Apomorphine

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  Subject Areas on Research

  • Apomorphine for the acute treatment of "off" episodes in Parkinson's disease. 
  • Apomorphine in the treatment of Parkinson's disease. 
  • Apomorphine: North American clinical experience. 
  • Apomorphine: a rapid rescue agent for the management of motor fluctuations in advanced Parkinson disease. 
  • Behavioral effects of dopamine agonists across the estrous cycle in rats. 
  • Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study. 
  • Chronic sulpiride increased 3H-spiperone binding and calmodulin dependent phosphorylation in rat striatum. 
  • Comparative dopamine-cholinergic mechanisms in the olfactory tubercle and the striatum: effects of metoclopramide. 
  • Direct radioligand measurement of dopamine receptors in the anterior pituitary gland. 
  • Does dopamine contribute to striatal damage caused by impaired mitochondrial function? 
  • Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides. 
  • Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists. 
  • Dopaminergic inhibition of adenylate cyclase correlates with high affinity agonist binding to anterior pituitary D2 dopamine receptors. 
  • Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats. 
  • Effects of dopamine agonists and antagonists in Tourette's disease. 
  • Enhanced affective aggression in genetically bred hypercholinergic rats. 
  • Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary. 
  • High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • II. Pharmacological studies with derivatives of 2-aminotetralin, benzhydro[f]quinoline, benzhydro[g]quinoline, apomorphine and clonidine suggest a pharmacological dissimilarity between peripheral presynaptic dopamine receptors and alpha-2 adrenoceptors. 
  • Interactions of nigrostriate synaptic transmission, iontophoretic O-methylated phenethylamines, dopamine, apomorphine and acetylcholine. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of parkinsonism. 
  • N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain. 
  • Neurobiochemical changes in tardive dyskinesia. 
  • Neurological disturbances, nigrostriate synapses, and iontophoretic dopamine and apomorphine after haloperidol. 
  • Other formulations and future considerations for apomorphine for subcutaneous injection therapy. 
  • Paradoxical response to dopamine agonists in tardive dyskinesia. 
  • Presynaptic inhibition of dopamine synthesis in rat striatum: effects of chronic dopamine depletion and receptor blockade. 
  • Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. 
  • Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat. 
  • Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans. 
  • The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum. 
  • Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function. 
  • [3H]dihydroergocryptine binding in rat brain. 
  • [Problem of neuronal reception and the dopamine hypothesis of schizophrenia].