification of a new gene on Saccharomyces cerevisiae chromosome III. 
  • Very high pressure gradient LC/MS/MS. 
  • Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. 
  • Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Viral receptor-binding site antibodies with diverse germline origins. 
  • Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual. 
  • Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. 
  • Visualization of P-selectin glycoprotein ligand-1 as a highly extended molecule and mapping of protein epitopes for monoclonal antibodies. 
  • WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4. 
  • WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. 
  • Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. 
  • Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents. 
  • Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration? 
  • Wild Mandrillus sphinx are carriers of two types of lentivirus. 
  • X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. 
  • XMAP215 is a long thin molecule that does not increase microtubule stiffness. 
  • Xenobiotic induction of quinone oxidoreductase activity in lens epithelial cells. 
  • Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. 
  • YbiV from Escherichia coli K12 is a HAD phosphatase. 
  • ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis 
  • ZIP kinase, a key regulator of myosin protein phosphatase 1. 
  • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. 
  • Zeta-crystallin versus other members of the alcohol dehydrogenase super-family. Variability as a functional characteristic. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • Zinc finger protein binding to DNA: an energy perspective using molecular dynamics simulation and free energy calculations on mutants of both zinc finger domains and their specific DNA bases. 
  • [GIPC: a new target for therapy in pancreatic adenocarcinoma?]. 
  • alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. 
  • alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo. 
  • beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. 
  • beta-Arrestin: a protein that regulates beta-adrenergic receptor function. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces. 
  • cAMP receptor and G-protein interactions control development in Dictyostelium. 
  • cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase. 
  • cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. 
  • cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. 
  • cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. 
  • cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. 
  • cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene. 
  • cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform. 
  • ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts. 
  • hrp gene-dependent induction of hin1: a plant gene activated rapidly by both harpins and the avrPto gene-mediated signal. 
  • iPABP, an inducible poly(A)-binding protein detected in activated human T cells. 
  • mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. 
  • p21ras is modified by a farnesyl isoprenoid. 
  • p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos. 
  • p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. 
  • p53 gene mutation spectrum in human unknown primary tumors. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • rac, a novel ras-related family of proteins that are botulinum toxin substrates. 
  • ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish. 
  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. 
  • von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene. 
  • ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. 
  • β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology