Aqueous Humor

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  Subject Areas on Research

  • A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. 
  • A Highly Effective and Ultra-Long-Acting Anti-Glaucoma Drug, with a Novel Periorbital Delivery Method. 
  • A Nine-Year Analysis of Practice Patterns, Microbiologic Yield, and Clinical Outcomes in Cases of Presumed Infectious Endophthalmitis. 
  • A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate. 
  • A model of the oscillatory mechanical forces in the conventional outflow pathway. 
  • A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium. 
  • A newer technique for glaucoma tube trimming. 
  • Acid mucopolysaccharides in the outflow apparatus. 
  • Age-related changes in eye morphology and aqueous humor dynamics in DBA/2J mice using contrast-enhanced ocular MRI. 
  • Age-related changes in the human outflow apparatus. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Annular peripheral choroidal detachment simulating aqueous misdirection after glaucoma surgery. 
  • Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew (Tupaia belangeri). 
  • Antithrombin III, a serpin family protease inhibitor, is a major heparin binding protein in porcine aqueous humor. 
  • Aquaporin-1 expression and conventional aqueous outflow in human eyes. 
  • Aqueous drainage device surgery in refractory pediatric glaucoma: II. Ocular motility consequences. 
  • Aqueous drainage device surgery in refractory pediatric glaucomas: I. Long-term outcomes. 
  • Aqueous humor factors and their effect on the immune response in the anterior chamber. 
  • Aqueous humor outflow: dynamics and disease. 
  • Aqueous humor outflow: what do we know? Where will it lead us? 
  • Aqueous humor sCD44 concentration and visual field loss in primary open-angle glaucoma. 
  • Aqueous shunt devices compared with trabeculectomy with Mitomycin-C for children in the first two years of life. 
  • Aqueous shunt devices compared with trabeculectomy with mitomycin-C for children in the first two years of life. 
  • Aqueous tube shunt to a preexisting episcleral encircling element in the treatment of complicated glaucomas. 
  • Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. 
  • Assays for the antiangiogenic and neurotrophic serpin pigment epithelium-derived factor. 
  • Autophagy and mechanotransduction in outflow pathway cells. 
  • Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. 
  • Bimatoprost, prostamide activity, and conventional drainage. 
  • Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. 
  • Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells. 
  • Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction. 
  • Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes. 
  • Cell senescence reduced the mechanotransduction sensitivity of porcine angular aqueous plexus cells to elevation of pressure. 
  • Cellular basis for bimatoprost effects on human conventional outflow. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Changes in the monkey outflow apparatus at graded levels of intraocular pressure: a qualitative analysis by light microscopy and scanning electron microscopy. 
  • Circumferential tensile stiffness of glaucomatous trabecular meshwork. 
  • Clearance of antitransferrin receptor immunotoxin from the rabbit eye. 
  • Clinical outcomes in cytomegalovirus-positive Posner-Schlossman syndrome patients treated with topical ganciclovir therapy. 
  • Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. 
  • Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. 
  • Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. 
  • Current understanding of conventional outflow dysfunction in glaucoma. 
  • Cytologic findings in vitreous fluids. Analysis of 74 specimens. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • Decreased outflow facility and Schlemm's canal defects in a mouse model of glaucoma. 
  • Detection and quantification of S-100 protein in ocular tissues and fluids from patients with intraocular melanoma. 
  • Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology. 
  • Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes. 
  • Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. 
  • Differential P1-purinergic modulation of human Schlemm's canal inner-wall cells. 
  • Differential effect of secondary aqueous humor from rabbit and cat on DNA synthesis of cultured bovine corneal endothelial cells. 
  • Differential effects of trabecular meshwork stiffness on outflow facility in normal human and porcine eyes. 
  • Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma. 
  • Doyne Lecture. The pathology of the outflow system in primary and secondary glaucoma. 
  • Effect of an intravitreal cyclosporine implant on experimental uveitis in horses. 
  • Effect of timolol on aqueous humor protein concentration in humans. 
  • Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. 
  • Effects of cholesterol-lowering statins on the aqueous humor outflow pathway. 
  • Effects of cyclic intraocular pressure on conventional outflow facility. 
  • Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow. 
  • Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. 
  • Effects of pilocarpine on the morphology of the human outflow apparatus. 
  • Effects of prolonged intracameral perfusion with mock aqueous humour on the morphology of the primate outflow apparatus. 
  • Efficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitis. 
  • Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork. 
  • Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Endophthalmitis after penetrating trauma. Risk factors and visual acuity outcomes. 
  • Endophthalmitis following Nd:YAG laser posterior capsulotomy. 
  • Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice. 
  • Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia. 
  • Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells. 
  • Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. 
  • Extravascular plasminogen activator and inhibitor activities detected at the site of a chronic mycobacterial-induced inflammation. 
  • Eye-derived cytokines and the immunosuppressive intraocular microenvironment: a review. 
  • Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma. 
  • Further observations on the process of haemophagocytosis in the human outflow system. 
  • GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. 
  • Giant vacuoles in the lining endothelium of the human Schlemm's canal after topical timolol maleate. 
  • Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells. 
  • Gold nanorods as a contrast agent for Doppler optical coherence tomography. 
  • Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. 
  • Human aqueous humor exosomes. 
  • Hydraulic pressure stimulates adenosine 3',5'-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal. 
  • IOP elevation reduces Schlemm's canal cross-sectional area. 
  • Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes. 
  • Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. 
  • Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. 
  • Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. 
  • Impact of cultures on management decisions following surgical repair of penetrating ocular trauma. 
  • In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model. 
  • Interleukin-2 immunotherapy of murine cytomegalovirus retinitis during MAIDS correlates with increased intraocular CD8+ T-cell infiltration. 
  • Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration. 
  • Intravitreal clearance of tissue plasminogen activator in the rabbit. 
  • Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis. 
  • Is the sutureless cataract incision a valve for bacterial inoculation? 
  • Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma. 
  • MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. 
  • Mathematical Modeling of Outflow Facility Increase With Trabecular Meshwork Bypass and Schlemm Canal Dilation. 
  • Mathematical modelling of aqueous humour outflow from the eye through the pores in the lining endothelium of Schlemm's canal. 
  • Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow. 
  • Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. 
  • Mechanisms of ATP release, the enabling step in purinergic dynamics. 
  • Mechanistic Effects of Baicalein on Aqueous Humor Drainage and Intraocular Pressure. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Mitomycin-C concentration in human aqueous humour following trabeculectomy. 
  • Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. 
  • Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics. 
  • Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography. 
  • Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humor. 
  • Myocilin-associated exosomes in human ocular samples. 
  • Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study. 
  • Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. 
  • Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. 
  • Ocular penetration and pharmacokinetics of topical gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions after keratoplasty. 
  • Ocular penetration of 5-fluorocytosine. 
  • Optimizing gene transfer to conventional outflow cells in living mouse eyes. 
  • Outflow physiology of the mouse eye: pressure dependence and washout. 
  • Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers. 
  • Pathways for the drainage of aqueous humour into Schlemm's canal. 
  • Pharmacokinetics of the fluocinolone/5-fluorouracil codrug in the gas-filled eye. 
  • Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes. 
  • Pharmacological regulation of outflow resistance distal to Schlemm's canal. 
  • Physical Factors Affecting Outflow Facility Measurements in Mice. 
  • Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia. 
  • Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow. 
  • Pigment epithelium-derived factor decreases outflow facility. 
  • Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT. 
  • Presence of SARS-CoV-2 Viral RNA in Aqueous Humor of Asymptomatic Individuals. 
  • Pressure-induced changes in the ultrastructure of the endothelium lining Schlemm's canal. 
  • Pressure-sensing Piezo1: the eyes have it. 
  • Protein profile of exosomes from trabecular meshwork cells. 
  • RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival. 
  • Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway. 
  • Regulation of myocilin-associated exosome release from human trabecular meshwork cells. 
  • Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. 
  • Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. 
  • Relationship between glaucoma and selenium levels in plasma and aqueous humour. 
  • Relationships between intraocular pressure and the morphology of the outflow apparatus. 
  • Results of 233 peripheral iridectomies for narrow-angle glaucoma. 
  • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. 
  • Rho kinase inhibitors for glaucoma treatment - Review. 
  • Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells. 
  • Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. 
  • Role of nitric oxide in murine conventional outflow physiology. 
  • Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research. 
  • Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity. 
  • S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. 
  • Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device. 
  • Schlemm's canal endothelia, lymphatic, or blood vasculature? 
  • Secondary aqueous humor stimulates the proliferation of cultured bovine corneal endothelial cells. 
  • Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure. 
  • Shear stress-triggered nitric oxide release from Schlemm's canal cells. 
  • Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes. 
  • Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia. 
  • Supplemental transscleral diode laser cyclophotocoagulation after aqueous shunt placement in refractory glaucoma. 
  • T cell activation within different intraocular compartments during experimental uveitis. 
  • TIGR/myocilin in human aqueous humor. 
  • Targeted Delivery of Cell Softening Micelles to Schlemm's Canal Endothelial Cells for Treatment of Glaucoma. 
  • Targeted gene transfer to Schlemm's canal by retroperfusion. 
  • Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma. 
  • The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. 
  • The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes. 
  • The autophagic lysosomal system in outflow pathway physiology and pathophysiology. 
  • The cell and molecular biology of glaucoma: mechanisms in the conventional outflow pathway. 
  • The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. 
  • The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. 
  • The effect of intraocular pressure on the absorption of air from the vitreous cavity. 
  • The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (1) Pressure effects within the near-physiological range (8-30 mmHg). 
  • The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (2) Pressures outside the physiological range (0 and 50 mmHg). 
  • The many faces of the trabecular meshwork cell. 
  • The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production. 
  • The permeability of the outer layers of limbus and anterior sclera. 
  • The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up. 
  • The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. 
  • The role of microRNAs in glaucoma. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The role of the prostaglandin EP4 receptor in the regulation of human outflow facility. 
  • The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice. 
  • The vital role for nitric oxide in intraocular pressure homeostasis. 
  • The β4-Subunit of the Large-Conductance Potassium Ion Channel KCa1.1 Regulates Outflow Facility in Mice. 
  • Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma. 
  • Thrombospondin-1 mediates Rho-kinase inhibitor-induced increase in outflow-facility. 
  • Topical ganciclovir treatment in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty. 
  • Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. 
  • Uveitis in children. 
  • VEGF as a Paracrine Regulator of Conventional Outflow Facility. 
  • Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. 
  • Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes. 
  • eNOS, a pressure-dependent regulator of intraocular pressure. 
  • miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure. 
  • sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. 
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  Keywords of People

  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics