Antigens, Differentiation, B-Lymphocyte
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Subject Areas on Research
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A frequent human CD20 (B1) differentiation antigen DNA polymorphism detected with MspI is located near 11q12-13.
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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.
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Analysis of the expression of CD5 by human B cells and correlation with functional activity.
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Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts.
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Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes.
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Antibody-dependent enhancement of simian immunodeficiency virus (SIV) infection in vitro by plasma from SIV-infected rhesus macaques.
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B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.
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B lymphocytes: how they develop and function.
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CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
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CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.
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CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity.
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CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7.
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CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification.
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CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.
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CD20: a regulator of cell-cycle progression of B lymphocytes.
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CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model.
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CD22 cross-linking generates B-cell antigen receptor-independent signals that activate the JNK/SAPK signaling cascade.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.
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CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor.
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CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms.
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CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling.
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Cell proliferation is necessary for the determination of male fate in the gonad.
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Characterization of an Epstein-Barr virus receptor on human epithelial cells.
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Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19.
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Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody.
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Diminished class II-associated Ii peptide binding to the juvenile dermatomyositis HLA-DQ alpha 1*0501/DQ beta 1*0301 molecule.
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Discontinuous expression of a membrane antigen (HB-7) during B lymphocyte differentiation.
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Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
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Epstein-Barr virus-negative diffuse large B cell lymphoma with aberrant expression of CD3 and other T cell-associated antigens: report of three cases with a review of the literature.
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Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases.
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H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
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Heterogeneity in the B1 (CD20) cell surface molecule expressed by human B-lymphocytes.
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Histiocytes in familial and infection-induced/idiopathic hemophagocytic syndromes may exhibit phenotypic differences.
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Human anti-pneumococcal polysaccharide antibodies are secreted by the CD5- B cell lineage.
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Hyper IgM syndrome associated with defective CD40-mediated B cell activation.
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Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand.
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Innate and adaptive receptors interact to balance humoral immunity.
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Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.
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Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
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Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.
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Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.
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Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
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Macrophages (histiocytes) in various reactive and inflammatory conditions express different antigenic phenotypes.
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Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
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Mononuclear cells from patients with the hyper-IgE syndrome produce little IgE when they are stimulated with recombinant human interleukin-4.
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Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes.
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Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
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Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain.
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Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1).
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Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes.
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Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.
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T cells or active Epstein-Barr virus infection in the development of lymphoproliferative disease in human B cell-injected severe combined immunodeficient mice.
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The B cell surface molecule B1 is functionally linked with B cell activation and differentiation.
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The B lymphocyte surface antigen CD75 is not an alpha-2,6-sialyltransferase but is a carbohydrate antigen, the production of which requires the enzyme.
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The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13.
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The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.
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The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.
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The CD19/CD21 signal transduction complex of B lymphocytes.
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The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-gamma.
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The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site.
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The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.
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Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.
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Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.
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Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.