Amino Acids

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  Subject Areas on Research

  • (1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein. 
  • 13N,15N isotope and kinetic evidence against hyponitrite as an intermediate in dentrification. 
  • A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data. 
  • A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels. 
  • A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. 
  • A comparison of the constituent polypeptides of the B-800--850 light-harvesting pigment-protein complex from Rhodopseudomonas sphaeroides. 
  • A comparison of the structure of hamster pancreatic insulin and insulin extracted from a transplantable hamster islet-cell carcinoma. 
  • A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. 
  • A cross sectional analysis of 5 different markers of collagen degradation in rheumatoid arthritis. 
  • A gradient-directed Monte Carlo approach for protein design. 
  • A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells. 
  • A kinetic investigation of the interaction of erythro-beta-hydroxyaspartic acid with aspartate aminotransferase. 
  • A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. 
  • A preliminary study of the fixation mechanism of collagen reaction with a polyepoxy fixative. 
  • A strong effect of AT mutational bias on amino acid usage in Buchnera is mitigated at high-expression genes. 
  • A thermodynamic investigation of reactions catalyzed by tryptophan synthase. 
  • AMINO ACID AND PROTEIN REQUIREMENTS OF INFANTS, CHILDREN AND ADULTS. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Absence of a role of gamma-glutamyl transpeptidase in the transport of amino acids by rat renal brushborder membrane vesicles. 
  • Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide. 
  • Adhesion properties of catechol-based biodegradable amino acid-based poly(ester urea) copolymers inspired from mussel proteins. 
  • Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. 
  • Affinity chromatography of beta-hydroxybutyrate dehydrogenase on Nad and hydrophobic chain derivatives of sepharose. 
  • Age related changes in blood-to-brain amino acid transport and incorporation into brain protein. 
  • Aged-related physiological studies comparing Candida albicans chlamydospores to yeasts. 
  • AglQ is a novel component of the Haloferax volcanii N-glycosylation pathway. 
  • Alpha-carbon coordinates for bovine Cu,Zn superoxide dismutase. 
  • Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat. 
  • Altered posttranslational modifications of collagen in keloid. 
  • Alternative fuels for cancer cells. 
  • Amino Acid Profile of Synovial Fluid Following Intra-articular Ankle Fracture. 
  • Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. 
  • Amino acid abundance and proteolytic potential in North American soils. 
  • Amino acid and lipid profiles following pig-to-primate liver xenotransplantation. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • Amino acid determinants for NMDA receptor inhibition by conantokin-T. 
  • Amino acid preferences for specific locations at the ends of alpha helices. 
  • Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages. 
  • Amino acid sequence of a major apoprotein from hen plasma very low density lipoproteins. 
  • Amino acid uptake by isolated renal brush border membrane vesicles in various buffers. 
  • Amino acid-level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise. 
  • Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling. 
  • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. 
  • Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. 
  • Amphitrite ornata erythrocruorin. I. Structural properties and characterization of subunit interactions. 
  • An HPLC assay for detection of elevated urinary S-sulphocysteine, a metabolic marker of sulphite oxidase deficiency. 
  • An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. 
  • Analysis of phenylthiohydantoin amino acid mixtures for sequencing by thermospray liquid chromatography/mass spectrometry. 
  • Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study. 
  • Anion modulation of the negative Bohr effect of haemoglobin from a primitive amphibian. 
  • Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Antineoplastic activity of a series of boron analogues of alpha-amino acids. 
  • Are mycoplasma membrane proteins affected by variations in membrane fatty acid composition? 
  • Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans. 
  • Berninamycin. 2. Products of acidic hydrolysis, methanolysis, and acetolysis of berninamycin A1. 
  • Beta cell monoamines: further evidence for their role in modulating insulin secretion. 
  • Biochemistry and theory of proton-coupled electron transfer. 
  • Biochemistry of amino acid racemization and clinical application to musculoskeletal disease. 
  • Biosynthesis of the second (C2) and fourth (C4) components of complement in vitro by tissues isolated from guinea-pigs with genetically determined C4 deficiency. 
  • Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists. 
  • Brain resuscitation. Medical management and innovations. 
  • Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. 
  • Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. 
  • Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface. 
  • Carbon tetrachloride poisoning treated with hemodialysis and total parenteral nutrition. 
  • Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo. 
  • Cellular autophagocytosis induced by deprivation of serum and amino acids in HeLa cells. 
  • Ceramides as modulators of cellular and whole-body metabolism. 
  • Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice. 
  • Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity. 
  • Changes in plasma amino acids during sobriety in alcoholic patients with and without liver disease. 
  • Characteristics of cultured human renal cortical epithelia. 
  • Characteristics of cystine uptake by cultured LLC-PK1 cells. 
  • Characterization of a chemotactic and cytotoxic proteinase from human skin. 
  • Characterization of fragment E from fibrinogen and cross-linked fibrin. 
  • Characterization of neutral and cationic amino acid transport in Xenopus oocytes. 
  • Characterization of putative amino acid transmitter release from slices of rat dentate gyrus. 
  • Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. 
  • Chemisorptions of bacterial receptors for hydrophobic amino acids and sugars on gold for biosensor applications: a surface plasmon resonance study of genetically engineered proteins. 
  • Chemistry and biology of copper-chelatin. 
  • Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn-->Lys) that can modulate cooperativity as well as oxygen affinity. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels. 
  • Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. 
  • Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. 
  • Cloning and molecular characterization of a cDNA clone to statin, a protein specifically expressed in nonproliferating quiescent and senescent fibroblasts. 
  • Codon bias and plasticity in immunoglobulins. 
  • Comparative analysis of two different amide-to-ester bond mutations in the beta-sheet of 4-oxalocrotonate tautomerase. 
  • Comparative chemical properties of avian oncornavirus polypeptides. 
  • Comparative quantitative trait loci mapping of aliphatic, indolic and benzylic glucosinolate production in Arabidopsis thaliana leaves and seeds. 
  • Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone. 
  • Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons. 
  • Comparison of a blend of milk products and linseed meal as protein supplements for young growing horses. 
  • Comparison of the binding of chicken alpha-macroglobulin and ovomacroglobulin to the mammalian alpha 2-macroglobulin receptor. 
  • Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine. 
  • Complete purification of dog renal renin. 
  • Comprehensive RNA Polymerase II Interactomes Reveal Distinct and Varied Roles for Each Phospho-CTD Residue. 
  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. 
  • Copper-chelatin: isolation from various eucaryotic sources. 
  • Copper-chelatin: purification and properties of a copper-binding protein from rat liver. 
  • Copper: an essential metal in biology. 
  • Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation. 
  • Covariability of V3 loop amino acids. 
  • Cross-linking of fibrin by fibrin=stabilizing factor. 
  • Decreased elastic fibers and desmosine content in incompetent cervix. 
  • Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogeneous enzyme from Escherichia coli. 
  • Design of supramolecular amino acids to template peptide folding. 
  • Determinants of Tenascin-C and HIV-1 envelope binding and neutralization. 
  • Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation. 
  • Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment. 
  • Development of new pharmacological agents for epilepsy: lessons from the kindling model. 
  • Dicarboxylic acid anhydrides as dissociating agents of protein-containing structures. 
  • Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures. 
  • Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. 
  • Differences in receptor binding and stability to enzymatic digestion between CCK-8 and CCK-58. 
  • Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. 
  • Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. 
  • Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. 
  • Distributions in protein conformation space: implications for structure prediction and entropy. 
  • Dysregulation of proteoglycan production by intrahepatic biliary epithelial cells bearing defective (delta-f508) cystic fibrosis transmembrane conductance regulator. 
  • EcoRI endonuclease. Physical and catalytic properties of the homogenous enzyme. 
  • Ecological genomics of Boechera stricta: identification of a QTL controlling the allocation of methionine- vs branched-chain amino acid-derived glucosinolates and levels of insect herbivory. 
  • Effect of adjacent histidine and cysteine residues on the spontaneous degradation of asparaginyl- and aspartyl-containing peptides. 
  • Effect of alphabet size and foldability requirements on protein structure designability. 
  • Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. 
  • Effect of chemical modification of dihydrouridine in yeast transfer ribonucleic acid on amino acid acceptor activity and ribosomal binding. 
  • Effect of cystine dimethylester on renal solute handling and isolated renal tubule transport in the rat: a new model of the Fanconi syndrome. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effect of pH and anions on functional properties of hemoglobin from Lemur fulvus fulvus. 
  • Effect of parenteral amino acid supplementation in alcoholic hepatitis. 
  • Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries. 
  • Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition. 
  • Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. 
  • Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs. 
  • Effects of copper and cross-linking on the extracellular matrix of tissue-engineered arteries. 
  • Effects of cysteamine therapy in nephropathic cystinosis. 
  • Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II). 
  • Effects of essential and nonessential amino acids on gastric emptying in the dog. 
  • Effects of fatty acid composition on the sensitivity of membrane functions to ethanol in Escherichia coli. 
  • Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. 
  • Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. 
  • Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach. 
  • Engineering protein stability and specificity using fluorous amino acids: the importance of packing effects. 
  • Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. 
  • Enhanced protein flexibility caused by a destabilizing amino acid replacement in BPTI. 
  • Erythrocyte Webb-type glycophorin C variant lacks N-glycosylation due to an asparagine to serine substitution. 
  • Erythrocyte membrane tropomyosin. Purification and properties. 
  • Estrogen induction of plasma vitellogenin in the cockerel: studies with a phosvitin antibody. 
  • Evaluation of collagen modification and surface properties of a bovine artery via polyepoxy compound fixation. 
  • Evolutionary rate variation in anthocyanin pathway genes. 
  • Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980. 
  • Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. 
  • First-principles data set of 45,892 isolated and cation-coordinated conformers of 20 proteinogenic amino acids. 
  • Foetal wound healing in a large animal model: the deposition of collagen is confirmed. 
  • Functional and structural properties of Murex fulvescens hemocyanin: isolation of two different subunits required for reassociation of a molluscan hemocyanin. 
  • Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. 
  • Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue. 
  • Further characterization of the platinum-reactive component of the alpha 2-macroglobulin-receptor recognition site. 
  • G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. 
  • Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. 
  • Gene Expression of Haloferax volcanii on Intermediate and Abundant Sources of Fixed Nitrogen. 
  • Gene expression level influences amino acid usage, but not codon usage, in the tsetse fly endosymbiont Wigglesworthia. 
  • Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria. 
  • Genetically engineered calmodulins differentially activate target enzymes. 
  • Global analysis of protein folding thermodynamics for disease state characterization. 
  • Glucose metabolism as a target of histone deacetylase inhibitors. 
  • Glutamine requirement for aerial mycelium growth in Neurospora crassa. 
  • Granulocyte-angiotensin system. Identification of angiotensinogen as the plasma protein substrate of leukocyte cathepsin G. 
  • Growth of explanted chick embryos on a chemically defined medium and effects of specific amino acid deficiencies. 
  • Hemocyanin of the horseshoe crab, Limulus polyphemus. Structural differentiation of the isolated components. 
  • Hemoglobin Kansas, a human hemoglobin with a neutral amino acid substitution and an abnormal oxygen equilibrium. 
  • Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. 
  • Hemoglobin Raleigh (beta1 valine replaced by acetylalanine). Structural and functional characterization. 
  • Hemoglobin components from trout (Salmo irideus): determination of the carboxyl and amino terminal sequences and their functional implications. 
  • Hemoglobins from trout: structural and functional properties. 
  • Hemoglobins of two terebellid polychaetes: Enoplobranchus sanguineus and Amphitrite ornata. 
  • Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. 
  • High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. 
  • Holocarboxylase synthetase deficiency: a biotin-responsive organic acidemia. 
  • Homocystine uptake in isolated rat renal cortical tubules. 
  • Hormonal and metabolic effects of carbohydrate restriction in children with Prader-Willi syndrome. 
  • Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin. 
  • Human erythrocyte ankyrin. Purification and properties. 
  • Human erythrocyte catalase: an improved method of isolation and a reevaluation of reported properties. 
  • Hydration and conformational mechanics of single, end-tethered elastin-like polypeptides. 
  • Hydrolysis of phthalyl amino acid esters of fluoroscein in the presence of leucine aminopeptidase. 
  • Hyperammonemia in women with a mutation at the ornithine carbamoyltransferase locus. A cause of postpartum coma. 
  • Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. 
  • Hypoallergenicity and efficacy of an amino acid-based formula in children with cow's milk and multiple food hypersensitivities. 
  • Identification and characterization of a second major peanut allergen, Ara h II, with use of the sera of patients with atopic dermatitis and positive peanut challenge. 
  • Identification of "embryonin" as bovine alpha 2-macroglobulin. 
  • Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach. 
  • Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor. 
  • Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-1alpha. 
  • Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase. 
  • Identification of nonsulfated cholecystokinin-58 in canine intestinal extracts and its biological properties. 
  • Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. 
  • In vitro chick embryo cell response to strain MC29 avian leukosis virus. 
  • In vitro reconstitution of nitrate reductase activity of the Neurospora crassa mutant nit-1: specific incorporation of molybdopterin. 
  • In-Depth Characterization and Validation of Human Urine Metabolomes Reveal Novel Metabolic Signatures of Lower Urinary Tract Symptoms. 
  • Inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid and effect on the enzyme of (E)-3-(1-aminocyclopropyl)-2-propenoic acid. 
  • Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. 
  • Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils. 
  • Influence of amino acids encoded in the 3' open reading frame of the SV40 early region on transformation and antigenicity of large T antigen. 
  • Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. 
  • Interaction of 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T) with the acyl-CoA: amino acid N-acyltransferase enzymes of bovine liver mitochondria. 
  • Intrinsically disordered proteins access a range of hysteretic phase separation behaviors. 
  • Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose? 
  • Isolation and characterization of a 180-kiloDalton salivary glycoprotein which mediates the attachment of Actinomyces naeslundii to human buccal epithelial cells. 
  • Isolation and characterization of the major apolipoprotein from chicken high density lipoproteins. 
  • Isolation and characterization of the two major apoproteins in human lipoprotein [a]. 
  • Isolation of polyribosomes and characteristics of an amino acid-incorporation system from the liver of a primate (Papio papio). 
  • Isolation of the 36-kD German (Blattella germanica) cockroach allergen using fast protein liquid chromatography. 
  • Isolation of the Maclura pomifera hemagglutinin on a deoxymelibiotol affinity support and preliminary characterization by buffer electrofocusing and high-performance liquid chromatography. 
  • Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses. 
  • Kinetic properties of iodinated ribonuclease A. 
  • Kinetic study of collagen fixation with polyepoxy fixatives. 
  • L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • LUTE (Local Unpruned Tuple Expansion): Accurate Continuously Flexible Protein Design with General Energy Functions and Rigid Rotamer-Like Efficiency. 
  • Laboratory analysis of amino acids, 2018 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG). 
  • Lack of relapse with tryptophan depletion following successful treatment with ECT. 
  • Ligatin from embryonic chick neural retina. 
  • Ligatin: a peripheral membrane protein with covalently bound palmitic acid. 
  • MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. 
  • Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. 
  • Making sense of hormone crosstalk during plant immune responses. 
  • Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis. 
  • Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Metabolic network failures in Alzheimer's disease: A biochemical road map. 
  • Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. 
  • Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans. 
  • Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects. 
  • Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. 
  • Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. 
  • Metal-induced formation of metallothionein in rat liver. 
  • Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. 
  • Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose. 
  • Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II). 
  • Molecular genetic study of human arginase deficiency. 
  • Molecular interactions and residues involved in force generation in the T4 viral DNA packaging motor. 
  • Molprobity's ultimate rotamer-library distributions for model validation. 
  • Monoamine precursors in the treatment of depression. 
  • Multifunctional reaper: sixty-five amino acids of fury. 
  • Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66. 
  • Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. 
  • Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. 
  • Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil. 
  • Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. 
  • N-(beta-Iodoethyl)trifluoroacetamide: a new reagent for the aminoethylation of thio groups in proteins. 
  • N-terminal amino acid sequences of three functionally different troponin T isoforms from rabbit fast skeletal muscle. 
  • NEMO binding domain of IKK-2 encompasses amino acids 735-745. 
  • NMDA antagonists: lack of protective effect against hypoxic damage in CA1 region of hippocampal slices. 
  • Native like helices in a specially designed β peptide in the gas phase. 
  • Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity. 
  • Neonatal plasminogen displays altered cell surface binding and activation kinetics. Correlation with increased glycosylation of the protein. 
  • Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species. 
  • Nitrogen-sparing intravenous fluids in postperative patients. 
  • No-carrier-added (4-fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]astato-4-fluorobenzyl)guanidine. 
  • Non-cholinergic strategies for treating and preventing Alzheimer's disease. 
  • Nuclease activity in a fragment of bacteriophage T4 deoxyribonucleic acid polymerase induced by the amber mutant am B22. 
  • Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family. 
  • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. 
  • Nutritional support in critically ill patients. 
  • Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. 
  • On the specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine. 
  • Optimal specificity and function for flexible biomolecular recognition. 
  • Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. 
  • Ovine placental lactogen, but not growth hormone, stimulates amino acid transport in fetal rat diaphragm. 
  • Oxygen binding domains of Helisoma trivolvis hemoglobin. 
  • P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Pancreatitis: the acid test. 
  • Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition. 
  • Parenteral nutrition: current status and concepts. 
  • Pathways of folding of reduced bovine pancreatic ribonuclease. 
  • Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). 
  • Peripheral blood metabolite profiles associated with new onset atrial fibrillation. 
  • Phosphorylation of Gz in human platelets. Selectivity and site of modification. 
  • Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides. 
  • Phylogenetic evidence for the transfer of Pseudomonas cocovenenans (van Damme et al. 1960) to the genus Burkholderia as Burkholderia cocovenenans (van Damme et al. 1960) comb. nov. 
  • Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity. 
  • Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans. 
  • Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing. 
  • Plant proteins in the amelioration of protein deficiency states. 
  • Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction. 
  • Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding. 
  • Plasmid pRQ7 from the hyperthermophilic bacterium Thermotoga species strain RQ7 replicates by the rolling-circle mechanism. 
  • Polymeric hemoglobins of the house mouse (Mus musculus L.): isolation of cysteinyl peptides. 
  • Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. 
  • Polypeptides of avian RNA tumor viruses. 1. Isolation and physical and chemical analysis. 
  • Polypeptides of avian RNA tumor viruses. II. Serological characterization. 
  • Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core. 
  • Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction. 
  • Practical considerations in the nutritional management of the cancer patient. 
  • Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation. 
  • Prognostic significance of amino acid transport imaging in patients with brain tumors. 
  • Properties of SEPT9 isoforms and the requirement for GTP binding. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Protein and aminoacid requirements of infants, children and adults. 
  • Protein biosynthesis on chick oviduct polyribosomes. I. Changes during estrogen-mediated tissue differentiation. 
  • Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. 
  • Protein design using continuous rotamers. 
  • Protein electron transfer rates set by the bridging secondary and tertiary structure. 
  • Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis. 
  • Protein-protein interfaces: properties, preferences, and projections. 
  • Proteins but not amino acids, carbohydrates, or fats stimulate cholecystokinin secretion in the rat. 
  • Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes. 
  • Proteomic analysis of arginine adducts on glyoxal-modified ribonuclease. 
  • Proteomics of Fuchs' endothelial corneal dystrophy support that the extracellular matrix of Descemet's membrane is disordered. 
  • Purification and characterization of a "half-molecule" alpha 2-macroglobulin from the southern grass frog: absence of binding to the mammalian alpha 2-macroglobulin receptor. 
  • Purification and characterization of a lecithin-D(-)- -hydroxybutyrate dehydrogenase complex. 
  • Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites. 
  • Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris. 
  • Purification and characterization of cysteine synthetase, a bifunctional protein complex, from Salmonella typhimurium. 
  • Purification and characterization of frog alpha-macroglobulin: receptor recognition of an amphibian glycoprotein. 
  • Purification and characterization of the Cu,Zn SOD from Escherichia coli. 
  • Purification and partial sequencing of the XL-I form of xenobiotic-metabolizing medium chain fatty acid:CoA ligase from bovine liver mitochondria, and its homology with the essential hypertension protein. 
  • Purification and properties of sulfite oxidase from chicken liver. Presence of molybdenum in sulfite oxidase from diverse sources. 
  • Purification and some properties of Cd-binding protein from rat liver. 
  • Purification of glycopeptides of human plasma proteins by high-performance liquid chromatography. 
  • Quantitative measurement of cerebral protein synthesis in vivo: theory and methodological considerations. 
  • Rapid self-healing hydrogels. 
  • Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor. 
  • Redox-based regulation of signal transduction: principles, pitfalls, and promises. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components. 
  • Reduced selective constraint in endosymbionts: elevation in radical amino acid replacements occurs genome-wide. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. 
  • Relative bioactivities of cholecystokinins-8 and -33 on rat pancreatic acini. 
  • Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. 
  • Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. 
  • Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. 
  • Ribonucleic acid components of BAI strain A (myeloblastosis) avian tumor virus. 
  • Ribosomal subunits of Landschütz ascites cells during changes in polysome distribution. 
  • Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora. 
  • Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo. 
  • Role of protein molecular and metabolic aberrations in aging, in the physiologic decline of the aged, and in age-associated diseases. 
  • S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization. 
  • Sequence in which essential amino acids become limiting for growth of rats fed rations containing cottonseed meal. 
  • Serum hepatic enzyme and bilirubin elevations during parenteral nutrition. 
  • Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats. 
  • Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS. 
  • Stimulation of cartilage amino acid uptake by growth hormone-dependent factors in serum. Mediation by adenosine 3':5'-monophosphate. 
  • Strain variation and morphogenesis of yeast- and mycelial-phase Candida albicans in low-sulfate, synthetic medium. 
  • Strain variation in composition and molecular size of the capsular polysaccharide of Cryptococcus neoformans serotype A. 
  • Structural comparison between the mitochondrial aralkyl-CoA and arylacetyl-CoA N-acyltransferases. 
  • Structural components of avian myeloblastosis virus. 
  • Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin. 
  • Structural studies of the heme domain of sulfite oxidase: CNBr fragments. 
  • Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy. 
  • Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II. 
  • Structure validation by Calpha geometry: phi,psi and Cbeta deviation. 
  • Studies on alpha-actinin-like proteins liberated during trypsin digestion of alpha-actinin and of myofibrils. 
  • Substituting ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. 
  • Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains. 
  • Suicide substrates for the alanine racemase of Escherichia coli B. 
  • Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. 
  • SymROP: ROP protein with identical helices redesigned by all-atom contact analysis and molecular dynamics. 
  • Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015. 
  • Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines. 
  • Synthesis and evaluation of compounds that facilitate the gastrointestinal absorption of heparin. 
  • Synthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids. 
  • Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate. 
  • TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity. 
  • Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups. 
  • Tau proteins-enhanced Ca2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II. 
  • Techniques for measuring the activity of carboxylic acid:CoA ligase and acyl-CoA:amino acid N-acyltransferase: the amino acid conjugation pathway. 
  • Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. 
  • The Fanconi syndrome and mechanisms of tubular transport dysfunction. 
  • The PICALM protein plays a key role in iron homeostasis and cell proliferation. 
  • The backrub motion: how protein backbone shrugs when a sidechain dances. 
  • The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine. 
  • The content of elastin in the uterine cervix. 
  • The domains of rat liver sulfite oxidase. Proteolytic separation and characterization. 
  • The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro. 
  • The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma. 
  • The effect of dilution of milk proteins with non-essential amino acids (L-alanine and L-glutamic acid) on nitrogen retention and biological value of the proteins in children. 
  • The effect of protein synthesis inhibition on the entry of messenger RNA into the cytoplasm of sea urchin embryos. 
  • The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. 
  • The hemoglobin of the crossopterygian fish, Latimeria chalumnae (Smith). Subunit structure and oxygen equilibria. 
  • The hydrophobic core of Escherichia coli thioredoxin shows a high tolerance to nonconservative single amino acid substitutions. 
  • The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. 
  • The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation. 
  • The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. 
  • The numbers of individual mitochondrial DNA molecules and mitochondrial DNA nucleoids in yeast are co-regulated by the general amino acid control pathway. 
  • The peeling skin syndrome. 
  • The penultimate rotamer library. 
  • The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium. 
  • The purification and subunit structure of cysteine desulfhydrase from Salmonella typhimurium. 
  • The relationship of physicochemical properties to the antioxidative activity of free amino acids in Fenton system. 
  • The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. 
  • The role of local backrub motions in evolved and designed mutations. 
  • The stoichiometry and kinetics of the inducible cysteine desulfhydrase from Salmonella typhimurium. 
  • The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. 
  • The structural basis for the selectivity of benzotriazole inhibitors of PTP1B. 
  • The structure and evolution of parvalbumins. I. Amino acid compositional studies of parvalbumins from four perciform species. 
  • The subunit structure of normal and hemophilic factor VIII. 
  • The subunit structures of human plasma and platelet factor XIII (fibrin-stabilizing factor). 
  • The surface of beta-sheet proteins contains amphiphilic regions which may provide clues about protein folding. 
  • The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface. 
  • Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands. 
  • Time-dependent mitotic recombination in Saccharomyces cerevisiae. 
  • Total parenteral nutrition. 
  • Toward Building Protein Force Fields by Residue-Based Systematic Molecular Fragmentation and Neural Network. 
  • Transamniotic fetal feeding. III. The effect of nutrient infusion on fetal growth retardation. 
  • Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. 
  • Transport of the synthetic opioid peptide DADLE ([D-Ala2,D-Leu5]-enkephalin) in neuronal cells. 
  • Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate. 
  • Trends for isolated amino acids and dipeptides: Conformation, divalent ion binding, and remarkable similarity of binding to calcium and lead. 
  • Turnover rates of amino acid neurotransmitters in regions of rat cerebellum. 
  • Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli. 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Use of excitatory amino acids to make axon-sparing lesions of hypothalamus. 
  • Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae. 
  • Viral glycoprotein synthesis under conditions of glucosamine block in cells transformed by avian sarcoma viruses. 
  • [A transformylation reaction--transfer of an N-formyl residue to amino acids and peptides in nucleophilic groups--as a side reaction of peptide synthesis]. 
  • [Enzyme activity and hyperaminoacidemia arising in a case of essential hypoproteinemia]. 
  • crl mutants of Saccharomyces cerevisiae resemble both mutants affecting general control of amino acid biosynthesis and omnipotent translational suppressor mutants. 
• 

  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Reiman Jr., Robert Ellis, Associate Professor of Radiology, Radiology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology