Antigens, Surface

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  Subject Areas on Research

  • (2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy. 
  • 1,10-Phenanthroline reversibility inhibits proliferation of two human prostate carcinoma cell lines (PC-3 and DU145). 
  • 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes. 
  • A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines. 
  • A monoclonal antibody reactive with a second epitope of the 67,000-dalton human T cell antigen. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • A visual assay to monitor purification of cell surface antigens reacting with monoclonal antibodies. 
  • ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. 
  • African-American heredity prostate cancer study: a model for genetic research. 
  • Age-related studies of SIg, Leu-4 and concanavalin A receptor densities and capping in human lymphocytes. 
  • Aging is not associated with bone marrow-resident progenitor cell depletion. 
  • An Improved 211At-Labeled Agent for PSMA-Targeted α-Therapy. 
  • An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. 
  • Analysis of factors associated with the tumorigenic potential of 12 tumor clones derived from a single rat colon adenocarcinoma. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. 
  • Antibodies to CD45 and other cell membrane antigens in systemic lupus erythematosus. 
  • Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. 
  • Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185. 
  • Antiinflammatory proteins associated with human and murine neoplasms. 
  • Antithymocyte globulin stimulates human hematopoietic progenitor cells. 
  • Assessing immunophenotyping performance: proficiency-validation for adopting improved flow cytometry methods. 
  • Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches. 
  • Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors. 
  • CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. 
  • CD40L expression in plasma of volunteers following LPS administration: A comparison between assay of CD40L on platelet microvesicles and soluble CD40L. 
  • CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. 
  • CD9 plays a role in Schwann cell migration in vitro. 
  • Carbohydrate changes in pre- and peri-implantation mouse embryos as detected by a monoclonal antibody. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Cell lines producing human T-cell lymphoma virus show altered HLA expression. 
  • Cell recognition processes in the differentiation of embryonic sea urchins. 
  • Cell surface differentiation antigens of the malignant T cell in Sezary syndrome and mycosis fungoides. 
  • Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides. 
  • Cellular events in the differentiation of antibody-secreting cells. 
  • Characterization of B-cell type chronic lymphocytic leukemia cells by surface markers and a monoclonal antibody. 
  • Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. 
  • Characterization of T lymphocyte and monocyte populations in HLA B8/DRw3 normal individuals and in patients with dermatitis herpetiformis. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. 
  • Characterization of renal neoplasms with monoclonal antibodies to leukocyte differentiation antigens. 
  • Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11. 
  • Clinical and immunologic significance of cholera-like toxin and cytotoxin production by Campylobacter species in patients with acute inflammatory diarrhea in the USA. 
  • Clinicopathologic aspects of E rosette negative T cell acute lymphocytic leukemia: a Pediatric Oncology Group study. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Combined chemoseparation and immunoseparation of clonogenic T lymphoma cells from human bone marrow using 2'-deoxycoformycin, deoxyadenosine, 3A1 monoclonal antibody, and complement. 
  • Comparison of serum prostate specific membrane antigen, prostate specific antigen, and free prostate specific antigen levels in radical prostatectomy patients. 
  • Composite tissue allotransplantation: classification of clinical acute skin rejection. 
  • Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. 
  • Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin. 
  • Coordinated posttranscriptional mRNA population dynamics during T-cell activation. 
  • Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state. 
  • Cyclosporine inhibition of CH series murine B-cell lymphomas. 
  • D6.1, a murine antimelanoma monoclonal antibody from congenitally athymic nude mice immunized with purified melanoma tumor-associated antigen. 
  • Demonstration of abnormalities in expression of thymic epithelial surface antigens in severe cellular immunodeficiency diseases. 
  • Demonstration of abnormalities in expression of thymic epithelial surface antigens in severe cellular immunodeficiency diseases. 
  • Demonstration of complex antigenic heterogeneity in a human glioma cell line and eight derived clones by specific monoclonal antibodies. 
  • Determinants of deoxyadenosine toxicity in hybrids between human T- and B- lymphoblasts as a model for the development of drug resistance in T-cell acute lymphoblastic leukemia. 
  • Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody. 
  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. 
  • Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma. 
  • Differentiation of human embryonic stem cells along a hepatic lineage. 
  • Direct in vivo measurement of targeted binding in a human tumor xenograft. 
  • Discontinuous expression of a membrane antigen (HB-7) during B lymphocyte differentiation. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • Echinonectin: a new embryonic substrate adhesion protein. 
  • Effect of thymectomy on peripheral lymphocyte subsets in myasthenia gravis: selective effect on T-cells in patients with thymic atrophy. 
  • Effects of reteplase and alteplase on platelet aggregation and major receptor expression during the first 24 hours of acute myocardial infarction treatment. GUSTO-III Investigators. Global Use of Strategies to Open Occluded Coronary Arteries. 
  • Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation. 
  • Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation. 
  • Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. 
  • Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses. 
  • Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases. 
  • Expression of a wide T cell receptor V beta repertoire in human T lymphocytes derived in vitro from embryonic liver cell precursors. 
  • Expression of antigens by cultured epithelial cells: comparison of epidermis and thymic epithelium. 
  • Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome. 
  • Expression of differentiation antigens by hybrids of human lymphoblastoid cells. 
  • Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. 
  • Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element. 
  • Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes. 
  • Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo. 
  • Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines. 
  • H-2K-, H-21- and H-2D-restricted hybridoma contact sensitivity effector cells. 
  • Heterogeneity of acute lymphocytic leukemia cell surface markers as detected by monoclonal antibodies. 
  • Human T cell antigen expression by primate T cells. 
  • Human T cell antigen expression during the early stages of fetal thymic maturation. 
  • Human T lymphocyte antigens as defined by monoclonal antibodies. 
  • Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parent. 
  • Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack. 
  • Human cytotoxic T cells specific for autologous melanoma cells: successful generation from lymph node cells in seven consecutive cases. 
  • Human erythrocyte antigens. Regulation of expression of a novel erythrocyte surface antigen by the inhibitor Lutheran In(Lu) gene. 
  • Human fetal brain antigen expression common to tumors of neuroectodermal tissue origin. 
  • Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations. 
  • Human medullary thymocyte p80 antigen and In(Lu)-related p80 antigen reside on the same protein. 
  • Human mononuclear phagocyte transglutaminase activity cross-links fibrin. 
  • Human splenic sinusoidal lining cells express antigens associated with monocytes, macrophages, endothelial cells, and T lymphocytes. 
  • Human thymocytes bind to autologous and allogeneic thymic epithelial cells in vitro. 
  • Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus. 
  • Ia+ T cells in new onset Graves' disease. 
  • Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. 
  • Identification of two subpopulations of rat monocytes expressing disparate molecular forms and quantities of CD43. 
  • IgE Fc receptor positive T and B lymphocytes in patients with the hyper IgE syndrome. 
  • Immune responses of human lymphocytes in vitro. 
  • Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. 
  • Immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen-positive childhood T-cell leukemia. A Pediatric Oncology Group Study. 
  • Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules. 
  • Increasing vaccine potency through exosome antigen targeting. 
  • Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. 
  • Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion. 
  • Interaction of monoclonal antibodies with cell surface antigens of human ovarian carcinomas. 
  • Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. 
  • Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. 
  • Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells. 
  • Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. 
  • Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. 
  • Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens. 
  • Lyme disease vaccination: are we ready to try again? 
  • Lyme disease vaccination: safety first - author's reply. 
  • Lymphokine-activated killer cell activity after cryopreservation. 
  • Metastatic behavior and cell surface properties of HT-29 human colon carcinoma variant cells selected for their differential expression of sialyl-dimeric Le(x)-antigen. 
  • Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens. 
  • Modified responses to recipient and donor B cells by genetically donor T cells from human haploidentical bone marrow chimeras. 
  • Monoclonal antibodies against the CD44 [In(Lu)-related p80], and Pgp-1 antigens in man recognize the Hermes class of lymphocyte homing receptors. 
  • Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation. 
  • Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells. 
  • Monoclonal antibodies to a human islet cell surface glycoprotein: 4F2 and LC7-2. 
  • Monoclonal antibodies to different epitopes on a prostate tumor-associated antigen. Implications for immunotherapy. 
  • Monoclonal antibodies to tissue-associated antigens as antitumor reagents. 
  • Monoclonal antibodies to tissue-specific cell surface antigens. I. Characterization of an antibody to a prostate tissue antigen. 
  • Monoclonal antibody 4F2 reactive with basal layer keratinocytes: studies in the normal and a hyperproliferative state. 
  • Monoclonal antibody defines human cell surface protein p80 on intrathymic T cells. 
  • Murine in vitro antigenic modification of tumor cells: effect on susceptibility to natural cell-mediated cytotoxicity. 
  • Natural killing target antigens as inducers of interferon: studies with an immunoselected, natural killing-resistant human T lymphoblastoid cell line. 
  • New advances in focal therapy for early stage prostate cancer. 
  • Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve. 
  • Ontogeny of the human thymus during fetal development. 
  • PILAR is a novel modulator of human T-cell expansion. 
  • Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies. 
  • Pertussis toxin triggers rapid second messenger production in human T lymphocytes. 
  • Phenotype and function of T cells propagated from donor-specific blood transfusion enhanced and autologous blood transfused rejecting rat renal allografts. 
  • Phenotypic and functional characterization of human malignant T cells. 
  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. 
  • Phenotypic characterization of cutaneous T-cell lymphoma. Use of monoclonal antibodies to compare with other malignant T cells. 
  • Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture. 
  • Phenotypic characterization of skin-infiltrating T cells in cutaneous T-cell lymphoma: comparison with benign cutaneous T-cell infiltrates. 
  • Phenotypic variation in the response to the human immunodeficiency virus among derivatives of the CEM T and WIL-2 B cell lines. 
  • Porcine endothelial cell membrane antigens recognized by human and baboon xenoreactive antibodies during organ perfusion. 
  • Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. 
  • Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals. 
  • Production and characterization of two human glioma xenograft-localizing monoclonal antibodies. 
  • Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens. 
  • Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. 
  • Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. 
  • Pulsing of dendritic cells with cell lysates from either B16 melanoma or MCA-106 fibrosarcoma yields equally effective vaccines against B16 tumors in mice. 
  • Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway. 
  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. 
  • Radioimmunotherapy of intracerebral human glioma xenografts with 131I-labeled F(ab')2 fragments of monoclonal antibody Mel-14. 
  • Real-time quantitative RT-PCR assay of prostate-specific antigen and prostate-specific membrane antigen in peripheral blood for detection of prostate cancer micrometastasis. 
  • Receptor-mediated monocytoid differentiation of human promyelocytic cells by tumor necrosis factor: synergistic actions with interferon-gamma and 1,25-dihydroxyvitamin D3. 
  • Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies. 
  • Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. 
  • Rheumatoid arthritis and sterile corneal ulceration. Analysis of tissue immune effector cells and ocular epithelial antigens using monoclonal antibodies. 
  • Role of JAK3 in CD40-mediated signaling. 
  • Separation of ectoderm and endoderm from sea urchin pluteus larvae and demonstration of germ layer-specific antigens. 
  • Soluble P-selectin is not a surrogate marker for platelet P-selectin: evidence from a multicenter chest pain study group. 
  • Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas. 
  • Stemming Lung Disease? 
  • Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • Studies of human bone marrow treated with soybean lectin and sheep erythrocytes: stepwise analysis of cell morphology, phenotype and function. 
  • Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma. 
  • Surface antigens involved in interactions of embryonic sea urchin cells. 
  • Surface antigens of human glioma cells shared with normal adult and fetal brain. 
  • Syntaxin 1A is transiently expressed in fetal lung mesenchymal cells: potential developmental roles. 
  • Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. 
  • Synthesis and preliminary evaluation of 211At-labeled inhibitors of prostate-specific membrane antigen for targeted alpha particle therapy of prostate cancer. 
  • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. 
  • Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. 
  • T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes. 
  • The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. 
  • The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. 
  • The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. 
  • The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. 
  • The Inab phenotype: characterization of the membrane protein and complement regulatory defect. 
  • The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice. 
  • The gene for a novel epidermal antigen maps near the neurofibromatosis 1 gene. 
  • The human thymic microenvironment. Phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies. 
  • The immunologic approach to analysis of malignant lymphoma. Mantle zone lymphoma of the ileocecal region. 
  • The interaction of a series of hybridoma IgGs with reovirus particles. Demonstration that the core protein lambda 2 is exposed on the particle surface. 
  • The phenotype of human placental macrophages and its variation with gestational age. 
  • The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. 
  • The role of leukocyte adhesion molecules in cellular interactions: implications for the pathogenesis of inflammatory synovitis. 
  • The role of receptors for complement in the induction of polyclonal B-cell proliferation and differentiation. 
  • The role of the L3T4 molecule in mitogen and antigen-activated signal transduction. 
  • Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. 
  • Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. 
  • Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens. 
  • Topology of cell adhesion molecules. 
  • Transcription of H-2 and Qa genes in embryonic and adult mice. 
  • Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL. 
  • Two embryonic, tissue-specific molecules identified by a double-label immunofluorescence technique for monoclonal antibodies. 
  • Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. 
  • Variability in B cell maturation and differentiation in X-linked agammaglobulinemia. 
  • Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology