Antigens, Differentiation

• 

  Subject Areas on Research

  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • Absence of phosphatidylinositol (PI)-linked proteins in a very early human multipotential haematopoietic marrow cell. 
  • Accelerated neural differentiation of mouse embryonic stem cells on aligned GYIGSR-functionalized nanofibers. 
  • Acidic stress promotes a glioma stem cell phenotype. 
  • Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: implications for a role of disturbances of endoplasmic reticulum calcium homeostasis. 
  • Acute and chronic phagocyte determinants of cardiac allograft vasculopathy. 
  • Age-related studies of SIg, Leu-4 and concanavalin A receptor densities and capping in human lymphocytes. 
  • Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15. 
  • Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. 
  • Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotype. 
  • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. 
  • CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. 
  • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. 
  • CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules. 
  • CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells. 
  • CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group. 
  • CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. 
  • Characteristics of the chemotactic activity of heparin cofactor II proteolysis products. 
  • Characterization of an Epstein-Barr virus receptor on human epithelial cells. 
  • Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes. 
  • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. 
  • Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels. 
  • Circulating natural killer cell phenotypes in men and women with major depression. Relation to cytotoxic activity and severity of depression. 
  • Clinicopathologic and cytogenic features of CD34 (My 10)-positive acute nonlymphocytic leukemia. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations. 
  • Con A-induced suppressor cell function depends on the activation of the CD4+CD45RA inducer T cell subpopulation. 
  • Control of cellular GADD34 levels by the 26S proteasome. 
  • Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice. 
  • Costimulatory molecules are active in the human xenoreactive T-cell response but not in natural killer-mediated cytotoxicity. 
  • Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. 
  • Cutting edge: membrane lymphotoxin regulates CD8(+) T cell-mediated intestinal allograft rejection. 
  • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. 
  • Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases. 
  • Detection of minimal residual T cell acute lymphoblastic leukemia by flow cytometry. 
  • Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency. 
  • Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues. 
  • Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells. 
  • Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy. 
  • Embryonic cellular organization: differential restriction of fates as revealed by cell aggregates and lineage markers. 
  • Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line. 
  • Expression of protooncogene c-myb in normal human hematopoietic cells. 
  • Expression of the 67-kD laminin receptor, galectin-1, and galectin-3 in advanced human uterine adenocarcinoma. 
  • Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. 
  • Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. 
  • Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. 
  • Flow cytometric identification of intracellular antigens: detection of minimal residual leukemia. 
  • GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells. 
  • GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway. 
  • Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. 
  • Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer. 
  • Glycosyl phosphatidylinositol-linked blood group antigens and paroxysmal nocturnal hemoglobinuria. 
  • Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. 
  • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • Hierarchical Bayesian mixture modelling for antigen-specific T-cell subtyping in combinatorially encoded flow cytometry studies. 
  • IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. 
  • Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. 
  • Immunophenotypic characterization of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). 
  • Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand. 
  • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. 
  • Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels. 
  • Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice. 
  • Isolation of oligodendrocyte-like cells from human umbilical cord blood. 
  • LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids. 
  • Lymphoid precursors. 
  • Mast cell modulation of the innate immune response to enterobacterial infection. 
  • Melanoma-specific cytotoxic T cells generated from peripheral blood lymphocytes. Implications of a renewable source of precursors for adoptive cellular immunotherapy. 
  • Molecular basis of T cell inactivation by CTLA-4. 
  • Monokines released during short-term Fc gamma receptor phagocytosis up-regulate polymorphonuclear leukocytes and monocyte-phagocytic function. 
  • Multiparameter-fluorescence activated cell sorting analysis of retroviral vector gene transfer into primitive umbilical cord blood cells. 
  • Multisite comparison of methods for the quantitation of the surface expression of CD38 on CD8(+) T lymphocytes. The ACTG Advanced Flow Cytometry Focus Group. 
  • Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity. 
  • Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse. 
  • Neurogenic differentiation of murine and human adipose-derived stromal cells. 
  • Non-erythroid effects of erythropoietin. 
  • PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue. 
  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. 
  • PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. 
  • Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100. 
  • Phase I clinical and pharmacokinetic trial of flavone acetic acid. 
  • Phenotype of infiltrating cells in an ex vivo model of human antiporcine hyperacute cardiac xenograft rejection. 
  • Photoreceptor synapses degenerate early in experimental choroidal neovascularization. 
  • Positively selected Leu-11a (CD16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected Raji. 
  • Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. 
  • Purification and partial characterization of a human hematopoietic precursor population. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. 
  • Regulation of human nucleus pulposus cells by peptide-coupled substrates. 
  • Relationship of Inb antigen to other antigens on In(Lu)-related p80. 
  • Role of interleukin 12 and costimulators in T cell anergy in vivo. 
  • Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance. 
  • Synovial microenvironment-T cell interactions. Human T cells bind to fibroblast-like synovial cells in vitro. 
  • Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function. 
  • TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. 
  • Technology evaluation: ipilimumab, Medarex/Bristol-Myers Squibb. 
  • The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. 
  • The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. 
  • The CD19/CD21 signal transduction complex of B lymphocytes. 
  • The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The common acute lymphoblastic leukemia antigen (neutral endopeptidase-3.4.24.11) gene is located on human chromosome 3. 
  • The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. 
  • The role of functionally distinct helper T lymphocyte subpopulations in the induction of human B cell differentiation. 
  • Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. 
  • Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. 
  • Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites. 
  • Umbilical Cord Blood-Derived Mononuclear Cells Exhibit Pericyte-Like Phenotype and Support Network Formation of Endothelial Progenitor Cells In Vitro. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Update on anti-CTLA-4 antibodies in clinical trials. 
  • Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord. 
• 

  Keywords of People

  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology