Antigens, Polyomavirus Transforming
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Subject Areas on Research
- A genetically tractable model of human glioma formation.
- A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice.
- A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent.
- A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
- A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
- Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.
- Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability.
- Bcl-2 accelerates multistep prostate carcinogenesis in vivo.
- Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice.
- Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen.
- Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation.
- Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation.
- Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS.
- Creation of human tumour cells with defined genetic elements.
- Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.
- Differential properties among clones of simian virus 40-transformed human epithelial cells.
- Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At.
- Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge.
- Fusigenic liposome-mediated DNA transfer into cardiac myocytes.
- Genetically engineered human cancer models utilizing mammalian transgene expression.
- Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
- Immortalized hypothalamic gonadotropin-releasing hormone neurons.
- Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.
- Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
- Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct.
- Localization of an immunorecessive epitope on SV40 T antigen by H-2Db-restricted cytotoxic T-lymphocyte clones and a synthetic peptide.
- Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.
- Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons.
- Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.
- Morphological and functional characterization of beta TC-6 cells--an insulin-secreting cell line derived from transgenic mice.
- Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro.
- Reconstitution of simian virus 40 DNA replication with purified proteins.
- Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice.
- Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia.
- Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
- Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication.
- Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences.
- Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy.
- T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123.
- Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells.
- Transactivation of BKV and SV40 early promoters by BKV and SV40 T-antigens.
- Transformation of chicken embryo fibroblasts and tumor induction by the middle T antigen of polyomavirus carried in an avian retroviral vector.