Aneuploidy

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  Subject Areas on Research

  • A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples. 
  • A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas. 
  • A role for maternal serum screening in detecting chromosomal abnormalities in fetuses with isolated choroid plexus cysts: a prospective multicentre study. 
  • A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole. 
  • A zebrafish model of germ cell aneuploidy. 
  • Aneuploid subpopulations in tumour-invaded lymph nodes from breast cancer patients. 
  • Aneuploidy of chromosome 9 and the tumor suppressor genes p16(INK4) and p15(INK4B) detected by in situ hybridization in locally advanced prostate cancer. 
  • Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection. 
  • Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner. 
  • Attitudes and Knowledge of Maternal-Fetal Medicine Fellows Regarding Noninvasive Prenatal Testing. 
  • Cell surface differentiation antigens of the malignant T cell in Sezary syndrome and mycosis fungoides. 
  • Cell-Free DNA Screening: Complexities and Challenges of Clinical Implementation. 
  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. 
  • Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions. 
  • Characterization of de novo duplications in eight patients by using fluorescence in situ hybridization with chromosome-specific DNA libraries. 
  • Chromosomal composition of four permanent cultured cell lines derived from human gliomas. 
  • Chromosome mutation tests for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program. 
  • Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. 
  • Clinical implications of aneuploid cytogenetic profiles in adult acute leukemia. 
  • Combined serum and ultrasound screening for detection of fetal aneuploidy. 
  • Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. 
  • Comparative linkage maps suggest that fission, not polyploidy, underlies near-doubling of chromosome number within monkeyflowers (Mimulus; Phrymaceae). 
  • Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study. 
  • Congenital Heart Disease: Prenatal Diagnosis and Genetic Associations. 
  • Cytogenetic studies and their clinical correlates in adults with acute leukemia. 
  • DEK over-expression promotes mitotic defects and micronucleus formation. 
  • DNA ploidy of malignant melanoma determined by image cytometry of fresh frozen and paraffin-embedded tissue. 
  • Damage Control in the Developing Brain: Tradeoffs and Consequences. 
  • Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. 
  • Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. 
  • Enlarged fetal gallbladder: prognostic importance for aneuploidy or biliary abnormality at antenatal US. 
  • Evidence for molecular heterogeneity in human ganglioneuroblastoma. 
  • Evidence that the ribosomal DNA genes of yeast are not on chromosome I. 
  • Expression in aneuploid Drosophila S2 cells. 
  • First trimester screening. 
  • First-trimester and second-trimester screening at a community hospital: experience from the first year of implementation. 
  • Flow cytometric DNA analysis of excised breast lesions: use of fresh tissue needle aspirates obtained under guidance with mammography of the specimen. 
  • Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma. 
  • Flow cytometric determination of ploidy in prostatic adenocarcinoma: a comparison with seminal vesicle involvement and histopathological grading as a predictor of clinical recurrence. 
  • Flow cytometry as a predictive indicator in patients with operable gastric cancer. 
  • Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. 
  • Genetic considerations in recurrent pregnancy loss. 
  • Genetics for the Women's Health Trainee: A Five-Module Curriculum. 
  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy. 
  • Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. 
  • Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae. 
  • Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. 
  • High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains. 
  • Histologic grade, DNA ploidy, and intraglandular tumor extent as indicators of tumor progression of clinical stage B prostatic carcinoma. A direct comparison. 
  • Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. 
  • Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy. 
  • Human embryos derived from in vitro and in vivo matured oocytes: analysis for chromosomal abnormalities and nuclear morphology. 
  • Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. 
  • Increased chromosomal instability in peripheral lymphocytes and risk of human gliomas. 
  • Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum. 
  • Induction of transformational changes in normal endothelial cells by cultured human astrocytoma cells. 
  • Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy. 
  • Intrachromosomal triplication of 2q11.2-q21 in a severely malformed infant: case report and review of triplications and their possible mechanism. 
  • Is the aneuploid chromosome in an apomictic Boechera holboellii a genuine B chromosome? 
  • Isolation of a human prostate carcinoma cell line (DU 145). 
  • Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers. 
  • Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa. 
  • Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex. 
  • Meiotic chromosome segregation in triploid strains of Saccharomyces cerevisiae. 
  • Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. 
  • Patterns of the early, gross chromosomal changes in malignant human gliomas. 
  • Ploidy analysis of epithelial ovarian cancers using image cytometry. 
  • Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage. 
  • Prenatal diagnosis of tetrasomy 9p. 
  • Prognostic significance of DNA ploidy in carcinoma of prostate. 
  • Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. 
  • Sex in fungi. 
  • Society for Maternal-Fetal Medicine Consult Series #57: Evaluation and management of isolated soft ultrasound markers for aneuploidy in the second trimester: (Replaces Consults #10, Single umbilical artery, October 2010; #16, Isolated echogenic bowel diagnosed on second-trimester ultrasound, August 2011; #17, Evaluation and management of isolated renal pelviectasis on second-trimester ultrasound, December 2011; #25, Isolated fetal choroid plexus cysts, April 2013; #27, Isolated echogenic intracardiac focus, August 2013). 
  • The association of aneuploidy and unexplained elevated maternal serum alpha-fetoprotein. 
  • The association of echogenic fetal lungs with trisomy 21. 
  • The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases. 
  • Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level. 
  • Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds. 
  • Triploid mosaicism in a 45,X/69,XXY infant. 
  • Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans. 
  • Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans. 
  • Utility of EGFR and PTEN numerical aberrations in the evaluation of diffusely infiltrating astrocytomas. Laboratory investigation. 
  • When next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re biopsy. 
  • Yeast ribosomal DNA genes are located on chromosome XII. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Fox, Donald T, Associate Professor of Pharmacology & Cancer Biology, Duke Science & Society
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society