Analgesics

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  Subject Areas on Research

  • 3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates. 
  • A clinical approach to diagnosis and management of Paget's disease of bone. 
  • A comparison of analgesic management for emergency department patients with sickle cell disease and renal colic. 
  • A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. 
  • A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. 
  • A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery. 
  • A study of the effectiveness of a pain management education booklet for parents of children having cardiac surgery 
  • Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. 
  • Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices. 
  • Adult cancer pain. 
  • Adult emergency department patients with sickle cell pain crisis: a learning collaborative model to improve analgesic management. 
  • Adult emergency department patients with sickle cell pain crisis: results from a quality improvement learning collaborative model to improve analgesic management. 
  • Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. 
  • Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. 
  • Altered prefrontal dopaminergic function in chronic recreational ketamine users. 
  • Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. 
  • American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients. 
  • An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. 
  • An evidence-based review of CGRP mechanisms in the propagation of chronic visceral pain. 
  • Analgesia in the surgical intensive care unit. 
  • Analgesic medication use and risk of epithelial ovarian cancer in African American women. 
  • Analgesic use at ovulation and implantation and human fertility. 
  • Analysis of clinical data with breached blindness: by Shein-Chung Chow and Jun Shao Statistics in Medicine 2004; 23:1185-1193. 
  • Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals. 
  • Antinociceptive activity of Syzygium jambos leaves extract on rats. 
  • Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation. 
  • Assessment of postoperative analgesia after application of ultrasound-guided regional anesthesia for surgery in a swine femoral fracture model. 
  • Association 'Between Gabapentinoids on the Day of Colorectal Surgery and Adverse Postoperative Respiratory Outcomes. 
  • Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. 
  • Behavior of patients with lung cancer: description and associations with oncologic and pain variables. 
  • Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease. 
  • Brief educational video plus telecare to enhance recovery for older emergency department patients with acute musculoskeletal pain: study protocol for the BETTER randomized controlled trial. 
  • Butalbital in the treatment of headache: history, pharmacology, and efficacy. 
  • Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives. 
  • Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface. 
  • Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice. 
  • Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. 
  • Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat. 
  • Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain. 
  • Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. 
  • Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Chemoradiotherapy toxicity during bone marrow transplantation: time course and variation in pain and nausea. 
  • Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data. 
  • Chronic Headache: a Review of Interventional Treatment Strategies in Headache Management. 
  • Chronic Lyme disease: the controversies and the science. 
  • Chronic administration of U50,488H fails to produce hypothalamo-pituitary-adrenal axis tolerance in neonatal rats. 
  • Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. 
  • Clinical practice guideline: acute otitis externa. 
  • Comparison of postoperative nausea between benign and malignant brain tumor patients undergoing awake craniotomy: a retrospective analysis. 
  • Comparison of postoperative pain outcomes after vertical or Pfannenstiel incision for major gynecologic surgery. 
  • Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. 
  • Concepts in pain management. 
  • Cost-minimization analysis of robotic-assisted, laparoscopic, and abdominal sacrocolpopexy. 
  • Cryotherapy temperature differences after total knee arthroplasty: a prospective randomized trial. 
  • Deconstructing Chronic Low Back Pain in the Older Adult-Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part II: Myofascial Pain. 
  • Degradable polymeric vehicles for postoperative pain management. 
  • Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices. 
  • Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics. 
  • Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. 
  • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. 
  • Does midline shift predict postoperative nausea in brain tumor patients undergoing awake craniotomy? A retrospective analysis. 
  • Don't ask, don't tell? Revealing placebo responses to research participants and patients. 
  • Dose-Dependent Association of Gabapentinoids with Pulmonary Complications After Total Hip and Knee Arthroplasties. 
  • Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs. 
  • Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs. 
  • Duloxetine: an emerging evidence for fibromyalgia. 
  • EMPOWER: an intervention to address barriers to pain management in hospice. 
  • Editorial comment. The value of intensive medical management of distal ureteral calculi in an effort to facilitate spontaneous stone passage. 
  • Effect of Diagnosis on Outcomes in the Setting of Enhanced Recovery Protocols. 
  • Effect of antipyretic analgesics on immune responses to vaccination. 
  • Effect of pain management on immunization efficacy in mice. 
  • Effects of neurotoxic destruction of descending noradrenergic pathways on cannabinoid antinociception in models of acute and tonic nociception. 
  • Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat. 
  • Emergency department management of acute pain episodes in sickle cell disease. 
  • Emergency provider analgesic practices and attitudes toward patients with sickle cell disease. 
  • Emerging roles of resolvins in the resolution of inflammation and pain. 
  • Enhanced Recovery After Surgery and Multimodal Strategies for Analgesia. 
  • Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers. 
  • Evidence-Based Medicine Approach to Abdominal Pain. 
  • Eye pain after vitreoretinal surgery: a prospective study of 185 patients. 
  • Factors associated with suboptimal analgesic use in community-dwelling elderly. 
  • For the patient. Do patients use prescribed medicine for osteoarthritis? 
  • Forced versus minimal intravenous hydration in the management of acute renal colic: a randomized trial. 
  • Gabapentin Use in the Neonatal Intensive Care Unit. 
  • Gabapentin and postoperative pain--a systematic review of randomized controlled trials. 
  • Gabapentin as an adjunct to paracervical block for perioperative pain management for first-trimester uterine aspiration: a randomized controlled trial. 
  • Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial. 
  • Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. 
  • HI-TENS reduces moderate-to-severe pain associated with most wound care procedures: a pilot study. 
  • Headache in guillain-barre syndrome. 
  • Health-related quality of life and health service use among older adults with osteoarthritis. 
  • Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons. 
  • High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors. 
  • Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic. 
  • Identification of provider characteristics influencing prescription of analgesics: a systematic literature review. 
  • Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials. 
  • Impact of liposomal bupivacaine administration on postoperative pain in patients undergoing total knee replacement. 
  • Impact of physician and patient gender on pain management in the emergency department--a multicenter study. 
  • Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis. 
  • Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy? 
  • Improving Quality of Care for Sickle Cell Patients in the Pediatric Emergency Department. 
  • Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey. 
  • Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling. 
  • Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol. 
  • Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. 
  • Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series. 
  • Ion channels in analgesia research. 
  • Is medication use by community-dwelling elderly people influenced by cognitive function? 
  • Is there a learning curve associated with the use of remifentanil? 
  • It still hurts! Persistent pain and use of pain medication one year after injury. 
  • Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. 
  • Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib. 
  • Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. 
  • Low-Dose Ketamine Infusion to Decrease Postoperative Delirium for Spinal Fusion Patients. 
  • Lumbar plexus and sciatic nerve block for knee arthroplasty: comparison of ropivacaine and bupivacaine. 
  • Lying for patients: physician deception of third-party payers. 
  • Management of cancer pain. 
  • Managing painful procedures in children with cancer. 
  • Marijuana and Cannabinoids in ESRD and Earlier Stages of CKD. 
  • Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group. 
  • Medical safety in the care of the person with end-stage kidney disease. 
  • Meta-analyses of colorectal cancer risk factors. 
  • Mitogen-activated protein kinases as potential targets for pain killers. 
  • Modeling choice behavior for new pharmaceutical products. 
  • Multiple outcomes and analyses in clinical trials create challenges for interpretation and research synthesis. 
  • Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. 
  • Natural history and treatment of herpes zoster. 
  • Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. 
  • Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain. 
  • New medications and techniques in ambulatory anesthesia. 
  • Nicotine for postoperative analgesia: a systematic review and meta-analysis. 
  • Nonprescription use of pain relievers by middle-aged and elderly community-living adults: National Survey on Drug Use and Health. 
  • Nonsurgical Management of Midsubstance Achilles Tendinopathy. 
  • Novel adamantyl cannabinoids as CB1 receptor probes. 
  • Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey. 
  • Opioid misuse in gastroenterology and non-opioid management of abdominal pain. 
  • Oral Multimodal Analgesia for Total Joint Arthroplasty. 
  • Osteoporosis. 
  • P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception. 
  • Pain and activity after vaginal reconstructive surgery for pelvic organ prolapse and stress urinary incontinence. 
  • Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury. 
  • Pain assessment and treatment disparities: a virtual human technology investigation. 
  • Pain coping in Latino populations. 
  • Pain in the emergency department: results of the pain and emergency medicine initiative (PEMI) multicenter study. 
  • Pain medication management in nursing homes and nursing scope of practice. 
  • Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. 
  • Palliative management of refractory dyspnea in COPD. 
  • Paravertebral Block for Inguinal Herniorrhaphy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 
  • Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study. 
  • Patient demographics and health plan paid costs in chronic inflammatory demyelinating polyneuropathy. 
  • Patient-Reported Physician Treatment Recommendations and Compliance Among U.S. Adults with Low Back Pain. 
  • Patient-controlled analgesia in postoperative pain: the relation of psychological factors to pain and analgesic use. 
  • Patients' preferences and trade-off during labour epidural analgesia: A discrete choice experiment. 
  • Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop. 
  • Pediatric nurses' use of behaviors to make medication administration decisions in infants recovering from surgery. 
  • Percutaneous nephrostolithotomy vs open surgery for renal calculi. A comparative study. 
  • Perioperative Gabapentinoids: Deflating the Bubble. 
  • Perioperative cardiac complications and 30-day mortality in patients undergoing intracranial aneurysmal surgery with adenosine-induced flow arrest: a retrospective comparative study. 
  • Perioperative pain management. 
  • Post-cesarean delivery analgesia. 
  • Postoperative Pain Management in Children of Hispanic Origin: A Descriptive Cohort Study. 
  • Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease. 
  • Postoperative pain after cesarean section: assessment and management in a tertiary hospital in a low-income country. 
  • Practice patterns in percutaneous image-guided intraabdominal abscess drainage: survey of academic and private practice centers. 
  • Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs. 
  • Predictors of duloxetine response in patients with oxaliplatin-induced painful chemotherapy-induced peripheral neuropathy (CIPN): a secondary analysis of randomised controlled trial - CALGB/alliance 170601. 
  • Preemptive analgesia for postoperative pain relief in thoracolumbosacral spine operations: a double-blind, placebo-controlled randomized trial. 
  • Prevalence of pain and analgesic use in men with metastatic prostate cancer using a patient-reported outcome measure. 
  • Progress in the treatment of rheumatoid arthritis. 
  • Prospective evaluation of pain medication requirements and recovery after radical perineal prostatectomy. 
  • Prostate cancer in the late 1990s: hormone refractory disease options. 
  • Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. 
  • Racial differences in analgesic/anti-inflammatory medication adherence among patients with osteoarthritis. 
  • Racial differences in analgesic/anti-inflammatory medication use and perceptions of efficacy. 
  • Randomized controlled trial investigating the effect of transcervical papaverine and bupivacaine on postoperative analgesia following laparoscopic sterilization. 
  • Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use. 
  • Recommendations for the management of herpes zoster. 
  • Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. 
  • Relationship between pain-specific beliefs and adherence to analgesic regimens in Taiwanese cancer patients: a preliminary study. 
  • Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations. 
  • Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 
  • Resolvins are potent analgesics for arthritic pain. 
  • Revisiting patient-related barriers to cancer pain management in the context of the US opioid crisis. 
  • Role of analgesic adjuncts in postoperative pain management. 
  • Role of pain medications, consultants, and other services in improved pain control of elderly adults with cancer in geriatric evaluation and management units. 
  • Roundtable on postherpetic neuralgia--what, why, how long, and what's next? 
  • STING suppresses bone cancer pain via immune and neuronal modulation. 
  • Safety and efficacy of pregabalin in adolescents with fibromyalgia: a randomized, double-blind, placebo-controlled trial and a 6-month open-label extension study. 
  • Safety in Acute Pain Medicine-Pharmacologic Considerations and the Impact of Systems-Based Gaps. 
  • Sedation, Analgesia, and Paralysis during Mechanical Ventilation of Premature Infants. 
  • Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life. 
  • Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • Sickle cell disease patients' perceptions of emergency department pain management. 
  • Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. 
  • Statistical Methods for the Analysis of Discrete Choice Experiments: A Report of the ISPOR Conjoint Analysis Good Research Practices Task Force. 
  • Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase. 
  • Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. 
  • Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo. 
  • Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. 
  • TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. 
  • Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain. 
  • Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. 
  • Temporal Changes in Prescription of Neuropharmacologic Drugs and Utilization of Resources Related to Neurologic Morbidity in Mechanically Ventilated Children With Bronchiolitis. 
  • The appropriate use of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: the Neuromodulation Appropriateness Consensus Committee. 
  • The appropriate use of neurostimulation: stimulation of the intracranial and extracranial space and head for chronic pain. Neuromodulation Appropriateness Consensus Committee. 
  • The costs and benefits of nonoperative management for adult scoliosis. 
  • The epidemiological, clinical, and pathological rationale for the herpes zoster vaccine. 
  • The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics. 
  • The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study. 
  • The influence of triage systems and triage scores on timeliness of ED analgesic administration. 
  • The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects. 
  • The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors. 
  • The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. 
  • The role of gabapentinoids in acute and chronic pain after surgery. 
  • The sedative and analgesic sparing effect of music. 
  • The use of an intrathecal pump to manage intractable cancer pain in a pediatric patient: a case report. 
  • Therapeutic Interactive Voice Response (TIVR) to reduce analgesic medication use for chronic pain management. 
  • Thoracic Nerve Root Entrapment by Intrathecal Catheter Coiling: Case Report and Review of the Literature. 
  • Treatment and prevention of postherpetic neuralgia. 
  • Treatment considerations for elderly and frail patients with neuropathic pain. 
  • Treatment of chronic orthopedic pain with zomepirac. 
  • Treatment of tinnitus with gabapentin: a pilot study. 
  • Trial design of comparing patient-specific versus weight-based protocols to treat vaso-occlusive episodes in sickle cell disease (COMPARE-VOE). 
  • Updates in Enhanced Recovery Pathways for Total Knee Arthroplasty. 
  • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. 
  • Urinary tract stones. 
  • Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. 
  • Utilization of spinal cord stimulation in patients with failed back surgery syndrome. 
  • Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment? 
  • [Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain]. 
  • [Three subanaesthetic dose ketamines mixed with butorphanol in the postoperative continuous intravenous analgesia]. 
  • mu-Opioid agonists stimulate growth hormone secretion in immature rats. 
  • κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. 
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  Keywords of People

  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Nackley, Andrea Gail, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine