Antigen-Antibody Complex

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  Subject Areas on Research

  • A Southeastern Cancer Study Group phase I/II trial with vaccinia melanoma oncolysates. 
  • Anomalous MLR responsiveness among siblings. 
  • Antibodies to DNA. A perspective. 
  • Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. 
  • Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes. 
  • Antibody inhibitors of nonmuscle myosin function and assembly. 
  • Antibody-antigen binding kinetics. A model for multivalency antibodies for large antigen systems. 
  • Antibody-dependent cytolysis (ADCC) of tumor cells by activated murine macrophages is a two-step process: quantification of target binding and subsequent target lysis. 
  • Application of an antibody biochip for p53 detection and cancer diagnosis. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Behçet's disease patients present high levels of deglycosylated anti-lipoteichoic acid IgG and high IL-8 production after lipoteichoic acid stimulation. 
  • Binding of rituximab, trastuzumab, cetuximab, or mAb T101 to cancer cells promotes trogocytosis mediated by THP-1 cells and monocytes. 
  • Biochemical and immunological properties of dog brain isorenin. 
  • Brain ankyrin. Purification of a 72,000 Mr spectrin-binding domain. 
  • Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates. 
  • CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model. 
  • Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis. 
  • Characterization of monoclonal antibodies to Acanthamoeba myosin-I that cross-react with both myosin-II and low molecular mass nuclear proteins. 
  • Characterization of the mucosal immune response to dietary antigens in patients with dermatitis herpetiformis. 
  • Circulating IgA immune complexes in patients with psoriasis. 
  • Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. 
  • Circulating immune complexes in dermatologic disease. 
  • Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants. 
  • Comparative localization of glioma-reactive monoclonal antibodies in vivo in an athymic mouse human glioma xenograft model. 
  • Comparisons of mixed leukocyte reactions with skin graft survival in families genotyped for HL-A. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes. 
  • Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease. 
  • DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen. 
  • Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. 
  • Defects in mononuclear phagocytic system (MPS) function in autoimmune MRL-lpr/lpr mice. 
  • Dermatitis herpetiformis: the skin and the gut. 
  • Dietary gluten challenge does not influence the levels of circulating immune complexes in patients with dermatitis herpetiformis. 
  • Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail. 
  • Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain. 
  • Drosophilia spectrin. I. Characterization of the purified protein. 
  • Drug-induced granulomatous interstitial nephritis in a pediatric patient. 
  • Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection. 
  • Effect of C4 depletion on the utilization of the terminal components of guinea-pig complement by endotoxin. 
  • Electron microscopic identification of exposed plasmin epitopes in alpha 2-macroglobulin-plasmin complex using monoclonal antibody-colloidal gold adducts. 
  • Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. 
  • Estrogen induction of plasma vitellogenin in the cockerel: studies with a phosvitin antibody. 
  • Evidence for a novel hybrid immunotoxin recognizing ricin A-chain by one antigen-combining site and a prostate-restricted antigen by the remaining antigen-combining site: potential for immunotherapy. 
  • Evidence for histidine-rich protein 2 immune complex formation in symptomatic patients in Southern Zambia. 
  • Evidence that the platinum-reactive methionyl residue of the alpha 2-macroglobulin receptor recognition site is not in the carboxyl-terminal receptor binding domain. 
  • Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. 
  • Expression of specific keratin markers by rabbit corneal, conjunctival, and esophageal epithelia during vitamin A deficiency. 
  • Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C42 sites. 
  • HIV at 40: kidney disease in HIV treatment, prevention, and cure. 
  • Heterogeneity in neutrophil responses to immune complexes. 
  • Human erythrocyte myosin: identification and purification. 
  • Human sulfite oxidase deficiency. Characterization of the molecular defect in a multicomponent system. 
  • Identification of a 20,000-dalton protein in SSV-transformed nonproducer cells. 
  • Identification of bacterial antigens in circulating immune complexes of infective endocarditis. 
  • Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites. 
  • IgA immune complexes in patients with dermatitis herpetiformis occur in the absence of IgA rheumatoid factor. 
  • IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schönlein purpura, systemic lupus erythematosus and other diseases. 
  • IgA-containing circulating immune complexes in gluten-sensitive enteropathy. 
  • IgA-containing circulating immune complexes in patients with igA nephropathy. 
  • IgA-containing immune complexes in patients with psoriatic arthritis. 
  • IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. 
  • Immune fever in the rabbit: responses of the hematologic and complement systems. 
  • Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. 
  • Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. 
  • Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences. 
  • Induction of tolerance to solubilized rat histocompatibility antigens. 
  • Influence of assay conditions on ELISA determinations of anti-DNA antibodies. 
  • Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses. 
  • Inhibition of acanthamoeba actomyosin-II ATPase activity and mechanochemical function by specific monoclonal antibodies. 
  • Integrating statistical pair potentials into protein complex prediction. 
  • Interaction of monoclonal antibodies with cell surface antigens of human ovarian carcinomas. 
  • Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes. 
  • Intramolecular immunological signal hypothesis revived--structural background of signalling revealed by using Congo Red as a specific tool. 
  • Kidney lesions in Rocky Mountain spotted fever: a light-, immunofluorescence-, and electron-microscopic study. 
  • Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. 
  • Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy. 
  • Lupus nephritis: update on pathogenesis and disease mechanisms. 
  • Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases. 
  • Microparticles in the blood of patients with SLE: Size, content of mitochondria and role in circulating immune complexes. 
  • Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations. 
  • Microtubule-associated protein 2, a microtubule-associated protein from brain, is immunologically related to the alpha subunit of erythrocyte spectrin. 
  • Minimal role for the alternative pathway in complement activation by HIT immune complexes. 
  • Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. 
  • Monoclonal antibody against human colonic sulfomucin: immunochemical detection of its binding sites in colonic mucosa, colorectal primary carcinoma, and metastases. 
  • Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance. 
  • Multi-analyte analysis system using an antibody-based biochip. 
  • Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2. 
  • Ocular cicatricial pemphigoid with granular IgA and complement deposition. 
  • Organized deposits in the kidney and look-alikes. 
  • Performance of a new, rapid, automated immunoassay for the detection of anti-platelet factor 4/heparin complex antibodies. 
  • Periodontal disease: a model for the study of inflammation. 
  • Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. 
  • Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. 
  • Pyoderma gangrenosum, altered delayed hypersensitivity and polyarthritis. 
  • Randomised trial of plasma exchange in mild systemic lupus erythematosus. 
  • Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis. 
  • Renal biopsy in systemic infections: expect the unexpected. 
  • Reticuloendothelial system fc receptor function in rheumatoid arthritis. 
  • Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. 
  • Selective inhibition of natural killer activity by the monoclonal antibodies OKT10 and VEP10 at the single cell level. 
  • Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant. 
  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. 
  • Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion. 
  • Systemic lupus erythematosus. 
  • The Inab phenotype: characterization of the membrane protein and complement regulatory defect. 
  • The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link? 
  • The binding of SLE autoantibodies to mitochondria. 
  • The central role of nucleic acids in the pathogenesis of systemic lupus erythematosus. 
  • The clearance of a monoclonal anti-DNA antibody following administration of DNA in normal and autoimmune mice. 
  • The effect of polyamines on the binding of anti-DNA antibodies from patients with SLE and normal human subjects. 
  • The interaction of anti-DNA antibodies with DNA antigen: Evidence for hysteresis for high avidity binding. 
  • The relationship of complement consumption to immune fever. 
  • The role of innate immunity in the induction of autoimmunity. 
  • The role of microparticles in the generation of immune complexes in murine lupus. 
  • The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. 
  • Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. 
  • Use of anti-idiotypic antibodies to establish that monoclonal antibody 7H11D6 binds to the alpha 2-macroglobulin receptor recognition site. 
  • Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol. 
  • Uveitis and arthritis: experimental models and clinical correlates. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • McCarthy, Janice Marie, Medical Instructor in Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering