Amyloid

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  Subject Areas on Research

  • A Bayesian perspective on Biogen's aducanumab trial. 
  • A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia. 
  • Abdominal fat pad aspiration biopsy for tissue confirmation of systemic amyloidosis: specificity, positive predictive value, and diagnostic pitfalls. 
  • Absence of mutation in the beta-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer's disease. 
  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • Amylin as a Potential Link between Type 2 Diabetes and Alzheimer Disease. 
  • Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. 
  • Amyloid-β PET Scan Results Disclosure and Care-Partner Emotional Well-Being Over Time. 
  • Amyloidoma of the neck: case report and review of the literature. 
  • Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. 
  • Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy. 
  • Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure. 
  • Characterization of the adhesive plaque of the barnacle Balanus amphitrite: amyloid-like nanofibrils are a major component. 
  • Clinical and Technical Considerations for Brain PET Imaging for Dementia. 
  • Congenital alacrima. 
  • Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries. 
  • Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort. 
  • Dysarthria and dysphagia from light chain amyloidosis. 
  • Effectiveness of Florbetapir PET Imaging in Changing Patient Management. 
  • Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. 
  • Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway. 
  • Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells. 
  • Extraocular muscle involvement in idiopathic primary amyloidosis. 
  • Focusing on IL-1-promotion of beta-amyloid precursor protein synthesis as an early event in Alzheimer's disease. 
  • Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. 
  • GSK3 involvement in amylin signaling in isolated rat soleus muscle. 
  • Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism. 
  • Genetic testing improves identification of transthyretin amyloid (ATTR) subtype in cardiac amyloidosis. 
  • Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. 
  • Histopathologic and immunochemical features of lattice corneal dystrophy type III. 
  • Increasing amyloid peptide precursor production and its impact on Alzheimer's disease. 
  • Inhibition of central amylin signaling increases food intake and body adiposity in rats. 
  • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. 
  • Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. 
  • Isolation and expression of multiple forms of beta amyloid protein precursor cDNAs. 
  • Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro. 
  • Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. 
  • Livers from patients with apolipoprotein A-I amyloidosis are not suitable as "domino" donors. 
  • Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth. 
  • Multiple forms of beta-amyloid peptide precursor RNAs in a single cell type. 
  • Nanoscale structures and mechanics of barnacle cement. 
  • Organized deposits in the kidney and look-alikes. 
  • Orthotopic liver transplantation for familial amyloidotic polyneuropathy: a pathological study. 
  • PET Imaging of Dementia: Update 2022. 
  • Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse. 
  • Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. 
  • Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells. 
  • Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive impairment. 
  • Primary systemic amyloidosis masquerading as giant cell arteritis. Case report and review of the literature. 
  • Protein amyloidose misfolding: mechanisms, detection, and pathological implications. 
  • Rat amylin: cloning and tissue-specific expression in pancreatic islets. 
  • Reactions to Amyloid PET Scan Results and Levels of Anxious and Depressive Symptoms: CARE IDEAS Study. 
  • Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults. 
  • Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. 
  • Sequestration of amyloid beta-peptide. 
  • Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. 
  • Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. 
  • Systemic Light Chain Amyloidosis, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. 
  • Tau induces formation of α-synuclein filaments with distinct molecular conformations. 
  • The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. 
  • The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells. 
  • The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16. 
  • Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro. 
  • Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation. 
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  Keywords of People

  • Roy Choudhury, Kingshuk, Adjunct Associate Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics