Antibodies

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  Subject Areas on Research

  • A 29-year-old woman with sudden anemia and arterial oxygen desaturation. 
  • A complement-resistant HeLa cell line (T638) is blocked at the step of C3 deposition. 
  • A computational framework for the analysis of peptide microarray antibody binding data with application to HIV vaccine profiling. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A monoclonal IgM with antibodylike specificity for phospholipids in a patient with lymphoma. 
  • A neutralizing epitope of the superantigen SEA has agonist activity on T cells. 
  • A new complement-mediated cytolytic mechanism--the C1-bypass activation pathway. 
  • A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement. 
  • A novel role for erythropoietin during fibrin-induced wound-healing response. 
  • A randomized comparison of two doses of human lymphoblastoid interferon-alpha in hairy cell leukemia. Wellcome HCL Study Group. 
  • A robust automated measure of average antibody staining in immunohistochemistry images. 
  • A self-adjuvanting supramolecular vaccine carrying a folded protein antigen. 
  • A tribute to Michael S. Neuberger. 
  • A visual assay to monitor purification of cell surface antigens reacting with monoclonal antibodies. 
  • Abciximab readministration: results of the ReoPro Readministration Registry. 
  • Accelerated rejection of skin grafts in recipients sensitized with extracted human histocompatibility antigens. 
  • Activation of complement by endotoxin. 
  • Acute cellular and antibody-mediated allograft rejection. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • Advances in the diagnosis and treatment of primary immunodeficiency diseases. 
  • Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations. 
  • Agammaglobulinemia, neutropenia, fever, and abdominal pain. 
  • Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. 
  • Amebiasis in a mental institution: serologic and epidemiologic studies. 
  • Amplification of antigen-antibody interactions based on biotin labeled protein-streptavidin network complex using impedance spectroscopy. 
  • An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. 
  • Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. 
  • Anti-Jka that are detected by solid-phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions. 
  • Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. 
  • Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. 
  • Anti-platelet factor 4/heparin antibodies: an independent predictor of 30-day myocardial infarction after acute coronary ischemic syndromes. 
  • Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. 
  • Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. 
  • Antibodies are back for thymic attack in cGVHD. 
  • Antibodies as specific renin inhibitors: studies with polyclonal and monoclonal antibodies and Fab fragments. 
  • Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin. 
  • Antibodies to prothrombin, factor V, and beta2-glycoprotein I and vascular access thrombosis. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Antibodies to topical bovine thrombin correlate with access thrombosis. 
  • Antibody-antigen binding kinetics. A model for multivalency antibodies for large antigen systems. 
  • Antibody-based immunotherapy for malignant glioma. 
  • Antibody-based nanoprobe for measurement of a fluorescent analyte in a single cell. 
  • Antibody-dependent enhancement of simian immunodeficiency virus (SIV) infection in vitro by plasma from SIV-infected rhesus macaques. 
  • Antibody-dependent lymphoid cell-mediated cytotoxicity: role of complement. 
  • Antibody-mediated rejection of the kidney after simultaneous pancreas-kidney transplantation. 
  • Antibody-targeted photodynamic therapy. 
  • Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. 
  • Antihuman plasma glutathione peroxidase antibodies: immunologic investigations to determine plasma glutathione peroxidase protein and selenium content in plasma. 
  • Applications of monoclonal antibodies in the diagnosis and treatment of primary brain tumors. 
  • Argatroban for anticoagulation during cardiopulmonary bypass in an infant. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Atrial natriuretic factor-specific antibody as a tool for physiological studies. Evidence for role of atrial natriuretic factor in aldosterone and renal electrolyte regulation. 
  • Autoimmunity and neurological disease: antibody modulation of synaptic transmission. 
  • Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. 
  • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. 
  • BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide. 
  • Bactericidal antibody after colonization with Neisseria meningitidis. 
  • Bilateral simultaneous central retinal artery occlusions in wegener granulomatosis. 
  • Bortezomib in the rapid reduction of high sustained antibody titers in disorders treated with therapeutic protein: lessons learned from Pompe disease. 
  • Bovine thrombin: history, use, and risk in the surgical patient. 
  • CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. 
  • CD4-independent binding of HIV-1 to the B lymphocyte receptor CR2 (CD21) in the presence of complement and antibody. 
  • CD9 PLAYS A ROLE IN SCHWANN-CELL MIGRATION IN-VITRO 
  • CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. 
  • COMPLEMENT AND HEMOLYTIC ANTIBODY: CHANGES IN THEIR ACTIVITY INDUCED BY MERCAPTOETHANOL. 
  • CRIM-negative infantile Pompe disease: characterization of immune responses in patients treated with ERT monotherapy 
  • Ca2+-dependent regulator. Production and characterization of a monospecific antibody. 
  • Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study. 
  • Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. 
  • Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. 
  • Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. 
  • Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts. 
  • Changes in protein levels of elongation factors, eEF1A-1 and eEF1A-2/S1, in long-term denervated rat muscle. 
  • Characterization and affinity isolation of xenoreactive human natural antibodies. 
  • Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of alpha 2-adrenergic receptor subtype-specific antibodies. 
  • Characterization of antibodies to canine renal renin. Studies of interspecies homology of renin using antibodies as probe. 
  • Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. 
  • Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2. 
  • Characterization of precipitating antibodies to ruminant serum and milk proteins in humans with selective IgA deficiency. 
  • Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins. 
  • Cigarette smoking and hemagglutination inhibition response to influenza after natural disease and immunization. 
  • Clinical findings for residents near a polyurethane foam manufacturing plant. 
  • Clinical practice. Heparin-induced thrombocytopenia. 
  • Clinical studies on the radioimmunodetection of tumors containing alpha-fetoprotein. 
  • Co-operativity in protein-protein association. The structure and stability of the actin filament. 
  • Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models. 
  • Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. 
  • Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. 
  • Comparison of an enzyme-linked immunoassay and a quantitative indirect fluorescent-antibody test with the conventional indirect fluorescent-antibody test for detecting antibodies to Toxoplasma gondii. 
  • Comparison of monoclonal versus polyclonal calretinin antibodies for immunohistochemical diagnosis of malignant mesothelioma. 
  • Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma. 
  • Complement sensitivity of paroxysmal nocturnal hemoglobinuria bone marrow cells. 
  • Complement-mediated vasoconstriction and graft rejection. 
  • Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells. 
  • Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli. 
  • Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. 
  • Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter. 
  • Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. 
  • Cytokine-secreting follicular T cells shape the antibody repertoire. 
  • DO-RIP-seq to quantify RNA binding sites transcriptome-wide. 
  • Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botryomycosis: immunological reconstitution by allogeneic bone marrow. 
  • Defects in mononuclear phagocytic system (MPS) function in autoimmune MRL-lpr/lpr mice. 
  • Dendritic cell-based immunotherapy in prevention and treatment of renal cell carcinoma: efficacy, safety, and activity of Ad-GM·CAIX in immunocompetent mouse models. 
  • Development of a radioimmunoassay for fetal antigen 2. 
  • Development of antibody-based fiber-optic sensors for detection of a benzo[a]pyrene metabolite. 
  • Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy. 
  • Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells. 
  • Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A. 
  • Discrimination of antineutrophil antibodies from antinuclear antibodies using immunofluorescence on neutrophils and HL60 cells. 
  • Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. 
  • Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4. 
  • Diverse humoral and cell-mediated effects of antisperm antibodies on reproduction. 
  • Do acetylcholine receptor and striated muscle antibodies predict the presence of thymoma in patients with myasthenia gravis? 
  • Drosophila genome-wide RNAi screens: are they delivering the promise? 
  • Drosophila spectrin: the membrane skeleton during embryogenesis. 
  • Drosophilia spectrin. I. Characterization of the purified protein. 
  • Dual functions of Lactobacillus acidophilus NCFM as protection against rotavirus diarrhea. 
  • Dynamic antibody-binding properties in the pathogenesis of HIT. 
  • Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina. 
  • Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. 
  • Effect of sera from myasthenia gravis patients on acetylcholine receptors in myotube cultures. 
  • Effect of xenogeneic chimerism in a human/sheep model on natural antibody. 
  • Effector mechanisms in transplant rejection. 
  • Effects of D-penicillamine on neuromuscular transmission in rats. 
  • Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency. 
  • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. 
  • Elimination of antibodies to recombinant enzyme in Pompe's disease. 
  • Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody. 
  • Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade. 
  • Enhanced response to enzyme replacement therapy in Pompe disease after the induction of immune tolerance. 
  • Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome. 
  • Evidence for renin in rat brain: differentiation from other reninlike enzymes. 
  • Evidence that rabbit gamma G haemolysin in capable of utilizing guinea-pig complement more efficiently than rabbit gamma M haemolysin. 
  • Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins. 
  • Ex vivo expansion, maturation, and activation of umbilical cord blood-derived T lymphocytes with IL-2, IL-12, anti-CD3, and IL-7. Potential for adoptive cellular immunotherapy post-umbilical cord blood transplantation. 
  • Experimental transfusion reactions and disseminated intravascular coagulation produced by incompatible plasma in monkeys. 
  • Exploring molecular diversity with combinatorial shape libraries. 
  • Exposure of mice to topical bovine thrombin induces systemic autoimmunity. 
  • Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. 
  • Factors affecting outcome in myasthenia gravis. 
  • Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding. 
  • Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. 
  • Free beta-chorionic gonadotropin: a cross-reactivity study of two immunometric assays used in prenatal maternal serum screening for Down's syndrome. 
  • Frequency of anti-heparin-platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis. 
  • Functional activity of anti-C6 antibodies elicited in C6-deficient rats reconstituted by liver allografts. Ability to inhibit hyperacute rejection of discordant cardiac xenografts. 
  • Functional expression of a MAP kinase kinase in COS cells and recognition by an anti-STE7/byr1 antibody. 
  • Gastric mucosal damage induced by 2-deoxy-D-glucose involves medullary TRH in the rat. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Generation of bone marrow and fetal liver chimeric mice. 
  • Glioma-associated antigen expression in oligodendroglial neoplasms. Tenascin and epidermal growth factor receptor. 
  • HIV vaccines: where we are and where we are going. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses. 
  • Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. 
  • Heparin-induced thrombocytopenia and thrombosis. 
  • Heparin-induced thrombocytopenia in left ventricular assist device bridge-to-transplant patients. 
  • Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery. 
  • Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect. 
  • Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling. 
  • High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass. 
  • Human erythrocyte myosin: identification and purification. 
  • Human interleukin-2 and lymphoproliferative (T-helper cell) responses to soluble HLA class I antigens in vitro: I. Specificity for polymorphic domains. 
  • Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. 
  • Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o). 
  • Idarucizumab for Dabigatran Reversal - Full Cohort Analysis. 
  • Identification and characterization of a galactosyl peptide mimetic. Implications for use in removing xenoreactive anti-A Gal antibodies. 
  • Identification of deacetylase substrates with the biotin switch approach. 
  • Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library. 
  • Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm. 
  • IgA immune complexes in patients with dermatitis herpetiformis occur in the absence of IgA rheumatoid factor. 
  • Immune fever in the rabbit: responses of the hematologic and complement systems. 
  • Immune modulation in Pompe disease treated with enzyme replacement therapy. 
  • Immunoaffinity chromatography of canine high-molecular-weight renin: partial purification and characterization. 
  • Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. IV. Characterization of the protective antibody in hyperimmune serum. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. V. Antibody-directed macrophages mediate tumor cell destruction. 
  • Immunological correspondence between arthropod hemocyanin subunits. II. Xiphosuran (Limulus) and spider (Eurypelma, Cupiennius) hemocyanin. 
  • Immunological studies of RNA polymerase II using antibodies to subunits of Drosophila and wheat germ enzyme. 
  • Immunological studies on eluates from human renal allografts. 
  • Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice. 
  • Impact of fertilization history and semen parameters on ICSI outcome. 
  • Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients. 
  • Important sources of variability in clinical studies of neutralizing antibodies against interferon beta. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. 
  • In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. 
  • In vitro studies of complement function in sera of C4-deficient guinea pigs. 
  • In vivo inhibition of renin by antirenin antibodies: potential experimental and clinical applications. 
  • In vivo studies in C4-deficient guinea pigs. 
  • Incompatible bone-marrow transplantation in lymphopenic immunologic deficiency. Circumvention of fatal graft-versus-host disease by immunologic enhancement. 
  • Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients. 
  • Inflammatory events in the blood and airways of guinea pigs immunized to toluene diisocyanate. 
  • Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients. 
  • Influence of sample collection and storage on the detection of platelet factor 4-heparin antibodies. 
  • Inhibition of acanthamoeba actomyosin-II ATPase activity and mechanochemical function by specific monoclonal antibodies. 
  • Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts. 
  • Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. 
  • Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. 
  • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. 
  • Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery. 
  • Intracisternal injection of TRH antibody blocks gastric emptying stimulated by 2-deoxy-D-glucose in rats. 
  • Intramolecular immunological signal hypothesis revived--structural background of signalling revealed by using Congo Red as a specific tool. 
  • Irritant symptoms and immunologic responses to multiple chemicals: importance of clinical and immunologic correlations. 
  • Is renin a factor in the etiology of essential hypertension? 
  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. 
  • L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma. 
  • L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. 
  • LOCALIZATION OF IMMUNOGLOBULINS IN CHRONIC THYROIDITIS. 
  • Lessons learned from counting molecules: how to lure CENP-A into the kinetochore. 
  • Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis. 
  • Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions. 
  • Localization of I-131-labeled goat and primate anti-carcinoembryonic antigen(CEA) antibodies in patients with cancer. 
  • Localization of substance P NK-1 receptors in rat tongue. 
  • Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. 
  • Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells. 
  • Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody. 
  • Macrophages and infertility: enhancement of human macrophage-mediated sperm killing by antisperm antibodies. 
  • Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. 
  • Many, but not all, outcome studies support exclusion of female plasma from the blood supply. 
  • Mechanical anchoring strength of L-selectin, beta2 integrins, and CD45 to neutrophil cytoskeleton and membrane. 
  • Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases. 
  • Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. 
  • Microchimerism in sensitized renal patients. 
  • Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II. 
  • Mixed connective tissue disease with arterial thrombosis, antiphospholipid antibodies and heparin induced thrombocytopenia. 
  • Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. 
  • Molecular barriers to xenotransplantation. 
  • Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. 
  • Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics. 
  • Monocyte-induced cytokine expression in cultured human retinal pigment epithelial cells. 
  • Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. 
  • MuSK-antibody positive myasthenia gravis: questions from the clinic. 
  • Multiple-analyte fluoroimmunoassay using an integrated optical waveguide sensor. 
  • Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. 
  • Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion. 
  • Myosins exist as homodimers of heavy chains: demonstration with specific antibody purified by nematode mutant myosin affinity chromatography. 
  • NCCN Clinical Practice Guidelines Occult primary. 
  • Nanosensor for in vivo measurement of the carcinogen benzo[a]pyrene in a single cell. 
  • Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications. 
  • Neonatal experimental autoimmune myasthenia gravis. 
  • Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. 
  • Non invasive high resolution in vivo imaging of alpha-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka. 
  • Non invasive high resolution in vivo imaging of alpha-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka. 
  • Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. 
  • On the measurement of cholecystokinin. 
  • Optimization of a murine immunization model for study of PF4/heparin antibodies. 
  • Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. 
  • Oxidative damage-induced inflammation initiates age-related macular degeneration. 
  • Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout. 
  • Persistent antibody depletion after rituximab in three children with autoimmune cytopenias. 
  • Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients. 
  • Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout. 
  • Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. 
  • Phenotypic characterization of cutaneous T-cell lymphoma. Use of monoclonal antibodies to compare with other malignant T cells. 
  • Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. 
  • Plasma antibodies to heat shock protein 60 and heat shock protein 70 are associated with increased risk of electrocardiograph abnormalities in automobile workers exposed to noise. 
  • Plasma glutathione peroxidase and its relationship to renal proximal tubule function. 
  • Plasmonic flow cytometry by immunolabeled nanorods. 
  • Platelet factor 4/heparin antibodies in blood bank donors. 
  • Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results. 
  • Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. 
  • Polarized distribution of Mr 210,000 and 190,000 analogs of erythrocyte ankyrin along the plasma membrane of transporting epithelia, neurons and photoreceptors. 
  • Polarized expression of cAMP-activated chloride channels in isolated epithelial cells. 
  • Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. 
  • Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866). 
  • Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. 
  • Posttransplant lymphoproliferative disorder following nonmyeloablative allogeneic stem cell transplantation. 
  • Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgery. 
  • Preparation of antibodies and development of an enzyme immunoassay for determination of atrazine in environmental samples. 
  • Prevalence of antithyroid antibodies in mood disorders. 
  • Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. 
  • Primary tumor of spleen with morphologic features of malignant fibrous histiocytoma. Immunohistochemical evidence for a macrophage origin. 
  • Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme. 
  • Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase. 
  • Production of polyclonal and monoclonal antibodies to calmodulin and utilization of these immunological probes. 
  • Protein inhibitor of cAMP-dependent protein kinase: production and characterization of antibodies and intracellular localization. 
  • Protein kinase C isoforms in human aortic smooth muscle cells. 
  • Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice. 
  • Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line. 
  • Purification and biochemical characterization of statin, a nonproliferation specific protein from rat liver. 
  • Purification and properties of sulfite oxidase from human liver. 
  • Quantifying the risk of incompatible kidney transplantation: a multicenter study. 
  • Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen. 
  • Rat sulfite oxidase antibodies cross-react with two gene family-related proteins: albumin and vitamin D-binding protein. 
  • Readministration of abciximab: interim report of the ReoPro readministration registry. 
  • Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies. 
  • Recombinant polyclonal antibody libraries. 
  • Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta. 
  • Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. 
  • Relationship of serum complement levels to events of the malarial paroxysm. 
  • Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. 
  • Release and activity of anti-TNFalpha therapeutics from injectable chitosan preparations for local drug delivery. 
  • Report from a consensus conference on antibody-mediated rejection in heart transplantation. 
  • Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. 
  • Risk of heparin-induced thrombocytopenia from heparin-bonded vascular prostheses. 
  • Role for hedgehog signaling in hepatic stellate cell activation and viability. 
  • Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies. 
  • Role of interleukin 12 and costimulators in T cell anergy in vivo. 
  • S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. 
  • SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. 
  • SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. 
  • Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation. 
  • Semiquantitative mIBG scoring as a prognostic indicator in patients with stage 4 neuroblastoma: a report from the Children's oncology group. 
  • Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. 
  • Serum IgE concentrations and skin reactivity to anti-IgE antibody in IgA-deficient patients. 
  • Serum complement and immunity in experimental simian malaria. I. Cyclical alterations in C4 related to schizont rupture. 
  • Serum elevation of B lymphocyte stimulator does not increase regulatory B cells in glioblastoma patients undergoing immunotherapy. 
  • Shapes of antibody binding sites: qualitative and quantitative analyses based on a geomorphic classification scheme. 
  • Significance of complement to the mechanism of action of endotoxin. 
  • Smooth muscle cell rigidity and extracellular matrix organization influence endothelial cell spreading and adhesion formation in coculture. 
  • Solid-phase microtiter radioimmunoassay blocking test for detection of antibodies to Escherichia coli heat-labile enterotoxin. 
  • Soluble interleukin-2 receptor levels in patients with dermatitis herpetiformis. 
  • Species specificity of antibodies to regulatory subunits of cyclic AMP-dependent protein kinases. 
  • Specificity and 6-month durability of immune responses induced by DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles. 
  • Spontaneous re-aggregation of IgM subunits and restoration of antibody activity after reduction and alkylation of rabbit anti-Forssman antibody. 
  • Spontaneously acquired anti-factor VIII antibodies: report of a patient with adenocarcinoma of the prostate. 
  • Stimulation of cell-free polypeptide synthesis by a protein fraction extracted from chick oviduct polyribosomes. 
  • Successful immune tolerance induction to enzyme replacement therapy in CRIM-negative infantile Pompe disease. 
  • Suppression of an antibody to adenosine-deaminase (ADA) in an ADA-deficient patient receiving polyethylene glycol modified adenosine deaminase. 
  • Surface-initiated enzymatic polymerization of DNA. 
  • TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. 
  • Technology evaluation: ipilimumab, Medarex/Bristol-Myers Squibb. 
  • The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. 
  • The abnormal surface characteristics of the red blood cell membrane in congenital dyserythropoietic anaemia type II (HEMPAS). 
  • The alternate complement pathway in cell damage: antibody-mediated cytolysis of erythrocytes and nucleated cells. 
  • The association between immunodeficiency and the development of autoimmune disease. 
  • The association of anti-platelet factor 4/heparin antibodies with early and delayed thromboembolism after cardiac surgery. 
  • The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. 
  • The effect of bursectomy on natural xenoreactive antibodies and vascularized rat cardiac xenograft rejection in the chicken. 
  • The effect of temperature on the reactivity of guinea-pig complement with gamma G and gamma M haemolytic antibodies. 
  • The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. 
  • The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness. 
  • The impact of antibodies in late-onset Pompe disease: a case series and literature review. 
  • The impact of antibodies on clinical outcomes in diseases treated with therapeutic protein: lessons learned from infantile Pompe disease. 
  • The influence of RS-61443 on antibody-mediated rejection. 
  • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. 
  • The nature of allergy. 
  • The production of transforming growth factor-beta activity by rat granulosa cell cultures. 
  • The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function. 
  • The receptor protein tyrosine phosphatase mu, PTPmu, regulates histogenesis of the chick retina. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The relationship between antibody affinity and the efficiency of complement fixation. 
  • The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants. 
  • The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the bloodstream. 
  • The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. 
  • The role of transmethylation reactions in regulating the binding of BCG-activated murine macrophages to neoplastic target cells. 
  • The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. 
  • The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literature. 
  • The superfast extraocular myosin (MYH13) is localized to the innervation zone in both the global and orbital layers of rabbit extraocular muscle. 
  • The uncertain significance of anti-glomerular basement membrane antibody among HIV-infected persons with kidney disease. 
  • Therapeutic Implications of Peripheral Nerve Hyperexcitability in Muscle Cramping: A Retrospective Review. 
  • Therapeutic apheresis before and after kidney transplantation. 
  • Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. 
  • Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis. 
  • Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs. 
  • Topology of cell adhesion molecules. 
  • Toxocara canis infection: clinical and epidemiological associations with seropositivity in kindergarten children. 
  • Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up. 
  • Transplantation of high panel-reactive antibody left ventricular assist device patients without crossmatch using on-bypass pheresis and alemtuzumab. 
  • Tumor necrosis factor alpha blockers and the induction of anti-DNA autoantibodies. 
  • Tunable leuko-polymersomes that adhere specifically to inflammatory markers. 
  • Two patients with an anti-N-methyl-D-aspartate receptor antibody syndrome-like presentation and negative results of testing for autoantibodies. 
  • Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides. 
  • UVA generates pyrimidine dimers in DNA directly. 
  • Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia. 
  • Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. 
  • Vascularized composite allotransplantation: a closer look at the banff working classification. 
  • Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium. 
  • Velaglucerase alfa enzyme replacement therapy compared with imiglucerase in patients with Gaucher disease. 
  • [Rituximab induced remission of pemphigus vulgaris: 2 cases] 
• 

  Keywords of People

  • Arepally, Gowthami Morey, Associate Professor of Medicine, Pathology
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Case, Laura Elizabeth, Assistant Professor of Orthopaedic Surgery, Orthopaedics, Physical Therapy
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Professor of Urology, Surgery
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology