Histocompatibility Antigens Class II
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Subject Areas on Research
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A Phase I clinical trial of immunotherapy with interferon-gamma gene-modified autologous melanoma cells: monitoring the humoral immune response.
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A human-human hybridoma secreting anti-HLA class II antibody.
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A serologic approach to the definition of human prostatic carcinoma antigens.
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A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.
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A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.
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African-American HLA class II allele and haplotype diversity.
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African-American HLA class II allele and haplotype diversity.
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Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages.
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Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts.
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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.
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Analysis of HLA-DM polymorphism in juvenile dermatomyositis (JDM) patients.
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Analysis of corneal and conjunctival microenvironments using monoclonal antibodies.
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Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation.
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Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes.
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Association of HLA alleles with Plasmodium falciparum severity in Malian children.
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Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
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B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.
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Binding kinetics of superantigen with TCR and MHC class II.
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CD4 binding to major histocompatibility complex class II antigens induces LFA-1-dependent and -independent homotypic adhesion of B lymphocytes.
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CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells.
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CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
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Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.
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Characterization of T lymphocyte and monocyte populations in HLA B8/DRw3 normal individuals and in patients with dermatitis herpetiformis.
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Chronic rejection of mouse kidney allografts.
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Class I and II HLA antibodies in pediatric patients with thalassemia major.
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Class II alloantibody and mortality in simultaneous liver-kidney transplantation.
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Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a Pediatric Oncology Group Study.
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Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
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Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin.
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Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.
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Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation.
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Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands.
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Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.
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Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization.
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Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects.
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Detailed analysis of gene expression during development of T cell lineages in the thymus.
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Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome.
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Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma.
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Diminished class II-associated Ii peptide binding to the juvenile dermatomyositis HLA-DQ alpha 1*0501/DQ beta 1*0301 molecule.
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Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny.
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ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
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Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling.
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Effect of interferon-gamma and human alpha 2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression.
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Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells.
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Engineering soluble major histocompatibility molecules: why and how.
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Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand.
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Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation.
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Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis.
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Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo.
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Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids.
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Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids.
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GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression.
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H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
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HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound.
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HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition.
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Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages.
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Histocompatibility and liver transplantation.
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Human B cell alloantigens: expression of MB and MT determinants.
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Human B cell alloantigens; alpha subunit variability.
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Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parent.
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Human splenic sinusoidal lining cells express antigens associated with monocytes, macrophages, endothelial cells, and T lymphocytes.
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Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state.
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Ia+ T cells in new onset Graves' disease.
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Identification of myeloid cell subsets in murine lungs using flow cytometry.
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Immunization with recombinant HLA classes I and II, HIV-1 gp140, and SIV p27 elicits protection against heterologous SHIV infection in rhesus macaques.
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Immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen-positive childhood T-cell leukemia. A Pediatric Oncology Group Study.
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Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease.
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Immunoregulatory disorders associated with hereditary angioedema. II. Serologic and cellular abnormalities.
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Immunotherapeutic targeting of Wilms' tumor protein.
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In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.
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In-vitro infection of chronic lymphocytic leukemia cells by Epstein-Barr virus (EBV).
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Increased Ia-antigen-bearing T cells in type I diabetes mellitus.
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Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus.
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Induction of immune responses by schistosome granuloma macrophages.
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Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.
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Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level.
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Inhibition of invariant chain expression in dendritic cells presenting endogenous antigens stimulates CD4+ T-cell responses and tumor immunity.
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Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is poorly responsive to IFNgamma stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC.
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Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.
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Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury.
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Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture.
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Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes.
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MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.
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MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain.
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Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation.
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MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury.
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Microglial reactions after subcutaneous formalin injection into the rat hind paw.
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Minors come of age: Minor histocompatibility antigens and graft-versus-host disease.
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Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.
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Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms.
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Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.
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Molecular composition of an antigen-specific, Ly-1 T suppressor inducer factor. One molecule binds antigen and is I-J-; another is I-J+, does not bind antigen, and imparts an Igh-variable region-linked restriction.
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Non-erythroid effects of erythropoietin.
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Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses.
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Pediatric oncology group utilization of immunologic markers in the designation of acute lymphocytic leukemia subgroups: influence on treatment response.
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Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells.
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Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
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Phenotypic characterization of human bone marrow granulocyte-macrophage forming progenitor cells.
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Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture.
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Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.
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Polymorphisms in HLA Class II Genes Are Associated With Susceptibility to Staphylococcus aureus Infection in a White Population.
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Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules.
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Prolonged survival of class II transactivator-deficient cardiac allografts.
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Protease-activated receptor-2 signaling triggers dendritic cell development.
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Reduced antigenicity of formaldehyde-fixed arterial allografts and their potential clinical application.
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Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
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Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney transplant model.
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Retrovirally transduced human dendritic cells can generate T cells recognizing multiple MHC class I and class II epitopes from the melanoma antigen glycoprotein 100.
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Rheumatoid arthritis and sterile corneal ulceration. Analysis of tissue immune effector cells and ocular epithelial antigens using monoclonal antibodies.
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Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells.
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Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.
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Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.
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Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.
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The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-gamma.
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The effect of alpha 2 macroglobulin-proteinase complexes on macrophage Ia expression in vivo.
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The importance of class I and class II HLA in cadaveric renal transplantation.
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The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.
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The molecular basis of class II MHC allelic control of T cell responses.
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Tolerance and the "Holy Grail" of transplantation.
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Transgenic tubular cell expression of class II is insufficient to initiate immune renal injury.
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Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.
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Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.
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Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages.
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Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
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