Anemia, Sickle Cell

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  Subject Areas on Research

  • 9p- in a girl with acute lymphocytic leukemia and sickle cell disease. 
  • A Prospective Emergency Department Quality Improvement Project to Improve the Treatment of Vaso-Occlusive Crisis in Sickle Cell Disease: Lessons Learned. 
  • A Survey-Based Needs Assessment of Barriers to Optimal Sickle Cell Disease Care in the Emergency Department. 
  • A benign sickle-cell disease in a Saudi subject with beta zero-thalassemia and glucose-6-phosphate dehydrogenase deficiency. 
  • A biopsychosocial-spiritual model of chronic pain in adults with sickle cell disease. 
  • A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease. 
  • A case series describing causes of death in pregnant women with sickle cell disease in a low-resource setting. 
  • A common functional PIEZO1 deletion allele associates with red blood cell density in sickle cell disease patients. 
  • A comparison of analgesic management for emergency department patients with sickle cell disease and renal colic. 
  • A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease. 
  • A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. 
  • A multi-institutional comparison of younger and older adults with sickle cell disease. 
  • A pilot study of hydroxyurea to prevent chronic organ damage in young children with sickle cell anemia. 
  • A prospective study of the relationship over time of behavior problems, intellectual functioning, and family functioning in children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease. 
  • A qualitative analysis of best self-management practices: sickle cell disease. 
  • A randomized controlled trial comparing two vaso-occlusive episode (VOE) protocols in sickle cell disease (SCD). 
  • A review of the literature on the multiple dimensions of chronic pain in adults with sickle cell disease. 
  • A study of oral pain experience in sickle cell patients. 
  • A systematic review of barriers and interventions to improve appropriate use of therapies for sickle cell disease. 
  • A telephonic mindfulness-based intervention for persons with sickle cell disease: study protocol for a randomized controlled trial. 
  • Abnormalities of platelet aggregation in the vaso-occlusive crisis of sickle-cell anemia. 
  • Acceptability and Feasibility of a Mindfulness-Based Intervention for Pain Catastrophizing among Persons with Sickle Cell Disease. 
  • Acute Vaso-Occlusive Pain is Temporally Associated with the Onset of Menstruation in Women with Sickle Cell Disease. 
  • Acute gastrointestinal vaso-occlusive ischemia in sickle cell disease: CT imaging features and clinical outcome. 
  • Acute silent cerebral ischemic events in children with sickle cell anemia. 
  • Adherence to hydroxyurea therapy in children with sickle cell anemia. 
  • Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease. 
  • Adult emergency department patients with sickle cell pain crisis: a learning collaborative model to improve analgesic management. 
  • Adult emergency department patients with sickle cell pain crisis: results from a quality improvement learning collaborative model to improve analgesic management. 
  • Adults with sickle cell disease may perform cognitive tests as well as controls when processing speed is taken into account: a preliminary case-control study. 
  • Alloimmunization in sickle cell disease: changing antibody specificities and association with chronic pain and decreased survival. 
  • Ambulatory care connections of Medicaid-insured children with sickle cell disease. 
  • Among emergency physicians, use of the term "Sickler" is associated with negative attitudes toward people with sickle cell disease. 
  • An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies. 
  • An intervention to increase coping and reduce health care utilization for school-age children and adolescents with sickle cell disease. 
  • An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease. 
  • An unequal burden: poor patient-provider communication and sickle cell disease. 
  • Application of a proactive risk analysis to emergency department sickle cell care. 
  • Assessing responsiveness over time of the PROMIS® pediatric symptom and function measures in cancer, nephrotic syndrome, and sickle cell disease. 
  • Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center. 
  • Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. 
  • Association between somatic growth trajectory and cognitive functioning in young children with sickle cell disease. 
  • Association of Transition Readiness to Intentional Self-Regulation and Hopeful Future Expectations in Youth With Illness. 
  • Attitudes toward clinical trials among patients with sickle cell disease. 
  • Attitudes toward patients with sickle cell disease in a multicenter sample of emergency department providers. 
  • B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. 
  • Bacteremia in sickle hemoglobinopathies. 
  • Barriers and facilitators to care for individuals with sickle cell disease in central North Carolina: The emergency department providers' perspective. 
  • Barriers to Care for Persons With Sickle Cell Disease: The Case Manager's Opportunity to Improve Patient Outcomes. 
  • Barriers to bone marrow transplantation for sickle cell anemia. 
  • Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. 
  • Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease. 
  • Blood donation and blood transfusion: special considerations for African Americans. 
  • Bone marrow transplantation for sickle cell disease. 
  • Bone marrow transplantation for sickle cell disease. 
  • Bone marrow transplantation for sickle cell disease. The United States experience. 
  • Burden of influenza-related hospitalizations among children with sickle cell disease. 
  • CE: Understanding the Complications of Sickle Cell Disease. 
  • CT abdominal imaging findings in patients with sickle cell disease: acute vaso-occlusive crisis, complications, and chronic sequelae. 
  • CT of Gastrointestinal Vasoocclusive Crisis Complicating Sickle Cell Disease. 
  • Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease. 
  • Care of children with sickle cell disease in the emergency department: parent and provider perspectives inform quality improvement efforts. 
  • Caring for patients with sickle cell disease in North Carolina. 
  • Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. 
  • Cerebral infarction in sickle cell trait. 
  • Challenges in Shifting Management Responsibility From Parents to Adolescents With Sickle Cell Disease. 
  • Changes in coping, pain, and activity after cognitive-behavioral training: a randomized clinical trial for pediatric sickle cell disease using smartphones. 
  • Characterization of the hypercoagulable state in patients with sickle cell disease. 
  • Childrens' and adolescents' use of diaries for sickle cell pain. 
  • Chronic granulocytic leukemia in a patient with sickle cell anemia. 
  • Clinical and metabolomic risk factors associated with rapid renal function decline in sickle cell disease. 
  • Clinical and sociodemographic factors predict coping styles among adults with sickle cell disease. 
  • Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. 
  • Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases. 
  • Coagulation disorders and their cutaneous presentations: Pathophysiology. 
  • Coexistent Sickle Cell Disease Has No Impact on the Safety or Outcome of Lytic Therapy in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke. 
  • Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions. 
  • Commentary: sickle cell disease. 
  • Community Health Workers as Support for Sickle Cell Care. 
  • Comparison of US Federal and Foundation Funding of Research for Sickle Cell Disease and Cystic Fibrosis and Factors Associated With Research Productivity. 
  • Complications of implantable venous access devices in patients with sickle cell disease. 
  • Computerized physician order entry improves compliance with a manual exchange transfusion protocol in the pediatric intensive care unit. 
  • Content validity of the PROMIS® pediatric family relationships measure for children with chronic illness. 
  • Contraceptive Methods and the Impact of Menstruation on Daily Functioning in Women with Sickle Cell Disease. 
  • Contribution of sickle cell disease to the occurrence of developmental disabilities: a population-based study. 
  • Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. 
  • Cooperative Study of Sickle Cell Disease: Demographic and socioeconomic characteristics of patients and families with sickle cell disease. 
  • Coping strategies in families of children with sickle cell disease. 
  • Correlates of successful transition in young adults with sickle cell disease. 
  • Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. 
  • Costs and length of stay for patients with and without sickle cell disease after hysterectomy, appendectomy, or knee replacement. 
  • Creation of a femoral cortical window to facilitate total hip arthroplasty in patients with sickle cell hemoglobinopathies. 
  • Criterion and convergent validity for 4 measures of pain in a pediatric sickle cell disease population. 
  • Daily mood and stress predict pain, health care use, and work activity in African American adults with sickle-cell disease. 
  • Daily stress and mood and their association with pain, health-care use, and school activity in adolescents with sickle cell disease. 
  • Defective release of tissue plasminogen activator in patients with sickle cell anemia. 
  • Definitions of the phenotypic manifestations of sickle cell disease. 
  • Dehydration and delayed proton equilibria of red blood cells suspended in isosmotic phosphate buffers. Implications for studies of sickled cells. 
  • Depression, suicidal ideation, and attempts in black patients with sickle cell disease. 
  • Design of the silent cerebral infarct transfusion (SIT) trial. 
  • Developing a risk-based composite neurologic outcome for a trial of hydroxyurea in young children with sickle cell disease. 
  • Development of quality indicators for transition from pediatric to adult care in sickle cell disease: A modified Delphi survey of adult providers. 
  • Diagnosis of Kikuchi-Fujimoto disease in an 11-year-old girl with fever and sickle cell disease. 
  • Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis. 
  • Discontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II. 
  • Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. 
  • Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion. 
  • Does Attendance at a Sickle Cell Educational Conference Improve Clinician Knowledge and Attitude Toward Patients with Sickle Cell Disease? 
  • Eccrine Chromhidrosis in an Adolescent with Sickle Cell Disease. 
  • Effect of Free Dental Services on Individuals with Sickle Cell Disease. 
  • Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. 
  • Effect of propranolol as antiadhesive therapy in sickle cell disease. 
  • Effects of hydroxyurea treatment for patients with hemoglobin SC disease. 
  • Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism. 
  • Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease. 
  • Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. 
  • Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes. 
  • Electroretinographic findings in sickle cell retinopathy. 
  • Emergency Department (ED), ED Observation, Day Hospital, and Hospital Admissions for Adults with Sickle Cell Disease. 
  • Emergency Department Sickle Cell Assessment of Needs and Strengths (ED-SCANS), a focus group and decision support tool development project. 
  • Emergency department analgesia without narcotics for adults with acute sickle cell pain crisis: case reports and review of crisis management. 
  • Emergency department management of acute pain episodes in sickle cell disease. 
  • Emergency provider analgesic practices and attitudes toward patients with sickle cell disease. 
  • Emotional reactions to pain predict psychological distress in adult patients with Sickle Cell Disease (SCD). 
  • Enalapril and hydroxyurea therapy for children with sickle nephropathy. 
  • End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain. 
  • Enuresis in children and adolescents with sickle cell anaemia is more frequent and substantially different from the general population. 
  • Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions. 
  • Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. 
  • Erythrocyte adhesion in sickle cell disease. 
  • Erythrocyte adhesion receptors: blood group antigens and related molecules. 
  • Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. 
  • Evaluation of a Sickle Cell Disease Educational Website for Emergency Providers. 
  • Evaluation of a train-the-trainer workshop on sickle cell disease for ED providers. 
  • Evaluation of partial and total splenectomy in children with sickle cell disease using an Internet-based registry. 
  • Evidence gaps in the management of sickle cell disease: A summary of needed research. 
  • Exploring Emergency Department Provider Experiences With and Perceptions of Weight-Based Versus Individualized Vaso-Occlusive Treatment Protocols in Sickle Cell Disease. 
  • Factors associated with survival in a contemporary adult sickle cell disease cohort. 
  • Family functioning, neurocognitive functioning, and behavior problems in children with sickle cell disease. 
  • Fast measurement of blood T1 in the human jugular vein at 3 Tesla. 
  • Fatal small-bowel necrosis and pulmonary hypertension in sickle cell disease. 
  • Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life. 
  • Fear of movement (kinesiophobia), pain, and psychopathology in patients with sickle cell disease. 
  • Fertility challenges for women with sickle cell disease. 
  • Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. 
  • Fludarabine-based nonmyeloablative stem cell transplantation for sickle cell disease with and without renal failure: clinical outcome and pharmacokinetics. 
  • Focus groups with African American adolescents: enhancing recruitment and retention in intervention studies. 
  • Follow-up of coping skills training in adults with sickle cell disease: analysis of daily pain and coping practice diaries. 
  • Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients. 
  • Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. 
  • Genetic polymorphisms associated with priapism in sickle cell disease. 
  • Genitourinary complications of sickle cell disease. 
  • Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy. 
  • Glycosylated hemoglobin levels in a benign form of sickle cell anemia in Saudi Arabia. 
  • Growing up with sickle cell disease: a pilot study of a transition program for adolescents with sickle cell disease. 
  • Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions. 
  • HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. 
  • Health related quality of life in sickle cell disease: just scratching the surface. 
  • Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. 
  • Health-related quality of life in sickle cell disease: past, present, and future. 
  • Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. 
  • Heme redox properties of S-nitrosated hemoglobin A0 and hemoglobin S: implications for interactions of nitric oxide with normal and sickle red blood cells. 
  • Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis. 
  • Hepatic biloma complicating sickle cell disease. A case report and a review of the literature. 
  • High rates of recurrent biliary tract obstruction in children with sickle cell disease. 
  • Homozygous sickle cell disease and cystic fibrosis in an adolescent. 
  • Hybrid Statistical and Mechanistic Mathematical Model Guides Mobile Health Intervention for Chronic Pain. 
  • Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. 
  • Hydroxyurea for Sickle Cell Disease: Now Is the Time! 
  • Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children. 
  • Hydroxyurea for the treatment of sickle cell disease. 
  • Hydroxyurea for the treatment of sickle cell disease: efficacy, barriers, toxicity, and management in children. 
  • Hydroxyurea: specific therapy for sickle cell anemia? 
  • IMPROVE trial: a randomized controlled trial of patient-controlled analgesia for sickle cell painful episodes: rationale, design challenges, initial experience, and recommendations for future studies. 
  • Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. 
  • Identifying Social-Behavioral Health Needs of Adults with Sickle Cell Disease in the Emergency Department. 
  • Impact of Medicaid expansion on access and healthcare among individuals with sickle cell disease. 
  • Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease. 
  • Impact of hydroxyurea on perioperative management and outcomes in children with sickle cell anemia. 
  • Impaired vasodilation by red blood cells in sickle cell disease. 
  • Implantation of penile prostheses in patients impotent after priapism. 
  • Implementation of an Emergency Department Screening and Care Management Referral Process for Patients With Sickle Cell Disease. 
  • Improving Inpatient Care for Individuals with Sickle Cell Disease Using the Project ECHO Model. 
  • Improving Quality of Care for Sickle Cell Patients in the Pediatric Emergency Department. 
  • Improving care for children with sickle cell disease/acute chest syndrome. 
  • Improving the Care of Individuals With Sickle Cell Disease in the Emergency Department Using a Quality Improvement Framework: The Emergency Department Sickle Cell Assessment of Needs and Strengths (ED-SCANS). 
  • Improving the Quality of Care for Adolescents and Adults With Sickle Cell Disease-It's a Long Road. 
  • Incidental findings on brain magnetic resonance imaging of children with sickle cell disease. 
  • Increased prevalence of potential right-to-left shunting in children with sickle cell anaemia and stroke. 
  • Indications and Results of HLA-Identical Sibling Hematopoietic Cell Transplantation for Sickle Cell Disease. 
  • Influence of penicillin prophylaxis on antimicrobial resistance in nasopharyngeal S. pneumoniae among children with sickle cell anemia. The Ancillary Nasopharyngeal Culture Study of Prophylactic Penicillin Study II. 
  • Initial Evaluation of the Pediatric PROMIS® Health Domains in Children and Adolescents With Sickle Cell Disease. 
  • Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange. 
  • Intranasal fentanyl improves time to analgesic delivery in sickle cell pain crises. 
  • Introduction to a symposium on sickle cell anemia: current results of comprehensive care and the evolving role of bone marrow transplantation. 
  • Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination. 
  • Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA). 
  • Is low dose hydroxyurea the solution to the global epidemic of sickle cell disease? 
  • Ischemic colitis in a young adult during sickle cell crisis: case report and review. 
  • Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study. 
  • Kikuchi-Fugimoto's disease in sickle cell disease: report of 2 cases. 
  • LW protein: a promiscuous integrin receptor activated by adrenergic signaling. 
  • Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease. 
  • Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease. 
  • Language processing deficits in sickle cell disease in young school-age children. 
  • Laparoscopic cholecystectomy in young patients with sickle hemoglobinopathies. 
  • Living with sickle cell disease: traversing 'race' and identity. 
  • Low cobalamin levels in African Americans with and without sickle cell disease. 
  • MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo. 
  • MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease. 
  • MR features of soft-tissue abnormalities due to acute marrow infarction in five children with sickle cell disease. 
  • MYH9 and APOL1 are both associated with sickle cell disease nephropathy. 
  • Management of Sickle Cell Disease in Children. 
  • Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. 
  • Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. 
  • Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. 
  • Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients. 
  • Mobile health intervention for youth with sickle cell disease: Impact on adherence, disease knowledge, and quality of life. 
  • Moderate chronic pain, weight and dietary intake in African-American adult patients with sickle cell disease. 
  • Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload. 
  • Morbidity associated with sickle cell disease in pregnancy. 
  • Multidisciplinary care results in similar maternal and perinatal mortality rates for women with and without SCD in a low-resource setting. 
  • Myeloid neoplasms in the setting of sickle cell disease: an intrinsic association with the underlying condition rather than a coincidence; report of 4 cases and review of the literature. 
  • NIH consensus development statement on hydroxyurea treatment for sickle cell disease. 
  • National Institutes of Health Consensus Development Conference statement: hydroxyurea treatment for sickle cell disease. 
  • Neurocognitive development of young children with sickle cell disease through three years of age. 
  • Neurocognitive testing and functioning in adults sickle cell disease. 
  • Neurodevelopmental screening in toddlers and early preschoolers with sickle cell disease. 
  • Neurologic complications after allogeneic marrow transplantation for sickle cell anemia. 
  • Neuropsychologic performance in school-aged children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease. 
  • Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. 
  • New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease. 
  • Newborn screening for sickle cell disease and other hemoglobinopathies. Techniques' comparison and report of the North Carolina experience. 
  • Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo. 
  • Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. 
  • Occlusion of large cerebral vessels in sickle-cell anemia. 
  • Opioid management and dependency among adult patients with sickle cell disease. 
  • Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial. 
  • Original Research: Acute chest syndrome in sickle cell disease: Effect of genotype and asthma. 
  • Osteomyelitis in sickle cell disease: You know it when you see it? 
  • Osteomyelitis. Common causes and treatment recommendations. 
  • Outcomes of acute chest syndrome in adult patients with sickle cell disease: predictors of mortality. 
  • Outcomes of inpatients with and without sickle cell disease after high-volume surgical procedures. 
  • Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. 
  • Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial. 
  • Parent education and biologic factors influence on cognition in sickle cell anemia. 
  • Parental substance abuse, reports of chronic pain and coping in adult patients with sickle cell disease. 
  • Patent foramen ovale in adults with sickle cell disease and stroke. 
  • Pathological effects of sickle cell anemia on the pulp. 
  • Patient-Centered eHealth Interventions for Children, Adolescents, and Adults With Sickle Cell Disease: Systematic Review. 
  • Patient-reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium. 
  • Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART). 
  • Perceived discrimination in health care is associated with a greater burden of pain in sickle cell disease. 
  • Perceived discrimination, patient trust, and adherence to medical recommendations among persons with sickle cell disease. 
  • Pericardial effusion in sickle cell anemia: a rare problem. 
  • Perioperative management for orthopaedic patients with sickle cell anaemia. 
  • Personalized Reminders Increase Screening for Stroke Risk in Children with Sickle Cell Anemia. 
  • Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. 
  • Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia. 
  • Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease. 
  • Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia. 
  • Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. 
  • Potential role for statins in sickle cell disease. 
  • Pregnancy associated with both insulin-dependent diabetes mellitus and sickle cell disease. A report of two cases. 
  • Prevalence and clinical correlates of glomerulopathy in children with sickle cell disease. 
  • Prevalence and risk factors of elevated pulmonary artery pressures in children with sickle cell disease. 
  • Preventive Care Delivery to Young Children With Sickle Cell Disease. 
  • Priapism: etiology, treatment, and results in series of 35 presentations. 
  • Primary Care Providers' Comfort Levels in Caring for Patients with Sickle Cell Disease. 
  • Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids. 
  • Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. 
  • Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. 
  • Principles and problems of transfusion in sickle cell disease. 
  • Promoting equity: developing quality measures for sickle cell disease. 
  • Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. 
  • Protrusio acetabuli in sickle-cell anemia. 
  • Psychological adjustment of adults with sickle cell anemia: stability over 20 months, correlates, and predictors. 
  • Psychological adjustment of children with sickle cell disease: stability and change over a 10-month period. 
  • Psychological adjustment of mothers of children and adolescents with sickle cell disease: the role of stress, coping methods, and family functioning. 
  • Psychosocial Burden of Childhood Sickle Cell Disease on Caregivers in Kenya. 
  • Pulmonary hypertension and nitric oxide depletion in sickle cell disease. 
  • Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes. 
  • Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. 
  • Quality improvement process in a sickle cell infusion center. 
  • Quantification of macular ischaemia in sickle cell retinopathy. 
  • Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2 -based oxygenation calibrations. 
  • Quantitative microscopy and nanoscopy of sickle red blood cells performed by wide field digital interferometry. 
  • RNA aptamer therapy for vaso-occlusion in sickle cell disease. 
  • RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes. 
  • Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease. 
  • Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use. 
  • Red blood cell surface adhesion molecules: their possible roles in normal human physiology and disease. 
  • Red cell antigens as functional molecules and obstacles to transfusion. 
  • Regulation of tissue plasminogen activator in sickle cell anemia. 
  • Reimmunization to pneumococcus in patients with sickle cell disease: do they or don't they respond? 
  • Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. 
  • Relationships between somatic growth and cognitive functioning in young children with sickle cell disease. 
  • Religiosity/spirituality and pain in patients with sickle cell disease. 
  • Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. 
  • Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption. 
  • Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia. 
  • Respiratory syncytial virus and seasonal influenza cause similar illnesses in children with sickle cell disease. 
  • Response to "The need for logical application-based extensions in sickle cell disease research findings to changing lives in the ethnic context". 
  • Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease. 
  • Responsiveness of PROMIS® Pediatric Measures to Hospitalizations for Sickle Pain and Subsequent Recovery. 
  • Results and complications of total hip arthroplasties in patients with sickle-cell hemoglobinopathies. Role of cementless components. 
  • Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia. 
  • Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors. 
  • Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors. 
  • Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. 
  • Role of adhesion molecules and vascular endothelium in the pathogenesis of sickle cell disease. 
  • Role of child and maternal processes in the psychological adjustment of children with sickle cell disease. 
  • Safety of an ED High-Dose Opioid Protocol for Sickle Cell Disease Pain. 
  • Secondhand Smoke Is an Important Modifiable Risk Factor in Sickle Cell Disease: A Review of the Current Literature and Areas for Future Research. 
  • Secondhand smoke is associated with more frequent hospitalizations in children with sickle cell disease. 
  • Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension. 
  • Sensitization to acute procedural pain in pediatric sickle cell disease: modulation by painful vaso-occlusive episodes, age, and endothelin-1. 
  • Serotype-specific immunoglobulin G antibody responses to pneumococcal polysaccharide vaccine in children with sickle cell anemia: effects of continued penicillin prophylaxis. 
  • Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts. 
  • Severe Mycoplasma pneumonia in three sisters with sickle cell disease. 
  • Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease. 
  • Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion. 
  • Shared Decision-Making in Hematopoietic Stem Cell Transplantation for Sickle Cell Disease. 
  • Shift in Emergency Department Provider Attitudes Toward Patients With Sickle Cell Disease. 
  • Should modulation of p50 be a therapeutic target in the critically ill? 
  • Sickle Cell Disease: A Review of Nonpharmacological Approaches for Pain. 
  • Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients. 
  • Sickle cell disease complications: Prevalence and resource utilization. 
  • Sickle cell disease in children and adolescents: the relation of child and parent pain coping strategies to adjustment. 
  • Sickle cell disease is associated with iron mediated hypercoagulability. 
  • Sickle cell disease management in the emergency department: what every emergency nurse should know. 
  • Sickle cell disease pain in children and adolescents: change in pain frequency and coping strategies over time. 
  • Sickle cell disease pain: relation of coping strategies to adjustment. 
  • Sickle cell disease patients' perceptions of emergency department pain management. 
  • Sickle cell disease. 
  • Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation. 
  • Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. 
  • Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response. 
  • Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. 
  • Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium. 
  • Significant responses to platinum-based chemotherapy in renal medullary carcinoma. 
  • Silent cerebral infarct definitions and full-scale IQ loss in children with sickle cell anemia. 
  • Silent cerebral infarction, income, and grade retention among students with sickle cell anemia. 
  • Skin and nail changes in children with sickle cell anemia receiving hydroxyurea therapy. 
  • Social and Behavioral Factors in Sickle Cell Disease: Employment Predicts Decreased Health Care Utilization. 
  • Somatization in the conceptualization of sickle cell disease. 
  • Splenectomy in sickle-cell disease. 
  • Stability and change in the psychological adjustment of mothers of children and adolescents with cystic fibrosis and sickle cell disease. 
  • Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia. 
  • Stem-cell transplantation for sickle cell disease. 
  • Stigma of Sickle Cell Disease: A Systematic Review. 
  • Subcutaneous panniculitis-like T-cell lymphoma in a 25-year-old male patient with sickle cell disease. 
  • Successful surgical outcome in children with sickle hemoglobinopathies: the Duke University experience. 
  • Surgical and obstetric outcomes in adults with sickle cell disease. 
  • Symptomatic Avascular Necrosis: An Understudied Risk Factor for Acute Care Utilization by Patients with SCD. 
  • Systematic Review of the Impact of Transition Interventions for Adolescents With Chronic Illness on Transfer From Pediatric to Adult Healthcare. 
  • Systematic review: Hydroxyurea for the treatment of adults with sickle cell disease. 
  • Tackling adherence in sickle cell disease with mHealth. 
  • Technologies for global health. 
  • The Association between Educational Attainment and Patterns of Emergency Department Utilization among Adults with Sickle Cell Disease. 
  • The Emergency Department Sickle Cell Assessment of Needs and Strengths (ED-SCANS): reliability and validity. 
  • The association of optimism and perceived discrimination with health care utilization in adults with sickle cell disease. 
  • The association of oral hydroxyurea therapy with improved cognitive functioning in sickle cell disease. 
  • The clinical severity of hemoglobin S/Black (A γδβ)0 -thalassemia. 
  • The epidemiology, evaluation and treatment of stroke in adults with sickle cell disease. 
  • The excess burden of stroke in hospitalized adults with sickle cell disease. 
  • The genomic analysis of erythrocyte microRNA expression in sickle cell diseases. 
  • The impact of race and disease on sickle cell patient wait times in the emergency department. 
  • The lung in sickle cell disease. 
  • The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. 
  • The sickle cell disease implementation consortium: Translating evidence-based guidelines into practice for sickle cell disease. 
  • Therapeutic strategies for sickle cell disease: towards a multi-agent approach. 
  • Third trimester and early postpartum period of pregnancy have the greatest risk for ACS in women with SCD. 
  • Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia. 
  • Transcranial Doppler screening of Medicaid-insured children with sickle cell disease. 
  • Transcutaneous electrical nerve stimulation treatment of sickle cell pain crises. 
  • Transfusion management in sickle cell disease. 
  • Transfusion practices for patients with sickle cell disease at a major academic medical center. 
  • Transfusion-transmitted babesiosis: achieving successful mitigation while balancing cost and donor loss. 
  • Transient open-angle glaucoma associated with sickle cell trait: report of 4 cases. 
  • Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity. 
  • Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning. 
  • Travelers with sickle cell disease. 
  • Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study. 
  • Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals. 
  • Twelve tips for teaching a comprehensive disease-focused course with a global perspective: A sickle cell disease example. 
  • Umbilical cord blood transplantation for children with thalassemia and sickle cell disease. 
  • Understanding and meeting the hospitalist's challenge: caring for adults with sickle cell disease. 
  • Understanding patient preferences for femoral central venous catheterization among patients with sickle cell disease. 
  • Understanding patterns and correlates of daily pain using the Sickle cell disease Mobile Application to Record Symptoms via Technology (SMART). 
  • Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience. 
  • Urgency of emergency department visits by children with sickle cell disease: a comparison of 3 chronic conditions. 
  • Usability and Feasibility of an mHealth Intervention for Monitoring and Managing Pain Symptoms in Sickle Cell Disease: The Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART). 
  • Use of Mobile Health Apps and Wearable Technology to Assess Changes and Predict Pain During Treatment of Acute Pain in Sickle Cell Disease: Feasibility Study. 
  • Use of handheld wireless technology for a home-based sickle cell pain management protocol. 
  • Use of the Spiritual Development Framework in Conducting Spirituality and Health Research with Adolescents. 
  • Use of the tourniquet during surgery in patients with sickle cell hemoglobinopathies. 
  • Utility of the Montreal Cognitive Assessment as a Screening Test for Neurocognitive Dysfunction in Adults with Sickle Cell Disease. 
  • Validation of a novel point of care testing device for sickle cell disease. 
  • Will submandibular TCD prevent stroke in children with sickle cell anemia? 
  • Would you terminate a pregnancy affected by sickle cell disease? Analysis of views of patients in Cameroon. 
  • [Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease. 
  • beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. 
  • microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. 
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  Keywords of People

  • Myers, John, Instructor in the School of Nursing, School of Nursing
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Reed, Shelby Derene, Professor in Population Health Sciences, Duke Science & Society
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology