Anti-Infective Agents

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  Subject Areas on Research

  • "Cracked-mud" ciprofloxacin precipitates on a corneal graft. 
  • 4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro. 
  • A Hybrid Approach to Radiation-Induced Axillary Artery Hemorrhage. 
  • A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV. 
  • A perspective essay on the use of Ga³⁺ as a proxy for Fe³⁺ in bioinorganic model studies and its successful use for therapeutic purposes. 
  • A prospective, open-label study of single-dose ciprofloxacin absorption after chemotherapy in patients with malignancy. 
  • A survey of infectious disease clinical practices among pediatric blood and marrow transplant programs in the United States. 
  • ASCRS White Paper: Management of infectious keratitis following laser in situ keratomileusis. 
  • Acceptability of microbicidal vaginal rings and oral pre-exposure prophylaxis for HIV prevention among female sex workers in a high-prevalence US city. 
  • Accuracy of Administrative Data for Antimicrobial Administration in Hospitalized Children. 
  • Additional considerations in presumptive brown recluse spider bites and dapsone therapy. 
  • Addressing Antimicrobial Resistance and Stewardship: The Priority Antimicrobial Value and Entry (PAVE) Award. 
  • Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. 
  • Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization. 
  • Alternative therapies for Clostridium difficile infections. 
  • Anaerobic antimicrobial therapy after necrotizing enterocolitis in VLBW infants. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Analysis of two- and three-year trends in antimicrobial resistance in intensive care units using unit-specific antibiograms. 
  • Antimicrobial Stewardship and Infection Prevention-Leveraging the Synergy: A Position Paper Update. 
  • Antimicrobial activity of a continuously active disinfectant against healthcare pathogens. 
  • Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study. 
  • Antimicrobial nanotechnology: its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology. 
  • Antimicrobial stewardship in solid organ transplant recipients: Current challenges and proposed metrics. 
  • Antimicrobial stewardship: another focus for patient safety? 
  • Antimicrobial stewardship: philosophy versus practice. 
  • Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production. 
  • Antimicrobial-Resistant Shigella spp. in San Diego, California, USA, 2017-2020. 
  • Application of antimicrobial stewardship to optimise management of community acquired pneumonia. 
  • Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis. 
  • Approaches for optimal sequential decision analysis in clinical trials. 
  • Aptamers: an emerging class of therapeutics. 
  • Assessment of the oxidant tolerance of Methanosarcina acetivorans. 
  • Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis. 
  • Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis. 
  • Association of Appropriate Empirical Antimicrobial Therapy With In-Hospital Mortality in Patients With Bloodstream Infections in the US. 
  • Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events. 
  • Barnacle Cement as Surface Anchor for "Clicking" of Antifouling and Antimicrobial Polymer Brushes on Stainless Steel. 
  • Benzoate treatment and the glycine index in nonketotic hyperglycinaemia. 
  • Best Care for Patients Achieved Through Multidisciplinary Stewardship. 
  • Care of Children with DiGeorge Before and After Cultured Thymus Tissue Implantation. 
  • Caveats associated with the use of human cervical tissue for HIV and microbicide research. 
  • Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era. 
  • Characterization of the aqueous iron(III) chelation chemistry of a potential Trojan Horse antimicrobial agent: chelate structure, stability and pH dependent speciation. 
  • Chitosan Derivatives Active against Multidrug-Resistant Bacteria and Pathogenic Fungi: In Vivo Evaluation as Topical Antimicrobials. 
  • Chronic wound repair and healing in older adults: current status and future research. 
  • Clinical impact of stress dose steroids in patients with septic shock: insights from the PROWESS-Shock trial. 
  • Clinical pharmacology considerations for children supported with ventricular assist devices. 
  • Clinical practice guideline: hoarseness (dysphonia). 
  • Community-Acquired Pneumonia in Adults: Diagnosis and Management. 
  • Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. 
  • Comparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis. 
  • Compartmental transport model of microbicide delivery by an intravaginal ring. 
  • Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists. 
  • Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses. 
  • Correlation Between Postoperative Antimicrobial Prophylaxis Use and Surgical Site Infection in Children Undergoing Nonemergent Surgery. 
  • Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy - the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial. 
  • Design of a semisolid vaginal microbicide gel by relating composition to properties and performance. 
  • Detection of QT prolongation using a novel electrocardiographic analysis algorithm applying intelligent automation: prospective blinded evaluation using the Cardiac Safety Research Consortium electrocardiographic database. 
  • Determination of sulfadiazine and sulfamethoxazole by capillary electrophoresis with end-column electrochemical detection. 
  • Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants. 
  • Developing drugs for developing countries. 
  • Development of bilateral acquired toxoplasmic retinochoroiditis during erlotinib therapy. 
  • Differential effects of levofloxacin and ciprofloxacin on the risk for isolation of quinolone-resistant Pseudomonas aeruginosa. 
  • Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow. 
  • Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. 
  • Donor-derived infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. 
  • Dosing in neonates: special considerations in physiology and trial design. 
  • Dressings for chronic wounds. 
  • Drotrecogin alfa (activated) in adults with septic shock. 
  • Drug-induced lung injury. 
  • Drug-induced transient myopia and angle-closure glaucoma associated with supraciliary choroidal effusion. 
  • Duration of Antimicrobial Therapy for Intra-Abdominal Infection after Source Control: Role of C-Reactive Protein. 
  • Editorial Commentary: Life-saving Antimicrobial Drugs: What Are We Doing to Pricing and Availability? 
  • Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial. 
  • Effect of closed-loop order processing on the time to initial antimicrobial therapy. 
  • Effect of trimethoprim-sulfamethoxazole prophylaxis on antimicrobial resistance of fecal Escherichia coli in HIV-infected patients in Tanzania. 
  • Effects of Sexual Network Connectivity and Antimicrobial Drug Use on Antimicrobial Resistance in Neisseria gonorrhoeae. 
  • Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal. 
  • Emergence of fluoroquinolone resistance among Bacteroides species. 
  • Endogenous salivary inhibitors of human immunodeficiency virus. 
  • Epidemiology and visual outcomes in patients with infectious scleritis. 
  • Epidemiology of bloodstream infections in a bacille Calmette-Guérin-vaccinated pediatric population in Malawi. 
  • Eradicating Multi-Drug-Resistant Helicobacter pylori with Four Times Daily Lansoprazole. 
  • Erosion of microbicide formulation coating layers: effects of contact and shearing with vaginal fluid or semen. 
  • Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy. 
  • Evaluation and management of patients with pulmonary nontuberculous mycobacterial infections. 
  • Expanding the Database of Signal-Anchor-Release Domain Endolysins Through Metagenomics. 
  • Expert Consensus on Metrics to Assess the Impact of Patient-Level Antimicrobial Stewardship Interventions in Acute-Care Settings. 
  • Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval. 
  • Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury. 
  • Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: final report of Cancer and Leukemia Group B study 19901. 
  • Fluoroquinolone resistance during 2000-2005: an observational study. 
  • Follow-up care after a diagnosis of Helicobacter pylori infection in an Asian immigrant cohort. 
  • Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. 
  • Genetic analysis of the requirements for SOS induction by nalidixic acid in Escherichia coli. 
  • Genetic dissection of systemic acquired resistance. 
  • Glucose homeostasis abnormalities associated with use of gatifloxacin. 
  • HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities. 
  • High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. 
  • Historical comparison of soft-tissue infections in a division 1 wrestling team after adoption of a novel pH barrier product. 
  • Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. 
  • Identifying context-specific domains for assessing antimicrobial stewardship programmes in Asia: protocol for a scoping review. 
  • Identifying predictors of antimicrobial exposure in hospitalized patients using a machine learning approach. 
  • Immune thrombocytopenia due to Trimethoprim-Sulfamethoxazole; under-recognized adverse drug reaction in children? 
  • Impacts of silver-coated antimicrobial screen covers on the cell-phone microbiome of resident physicians. 
  • Improved survival but marginal allograft function in patients treated with extracorporeal membrane oxygenation after lung transplantation. 
  • In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. 
  • Incidence of and risk factors for community-associated Clostridium difficile infection: a nested case-control study. 
  • Indirect Standardization as a Case Mix Adjustment Method to Improve Comparison of Children's Hospitals' Antimicrobial Use. 
  • Infection and cyclosporine. 
  • Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. 
  • Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. 
  • Information technology for optimizing the management of infectious diseases. 
  • Inpatient Antimicrobial Stewardship in Pediatrics: A Systematic Review. 
  • Insights from the Society of Infectious Diseases Pharmacists on antimicrobial stewardship guidelines from the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. 
  • Interpretive criteria and quality control parameters for testing bacterial susceptibility to the fluoroquinolone PD131628. 
  • Intestinal fatty-acid binding protein and metronidazole response in premature infants. 
  • Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans 
  • Invited comment on R. L. Nelson et al. "Topical antimicrobial prophylaxis in colorectal surgery for the prevention of surgical wound infection: a systematic review and meta-analysis". 
  • Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. 
  • Label-Free Measurements of Tenofovir Diffusion Coefficients in a Microbicide Gel Using Raman Spectroscopy. 
  • Label-free measurement of microbicidal gel thickness using low-coherence interferometry. 
  • Layer-by-Layer Click Deposition of Functional Polymer Coatings for Combating Marine Biofouling 
  • Length of stay and mortality associated with febrile neutropenia among children with cancer. 
  • Letter to the editor regarding: "Effectiveness of local vancomycin powder to decrease surgical site infections: a meta-analysis" by Chiang et al. 
  • Local Burn Injury Promotes Defects in the Epidermal Lipid and Antimicrobial Peptide Barriers in Human Autograft Skin and Burn Margin: Implications for Burn Wound Healing and Graft Survival. 
  • MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. 
  • Mast cell activators as novel immune regulators. 
  • Measuring macrodiffusion coefficients in microbicide hydrogels via postphotoactivation scanning. 
  • Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation. 
  • Metronidazole: newly recognized cause of autonomic neuropathy. 
  • Moxifloxacin-induced torsades de pointes. 
  • Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides. 
  • Multiplexed low coherence interferometry instrument for measuring microbicide gel thickness distribution. 
  • Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors. 
  • Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles. 
  • National Adherence to Guidelines for Antimicrobial Prophylaxis for Patients Undergoing Radical Cystectomy. Letter. 
  • Natural orifice transluminal endoscopic surgery (NOTES): assessment of peritoneal bacterial load after intraperitoneal antimicrobial wash and evaluation of hemodynamic changes in a porcine model. 
  • Nonoperative management of diabetic foot infections. 
  • Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo. 
  • Ocular penetration and pharmacokinetics of topical gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions after keratoplasty. 
  • Ofloxacin, a new broad-spectrum fluoroquinolone. Results from a Multicenter, National Comparative Activity Surveillance Study. The Ofloxacin Surveillance Group. 
  • Opportunities for Improving Antimicrobial Stewardship: Findings From a Prospective, Multi-Center Study in Three Low- or Middle-Income Countries. 
  • Optimizing therapy for methicillin-resistant Staphylococcus aureus bacteremia. 
  • Periannular complications in infective endocarditis involving native aortic valves. 
  • Periannular complications in infective endocarditis involving prosthetic aortic valves. 
  • Pharmacist-managed antimicrobial stewardship program for patients discharged from the emergency department. 
  • Pleural space infections: microbiology and antimicrobial therapy. 
  • Point-of-prescription interventions to improve antimicrobial stewardship. 
  • Point-prevalence study of antimicrobial use in public hospitals in southern Sri Lanka identifies opportunities for improving prescribing practices. 
  • Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants. 
  • Practice guidelines for the management of infectious diarrhea. 
  • Preclinical Testing of Vaccines and Therapeutics for Gonorrhea in Female Mouse Models of Lower and Upper Reproductive Tract Infection. 
  • Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients. 
  • Prevention of surgical-site infections. 
  • Principles of Anti-infective Dosing in Pregnancy. 
  • Priorities for the Priority Review Voucher. 
  • Proceedings of the 99th meeting of the Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee. May 29th and 30th, 2003. 
  • Pulmonary manifestations of nontuberculous Mycobacterium. 
  • Quinolones for community-acquired pneumonia. 
  • Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial. 
  • Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin. 
  • Recalcitrant rhinosinusitis, innate immunity, and mannose-binding lectin. 
  • Reevaluating fluoroquinolone breakpoints for Salmonella enterica serotype Typhi and for non-Typhi salmonellae. 
  • Regarding Collaboration in Antimicrobial Stewardship. 
  • Renal transplantation in children. 
  • Safety of dapsone as Pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus-infected patients with allergy to trimethoprim/sulfamethoxazole. 
  • Saline vs Tissue Plasminogen Activator Irrigations after Drain Placement for Appendicitis-Associated Abscess: A Prospective Randomized Trial. 
  • Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA. 
  • Self-medication with non-prescribed pharmaceutical agents in an area of low malaria transmission in northern Tanzania: a community-based survey. 
  • Semi-solid gels function as physical barriers to human immunodeficiency virus transport in vitro. 
  • Sepsis in Pregnancy: Identification and Management. 
  • Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine. 
  • Shape-Dependent Surface Reactivity and Antimicrobial Activity of Nano-Cupric Oxide. 
  • Short-course therapy for bloodstream infections in immunocompetent adults. 
  • Simultaneous pancreas-kidney transplantation at the University of Wisconsin. 
  • Single and multiple pyogenic liver abscesses. Natural history, diagnosis and treatment, with emphasis on percutaneous drainage. 
  • Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from Sphaerostilbella toxica. 
  • Strategies for the prevention of infection after solid organ transplantation. 
  • Strategies to prevent central line-associated bloodstream infections in acute care hospitals. 
  • Subtle desaturation and perioperative methemoglobinemia. The need for continued vigilance. 
  • Successful prophylaxis against Pneumocystis carinii pneumonia in HIV-infected children using smaller than recommended dosages of trimethoprim-sulfamethoxazole. 
  • Supportive care of the marrow transplant recipient: the Seattle Experience. 
  • Tailoring nitric oxide release with additive manufacturing to create antimicrobial surfaces. 
  • Taste and smell complaints in HIV-infected patients. 
  • Technologies for global health. 
  • The management of chronic graft-versus-host disease. 
  • The medical management of central nervous system infections in Uganda and the potential impact of an algorithm-based approach to improve outcomes. 
  • The rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention. 
  • The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: an analysis from the ICE Prospective Cohort Study (ICE-PCS). 
  • The trial to reduce antimicrobial use in nursing home residents with Alzheimer's disease and other dementias: study protocol for a cluster randomized controlled trial. 
  • The use of recombinant human activated protein C (drotrecogin alpha) in solid organ transplant recipients: case series and review of the literature. 
  • The world's most neglected diseases. 
  • Three vs 10 days of trimethoprim/sulfamethoxazole for acute maxillary sinusitis. 
  • Tigecycline: a new glycylcycline antimicrobial. 
  • Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy. 
  • Top Myths of Diagnosis and Management of Infectious Diseases in Hospital Medicine. 
  • Topical Therapy Primer for Nondermatologists. 
  • Torsades de pointes associated with fluoroquinolones. 
  • Toward tailored functional design of multi-walled carbon nanotubes (MWNTs): electrochemical and antimicrobial activity enhancement via oxidation and selective reduction. 
  • Toxicity and efficacy of daily vs. weekly dapsone for prevention of Pneumocystis carinii pneumonia in children infected with human immunodeficiency virus. ACTG 179 Study Team. AIDS Clinical Trials Group. 
  • Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. 
  • Transport theory for HIV diffusion through in vivo distributions of topical microbicide gels. 
  • Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings. 
  • Treatment of Acanthamoeba Encephalitis. 
  • Trends in antimicrobial resistance among Bacteroides species and Parabacteroides species in the United States from 2010-2012 with comparison to 2008-2009. 
  • Tuberculous meningitis. 
  • Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells. 
  • Update on infective endocarditis. 
  • Uptake of silver nanoparticles and toxicity to early life stages of Japanese medaka (Oryzias latipes): effect of coating materials. 
  • Urinary tract infection concordance with positive blood and cerebrospinal fluid cultures in the neonatal intensive care unit. 
  • Use of a novel sediment exposure to determine the effects of triclosan on estuarine benthic communities. 
  • Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. 
  • Well-being tradeoffs: Effect of loosening overnight restrictions on antimicrobial starts. 
  • Wound botulism acquired in the Amazonian rain forest of Ecuador. 
  • Wound dressings: selecting the most appropriate type. 
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  Keywords of People

  • Cohen, Seth Morris, Professor of Head and Neck Surgery & Communication Sciences, Head and Neck Surgery & Communication Sciences
  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering