Androgens

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  Subject Areas on Research

  • 7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties. 
  • A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. 
  • A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. 
  • A randomized controlled trial comparing changes in fitness with or without supervised exercise in patients initiated on enzalutamide and androgen deprivation therapy for non-metastatic castration-sensitive prostate cancer (EXTEND). 
  • Actions of steroids in mitochondria. 
  • Adrenal androgen levels as predictors of outcome in prostate cancer patients treated with ketoconazole plus antiandrogen withdrawal: results from a cancer and leukemia group B study. 
  • Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm. 
  • Adrenal physiology and pharmacology. 
  • Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer. 
  • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • An intergenerational androgenic mechanism of female intrasexual competition in the cooperatively breeding meerkat. 
  • Anabolic steroids. 
  • Androgen and estrogen treatment, alone or in combination, differentially influences bone maturation and hypothalamic mechanisms that time puberty in the male rhesus monkey (Macaca mulatta). 
  • Androgen binding protein as a biochemical marker of formation of the blood-testis barrier. 
  • Androgen decline and survival during docetaxel therapy in metastatic castration resistant prostate cancer (mCRPC). 
  • Androgen decreases dopamine neurone survival in rat midbrain. 
  • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. 
  • Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting. 
  • Androgen-deprivation therapy and metabolic syndrome in men with prostate cancer. 
  • Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells. 
  • Androgen-mediated immune function is altered by the apolipoprotein E gene. 
  • Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1. 
  • Androgens amplify beta-adrenergic and FSH stimulation of granulosa cells. 
  • Androgens and Overall Survival in Patients With Metastatic Castration-resistant Prostate Cancer Treated With Docetaxel. 
  • Androgens and endometrium: new lessons from the corpus luteum via the adrenal cortex? 
  • Androgens and isolation from adult tutors differentially affect the development of songbird neurons critical to vocal plasticity. 
  • Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 3. Effects of juvenile gonadectomy. 
  • Androgens modulate NMDA receptor-mediated EPSCs in the zebra finch song system. 
  • Androgens predict parasitism in female meerkats: a new perspective on a classic trade-off. 
  • Androgens promote prostate cancer cell growth through induction of autophagy. 
  • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. 
  • Assessment of sex steroid action in vitro. 
  • Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial. 
  • Bcl-2 accelerates multistep prostate carcinogenesis in vivo. 
  • Bonobos have a more human-like second-to-fourth finger length ratio (2D:4D) than chimpanzees: a hypothesized indication of lower prenatal androgens. 
  • CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. 
  • CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem. 
  • Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers. 
  • Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer. 
  • Combination external beam radiation and brachytherapy boost with androgen suppression for treatment of intermediate-risk prostate cancer: an initial report of CALGB 99809. 
  • Copper signaling axis as a target for prostate cancer therapeutics. 
  • Correlations between hormonal intrauterine devices and androgenic skin conditions: A retrospective cohort study. 
  • Cortisol, estradiol, and androgens in acutely ill paranoid schizophrenics. 
  • Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer. 
  • Determination of hormonal steroid concentrations in biological extracts by high resolution mass fragmentography. 
  • Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta). 
  • Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor. 
  • Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women. 
  • Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer. 
  • Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model. 
  • Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats. 
  • Effects of neoadjuvant hormonal therapy on prostate biopsy results after (125)I and (103)Pd seed implantation. 
  • Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocuta. 
  • Efficacious Androgen Hormone Administration in Combination with Adeno-Associated Virus Vector-Mediated Gene Therapy in Female Mice with Pompe Disease. 
  • Efficacy of second versus third generation oral contraceptives in the treatment of hirsutism. 
  • Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. 
  • Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. 
  • Endocrine correlates of pregnancy in the ring-tailed lemur (Lemur catta): implications for the masculinization of daughters. 
  • Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. 
  • Enrichment of putative prostate cancer stem cells after androgen deprivation: upregulation of pluripotency transactivators concurs with resistance to androgen deprivation in LNCaP cell lines. 
  • Enzalutamide with androgen deprivation therapy in Japanese men with metastatic hormone-sensitive prostate cancer: A subgroup analysis of the phase III ARCHES study. 
  • Estrogen and progesterone production by granulosa cell monolayers derived from in vitro fertilization procedures: lack of evidence for modulation by androgen. 
  • Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen. 
  • Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male mating. 
  • Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer. 
  • External beam radiation therapy for clinically localized prostate cancer: when and how we optimize with concurrent hormonal deprivation. 
  • FSH-induction of androgen binding protein in testes of Sertoli cell-only rats. 
  • Female pattern hair loss. 
  • Follicle stimulating hormone regulation of protein kinase activity and protein synthesis in testis. 
  • Getting over testosterone: postulating a fresh start for etiologic studies of prostate cancer. 
  • Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. 
  • Gonadotropin release in patients with androgen insensitivity. Testicular feminization syndrome. 
  • Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy. 
  • Hormone receptor activities of complex mixtures of known and suspect chemicals in personal silicone wristband samplers worn in office buildings. 
  • Hyperandrogenemia in human immunodeficiency virus-infected women with the lipodystrophy syndrome. 
  • Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. 
  • In vivo regulation of hTERT expression and telomerase activity by androgen. 
  • Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. 
  • Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats. 
  • Influence of androgen on translatable renin mRNA in the mouse submandibular gland. 
  • Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238. 
  • Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. 
  • Insulin-like growth factor binding protein 2: an androgen-dependent predictor of prostate cancer survival. 
  • Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF. 
  • Integrating the female masculinization and challenge hypotheses: Female dominance, male deference, and seasonal hormone fluctuations in adult blue-eyed black lemurs (Eulemur flavifrons). 
  • Integrin involvement in freeze resistance of androgen-insensitive prostate cancer. 
  • Is time to castration resistant prostate cancer a potential intermediate end-point for time to metastasis among men initiating androgen deprivation therapy for non-metastatic prostate cancer with rapid PSA doubling time (<9 months)? 
  • Isolation and characterization of a novel human prostatic stromal cell culture: DuK50. 
  • LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression. 
  • Laparoscopic removal of gonads containing on occult seminoma in a woman with complete androgen resistance. 
  • Lessons From the Testosterone Trials. 
  • Ligand-specific dynamics of the androgen receptor at its response element in living cells. 
  • Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. 
  • Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. 
  • Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. 
  • Mammalian sexual differentiation: lessons from the spotted hyena. 
  • Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. 
  • Meerkat manners: Endocrine mediation of female dominance and reproductive control in a cooperative breeder. 
  • Modeling endocrine control of the pituitary-ovarian axis: androgenic influence and chaotic dynamics. 
  • Molecular cloning of the cDNA for androgen-dependent sperm-coating glycoproteins secreted by the rat epididymis. 
  • Molecular cloning of the cDNA for two major androgen-dependent secretory proteins of 18.5 kilodaltons synthesized by the rat epididymis. 
  • Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription. 
  • Neoadjuvant docetaxel before radical prostatectomy in patients with high-risk localized prostate cancer. 
  • New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. 
  • Niraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial. 
  • Non-human primates avoid the detrimental effects of prenatal androgen exposure in mixed-sex litters: combined demographic, behavioral, and genetic analyses. 
  • PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. 
  • PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. 
  • Pancreatic islet cell carcinoma associated with multiple hormone secretion and pancytopenia. Evidence of a serum factor suppressing hematopoiesis. 
  • Performance-enhancing sports supplements: role in critical care. 
  • Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. 
  • Phase 3 Randomized Controlled Trial of Androgen Deprivation Therapy with or Without Docetaxel in High-risk Biochemically Recurrent Prostate Cancer After Surgery (TAX3503). 
  • Phase II Trial of Enzalutamide and Androgen Deprivation Therapy with Salvage Radiation in Men with High-risk Prostate-specific Antigen Recurrent Prostate Cancer: The STREAM Trial. 
  • Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design. 
  • Phospholipids in the androgen stimulated sexual segment of the kidney of the Indian house lizard, Hemidactylus flaviviridis Rüppell. 
  • Physiological and psychological effects of testosterone during severe energy deficit and recovery: A study protocol for a randomized, placebo-controlled trial for Optimizing Performance for Soldiers (OPS). 
  • Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. 
  • Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. 
  • Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy. 
  • Proceedings: Hormonal control of steroid synthesis by a feminizing adrenal tumour. 
  • Proceedings: Measurement of endogenous steroid levels in human breast tumours by mass fragmentography. 
  • Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer. 
  • Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats. 
  • Puberty and depression. 
  • Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency. 
  • Quantitative expression profile of androgen-regulated genes in prostate cancer cells and identification of prostate-specific genes. 
  • Radiation therapy versus delayed androgen deprivation for stage C carcinoma of the prostate. 
  • RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation. 
  • Re: Adaptive therapy for androgen-independent prostate cancer: a randomized selection trial of four regimens. 
  • Remission of progressive metastatic castration-resistant prostate cancer during abiraterone therapy following unilateral adrenalectomy for a functioning adrenal adenoma. 
  • Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause. 
  • Response to bipolar androgen therapy and PD-1 inhibition in a patient with metastatic castration-resistant prostate cancer and a germline CHEK2 mutation. 
  • Selective aromatase inhibition for patients with androgen-independent prostate carcinoma. 
  • Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease. 
  • Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. 
  • Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. 
  • Short day lengths enhance skin immune responses in gonadectomised Siberian hamsters. 
  • Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response. 
  • Spotted hyaenas and the sexual spectrum: reproductive endocrinology and development. 
  • Steroid hormone regulation of specific gene expression. 
  • Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP). 
  • Steroids LXXVI. Stereospecific formation of alpha- and beta-epoxides in the reaction of dimethylsulfonium methylide and dimethylsulfoxonium methylide with dihydrotestosterone. 
  • Stress and parental care in a wild Teleost fish: insights from exogenous supraphysiological cortisol implants. 
  • Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis. 
  • Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555). 
  • Testosterone Therapy on Active Surveillance and Following Definitive Treatment for Prostate Cancer. 
  • Testosterone in prostate cancer: the Bethesda consensus. 
  • Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle. 
  • Testosterone therapy in women with heart failure "why can't a woman be more like a man?". 
  • The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model. 
  • The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo. 
  • The menstrual cycle in context, II: Human gonadal steroid hormone variability 
  • The regulation of granulosa cell proopiomelanocortin messenger ribonucleic acid by androgens and gonadotropins. 
  • Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation. 
  • Toy story: why do monkey and human males prefer trucks? Comment on "Sex differences in rhesus monkey toy preferences parallel those of children" by Hassett, Siebert and Wallen. 
  • Trophic effects of androgen: development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus. 
  • Unique Primary Care Needs of Transgender and Gender Non-Binary People. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. 
  • XIAP as target for therapeutic apoptosis in prostate cancer. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology