Analgesics, Opioid

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  Subject Areas on Research

  • "Choose Physical Therapy" for Neonatal Abstinence Syndrome: Clinical Management for Infants Affected by the Opioid Crisis. 
  • "It's probably going to save my life;" attitudes towards treatment among people incarcerated in the era of fentanyl. 
  • A Pathway for Developing Postoperative Opioid Prescribing Best Practices. 
  • A Primary Care-Based Cognitive Behavioral Therapy Intervention for Long-Term Opioid Users With Chronic Pain : A Randomized Pragmatic Trial. 
  • A Systematic Review Evaluating Neuraxial Morphine and Diamorphine-Associated Respiratory Depression After Cesarean Delivery. 
  • A case of infant delirium in the neonatal intensive care unit. 
  • A comparison of Depodur, a novel, single-dose extended-release epidural morphine, with standard epidural morphine for pain relief after lower abdominal surgery. 
  • A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. 
  • A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients. 
  • A methodology to explore ventilatory chemosensitivity and opioid-induced respiratory depression risk. 
  • A multisociety organizational consensus process to define guiding principles for acute perioperative pain management. 
  • A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. 
  • A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. 
  • A preliminary investigation of remifentanil as a labor analgesic. 
  • A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis. 
  • A randomized controlled trial comparing two vaso-occlusive episode (VOE) protocols in sickle cell disease (SCD). 
  • A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. 
  • A randomized trial of transcutaneous electric acupoint stimulation as adjunctive treatment for opioid detoxification. 
  • A randomized, open label trial of methadone continuation versus forced withdrawal in a combined US prison and jail: Findings at 12 months post-release. 
  • A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster. 
  • A retrospective assessment of the incidence of respiratory depression after neuraxial morphine administration for postcesarean delivery analgesia. 
  • A retrospective comparison of anesthetic management of robot-assisted laparoscopic radical prostatectomy versus radical retropubic prostatectomy. 
  • A retrospective study of opioid prescribing patterns at hospital discharge in surgical patients with obstructive sleep apnea. 
  • A risk score for postoperative nausea and/or vomiting in women undergoing cesarean delivery with intrathecal morphine. 
  • A statewide comparison of opioid prescribing in teaching versus nonteaching hospitals. 
  • Acupuncture and related techniques for postoperative pain: a systematic review of randomized controlled trials. 
  • Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty. 
  • Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. 
  • Acute pain on and off the battlefield: what we do, what we know, and future directions. 
  • Addressing the Opioid Crisis: A Dynamic Case-Based Module Set for Interprofessional Educators, Learners, and Clinicians. 
  • Adoptive immunotherapy with autologous T-cell infusions reduces opioid requirements in advanced cancer patients. 
  • Alcohol use and consequences in matriculating US college students by prescription stimulant/opioid nonmedical misuse status. 
  • American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Management of Patients on Preoperative Opioid Therapy. 
  • American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Opioid Minimization in Opioid-Naïve Patients. 
  • American Society for Enhanced Recovery and Perioperative Quality Initiative-4 Joint Consensus Statement on Persistent Postoperative Opioid Use: Definition, Incidence, Risk Factors, and Health Care System Initiatives. 
  • Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats. 
  • An Interrupted Time Series Analysis of the Dissemination of a Sickle Cell Vaso-Occlusive Episode Treatment Algorithm and a Case Management Referral Form for Individuals With Sickle Cell Disease in the Emergency Department. 
  • Analgesia After Cesarean Delivery in the United States 2008-2018: A Retrospective Cohort Study. 
  • Analgesia in the surgical intensive care unit. 
  • Analgesic Effects of a Novel Combination of Regional Anesthesia After Pediatric Cardiac Surgery: A Retrospective Cohort Study. 
  • Analgesic and antiemetic needs following minimally invasive vs open staging for endometrial cancer. 
  • Analgesic use after vaginal delivery in women with perineal lacerations: a retrospective cohort study. 
  • Anesthetic induction with fentanyl and intravenous lidocaine for coronary artery surgery. 
  • Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes. 
  • Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies. 
  • Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. 
  • Anticipated Barriers to Sustained Engagement in Treatment With Medications for Opioid Use Disorder After Release From Incarceration. 
  • Antinociceptive activity of Syzygium jambos leaves extract on rats. 
  • Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation. 
  • Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain. 
  • Application of continuous incisional infusion of local anesthetic after major pediatric urological surgery: prospective randomized controlled trial. 
  • Are Exercise and Physical Therapy Common Forms of Conservative Management in the Year Before Lumbar Spine Surgery? 
  • Assessing Practice Patterns and Influential Factors for Nurse Practitioners Who Manage Chronic Pain. 
  • Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe. 
  • Association Among Opioid Use, Treatment Preferences, and Perceptions of Physician Treatment Recommendations in Patients With Neck and Back Pain. 
  • Association Between Gabapentinoids and Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery. 
  • Association Between Long-term Opioid Use in Family Members and Persistent Opioid Use After Surgery Among Adolescents and Young Adults. 
  • Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population. 
  • Association between traumatic brain injuries and ketamine infusion side effects following combat injury. 
  • Association of Current Opioid Use With Serious Adverse Events Among Older Adult Survivors of Breast Cancer. 
  • Association of Early Physical Therapy With Long-term Opioid Use Among Opioid-Naive Patients With Musculoskeletal Pain. 
  • Association of Hydrocodone Schedule Change With Opioid Prescriptions Following Surgery. 
  • Association of Opioid Prescribing With Opioid Consumption After Surgery in Michigan. 
  • Association of Opioids and Nonsteroidal Anti-inflammatory Drugs With Outcomes in CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study. 
  • Association of Postoperative Opioid Prescription Size and Patient Satisfaction. 
  • Association of State Opioid Duration Limits With Postoperative Opioid Prescribing. 
  • Association of gabapentinoid utilization with postoperative pulmonary complications in gynecologic surgery: a retrospective cohort study. 
  • Associations between cigarette smoking and pain among veterans. 
  • Barriers and facilitators to care for individuals with sickle cell disease in central North Carolina: The emergency department providers' perspective. 
  • Beyond opioid patient-controlled analgesia: a systematic review of analgesia after major spine surgery. 
  • Bioavailabilities of rectal and oral methadone in healthy subjects. 
  • Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state. 
  • Brachial Plexus Block with Liposomal Bupivacaine for Shoulder Surgery Improves Analgesia and Reduces Opioid Consumption: Results from a Multicenter, Randomized, Double-Blind, Controlled Trial. 
  • Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. 
  • Buprenorphine for prescription opioid addiction in a patient with depression and alcohol dependence. 
  • Buprenorphine in postoperative pain management. 
  • Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. 
  • CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids. 
  • CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. 
  • Cannabis Use Disorder and Epilepsy: A Cross-National Analysis of 657 072 Hospitalized Patients. 
  • Caring for the suffering: meeting the Ebola crisis responsibly. 
  • Central effect of mu-opioid agonists on antral motility in conscious rats. 
  • Central effects of morphine on GI motility in conscious dogs. 
  • Changes in religious coping and relapse to drug use among opioid-dependent patients following inpatient detoxification. 
  • Characteristics of Individuals in the United States Who Used Opioids During Pregnancy. 
  • Characteristics of New Opioid Use Among Medicare Beneficiaries: Identifying High-Risk Patterns. 
  • Children And The Opioid Epidemic: Age-Stratified Exposures And Harms. 
  • Chronic non-cancer pain among adults with substance use disorders: Prevalence, characteristics, and association with opioid overdose and healthcare utilization. 
  • Chronic pain and analgesic use in CKD: implications for patient safety. 
  • Classifying Preoperative Opioid Use for Surgical Care. 
  • Clinical Decision Support for Symptom Management in Lung Cancer Patients: A Group RCT. 
  • Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. 
  • Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. 
  • Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. 
  • Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Headache. 
  • Clinical value of tapentadol extended-release in painful diabetic peripheral neuropathy. 
  • Clinician Perspectives on Managing Chronic Pain After Curative-Intent Cancer Treatment. 
  • Cognitive Impairment among People Who Use Heroin and Fentanyl: Findings from the Miami Adult Studies on HIV (MASH) Cohort. 
  • Comment on "Postoperative Opioid Prescribing and Pain". 
  • Commercial features of placebo and therapeutic efficacy. 
  • Comorbid Insomnia and Sleep Apnea are Associated with Greater Downstream Health Care Utilization and Chronic Opioid Use after Arthroscopic Hip Surgery. 
  • Comparative analysis of length of stay, hospitalization costs, opioid use, and discharge status among spine surgery patients with postoperative pain management including intravenous versus oral acetaminophen. 
  • Comparison of Downstream Health Care Utilization, Costs, and Long-Term Opioid Use: Physical Therapist Management Versus Opioid Therapy Management After Arthroscopic Hip Surgery. 
  • Comparison of Opioid-Based Patient-Controlled Analgesia with Physician-Directed Analgesia in Acute Pancreatitis: A Retrospective Cohort Study. 
  • Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain. 
  • Complementary modulation of somatic inhibition by opioids and cannabinoids. 
  • Concurrent Opioid and Benzodiazepine Prescriptions Among Older Women Diagnosed With Breast Cancer. 
  • Concurrent prescribing of opioids with other sedating medications after cancer diagnosis: a population-level analysis. 
  • Concurrent substance abuse is associated with sexual risk behavior among adults seeking treatment for prescription opioid dependence. 
  • Conservative Management of Neuropathic Pain in a Patient With Pancoast-Tobias Syndrome: A Case Report. 
  • Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents. 
  • Contemporary clinical opioid use: opportunities and challenges. 
  • Continuous adductor canal blockade facilitates increased home discharge and decreased opioid consumption after total knee arthroplasty. 
  • Controlled Substance Lock-In Programs: Examining An Unintended Consequence Of A Prescription Drug Abuse Policy. 
  • Conversion to oral controlled-release oxycodone from intravenous opioid analgesic in the postoperative setting. 
  • Cost analysis of remifentanil and fentanyl for neurosurgical anesthesia. 
  • Criminal justice continuum for opioid users at risk of overdose. 
  • Critical Risk Factors for Opioid Demand after Pelvic and Acetabular Fracture Surgery. 
  • Cross-Sectional Analysis of Per Capita Supply of Doctors of Chiropractic and Opioid Use in Younger Medicare Beneficiaries. 
  • Current Concepts in Methadone Metabolism and Transport. 
  • Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics. 
  • Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics. 
  • De-implementation of extended-release opioids from peri-operative pathways. 
  • DepoDur extended-release epidural morphine: reshaping postoperative care. What perioperative nurses need to know. 
  • Depression and Long-Term Prescription Opioid Use and Opioid Use Disorder: Implications for Pain Management in Cancer. 
  • Design considerations for a remote randomized multi-site clinical trial evaluating an e-health self-management program for chronic pain patients receiving opioid therapy. 
  • Despite warnings, some graduating otolaryngology residents planning to use codeine for posttonsillectomy pain control. 
  • Determination of the effective therapeutic dose of intrathecal sufentanil for extracorporeal shock wave lithotripsy. 
  • Determination of the potency of remifentanil compared with alfentanil using ventilatory depression as the measure of opioid effect. 
  • Developing a risk stratification tool for predicting opioid-related respiratory depression after non-cardiac surgery: a retrospective study. 
  • Development and Validation of a Model for Opioid Prescribing Following Gynecological Surgery. 
  • Development and longitudinal validation of the overall benefit of analgesia score: a simple multi-dimensional quality assessment instrument. 
  • Development and validation of an electronic health records-based opioid use disorder algorithm by expert clinical adjudication among patients with prescribed opioids. 
  • Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis. 
  • Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. 
  • Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. 
  • Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats. 
  • Differences in Characteristics and Downstream Drug Use Among Opioid-Naïve and Prior Opioid Users with Low Back Pain. 
  • Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine Stimulation. 
  • Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Differential prescribing of opioid analgesics according to physician specialty for Medicaid patients with chronic noncancer pain diagnoses. 
  • Discharge prescribing of enteral opioids after initiation as a weaning strategy from continuous opioid infusions in the Intensive Care Unit. 
  • Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity. 
  • Do Patients Fill Their Postoperative Opioid Prescription After Mohs Surgery? A Retrospective Study. 
  • Do opiates affect the clinical evaluation of patients with acute abdominal pain? 
  • Does Engaging Patients with Relevant Education About Long-Term Opioid Use Before Spine Surgery Affect Long-term Opioid Use? A Randomized Controlled Trial. 
  • Does Health Care Utilization Before Hip Arthroscopy Predict Health Care Utilization After Surgery in the US Military Health System? An Investigation Into Health-Seeking Behavior. 
  • Does functional ability in the postoperative period differ between remifentanil- and fentanyl-based anesthesia? 
  • Drug interactions: volatile anesthetics and opioids. 
  • Drug-drug-gene interaction risk among opioid users in the U.S. Department of Veterans Affairs. 
  • Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors. 
  • Duloxetine for the reduction of opioid use in elective orthopedic surgery: a systematic review and meta-analysis. 
  • Early Initiation of Sub-Anesthetic Ketamine Infusion in Adults with Vaso-Occlusive Crises Is Associated with Greater Reduction in Sickle Cell Pain Intensity: A Single Center's Experience. 
  • Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach study protocol for a multi-center, stepped-wedge randomized controlled trial. 
  • Editorial Commentary: Postoperative Pain Management After Anterior Cruciate Ligament Reconstruction Can Minimize Opioid Use and Allow Early Rehabilitation. 
  • Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl). 
  • Effect of Multimodal Analgesia on Opioid Use After Open Ventral Hernia Repair. 
  • Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial. 
  • Effect of Smartphone App-Based Education on Clinician Prescribing Habits in a Learning Health Care System: A Randomized Cluster Crossover Trial. 
  • Effect of education and guidelines for treatment of uncomplicated dental pain on patient and provider behavior. 
  • Effect of intrathecal fentanyl dose on the duration of labor analgesia. 
  • Effect of neuromuscular blockers and opiates on the cerebrovascular response to endotracheal suctioning in adults with severe head injuries. 
  • Effect of new persistent opioid use on physiologic and psychologic outcomes following bariatric surgery. 
  • Effect of ritonavir-induced cytochrome P450 3A4 inhibition on plasma fentanyl concentrations during patient-controlled epidural labor analgesia: a pharmacokinetic simulation. 
  • Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium. 
  • Effects of cabozantinib on pain and narcotic use in patients with castration-resistant prostate cancer: results from a phase 2 nonrandomized expansion cohort. 
  • Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. 
  • Effects of remifentanil and alfentanil on the cardiovascular responses to induction of anaesthesia and tracheal intubation in the elderly. 
  • Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans. 
  • Efficacy of single-dose, multilevel paravertebral nerve blockade for analgesia after thoracoscopic procedures. 
  • Electronic medical records as a replacement for prospective research data collection in postoperative pain and opioid response studies. 
  • Electronic self-administered screening for substance use in adult primary care patients: feasibility and acceptability of the tobacco, alcohol, prescription medication, and other substance use (myTAPS) screening tool. 
  • Embedding Learning in a Learning Health Care System to Improve Clinical Practice. 
  • Emergency Department Attending Physician Variation in Opioid Prescribing in Low Acuity Back Pain. 
  • Emergency Department Prescription Opioids as an Initial Exposure Preceding Addiction. 
  • Emergency provider analgesic practices and attitudes toward patients with sickle cell disease. 
  • Emotion regulation as a transdiagnostic factor underlying co-occurring chronic pain and problematic opioid use. 
  • Endovascular surgery is not protective against new persistent opioid use development compared to open vascular surgery. 
  • Engaging Education About Risks of Opioid Use With Patients Before Elective Surgery of the Lower Extremity Did Not Reduce Postoperative Opioid Utilization: A Randomized Controlled Trial. 
  • Enhanced Recovery After Surgery (ERAS) for Spine Surgery: A Systematic Review. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Essentials of Our Current Understanding: Abdominal Wall Blocks. 
  • Estimating the impact of wide scale uptake of screening and medications for opioid use disorder in US prisons and jails. 
  • Evaluating Outcomes and Misuse in Opioid-Dependent Chronic Pancreatitis Using a State-Mandated Monitoring System. 
  • Evaluating short- and long-term impacts of a Medicaid "lock-in" program on opioid and benzodiazepine prescriptions dispensed to beneficiaries. 
  • Evaluating the Implementation of a Preemptive, Multimodal Analgesia Protocol in a Plastic Surgery Office. 
  • Evaluation of Opioid Use in Acute Pancreatitis in Absence of Chronic Pancreatitis: Absence of Opioid Dependence an Important Feature. 
  • Evaluation of a Medicaid Lock-in Program: Increased Use of Opioid Use Disorder Treatment but No Impact on Opioid Overdose Risk. 
  • Evaluation of a Quality Improvement Intervention That Eliminated Routine Use of Opioids After Cesarean Delivery. 
  • Evaluation of a single-dose, extended-release epidural morphine formulation for pain after knee arthroplasty. 
  • Evaluation of an Opioid-Free Anesthesia Protocol for Elective Abdominal Surgery in a Community Hospital. 
  • Evidence-based oral transmucosal fentanyl citrate (OTFC) dosing guidelines. 
  • Evolving the management of acute perioperative pain towards opioid free protocols: a narrative review. 
  • Exploring Emergency Department Provider Experiences With and Perceptions of Weight-Based Versus Individualized Vaso-Occlusive Treatment Protocols in Sickle Cell Disease. 
  • FACS analysis of neuronal-glial interactions in the nucleus accumbens following morphine administration. 
  • Facilitators and Barriers to Naloxone Kit Use Among Opioid-Dependent Patients Enrolled in Medication Assisted Therapy Clinics in North Carolina. 
  • Factors Associated With Narcotic Use After Clavicle Fractures. 
  • Factors Associated With New Persistent Opioid Usage After Lung Resection. 
  • Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis. 
  • Factors associated with opioid use after endoscopic sinus surgery. 
  • Factors associated with postoperative nausea or vomiting in parturients undergoing caesarean delivery under spinal anaesthesia with intrathecal morphine: A prospective cohort study. 
  • Fascia Iliaca Blockade With the Addition of Liposomal Bupivacaine Versus Plain Bupivacaine for Perioperative Pain Management During Hip Arthroscopy: A Double-Blinded Prospective Randomized Control Trial. 
  • Fascia iliaca blockade with the addition of liposomal bupivacaine vs. plain bupivacaine for perioperative pain management following hip arthroscopy. 
  • Feasibility Study of a Quasi-experimental Regional Opioid Safety Prescribing Program in Veterans Health Administration Emergency Departments. 
  • Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. 
  • Follow-up to Nonfatal Opioid Overdoses. 
  • Forty-eight hours of postoperative pain relief after total hip arthroplasty with a novel, extended-release epidural morphine formulation. 
  • Four States With Robust Prescription Drug Monitoring Programs Reduced Opioid Dosages. 
  • Fracture location impacts opioid demand in upper extremity fracture surgery. 
  • Freedom From Opioids After Total Knee Arthroplasty. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial. 
  • Gender differences in drug effects: implications for anesthesiologists. 
  • Geographic variation in the prescription of schedule II opioid analgesics among outpatients in the United States. 
  • HIV risk behavior in treatment-seeking opioid-dependent youth: results from a NIDA clinical trials network multisite study. 
  • Harms and benefits of opioids for management of non-surgical acute and chronic low back pain: a systematic review. 
  • Health Care Spending and New Persistent Opioid Use After Surgery. 
  • Hemodynamics and emergence profile of remifentanil versus fentanyl prospectively compared in a large population of surgical patients. 
  • Hepatitis C Virus Treatment Delivered via Telemedicine to Persons With Opioid Use Disorder. 
  • Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism. 
  • How Many Steps Per Day During the Early Postoperative Period are Associated With Patient-Reported Outcomes of Disability, Pain, and Opioid Use After Lumbar Spine Surgery? 
  • How North Carolina Hospitals, Health Systems, and Care Providers are Uniting to Fight the Opioid Epidemic. 
  • How do emergency department patients store and dispose of opioids after discharge? A pilot study. 
  • Human Genetic Variability Contributes to Postoperative Morphine Consumption. 
  • IMPROVE trial: a randomized controlled trial of patient-controlled analgesia for sickle cell painful episodes: rationale, design challenges, initial experience, and recommendations for future studies. 
  • Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms. 
  • Identification of Functioning Domains in the Presurgical Period and Their Relationships with Opioid Use and Pain Catastrophizing. 
  • Identifying optimal dosage regimes under safety constraints: An application to long term opioid treatment of chronic pain. 
  • Iliohypogastric-ilioinguinal peripheral nerve block for post-Cesarean delivery analgesia decreases morphine use but not opioid-related side effects. 
  • Impact of Preoperative Opioid Use After Emergency General Surgery. 
  • Impact of Spinal Cord Stimulation on Opioid Dose Reduction: A Nationwide Analysis. 
  • Impact of a multimodal analgesic protocol modification on opioid consumption after cesarean delivery: a retrospective cohort study. 
  • Impact of an Opioid Safety Initiative on Patients Undergoing Total Knee Arthroplasty: A Time Series Analysis. 
  • Impact of enhanced recovery after cesarean delivery on maternal outcomes: A systematic review and meta-analysis. 
  • Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice. 
  • Impact of intraoperative dexmedetomidine on postoperative analgesia following gynecologic surgery. 
  • Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis. 
  • Impact of physician and patient gender on pain management in the emergency department--a multicenter study. 
  • Impacts of an Opioid Safety Initiative on US Veterans Undergoing Cancer Treatment. 
  • Impacts of an opioid overdose prevention intervention delivered subsequent to acute care. 
  • Implementation of Perioperative Music Using the Consolidated Framework for Implementation Research. 
  • Implementation of a Multimodal Analgesia Protocol Among Outpatient Neurosurgical Patients Undergoing Spine Surgery to Improve Patient Outcomes. 
  • Implementation of a comprehensive hospitalist-led initiative to improve care for patients with opioid use disorder. 
  • Implementation of mandatory opioid prescribing limits in North Carolina: healthcare administrator and prescriber perspectives. 
  • Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators. 
  • Implications of the Opioid Epidemic for the Clinical Gastroenterology Practice. 
  • Improving Quality of Care for Sickle Cell Patients in the Pediatric Emergency Department. 
  • In inpatients with cirrhosis opioid use is common and associated with length of stay and persistent use post-discharge. 
  • In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study. 
  • Inadequate provision of postintubation anxiolysis and analgesia in the ED. 
  • Incidence of Opioid-Associated Deaths in Cancer Survivors in the United States, 2006-2016: A Population Study of the Opioid Epidemic. 
  • Incidence of opioid-managed pelvic pain after hysteroscopic sterilization versus laparoscopic sterilization, US 2005-2012. 
  • Incidence of serotonin syndrome in patients treated with fentanyl on serotonergic agents. 
  • Increased Risk of Chronic Opioid Use and Revision After Anterior Cervical Diskectomy and Fusion in Patients with Prior Shoulder Arthroscopy. 
  • Increasing collaboration on substance use disorder research with primary care practices through the National Drug Abuse Treatment Clinical Trials Network. 
  • Index of suspicion. Case 1: Infant who has respiratory distress. Case 2: Abnormal behavior, seizures, and altered sensorium in a 7-year-old boy. Case 3: Fever and dysphagia in a 4-year-old girl. 
  • Ineffective Policies to Address the Opioid Epidemic. 
  • Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial. 
  • Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate. 
  • Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. 
  • Interdisciplinary team-based care for patients with chronic pain on long-term opioid treatment in primary care (PPACT) - Protocol for a pragmatic cluster randomized trial. 
  • Interferences with urine drug screens. 
  • Interscalene block with liposomal bupivacaine versus continuous interscalene catheter in primary total shoulder arthroplasty. 
  • Interscalene brachial plexus block with a continuous catheter insertion system and a disposable infusion pump. 
  • Interscalene brachial plexus block with continuous intraarticular infusion of ropivacaine. 
  • Intracranial pressure and hemodynamic effects of remifentanil versus alfentanil in patients undergoing supratentorial craniotomy. 
  • Intranasal fentanyl improves time to analgesic delivery in sickle cell pain crises. 
  • Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit. 
  • Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients. 
  • Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study. 
  • Intraoperative ketorolac and eye pain after vitreoretinal surgery: a prospective, randomized, placebo-controlled study. 
  • Intrathecal PLC(β3) oligodeoxynucleotides antisense potentiates acute morphine efficacy and attenuates chronic morphine tolerance. 
  • Intrathecal morphine for analgesia after postpartum bilateral tubal ligation. 
  • Intrathecal morphine for postpartum bilateral tubal ligation. 
  • Intravenous acetaminophen analgesia after cardiac surgery: A randomized, blinded, controlled superiority trial. 
  • Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. 
  • Introduction of an Analgesia Prescription Guideline Can Reduce Unused Opioids After Cardiac Surgery: A Before and After Cohort Study. 
  • Is it time to drug test your chronic pain patient? 
  • Is there a learning curve associated with the use of remifentanil? 
  • Labor prior to cesarean delivery associated with higher post-discharge opioid consumption. 
  • Legislation Only Limiting Opioid Prescription Length Has Minimal Impact on Prescribing in Orthopaedic Trauma. 
  • Letter: are opioid prescriptions associated with hepatic encephalopathy in patients with compensated cirrhosis? Authors' reply. 
  • Letting the gene out of the bottle: OPRM1 interactions. 
  • Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. 
  • Lidocaine patch for acute pain management: a meta-analysis of prospective controlled trials. 
  • Limitations on Postoperative Opioid Prescriptions and Effects on Health Care Resource Use Following Elective Anterior Cervical Discectomy and Fusion. 
  • Liposomal bupivacaine in forefoot surgery. 
  • Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature. 
  • Local anesthetics and mode of delivery: bupivacaine versus ropivacaine versus levobupivacaine. 
  • Long-Term Outcomes of Restorative Neurostimulation in Patients With Refractory Chronic Low Back Pain Secondary to Multifidus Dysfunction: Two-Year Results of the ReActiv8-B Pivotal Trial. 
  • Long-term administration of controlled-release oxycodone tablets for the treatment of cancer pain. 
  • Long-term analgesic use: sometimes less is not more. 
  • Long-term opioid therapy definitions and predictors: A systematic review. 
  • Long-term opioid use after bariatric surgery. 
  • Long-term use of narcotic analgesics in chronic pain. 
  • Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis. 
  • Low barrier medication for opioid use disorder at a federally qualified health center: a retrospective cohort study. 
  • Low theoretical fidelity hinders the research on health coaching for opioid reduction: A systematic review of randomized controlled trials. 
  • Low-Dose Ketamine Infusion to Decrease Postoperative Delirium for Spinal Fusion Patients. 
  • Low-dose naloxone infusion for the treatment of intractable nausea and vomiting after intrathecal morphine in a parturient. 
  • Machine Learning to Predict Successful Opioid Dose Reduction or Stabilization After Spinal Cord Stimulation. 
  • Machine learning for phenotyping opioid overdose events. 
  • Making a business plan for starting a transitional pain service within the US healthcare system. 
  • Management of dyspnea within a rapid learning healthcare model. 
  • Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. 
  • Managing Acute Pain With Opioids in the Emergency Department: A Teachable Moment? 
  • Managing Chronic Pain in Cancer Survivors Prescribed Long-Term Opioid Therapy: A National Survey of Ambulatory Palliative Care Providers. 
  • Maternal deaths due to suicide and overdose in the state of Michigan from 2008 to 2018. 
  • Measurement-based care using DSM-5 for opioid use disorder: can we make opioid medication treatment more effective? 
  • Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience. 
  • Medication use quality and safety in older adults: 2020 update. 
  • Medication-Based Treatment to Address Opioid Use Disorder. 
  • Medications that prolong the QT interval. 
  • Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. 
  • Mental health and substance use affect perioperative opioid demand in upper extremity trauma surgery. 
  • Meperidine: a critical review. 
  • Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. 
  • Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism. 
  • Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity. 
  • Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis. 
  • Minimum effective dose of spinal ropivacaine with and without fentanyl for postpartum tubal ligation. 
  • Modifying Institutional Guidelines Reduces the Likelihood of Oversedation During Interventional Procedures. 
  • Monitoring, prevention and treatment of side effects of long-acting neuraxial opioids for post-cesarean analgesia. 
  • More Than 1 in 3 Patients With Chronic Low Back Pain Continue to Use Opioids Long-term After Spinal Fusion: A Systematic Review. 
  • More educated emergency department patients are less likely to receive opioids for acute pain. 
  • Morphine and Cardiovascular Outcomes Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Undergoing Coronary Angiography. 
  • Mouse model of OPRM1 (A118G) polymorphism has altered hippocampal function. 
  • Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. 
  • Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia. 
  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. 
  • Multimodal Pain Management for Major Joint Replacement Surgery. 
  • Multimodal analgesia using opioid-sparing regimen in patients undergoing left ventricular assist device implantation. 
  • Musculoskeletal Health: Addressing the Leading Causes of Disability. 
  • Nasal administration of opioids for pain management in adults. 
  • National Institutes of Health Pathways to Prevention Workshop: the role of opioids in the treatment of chronic pain. 
  • National Variation in Opioid Prescription Fills and Long-Term Use in Opioid Naïve Patients after Urological Surgery. 
  • Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. 
  • New Persistent Opioid Use After Postoperative Intensive Care in US Veterans. 
  • New Persistent Opioid Use Among Patients With Cancer After Curative-Intent Surgery. 
  • New persistent opioid use after acute opioid prescribing in pregnancy: a nationwide analysis. 
  • Nicotine for postoperative analgesia: a systematic review and meta-analysis. 
  • Nonmedical Opioid Pain Relievers and All-Cause Mortality: A 27-Year Follow-Up From the Epidemiologic Catchment Area Study. 
  • Nonopioid Treatments for Chronic Pain-Integrating Multimodal Biopsychosocial Approaches to Pain Management. 
  • Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians. 
  • OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. 
  • Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey. 
  • Oliceridine in the treatment of moderate to severe acute pain. 
  • One-year results from the first US-based enhanced recovery after cardiac surgery (ERAS Cardiac) program. 
  • Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine. 
  • Opioid Abuse and Dependence in Those Hospitalized Due to Head and Neck Cancer. 
  • Opioid Crisis through the Lens of Social Justice. 
  • Opioid Dependence and Associated Health Care Utilization and Cost in Traumatic Spinal Cord Injury Population: Analysis Using Marketscan Database. 
  • Opioid Half-lives and Hemlines: The Long and Short of Fashion. 
  • Opioid Induced Hyperalgesia. 
  • Opioid Legislation Decreases Opioid Prescribing in Total Knee Arthroplasty. 
  • Opioid Management in Pregnancy and Postpartum. 
  • Opioid Prescribing After Curative-Intent Surgery: A Qualitative Study Using the Theoretical Domains Framework. 
  • Opioid Prescribing After Nonfatal Overdose and Association With Repeated Overdose. 
  • Opioid Prescribing After Nonfatal Overdose and Association With Repeated Overdose: A Cohort Study. 
  • Opioid Prescribing and Use Among Cancer Survivors: A Mapping Review of Observational and Intervention Studies. 
  • Opioid Prescribing in the 2016 Medicare Fee-for-Service Population. 
  • Opioid Prescription After Carpal Tunnel Release Is Declining Independent of State Laws. 
  • Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats. 
  • Opioid Sensitivity in Children with and without Obstructive Sleep Apnea. 
  • Opioid Use Among Veterans of Recent Wars Receiving Veterans Affairs Chiropractic Care. 
  • Opioid Use in Hemodialysis Patients. 
  • Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates. 
  • Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial. 
  • Opioid exposure is associated with nonunion risk in a traumatically injured population: An inception cohort study. 
  • Opioid legislation and narcotic filling in total hip arthroplasty: descriptive study of time and state-level trends in the United States. 
  • Opioid management and dependency among adult patients with sickle cell disease. 
  • Opioid misuse in gastroenterology and non-opioid management of abdominal pain. 
  • Opioid patient controlled analgesia use during the initial experience with the IMPROVE PCA trial: a phase III analgesic trial for hospitalized sickle cell patients with painful episodes. 
  • Opioid prescribing exceeds consumption following common surgical oncology procedures. 
  • Opioid prescriptions are associated with hepatic encephalopathy in a national cohort of patients with compensated cirrhosis. 
  • Opioid sparing during endotracheal intubation using McCoy laryngoscope in neurosurgical patients: the comparison of haemodynamic changes with Macintosh blade in a randomized trial. 
  • Opioid therapy and persistent pain: can cognitive behavioral therapy help? 
  • Opioid therapy for the treatment of refractory pain in children with juvenile rheumatoid arthritis. 
  • Opioid tolerance--a predictor of increased length of stay and higher readmission rates. 
  • Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial. 
  • Opioid use affects antioxidant activity and purine metabolism: preliminary results. 
  • Opioid-Associated Out-of-Hospital Cardiac Arrest: Distinctive Clinical Features and Implications for Health Care and Public Responses: A Scientific Statement From the American Heart Association. 
  • Opioid-Based Analgesia: Impact on Total Joint Arthroplasty. 
  • Opioid-free Anesthesia: Reply. 
  • Opioid-free Anesthesia: Time to Regain Our Balance. 
  • Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information. 
  • Opioid-related respiratory and gastrointestinal adverse events in patients with acute postoperative pain: prevalence, predictors, and burden. 
  • Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. 
  • Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. 
  • Opioids and Public Health: The Prescription Opioid Ecosystem and Need for Improved Management. 
  • Opioids. 
  • Optimization of conscious sedation in plastic surgery. 
  • Oral Multimodal Analgesia for Total Joint Arthroplasty. 
  • Oral transmucosal fentanyl citrate as an anaesthetic premedication when dosed to an opioid effect vs total opioid consumption. 
  • Orthopedic Surgeon Decision-Making Processes for Postsurgical Opioid Prescribing. 
  • Orthotopic liver transplant patients require less postoperative morphine than do patients undergoing hepatic resection. 
  • Outbreak of bacteremia due to Burkholderia contaminans linked to intravenous fentanyl from an institutional compounding pharmacy. 
  • PCA safety data review after clinical decision support and smart pump technology implementation. 
  • PENTAZOCINE VERSUS PENTAZOCINE WITH RECTAL DICLOFENAC FOR POSTOPERATIVE PAIN RELIEF AFTER CESAREAN SECTION- A DOUBLE BLIND RANDOMIZED PLACEBO CONTROLLED TRIAL IN A LOW RESOURCE AREA. 
  • Pain Catastrophizing Predicts Opioid and Health-Care Utilization After Orthopaedic Surgery: A Secondary Analysis of Trial Participants with Spine and Lower-Extremity Disorders. 
  • Pain Control in Breast Surgery: Survey of Current Practice and Recommendations for Optimizing Management-American Society of Breast Surgeons Opioid/Pain Control Workgroup. 
  • Pain as an indication for rib fixation: a bi-institutional pilot study. 
  • Pain management following robotic-assisted radical prostatectomy: transitioning to an opioid free regimen. 
  • Pain management in chronic pancreatitis incorporating safe opioid practices: Challenge accepted. 
  • Pain management in knee surgery. 
  • Pain management, fluid therapy and thromboprophylaxis after pancreatoduodenectomy: a worldwide survey among surgeons. 
  • Painful acute radiation thyroiditis induced by 131I treatment of Graves' disease. 
  • Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. 
  • Paravertebral somatic nerve block compared with peripheral nerve blocks for outpatient inguinal herniorrhaphy. 
  • Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway. 
  • Patient demographics and clinical characteristics influence opioid and nonopioid pain management prescriptions of primary care NPs, PAs, and physicians. 
  • Patient-Reported Chronic Pain Outcomes After Lung Transplantation. 
  • Patient-centered outcomes: Domain importance predicts health care use following physical therapy. 
  • Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial. 
  • Patient-specific factors affecting patient-controlled analgesia dosing. 
  • Patients Who Undergo Primary Lumbar Spine Fusion After Recent but Not Remote Total Hip Arthroplasty Are at Increased Risk for Complications, Revision Surgery, and Prolonged Opioid Use. 
  • Patterns and predictors of pain following lung transplantation. 
  • Patterns of Initial Opioid Prescribing to Opioid-Naive Patients. 
  • Patterns of NSAIDs Use and Their Association with Other Analgesic Use in CKD. 
  • Patterns of Opioid Prescription and Use After Cesarean Delivery. 
  • Patterns of opioid analgesic prescription among patients with osteoarthritis. 
  • Patterns of withdrawal in patients with opioid use disorder (OUD) transitioning from untreated OUD or buprenorphine treatment to extended-release naltrexone. 
  • Perioperative COX-2 inhibitors: knowledge and challenges. 
  • Perioperative Opioids and Public Health. 
  • Perioperative Pain Management for Elective Spine Surgery: Opioid Use and Multimodal Strategies. 
  • Perioperative Serum 25-Hydroxyvitamin D Levels as a Predictor of Postoperative Opioid Use and Opioid Use Disorder: a Cohort Study. 
  • Perioperative pharmacokinetics of methadone in adolescents. 
  • Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. 
  • Peripherally Acting μ-Opioid Receptor Antagonists in the Management of Postoperative Ileus: a Clinical Review. 
  • Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis. 
  • Persistent Opioid Use Among Pediatric Patients After Surgery. 
  • Persistent Opioid Use and High-Risk Prescribing in Body Contouring Patients. 
  • Persistent Postoperative Opioid Use: Perception, Progress, and Promise. 
  • Persistent pain associated with long-term intrathecal morphine administration. 
  • Perspectives on the genetic basis of opioid-induced hyperalgesia. 
  • Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. 
  • Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. 
  • Pharmacokinetics of remifentanil in anesthetized pediatric patients undergoing elective surgery or diagnostic procedures. 
  • Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001). 
  • Post-Thoracotomy Pain: Current Strategies for Prevention and Treatment. 
  • Post-cesarean delivery analgesia. 
  • Post-operative opioid pain management patterns for patients who receive hip surgery. 
  • Postoperative Opioid Prescribing and the Pain Scores on Hospital Consumer Assessment of Healthcare Providers and Systems Survey. 
  • Postoperative opioid prescribing is not my job: A qualitative analysis of care transitions. 
  • Postoperative pain after cesarean section: assessment and management in a tertiary hospital in a low-income country. 
  • Postpartum Respiratory Depression. 
  • Pramipexole Augmentation of Buprenorphine Improves Pain and Depression in Opioid Use Disorder: A Case Report. 
  • Pre- Versus Post-Tonsillectomy Intraoperative Bupivacaine Injection in the Pediatric Population: An Age- and Surgical Indication-Stratified Analysis. 
  • Precise Analgesic Instructions Improve Narcotic Usage: A Randomized Trial. 
  • Predicting Opioid Use, Increased Health Care Utilization and High Costs for Musculoskeletal Pain: What Factors Mediate Pain Intensity and Disability? 
  • Predicting Persistent Opioid Use, Abuse, and Toxicity Among Cancer Survivors. 
  • Predictors of Chronic Opioid Use: A Population-Level Analysis of North Carolina Cancer Survivors Using Multi-Payer Claims. 
  • Predictors of continued opioid use 6 months after total joint arthroplasty: a multi-site study. 
  • Preemptive analgesia for postoperative pain relief in thoracolumbosacral spine operations: a double-blind, placebo-controlled randomized trial. 
  • Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. 
  • Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery. 
  • Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice. 
  • Prenatal opioid exposure inhibits microglial sculpting of the dopamine system selectively in adolescent male offspring. 
  • Preoperative and Postoperative Opioid Prescription Rates in the Total Hip Replacement Surgical Patient. 
  • Preoperative cotreatment with dextromethorphan and ketorolac provides an enhancement of pain relief after laparoscopic-assisted vaginal hysterectomy. 
  • Prescription Opioid Use Before and After Hip Arthroscopy: A Caution to Prescribers. 
  • Prescription pain reliever abuse and dependence among adolescents: a nationally representative study. 
  • Presurgical and Postsurgical Opioid Rates in Patients Undergoing Total Shoulder Replacement Surgery. 
  • Prevalence and Health Characteristics of Prescription Opioid Use, Misuse, and Use Disorders Among U.S. Adolescents. 
  • Prevalence and Patterns of Opioid Use Before and After Liver Transplantation. 
  • Primary Care Providers And Specialists Deliver Comparable Buprenorphine Treatment Quality. 
  • Processed EEG (bispectral index) is not appropriate for characterizing opioid sedation. 
  • Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. 
  • Prophylaxis and treatment of the side-effects of neuraxial morphine analgesia following cesarean delivery. 
  • Prospective, Observational Study of Opioid Use After Hip Arthroscopy for Femoroacetabular Impingement Syndrome. 
  • Provider Bias in prescribing opioid analgesics: a study of electronic medical Records at a Hospital Emergency Department. 
  • Provider Characteristics Associated With Outpatient Opioid Prescribing After Surgery. 
  • Pupillary response in patients receiving intrathecal sufentanil. 
  • Quality Measures to Reduce Opioid Use After Common Soft Tissue Hand and Wrist Procedures. 
  • Quality improvement process in a sickle cell infusion center. 
  • Quality of life outcomes for patients with metastatic castration-resistant prostate cancer and pretreatment prognostic score. 
  • Racial Variations in Pain Management and Outcomes in Hospitalized Patients With Acute Pancreatitis. 
  • Racial disparities across provider specialties in opioid prescriptions dispensed to medicaid beneficiaries with chronic noncancer pain. 
  • Racial, Ethnic, and Socioeconomic Discrepancies in Opioid Prescriptions Among Older Patients With Cancer. 
  • Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use. 
  • Randomized trial of transversus abdominis plane block with liposomal bupivacaine after cesarean delivery with or without intrathecal morphine. 
  • Randomized trial of web-based training about opioid therapy for chronic pain. 
  • Rates of opioid dispensing and overdose after introduction of abuse-deterrent extended-release oxycodone and withdrawal of propoxyphene. 
  • Rational Perioperative Opioid Management in the Era of the Opioid Crisis. 
  • Rational Perioperative Opioid Management in the Era of the Opioid Crisis: Reply. 
  • Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy. 
  • Real-world opioid prescribing after cataract surgery among patients who received intracameral phenylephrine and ketorolac 1.0%/0.3. 
  • Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. 
  • Reduction in Opioid Prescribing Through Evidence-Based Prescribing Guidelines. 
  • Reduction in opioid use and postoperative pain scores after elective laparotomy with implementation of enhanced recovery after surgery protocol on a gynecologic oncology service. 
  • Regional Anesthesia Associated With Decreased Inpatient and Outpatient Opioid Demand in Tibial Plateau Fracture Surgery. 
  • Regional anesthesia reduces inpatient and outpatient perioperative opioid demand in periarticular elbow surgery. 
  • Remifentanil and pain relief in labour. 
  • Remifentanil and pain relief in labour. 
  • Remifentanil for labor pain: is the drug or the method the problem? 
  • Reply to Drs. Wang et al. 
  • Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. 
  • Reply to the Letter to the Editor: Can Predictive Modeling Tools Identify Patients at High Risk of Prolonged Opioid Use after ACL Reconstruction? 
  • Reported lifetime aberrant drug-taking behaviors are predictive of current substance use and mental health problems in primary care patients. 
  • Research priorities for expanding access to methadone treatment for opioid use disorder in the United States: A National Institute on Drug Abuse Center for Clinical Trials Network Task Force report. 
  • Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression. 
  • Respiratory depression after administration of single-dose neuraxial morphine for post-cesarean delivery analgesia: a retrospective cohort study. 
  • Responding to signals of mental and behavioral health risk in pragmatic clinical trials: Ethical obligations in a healthcare ecosystem. 
  • Response to "Further concerns regarding opioids after tonsillectomy in children". 
  • Response to Editor "Continuous adductor canal blockade facilitates increased home discharge and decreased opioid consumption after total knee arthroplasty". 
  • Response to Shen et al regarding "Regional anesthesia reduces inpatient and outpatient perioperative opioid demand in peri-articular elbow surgery". 
  • Response to Strassels and Durham. 
  • Response to commentaries. 
  • Response to open peer commentaries on "Caring for the suffering: meeting the Ebola crisis responsibly". 
  • Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care. 
  • Risk Factors and Outcomes of Opioid Users with and Without Concurrent Benzodiazepine Use in the North Carolina Medicaid Population. 
  • Risk Factors for Opioid Utilization in Patients with Intracerebral Hemorrhage. 
  • Risk Factors for Severe Opioid-Related Adverse Events in a National Cohort of Medical Hospitalizations. 
  • Risk and Risk Factors for Chronic Opioid Use Among Opioid-Naive Patients With Newly Diagnosed Musculoskeletal Pain in the Neck, Shoulder, Knee, or Low Back. 
  • Risk of Revision Shoulder Surgery, Complications, and Prolonged Opioid Use in Patients Undergoing Shoulder Arthroscopy Who Have Previously Undergone Anterior Cervical Discectomy and Fusion. 
  • Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. 
  • Role of cytochrome P4502B6 in methadone metabolism and clearance. 
  • Ropivacaine and Ketorolac Wound Infusion for Post-Cesarean Delivery Analgesia: A Randomized Controlled Trial. 
  • Running the Numbers: County Level Dynamics of Heroin Mortality in North Carolina. 
  • Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty. 
  • Safety evaluation of oliceridine for the management of postoperative moderate-to-severe acute pain. 
  • Safety of an ED High-Dose Opioid Protocol for Sickle Cell Disease Pain. 
  • Screening in Trauma for Opioid Misuse Prevention (STOMP): Results from a prospective cohort of victims of traumatic injury. 
  • Screening in Trauma for Opioid Misuse Prevention (STOMP): study protocol for the development of an opioid risk screening tool for victims of injury. 
  • Sedation of children for emergency imaging. 
  • Sedation practices in a cohort of critically ill patients receiving prolonged mechanical ventilation. 
  • Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. 
  • Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS). 
  • Self-extraction of intrathecal pump opioid. 
  • Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. 
  • Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. 
  • Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine. 
  • Short- and long-term opioid use in survivors of subarachnoid hemorrhage. 
  • Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. 
  • Single-dose extended-release epidural morphine for pain after hip arthroplasty. 
  • Single-dose extended-release epidural morphine for pain following hip arthroplasty. 
  • Site-Level Variation in the Characteristics and Care of Infants With Neonatal Opioid Withdrawal. 
  • Society for Obstetric Anesthesia and Perinatology Consensus Statement: Monitoring Recommendations for Prevention and Detection of Respiratory Depression Associated With Administration of Neuraxial Morphine for Cesarean Delivery Analgesia. 
  • Sources of Misused Prescription Opioids and Their Association with Prescription Opioid Use Disorder in the United States: Sex and Age Differences. 
  • Spillover Effect of Evidence-Based Postoperative Opioid Prescribing. 
  • State regulation positively impacts opioid prescribing patterns in ankle fracture surgery: A national and state-level analysis. 
  • Strategies to Identify Patient Risks of Prescription Opioid Addiction When Initiating Opioids for Pain: A Systematic Review. 
  • Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling. 
  • Subarachnoid meperidine (Pethidine) causes significant nausea and vomiting during labor. The Duke Women's Anesthesia Research Group. 
  • Subtypes of nonmedical opioid users: results from the national epidemiologic survey on alcohol and related conditions. 
  • Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding. 
  • Surgeon-Performed High-Dose Bupivacaine Periarticular Injection With Intra-Articular Saphenous Nerve Block Is Not Inferior to Adductor Canal Block in Total Knee Arthroplasty. 
  • Synthesis and biological activity of a novel methylamine-bridged enkephalin analogue (MABE): a new route to cyclic peptides and peptidomimetics. 
  • Tales from the frontlines: An alarming rise in hospitalizations related to opioid use disorder in the era of COVID-19. 
  • Telehealth acceptability and opioid prescribing patterns of providers of painful chronic diseases during the COVID-19 pandemic: A survey of sickle cell providers. 
  • Temporal Trends and Predictors of Opioid Use Among Older Patients With Cancer. 
  • The Association Between the Supply of Nonpharmacologic Providers, Use of Nonpharmacologic Pain Treatments, and High-risk Opioid Prescription Patterns Among Medicare Beneficiaries With Persistent Musculoskeletal Pain. 
  • The Effect of Adductor-Canal-Blockade on Outcome after Medial Unicondylar Knee Arthroplasty: A Preliminary Study. 
  • The Impact of Alvimopan on Return of Bowel Function After Major Spine Surgery - A Prospective, Randomized, Double-Blind Study. 
  • The Impact of Early Epidural Discontinuation on Pain, Opioid Usage, and Length of Stay After Periacetabular Osteotomy. 
  • The Impact of Education and Prescribing Guidelines on Opioid Prescribing for Breast and Melanoma Procedures. 
  • The Impact of Nonsteroidal Anti-inflammatory Drugs on Older Adult Trauma Patients With Hip Fractures. 
  • The Impact of Time and State Opioid Legislation on Opioid Prescription Filling in Total Ankle Arthroplasty. 
  • The Influence of Mediators on the Relationship Between Antenatal Opioid Agonist Exposure and the Severity of Neonatal Opioid Withdrawal Syndrome. 
  • The Influence of a Guideline-Concordant Stepped Care Approach on Downstream Health Care Utilization in Patients with Spine and Shoulder Pain. 
  • The James A. Rand Young Investigator's Award: Battling the Opioid Epidemic with Prospective Pain Threshold Measurement. 
  • The Opioid Epidemic Blunted the Mortality Benefit of Medicaid Expansion. 
  • The Opioid Epidemic in NC: Progress, Challenges, and Opportunities. 
  • The Opioid-Tolerant Patient: Opioid Optimization. 
  • The Risk of Prior Opioid Exposure on Future Opioid Use and Comorbidities in Individuals With Non-Acute Musculoskeletal Knee Pain. 
  • The Role of Emergency Medical Services in the Opioid Epidemic. 
  • The Role of Opioids and Their Receptors in Urological Malignancy: A Review. 
  • The association between the supply of select nonpharmacologic providers for pain and use of nonpharmacologic pain management services and initial opioid prescribing patterns for Medicare beneficiaries with persistent musculoskeletal pain. 
  • The association of opioid use with incident lower extremity fractures in spinal cord injury. 
  • The comparative effectiveness of quadratus lumborum blocks and paravertebral blocks in radical cystectomy patients. 
  • The effect of Medicaid expansion on use of opioid agonist treatment and the role of provider capacity constraints. 
  • The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery. 
  • The effect of intraoperative methadone during pediatric cardiac surgery on postoperative opioid requirements. 
  • The effect of stimulating versus conventional perineural catheters on postoperative analgesia following ultrasound-guided femoral nerve localization. 
  • The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. 
  • The effects of medicare advantage on opioid use. 
  • The efficacy and resource utilization of remifentanil and fentanyl in fast-track coronary artery bypass graft surgery: a prospective randomized, double-blinded controlled, multi-center trial. 
  • The herbal medicine, Dai-Kenchu-to, accelerates delayed gastrointestinal transit after the operation in rats. 
  • The impact of regional anesthesia on opioid demand in distal radius fracture surgery. 
  • The influence of a MOBile-based video Instruction for Low back pain (MOBIL) on initial care decisions made by primary care providers: a randomized controlled trial. 
  • The influence of lockout intervals and drug selection on patient-controlled analgesia following gynecological surgery. 
  • The influence of prior opioid use on healthcare utilization and recurrence rates for non-surgical patients seeking initial care for patellofemoral pain. 
  • The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy. 
  • The lock-in loophole: Using mixed methods to explain patient circumvention of a Medicaid opioid restriction program. 
  • The morphine-sparing effect of metoclopramide on postoperative laparoscopic tubal ligation patients. 
  • The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors. 
  • The opioid crisis and HIV in the USA: deadly synergies. 
  • The opioid use disorder core outcomes set (OUD-COS) for treatment research: findings from a Delphi consensus study. 
  • The prevention of emesis in plastic surgery: a randomized, prospective study. 
  • The relative potency of oral transmucosal fentanyl citrate compared with intravenous morphine in the treatment of moderate to severe postoperative pain. 
  • The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats. 
  • The use of analgesics in the management of pain in rheumatic diseases. 
  • The use of controlled-release oxycodone for the treatment of chronic cancer pain: a randomized, double-blind study. 
  • The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients. 
  • The value of the P-value. 
  • Therapeutic Interactive Voice Response (TIVR) to reduce analgesic medication use for chronic pain management. 
  • Three-Year Durability of Restorative Neurostimulation Effectiveness in Patients With Chronic Low Back Pain and Multifidus Muscle Dysfunction. 
  • Timing of physical therapy consultation on 1-year healthcare utilization and costs in patients seeking care for neck pain: a retrospective cohort. 
  • Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine. 
  • Toward precision prescribing for methadone: Determinants of methadone deposition. 
  • Training in Safe Opioid Prescribing and Treatment of Opioid Use Disorder in Internal Medicine Residencies: a National Survey of Program Directors. 
  • Trajectories of dispensed prescription opioids among beneficiaries enrolled in a Medicaid controlled substance "lock-in" program. 
  • Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists. 
  • Transition to post-operative epidural or patient-controlled intravenous analgesia following total intravenous anaesthesia with remifentanil and propofol for abdominal surgery. 
  • Transitions of Care for Postoperative Opioid Prescribing in Previously Opioid-Naïve Patients in the USA: a Retrospective Review. 
  • Transversus abdominis plane block for analgesia after Cesarean delivery: a systematic review and meta-analysis. 
  • Treating Persistent Pain: A Nurse Co-Led, Interdisciplinary Model for Primary Care. 
  • Treatment and prevention of postherpetic neuralgia. 
  • Treatment considerations for elderly and frail patients with neuropathic pain. 
  • Treatment of pain in juvenile idiopathic arthritis: a survey of pediatric rheumatologists. 
  • Treatment outcomes associated with medications for opioid use disorder (MOUD) among criminal justice-referred admissions to residential treatment in the U.S., 2015-2018. 
  • Treatment preference for opioid use disorder among people who are incarcerated. 
  • Treatment utilization among persons with opioid use disorder in the United States. 
  • Trends in Chronic Opioid Use Around Inpatient Surgery Within the Veterans Health Administration. 
  • Trends in Opioid Utilization Before and After Total Knee Arthroplasty. 
  • Trends in opioid prescribing and co-prescribing of sedative hypnotics for acute and chronic musculoskeletal pain: 2001-2010. 
  • Ultrasound-guided genicular nerve blocks following total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. 
  • Understanding the patient experience of pain and discomfort during cardiac catheterization. 
  • Underutilization of Acetaminophen in Older Adult Trauma Patients. 
  • Unique Intradural Inflammatory Mass Containing Precipitated Morphine: Confirmatory Analysis by LESA-MS and MALDI-MS. 
  • Urolithiasis in the COVID Era: An Opportunity to Reassess Management Strategies. 
  • Use of Mobile Health Apps and Wearable Technology to Assess Changes and Predict Pain During Treatment of Acute Pain in Sickle Cell Disease: Feasibility Study. 
  • Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline. 
  • Use of diagnosis codes for detection of clinically significant opioid poisoning in the emergency department: A retrospective analysis of a surveillance case definition. 
  • Use of physiologically-based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity. 
  • Use of remifentanil in infants. 
  • Using implementation interventions and peer recovery support to improve opioid treatment outcomes in community supervision: Protocol. 
  • Utility of catastrophizing, body symptom diagram score and history of opioid use to predict future health care utilization after a primary care visit for musculoskeletal pain. 
  • Utilization of complementary and integrative health services and opioid therapy by patients receiving Veterans Health Administration pain care. 
  • Validation of an oncology-specific opioid risk calculator in cancer survivors. 
  • Variability in opioid prescribing in veterans affairs emergency departments and urgent cares. 
  • Variation in Opioid Prescribing After Vaginal and Cesarean Birth: A Statewide Analysis. 
  • Variation in care between pediatric and adult patients presenting with nephrolithiasis to tertiary care pediatric emergency departments in the United States (2009-2020). 
  • Variations in Postoperative Management of Pediatric Open-Vault Craniosynostosis. 
  • Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial. 
  • Vitamin D deficiency exacerbates UV/endorphin and opioid addiction. 
  • What we know and what we don't know about the perioperative use of methadone in children and adolescents. 
  • What’s New in Obstetric Anesthesia? The 2018 Gerard W. Ostheimer Lecture. 
  • Wheal and flare responses to opioids in humans. 
  • When is a bispectral index of 60 too low?: Rational processed electroencephalographic targets are dependent on the sedative-opioid ratio. 
  • [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. 
  • [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. 
  • β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. 
  • μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision. 
  • μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids. 
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  Keywords of People

  • Anwar, Muhammad Farooq, Assistant Professor of Anesthesiology, Anesthesiology, Pain Management
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Jowell, Paul Simon, Professor of Medicine, Medicine, Gastroenterology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine