Antigen-Presenting Cells
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Subject Areas on Research
- A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens.
- A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone.
- A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.
- A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily.
- A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis.
- Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques.
- Adjuvant-free in vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation.
- Age-Related Changes in Thymic Central Tolerance.
- Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.
- Allogeneic microchimerism and donor antigen-specific hyporeactivity in lung transplant recipients.
- Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation.
- Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines.
- Apoptotic Donor Cells in Transplantation.
- Aqueous humor factors and their effect on the immune response in the anterior chamber.
- Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.
- CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.
- CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.
- CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.
- CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis.
- CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells.
- Cells treated with TAP-2 antisense oligonucleotides are potent antigen-presenting cells in vitro and in vivo.
- Cellular and molecular targeting for nanotherapeutics in transplantation tolerance.
- Checkpoint inhibitors in hematological malignancies.
- Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines.
- Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
- Computational investigations into the origins of short-term biochemical memory in T cell activation.
- Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice.
- Critical role for mouse marginal zone B cells in PF4/heparin antibody production.
- Dendritic cell CD83: a therapeutic target or innocent bystander?
- Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.
- Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival?
- Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy.
- Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells.
- Efficient Culture of Human Naive and Memory B Cells for Use as APCs.
- Engineering B cells with mRNA.
- Epigallocatechin gallate affects human dendritic cell differentiation and maturation.
- Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
- Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.
- Functional development of the T cell receptor for antigen.
- HIV immunization. Fresh pathways to follow.
- HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway.
- Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance.
- Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation.
- IL-2, IL-4, and IFN-gamma gene expression versus secretion in superantigen-activated T cells. Distinct requirement for costimulatory signals through adhesion molecules.
- Immune mechanisms in inflammatory and degenerative eye disease.
- Immune pathogenesis of heparin-induced thrombocytopenia.
- Immunology of vascularized composite allotransplantation: a primer for hand surgeons.
- Immunoregulation on the ocular surface: 2nd Cullen Symposium.
- Immunosuppressive protocols and immunological challenges related to hand transplantation.
- Immunotherapy of malignant brain tumors.
- Immunotherapy of type 1 diabetes: where are we and where should we be going?
- In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides.
- Increasing vaccine potency through exosome antigen targeting.
- Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
- Induction in vitro of primary cytotoxic T-lymphocyte responses with DNA encoding herpes simplex virus proteins.
- Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88.
- Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.
- Interferon-γ-secreting NK cells promote induction of dry eye disease.
- Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions.
- Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization.
- Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells.
- Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.
- Measurement of cytokine release at the single cell level using the ELISPOT assay.
- Microchimerism in children with rheumatic disorders: what does it mean?
- Minors come of age: Minor histocompatibility antigens and graft-versus-host disease.
- Modified MHC restriction of donor-origin T cells in humans with severe combined immunodeficiency transplanted with haploidentical bone marrow stem cells.
- Modulation of CD45 tyrosine phosphatase activity by antigen.
- Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms.
- Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells.
- Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.
- Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity.
- Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota.
- Ocular molecules and cells that regulate immune responses in situ.
- Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.
- Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells.
- Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators.
- Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients.
- Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation.
- Positively selected Leu-11a (CD16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected Raji.
- Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages.
- Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells.
- Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse.
- Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts.
- Release of endogenous danger signals from HIFU-treated tumor cells and their stimulatory effects on APCs.
- Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation.
- Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation.
- Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells.
- Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.
- Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.
- Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.
- Standardization and validation issues of the ELISPOT assay.
- Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response.
- Targeting the Leukemia Antigen PR1 with Immunotherapy for the Treatment of Multiple Myeloma.
- Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells.
- Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.
- The antigenic properties of bacterial DNA in normal and aberrant immunity.
- The molecular basis of class II MHC allelic control of T cell responses.
- The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.
- Thrombospondin-1 derived from APCs regulates their capacity for allosensitization.
- To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells.
- Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells.
- Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.
- Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells.
- Vascular leukocytes: a population with angiogenic and immunossuppressive properties highly represented in ovarian cancer.
- Workshop on immunizations in older adults: identifying future research agendas.
- miR-181a is an intrinsic modulator of T cell sensitivity and selection.
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Keywords of People
- Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
- Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
- Lagoo, Anand Shreeram, Professor of Pathology, Pathology
- Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
- Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
- Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology