Antibodies, Anti-Idiotypic

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  Subject Areas on Research

  • 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity. 
  • A case of spurious hypercalcitoninemia: a cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia. 
  • A phase II prospective multi-institutional trial of adjuvant active specific immunotherapy following curative resection of colorectal cancer hepatic metastases: cancer and leukemia group B study 89903. 
  • Aberrant interaction of B-cell lymphocytic leukemia cells with antibody coated polyacrylamide beads. 
  • Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation. 
  • Anaphylactic reactions to plasma infusions in patients with hypogammaglobulinemia and anti-IgA antibodies. 
  • Anti-GD2 antibody therapy for GD2-expressing tumors. 
  • Anti-idiotypic monoclonal Ig specific for an anti-laminin Ig heavy chain transgene variable region. 
  • Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins. 
  • Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation. 
  • Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel. 
  • Autoantibodies and their idiotypes. 
  • Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry. 
  • B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. 
  • Biophysical characteristics of anti-Gal(alpha)1-3Gal IgM binding to cell surfaces: implications for xenotransplantation. 
  • Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. 
  • Cardiac transplant outcomes in pediatric patients with pre-formed anti-human leukocyte antigen antibodies and/or positive retrospective crossmatch. 
  • Characterization of the mucosal immune response to dietary antigens in patients with dermatitis herpetiformis. 
  • Combinational diversity within variable regions bearing the predominant anti-p-azophenylarsonate idiotype of strain A mice. 
  • Common allergens in avian meats. 
  • Control idiotope expression by monoclonal anti-idiotope antibodies. 
  • Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity. 
  • De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation. 
  • Detection of cross-reactive idiotypes in the serum of patients with bullous pemphigoid. 
  • Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice. 
  • Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus? 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Effects of protamine on histamine release from human lung. 
  • Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. 
  • Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. 
  • Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. 
  • Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid. 
  • Extracorporeal liver perfusion using human and pig livers for acute liver failure. 
  • Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes. 
  • Hereditary C6 deficiency in man. 
  • Human EBV-transformed lymphocytes of patients with Schistosoma japonicum infection secrete idiotypically related immunoregulatory antibodies. 
  • Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes. 
  • Identification and characterization of a novel regulatory factor: IgA-inducing protein. 
  • Idiotypes, anti-idiotypes, and autoimmunity. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. 
  • Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. 
  • IgG antibodies from patients with bullous pemphigoid bind to fusion proteins encoded by BPAg1 cDNA. 
  • Immunobiology of primary intracranial tumors. Part 8: Serological responses to active immunization of patients with anaplastic gliomas. 
  • Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. 
  • Immunopathologic studies of an experimental model resembling Goodpasture's syndrome. 
  • Immunoreactivity, pharmacokinetics and bone marrow dosimetry of intrathecal radioimmunoconjugates. 
  • Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques. 
  • Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium. 
  • Newborn baboon immunity: lessons in cross-species transplantation. 
  • Omalizumab : other indications and unanswered questions. 
  • Performance of a new, rapid, automated immunoassay for the detection of anti-platelet factor 4/heparin complex antibodies. 
  • Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects. 
  • Plasma therapy in immunodeficiency diseases. 
  • Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. 
  • Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals. 
  • Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer. 
  • Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus. 
  • Rapid serologic diagnosis of serum sickness from antithymocyte globulin therapy using enzyme immunoassay. 
  • Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. 
  • Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation. 
  • Regulation of the immune response. II. Concomitant idiotope-specific enhancement and suppression can result in a phenotypically normal response. 
  • Role of antibody and complement in the immune clearance and destruction of erythrocytes. I. In vivo effects of IgG and IgM complement-fixing sites. 
  • Selective IgA deficiency. 
  • Systemic lupus erythematosus: a matter of life and death. 
  • The Preuss Foundation Seminar on vaccine therapy for malignant primary brain tumors. February 15-17, 1998, La Jolla, Calif. 
  • The clinical and environmental determinants of airway transcriptional profiles in allergic asthma. 
  • The clinical utility of measuring complement and anti-dsDNA antibodies during pregnancy in patients with systemic lupus erythematosus. 
  • The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. 
  • The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. 
  • Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology