Antigens, Viral

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  Subject Areas on Research

  • A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP. 
  • A dimensionless number for understanding the evolutionary dynamics of antigenically variable RNA viruses. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs. 
  • A proposed nomenclature for the virion proteins of oncogenic RNA viruses. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E. 
  • AIDS response. 
  • Abortive and productive infections of human mononuclear phagocytes by type I herpes simplex virus. 
  • Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection. 
  • Acute hepatitis due to epstein-barr virus in an immunocompetent patient. 
  • Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. 
  • Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development. 
  • Antibodies to human T-cell lymphotropic virus-I membrane antigens and inverted T4/T8 ratios in hemophiliacs. 
  • Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. 
  • Antigenic activity of human urothelial tissue. 
  • Antigenic comparison of virus strains of mild and classical types of epidemic haemorrhagic fever isolated in China and adaptation of these to cultures of normal cells. 
  • Antigenic difference between viral strains causing classical and mild types of epidemic hemorrhagic fever with renal syndrome in China. 
  • Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. 
  • Antigenic relationships between murine, feline and primate RNA tumor viruses and membrane antigens of human leukemic cells. 
  • Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1. 
  • Application of Epstein-Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma. 
  • Approaches to HIV vaccine design. 
  • Avian Influenza A(H7N9) virus antibodies in close contacts of infected persons, China, 2013-2014. 
  • Avian influenza A (H5N1) infection in a patient in China, 2006. 
  • B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques. 
  • C-terminal region of human T cell lymphotropic virus type I (HTLVI) p19 core protein is immunogenic in humans and contains an HTLVI-specific epitope. 
  • CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection. 
  • COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. 
  • Cellular immunity in rats with primary brain tumors: inhibition of macrophage migration by soluble extracts of avian sarcoma virus-induced tumors. 
  • Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection. 
  • Characterization of a trimeric MPER containing HIV-1 gp41 antigen. 
  • Characterization of antigens in SSV nonproducer cells. 
  • Chimeric alphavirus vaccine candidates for chikungunya. 
  • Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex. 
  • Clonal isolate of the simian sarcoma virus codes for a Gag-related 65,000-dalton protein. 
  • Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes. 
  • Comparative In Vitro and In Vivo Studies of Porcine Rotavirus G9P[13] and Human Rotavirus Wa G1P[8]. 
  • Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost. 
  • Comparison of glycoproteins isolated by phenol-water partition of human erythrocyte membranes. 
  • Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein. 
  • Contained indirect viable-cell membrane immunofluorescence microassay for surface antigen analysis of cells infected with hazardous viruses. 
  • Contribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection. 
  • Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform. 
  • Correlation between interferon- gamma secretion and cytotoxicity, in virus-specific memory T cells. 
  • Correlation of apparent molecular weight and antigenicity of viral proteins: an SDS-page separation followed by acrylamide-agarose electrophoresis and immunoprecipitation. 
  • Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state. 
  • Cross-reactions of virally and chemically induced mouse sarcomas: surface expression of a common viral antigen. 
  • Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV-I, -II, -III). 
  • Cytomegalovirus keratitis after penetrating keratoplasty. 
  • Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. 
  • DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge. 
  • Dendritic cells improve the generation of Epstein-Barr virus-specific cytotoxic T lymphocytes for the treatment of posttransplantation lymphoma. 
  • Detection of Epstein-Barr virus in transformations of low-grade B-cell lymphomas after fludarabine treatment. 
  • Detection of oncornavirus antigenic activity in human urothelial tissues. 
  • Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection. 
  • Development of a monoclonal antibody specific for serotype 3 rotavirus strains. 
  • Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay. 
  • Effect of herpes simplex virus types 1 and 2 on surface expression of class I major histocompatibility complex antigens on infected cells. 
  • Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. 
  • Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions. 
  • Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity. 
  • Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. 
  • Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. 
  • Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. 
  • Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia. 
  • Epstein-Barr virus antibodies in whole blood spots: a minimally invasive method for assessing an aspect of cell-mediated immunity. 
  • Equine influenza A(H3N8) virus infection in cats. 
  • Etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome). 
  • Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas. 
  • Feasibility of renal transplantation in systemic lupus erythematosus. 
  • Focal encephalitis with enterovirus infections. 
  • Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. 
  • Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages. 
  • Gonadotropin-releasing hormone neuronal cell lines. 
  • HIV immunization. Fresh pathways to follow. 
  • Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. 
  • Human lymphocyte proliferation responses following primary immunization with rabies vaccine as neoantigen. 
  • Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen. 
  • Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis. 
  • Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis. 
  • Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. 
  • Immunization with trivalent inactivated influenza vaccine in partially immunized toddlers. 
  • Immuno-prophylaxis and -therapy of C-type oncorna viral diseases in mice and cats. 
  • Immunobiologic aspects of the brain and human gliomas. A review. 
  • Immunobiology of human gliomas. 
  • Immunogenic determinants of a neuropathogenic murine leukemia virus. 
  • Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry. 
  • Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. II. Tumor immunity associated with a Friend--Moloney--Ra,scher-type virus. 
  • Immunological properties of avian oncornavirus polypeptides. 
  • Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. 
  • Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT. 
  • Impact of infection on transplantation tolerance. 
  • Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. 
  • In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes. 
  • In vivo antigenic modification of tumor cells. I. Introduction of murine leukemia virus antigens on non-virus-producing murine sarcomas. 
  • In vivo antigenic modification of tumor cells. II. Distribution of virus in sarcoma-bearing mice. 
  • In vivo antigenic modification of tumor cells. III. Metastatic thymic lymphoma specifically infected by thymotropic retrovirus. 
  • Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles. 
  • Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice. 
  • Induction in vitro of primary cytotoxic T-lymphocyte responses with DNA encoding herpes simplex virus proteins. 
  • Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. 
  • Infection of normal human thymic epithelial cells by Epstein-Barr virus (EBV) following implantation of EBV receptors. 
  • Infection of the HTLV-II-bearing T-cell line C3 with HTLV-III/LAV is highly permissive and lytic. 
  • Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming? 
  • Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus. 
  • Interspecies determinants of Friend leukemia virus antigens involved in cytolysis of virus-pfoducing cells. 
  • Interspecies reactivity of type C and D retrovirus p 15E and p 15C proteins. 
  • Intracellular cleavage of an SSV coded gag-related protein. 
  • Isolation of a transplantable cell line induced by the MC29 avian leukosis virus. 
  • Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses. 
  • Liposomes as antigen delivery systems in viral immunity. 
  • Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants. 
  • Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. 
  • Loss of tumorigenicity following in vitro MuLV infection is associated with induction of peritoneal natural killer cell activity. 
  • Lyt phenotype of H-2b CTL effectors and precursors specific for the SV40 transplantation rejection antigen. 
  • Mammalian C-type oncorna viruses. Relationships between structural virus and cell surface antigens and their possible significance in immunological defense mechanisms. 
  • Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission. 
  • Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV. 
  • Monoclonal antibodies reactive with human T cell lymphotropic virusI (HTLVI) p19 internal core protein: cross-reactivity with normal tissues and differential reactivity with HTLV types I and II. 
  • Morphological, chemical, and antigenic organization of mammalian C-type viruses. 
  • Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. 
  • Murine in vitro antigenic modification of tumor cells: effect on susceptibility to natural cell-mediated cytotoxicity. 
  • Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells. 
  • Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins. 
  • Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection. 
  • Neutralization tiers of HIV-1. 
  • Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers. 
  • Normal chicken cells (chf-) express a surface antigen which cross-reacts with determinants of the major envelope glycoprotein (gp85) of avian myeloblastosis virus. 
  • Oncogenic and immunogenic potential of cloned HIX virus in mice and cats. 
  • Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV. 
  • Outer membrane of avian myeloblastosis virus. 
  • Persistent coinfection of T lymphocytes with HTLV-II and HIV and the role of syncytium formation in HIV-induced cytopathic effect. 
  • Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. 
  • Polyoma mutants that productively infect F9 embryonal carcinoma cells do not rescue wild-type polyoma in F9 cells. 
  • Polyoma virus infection of retinoic acid-induced differentiated teratocarcinoma cells. 
  • Polypeptides of avian RNA tumor viruses. IV. Components of the viral envelope. 
  • Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core. 
  • Polypeptides of mammalian oncornaviruses. IV. Structural components of murine leukemia virus released as soluble antigens in cell culture. 
  • Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. 
  • Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012-2013. 
  • Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. 
  • Potential leukemia virus subunit vaccines: discussion. 
  • Prevention of herpes keratitis by monoclonal antibodies specific for discontinuous and continuous epitopes on glycoprotein D. 
  • Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. 
  • Probable and possible transfusion-transmitted dengue associated with NS1 antigen-negative but RNA confirmed-positive red blood cells. 
  • Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis. 
  • Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with Herpes simplex virus. 
  • Prolonged clinical latency and survival of macaques given a whole inactivated simian immunodeficiency virus vaccine. 
  • Properties of mouse leukemia viruses. II. Isolation of viral components. 
  • Prostate and transitional cell carcinoma: radioimmunoassay of viral tumor-associated antigens. 
  • Protective immunity to SIV challenge elicited by vaccination of macaques with multigenic DNA vaccines producing virus-like particles. 
  • Quantification of antibody avidities and accurate detection of SARS-CoV-2 antibodies in serum and saliva on plasmonic substrates. 
  • Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs. 
  • Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers. 
  • Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. 
  • Regulation of the B cell response to T-dependent antigens by classical pathway complement. 
  • Relationships between membrane antigens of human leukemic cells and oncogenic RNA virus structural components. 
  • Replication of type I herpes simplex virus in primary cultures of hairy cell leukemic leukocytes. 
  • Residues critical for duck hepatitis B virus neutralization are involved in host cell interaction. 
  • Respiratory syncytial virus and influenza A infections in the hospitalized elderly. 
  • Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein. 
  • Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy. 
  • Role of germinal centers for the induction of broadly-reactive memory B cells. 
  • Role of immune responses against the envelope and the core antigens of simian immunodeficiency virus SIVmne in protection against homologous cloned and uncloned virus challenge in Macaques. 
  • SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation. 
  • SIV infection duration largely determines broadening of neutralizing antibody response in macaques. 
  • SIV vaccine protection of rhesus monkeys. 
  • Selection of TCR V alpha by MHC class II predicts superantigen reactivity. 
  • Serological Evidence and Risk Factors for Swine Influenza Infections among Chinese Swine Workers in Guangdong Province. 
  • Serological responses in chimpanzees inoculated with human immunodeficiency virus glycoprotein (gp120) subunit vaccine. 
  • Specificity and distribution of the determinants of the major glycoprotein (gp71) of murine oncornaviruses as detected by an in vitro cytotoxicity assay. 
  • Specificity of peptide binding by the HLA-A2.1 molecule. 
  • Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors. 
  • Structural components of avian myeloblastosis virus. 
  • Structural components of rna tumor viruses. 
  • Structure and specific antigens of avian leukosis viruses. 
  • Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion. 
  • Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein. 
  • Summary of session on oncornaviruses I. Virus-cell interactions and virus structure analyses. 
  • The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. 
  • The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. 
  • The effects of leukemosuppressive immunotherapy on bone marrow infectious cell centers in AKR mice. 
  • The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. 
  • The fine structure of canine gliomas and intracranial sarcomas induced by the Schmidt-Ruppin strain of the Rous sarcoma virus. 
  • The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors. 
  • The principal neutralization determinant of simian immunodeficiency virus differs from that of human immunodeficiency virus type 1. 
  • The role of monogamous bivalency and Fc interactions in the binding of anti-DNA antibodies to DNA antigen. 
  • The virogenesis of bluetongue virus in Culicoides variipennis. 
  • Two levels of restriction by mouse or cat cells of murine sarcoma virus coated by endogenous xenotropic oncornavirus. 
  • Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge. 
  • Virus-cell relationships in dog brain tumors induced with Schmidt-Ruppin Rous sarcoma virus. 
  • Will antibody-dependent enhancement of HIV-1 infection be a problem with AIDS vaccines? 
  • XVIII. Effective treatment of AKR leukemia with antibody to gp7 1 eliminates the neonatal burst of ecotropic AKR virus producing cells. 
  • Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. 
  • [Antigenicity analysis of hemorrhagic fever with renal syndrome viruses by McAbs I]. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis]. 
  • [Detection of antigens and analysis of antigenicity of hemorrhagic fever with renal syndrome viruses by immune adherence hemagglutination assay (IAHA)]. 
  • [Morphogenesis and structure of RNA tumor viruses. Electron microscopy studies on C-type viruses]. 
  • [New evidence of the antigenic relation between the viruses of epidemic neuropathy and the human nervous system. A study of the immune cellular response in patients with epidemic neuropathy and controls. A review of the topic]. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Cunningham, Coleen Kathryn, Adjunct Professor in the Department of Pediatrics, Pediatrics
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology