Antigen-Antibody Reactions

• 

  Subject Areas on Research

  • A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. 
  • A monoclonal antibody reactive with a second epitope of the 67,000-dalton human T cell antigen. 
  • A quantitative analysis of C3 binding to O-antigen capsule, lipopolysaccharide, and outer membrane protein of E. coli 0111B4. 
  • A serologic approach to the definition of human prostatic carcinoma antigens. 
  • A visual assay to monitor purification of cell surface antigens reacting with monoclonal antibodies. 
  • Acquired angioedema: observations on the mechanism of action of autoantibodies directed against C1 esterase inhibitor. 
  • Amplification of antigen-antibody interactions based on biotin labeled protein-streptavidin network complex using impedance spectroscopy. 
  • Analysis of expression of CD2, CD3, and T cell antigen receptor molecules during early human fetal thymic development. 
  • Another step towards xenotransplantation. 
  • Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase. 
  • Antiadhesive properties of a quaternary structure-specific hybridoma antibody against type 1 fimbriae of Escherichia coli. 
  • Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. 
  • Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation. 
  • Antibodies to granulocyte precursors in selective myeloid hypoplasia and other suspected autoimmune neutropenias: use of HL-60 cells as targets. 
  • Antibody against T lymphoblastic leukemia-associated antigen (3-40) identifies vimentin and keratin intermediate filaments in normal cells. 
  • Antibody-antigen binding kinetics. A model for multivalency antibodies for large antigen systems. 
  • Bactericidal but not nonbactericidal C5b-9 is associated with distinctive outer membrane proteins in Neisseria gonorrhoeae. 
  • Bone marrow-derived lymphoid cells (B cells): functional depletion with cobra factor and fresh serum. 
  • Brain tumors induced in dogs by the Schmidt-Ruppin strain of Rous sarcoma virus. Neuropathological and immunological observations. 
  • C-terminal region of human T cell lymphotropic virus type I (HTLVI) p19 core protein is immunogenic in humans and contains an HTLVI-specific epitope. 
  • Ca2+/calmodulin-dependent protein kinase II from hen brain. Purification and characterization. 
  • Captopril-enhanced binding of PlA1 (HPA-1a) antibodies in posttransfusion purpura. 
  • Characterization of a B lymphoblastoid cell line mutant that secretes HLA-A2. 
  • Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. 
  • Characterization of an acquired inhibitor to coagulation factor V. Antibody binding to the second C-type domain of factor V inhibits the binding of factor V to phosphatidylserine and neutralizes procoagulant activity. 
  • Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. 
  • Chemotaxis of inflammatory cells. 
  • Cold agglutinins and cold-agglutinin disease. 
  • Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation. 
  • Creation and properties of histocompatibility antigen-cell conjugates. I. Preparation and immunological properties of rat histocompatibility antigens. 
  • Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. 
  • Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody. 
  • Dynamic antibody-binding properties in the pathogenesis of HIT. 
  • Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. 
  • Expression of newborn pig endothelial cell xenoantigens recognized by baboon natural xenoantibody. 
  • Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. 
  • Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant. 
  • Genetic therapies for xenotransplantation. 
  • Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat. 
  • Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. 
  • Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis. 
  • Hereditary alterations in the immune response: coexistence of "agammaglobulinemia", acquired hypogammaglobulinemia and selective immunoglobulin deficiency in a sibship. 
  • Human erythrocyte antigens: II. The In(Lu) gene regulates expression of an antigen on an 80-kilodalton protein of human erythrocytes. 
  • Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression. 
  • Humoral immunostimulation. IV. Role of complement. 
  • Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody. 
  • Immunologic reactions and periodontal inflammation. 
  • Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. 
  • Immunoradiometric assay for examination and quantitation of Brucella abortus-specific antibodies reactive with the antigen(s) used in the indirect hemolysis test. 
  • Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1. 
  • Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. 
  • Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes. 
  • Interactions of a nonneutralizing IgM antibody and complement in parainfluenza virus neutralization. 
  • Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. 
  • Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera. 
  • Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses. 
  • LOCALIZATION OF IMMUNOGLOBULINS IN CHRONIC THYROIDITIS. 
  • Mammalian C-type oncornaviruses: relationships between viral structural and cell-surface antigens and their possible significance in immunological defense mechanisms. 
  • Microchimerism in sensitized renal patients. 
  • Modulation of immunologic responses to HIV-1MN recombinant gp160 vaccine by dose and schedule of administration. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group. 
  • Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV. 
  • Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells. 
  • Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes. 
  • Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny. 
  • Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection. 
  • Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E. 
  • Neurite outgrowth is enhanced by anti-idiotypic monoclonal antibodies to the ganglioside GM1. 
  • Neurological disorders with abnormalities of immunoglobulin metabolism. 
  • Neutralization of sensitized virus by the fourth component of complement. 
  • Ovalbumin messenger RNA of chick oviduct: partial characterization, estrogen dependence, and translation in vitro. 
  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. 
  • Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. 
  • Potent functional antibody responses elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults. 
  • Production of congenital malformations using tissueantisera. 8. Effectiveness of reduced, alkylated and digested anti-kidney antibodies. 
  • Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. 
  • RBC transfusions in paroxysmal nocturnal hemoglobinuria. 
  • Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes. 
  • Reactions of human HL-A sera with orangutan and gorilla lymphocytes. 
  • Relaxation spectrometry of biological systems. 
  • Renin-specific antibody for study of cardiovascular homeostasis. 
  • Role of antibody and complement in the immune clearance and destruction of erythrocytes. II. Molecular nature of IgG and IgM complement-fixing sites and effects of their interaction with serum. 
  • Role of complement in the pathophysiology of hematologic diseases. 
  • STUDIES ON THE TERMINAL STEPS OF IMMUNE HEMOLYSIS. I. INHIBITION BY TRISODIUM ETHYLENEDIAMINETETRAACETATE (EDTA). 
  • Serum complement and immunity in experimental simian malaria. I. Cyclical alterations in C4 related to schizont rupture. 
  • Shapes of antibody binding sites: qualitative and quantitative analyses based on a geomorphic classification scheme. 
  • Significance of complement to the mechanism of action of endotoxin. 
  • Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins. 
  • Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. 
  • Studies on photosystem I. I. Relationship of plastocyanin, cytochrome f and P700. 
  • Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions. 
  • The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment. 
  • The human thymic microenvironment: thymic epithelium contains specific keratins associated with early and late stages of epidermal keratinocyte maturation. 
  • The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O). 
  • The nature of allergy. 
  • The relationship of complement to allergic disease. 
  • The role of monogamous bivalency and Fc interactions in the binding of anti-DNA antibodies to DNA antigen. 
  • The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins. 
  • Tunable leuko-polymersomes that adhere specifically to inflammatory markers. 
  • Two-dimensional fluorescence intensity distribution analysis: theory and applications. 
  • Use of monoclonal antibodies to probe subunit- and polymer-specific epitopes of 987P fimbriae of Escherichia coli. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis] 
  • [Morphogenesis and structure of RNA tumor viruses. Electron microscopy studies on C-type viruses] 
• 

  Keywords of People

  • Arepally, Gowthami Morey, Professor of Medicine, Pathology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology