Antifibrinolytic Agents

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  Subject Areas on Research

  • A Randomized Controlled Trial of Low-Dose Tranexamic Acid versus Placebo to Reduce Red Blood Cell Transfusion During Complex Multilevel Spine Fusion Surgery. 
  • A double-blind, placebo-controlled trial of epsilon-aminocaproic acid for reducing blood loss in coronary artery bypass grafting surgery. 
  • A phase III, multicenter, randomized, placebo-controlled clinical trial of topical aminocaproic acid (Caprogel) in the management of traumatic hyphema. 
  • AANA Journal Course: Update for Nurse Anesthetists-Part 5-Use of Tranexamic Acid in Preventing Postpartum Hemorrhage. 
  • Antifibrinolytic Therapy and Perioperative Considerations. 
  • Antifibrinolytic Therapy for Cardiac Surgery: An Update. 
  • Antifibrinolytic agents make alpha1- and beta2-microglobulinuria poor markers of postcardiac surgery renal dysfunction. 
  • Antifibrinolytic agents reduce tissue plasminogen activator-mediated neuronal toxicity in vitro. 
  • Antifibrinolytic therapy in the management of the Kasabach Merritt syndrome. 
  • Antifibrinolytic therapy: new data and new concepts. 
  • Antifibrinolytic use during cardiac and hepatic surgery makes tubular proteinuria-based early biomarkers poor tools to diagnose perioperative acute kidney injury. 
  • Application of a plasmin generation assay to define pharmacodynamic effects of tranexamic acid in women undergoing cesarean delivery. 
  • Aprotinin versus tranexamic acid: the controversy continues. 
  • Association between CK-MB Area Under the Curve and Tranexamic Acid Utilization in Patients Undergoing Coronary Artery Bypass Surgery. 
  • Bleeding and management of coagulopathy. 
  • Bleeding during thrombolytic therapy for acute myocardial infarction: mechanisms and management. 
  • Blood Management in Outpatient Total Hip Arthroplasty. 
  • Body mass index and effectiveness of reperfusion strategies: implications for the management of patients with ST-elevation myocardial infarction. 
  • Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. 
  • Challenges for providing effective hemostasis in surgery and trauma. 
  • Clinical Impact of Routine Complete Blood Counts Following Total Knee Arthroplasty. 
  • Coagulopathy and inflammation in neonatal heart surgery: mechanisms and strategies. 
  • Comparative analysis of antifibrinolytic medications in pediatric heart surgery. 
  • Coronary artery bypass grafting after aprotinin: are we doing better? 
  • Cost-benefit and efficacy of aprotinin compared with epsilon-aminocaproic acid in patients having repeated cardiac operations: a randomized, blinded clinical trial. 
  • Definite hereditary hemorrhagic telangiectasia in a 60-year-old black Kenyan woman: a case report. 
  • Development of a novel blood-sparing agent in cardiac surgery: do we need another agent? 
  • Differences in bleeding phenotype and provider interventions in postmenarchal adolescents when compared to adult women with bleeding disorders and heavy menstrual bleeding. 
  • Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures. 
  • Economics of low-molecular weight heparins. 
  • Effect of Antifibrinolytic Therapy on Complications, Thromboembolic Events, Blood Product Utilization, and Fusion in Adult Spinal Deformity Surgery. 
  • Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: a randomised, controlled study. 
  • Effects of recombinant activated factor VII on thrombin-mediated feedback activation of coagulation. 
  • Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty. 
  • Evaluation and management of bleeding during cardiac surgery. 
  • Evaluation of paradoxic beneficial effects of smoking in patients receiving thrombolytic therapy for acute myocardial infarction: mechanism of the "smoker's paradox" from the GUSTO-I trial, with angiographic insights. Global Utilization of Streptokinase and Tissue-Plasminogen Activator for Occluded Coronary Arteries. 
  • Facilitated versus primary PCI for acute myocardial infarction. 
  • Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage. 
  • Intra-arterial thrombolysis for basilar artery thrombosis: trial it. 
  • Intravenous tranexamic acid vs. topical thrombin in total shoulder arthroplasty: a comparative study. 
  • Ischemic Preconditioning and the Role of Antifibrinolytic Drugs: Translation From Bench to Bedside. 
  • Laryngeal Edema in a Child with Hereditary Angioedema with Normal C1 Inhibitor. 
  • Management of gynecologic surgery in the patient with factor XI deficiency: a review of the literature. 
  • Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH. 
  • Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial. 
  • Managing Heavy Menstrual Bleeding in Women at Risk of Thrombosis. 
  • Managing clotting: a North American perspective. 
  • Myocardial ischemia correlates with reduced fibrinolytic activity following peripheral vascular surgery. 
  • National trends in tranexamic acid use in the peripartum period, 2015-2019. 
  • Nonsurgical management of heavy menstrual bleeding: a systematic review. 
  • Novel pharmacologic approaches to reduce bleeding. 
  • Optimal Tranexamic Acid Dosing Regimen in Cardiac Surgery: What Are the Missing Pieces? 
  • Perioperative Management in Shoulder Arthroplasty: A Review of Current Practice. 
  • Population pharmacokinetics and pharmacodynamics of Tranexamic acid in women undergoing caesarean delivery. 
  • Postpartum hemorrhage management in 2012: predicting the future. 
  • Predictors of transfusion outcomes in pediatric complex cranial vault reconstruction: a multicentre observational study from the Pediatric Craniofacial Collaborative Group. 
  • Preoperative Hemoglobin Predicts Postoperative Transfusion Despite Antifibrinolytics During Total Knee Arthroplasty. 
  • Prohemostatic agents to prevent perioperative blood loss. 
  • Prohemostatic treatment in cardiac surgery. 
  • Prospective comparison of hemorrhagic complications after treatment with enoxaparin versus unfractionated heparin for unstable angina pectoris or non-ST-segment elevation acute myocardial infarction. 
  • Quality of clinical documentation and anticoagulation control in patients with chronic nonvalvular atrial fibrillation in routine medical care. 
  • Quantitative assessment of fibrinogen cross-linking by epsilon aminocaproic acid in patients with end-stage liver disease. 
  • Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education. 
  • Refractory status epilepticus after inadvertent intrathecal injection of tranexamic acid treated by magnesium sulfate. 
  • Reperfusion strategies in acute ST-segment elevation myocardial infarction: a comprehensive review of contemporary management options. 
  • Reperfusion strategy and mortality in ST-elevation myocardial infarction among patients with and without impaired renal function. 
  • Rivaroxaban reversal with prothrombin complex concentrate or tranexamic acid in healthy volunteers. 
  • Rotational thromboelastometry-guided transfusion during lumbar pedicle subtraction osteotomy for adult spinal deformity: preliminary findings from a matched cohort study. 
  • Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group. 
  • Safety of antifibrinolytics in cranial vault reconstructive surgery: a report from the pediatric craniofacial collaborative group. 
  • The association of epsilon-aminocaproic acid with postoperative decrease in creatinine clearance in 1502 coronary bypass patients. 
  • The cellular basis of traumatic bleeding. 
  • The effect of aprotinin on outcome after coronary-artery bypass grafting. 
  • The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients. 
  • The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgery. 
  • The risk of thromboembolic events with early intravenous 2- and 4-g bolus dosing of tranexamic acid compared to placebo in patients with severe traumatic bleeding: A secondary analysis of a randomized, double-blind, placebo-controlled, single-center trial. 
  • The role of anti-fibrinolytics, rFVIIa and other pro-coagulants: prophylactic versus rescue? 
  • Thrombin generation and fibrinolysis in anti-factor IX treated blood and plasma spiked with factor VIII inhibitor bypassing activity or recombinant factor VIIa. 
  • Tranexamic Acid for Acute Hemorrhage: When Is Enough Evidence Enough? 
  • Tranexamic Acid for Prevention and Treatment of Postpartum Hemorrhage: An Update on Management and Clinical Outcomes. 
  • Tranexamic acid or epsilon-aminocaproic acid in total joint arthroplasty? A randomized controlled trial. 
  • Using antifibrinolytics in the peripartum period - concern for a hypercoagulable effect? 
  • Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects. 
  • Von Willebrand factor for menorrhagia: a survey and literature review. 
  • What Should Define Preoperative Anemia in Primary THA? 
  • When Should Complete Blood Count Tests Be Performed in Primary Total Hip Arthroplasty Patients? 
  • [Efficacy and safety of tranexamic acid administration for the prevention and/or the treatment of post-partum haemorrhage: a systematic review with meta-analysis]. 
  • [Enzyme activity and hyperaminoacidemia arising in a case of essential hypoproteinemia]. 
  • eComment: Treating endoleak type 2 and disseminated intravascular coagulopathy after EVAR with tranexamic acid: the efficacy of killing two birds with one stone. 
  • epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass. 
  • von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). 
  • ε-Aminocaproic acid and clinical value in cardiac anesthesia. 
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  Keywords of People

  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics