Arginine

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  Subject Areas on Research

  • 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells. 
  • A P(E)RM(I)T for BMP signaling. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation. 
  • A physiologic role for somatostatin 28 as a regulator of insulin secretion. 
  • A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C. 
  • A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. 
  • A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding. 
  • APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. 
  • Abl tyrosine kinases are required for infection by Shigella flexneri. 
  • Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. 
  • Activation-dependent conformational changes in {beta}-arrestin 2. 
  • Allosteric interactions in non-alpha chains isolated from normal human hemoglobin, fetal hemoglobin, and hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). 
  • Ambient temperature and dietary supplementation interact to shape mosquito vector competence for malaria. 
  • Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling. 
  • Analysis of responses to serotonin in the pulmonary vascular bed of the cat. 
  • Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. 
  • Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Apolipoprotein-E allele-specific regulation of nitric oxide production. 
  • Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. 
  • Argininamide binding arrests global motions in HIV-1 TAR RNA: comparison with Mg2+-induced conformational stabilization. 
  • Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. 
  • Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. 
  • Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. 
  • Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort. 
  • Autosomal-dominant retinitis pigmentosa associated with an Arg-135-Trp point mutation of the rhodopsin gene. Clinical features and longitudinal observations. 
  • Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. 
  • Biochemical properties of recombinant human and mouse N-acetylglutamate synthase. 
  • Biochemistry of nitric oxide and its redox-activated forms. 
  • Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. 
  • Ca(2+)-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells. 
  • Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity. 
  • Characteristics of lysine transport by isolated rat renal cortical tubule fragments. 
  • Characterization of a putative periplasmic transport system for octopine accumulation encoded by Agrobacterium tumefaciens Ti plasmid pTiA6. 
  • Characterization of the insulinotropic potency of polyunsaturated fatty acids. 
  • Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. 
  • Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin. 
  • Clinical evidence for pharmaconutrition in major elective surgery. 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP. 
  • Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. 
  • Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis. 
  • Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. 
  • Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. 
  • Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. 
  • Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. 
  • Development of a novel quadruple auxotrophic host transformation system by argB gene disruption using adeA gene and exploiting adenine auxotrophy in Aspergillus oryzae. 
  • Diabetic urethropathy compounds the effects of diabetic cystopathy. 
  • Digital switching of local arginine density in a genetically encoded self-assembled polypeptide nanoparticle controls cellular uptake. 
  • Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. 
  • Discontinuation and Management of Direct-Acting Anticoagulants for Emergency Procedures. 
  • Discontinuation and management of direct-acting anticoagulants for emergency procedures. 
  • Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Effect of DNA conformation on cisplatin adduct formation. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effect of nitric oxide synthase inhibition on bleeding time in humans. 
  • Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. 
  • Effects of arginase isoforms on NO Production by nNOS. 
  • Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung. 
  • Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness. 
  • Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships. 
  • Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans. 
  • Engagement of arginine finger to ATP triggers large conformational changes in NtrC1 AAA+ ATPase for remodeling bacterial RNA polymerase. 
  • Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line. 
  • Essential role of conserved arginine 160 in intramolecular electron transfer in human sulfite oxidase. 
  • Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. 
  • Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor. 
  • Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy. Collaborative Study Group. 
  • Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy. 
  • Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. 
  • Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. 
  • Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. 
  • Growth retardation in the Lesch-Nyhan syndrome. 
  • Hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site. 
  • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. 
  • High-level misincorporation of lysine for arginine at AGA codons in a fusion protein expressed in Escherichia coli. 
  • Homocystine uptake in isolated rat renal cortical tubules. 
  • Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate. 
  • Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin. 
  • Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. 
  • Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury. 
  • Immune hemolytic transfusion reactions in monkeys: activation of the kallikrein system. 
  • Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. 
  • Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. 
  • Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice. 
  • Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. 
  • Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock. 
  • Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. 
  • Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils. 
  • Induction of superoxide anion and nitric oxide production in cultured microglia. 
  • Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. 
  • Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed. 
  • Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant. 
  • Inhibition of bile flow by intravenous arginine hydrochloride. 
  • Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. 
  • Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen. 
  • Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats. 
  • Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. 
  • Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. 
  • L-arginine enhances injury in the isolated rabbit lung during hyperoxia. 
  • L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. 
  • L-arginine or tempol supplementation improves renal and cardiovascular function in rats with reduced renal mass and chronic high salt intake. 
  • Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. 
  • Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 
  • Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. 
  • Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. 
  • Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. 
  • Methed-up FOXOs can't in-Akt-ivate. 
  • Methodological remarks concerning the recent meta-analysis on p53 codon 72 polymorphism and colorectal cancer risk. 
  • Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat. 
  • Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. 
  • Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II). 
  • Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism. 
  • Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines. 
  • Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae. 
  • Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA. 
  • Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity. 
  • Mutations at arginine residues in two Asian hemophilia B patients. 
  • N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. 
  • Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H. 
  • Neural control of urethral outlet activity in vivo: role of nitric oxide. 
  • Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 
  • Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity. 
  • Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients. 
  • Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease. 
  • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. 
  • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. 
  • Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. 
  • Nitric oxide decreases oxidant-mediated hepatocyte injury. 
  • Nitric oxide is required for tactile learning in Octopus vulgaris. 
  • Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. 
  • Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. 
  • Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. 
  • Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. 
  • Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma. 
  • Novel oral anticoagulants and reversal agents: Considerations for clinical development. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Nutritional pharmacology in surgery and critical care: 'you must unlearn what you have learned'. 
  • Nutritional support in critically ill patients. 
  • Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice. 
  • Organic nitrogen uptake of Scots pine seedlings is independent of current carbohydrate supply. 
  • Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. 
  • Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site. 
  • Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity. 
  • Performance-enhancing sports supplements: role in critical care. 
  • Perioperative use of arginine-supplemented diets: a systematic review of the evidence. 
  • Pharmaconutrition review: physiological mechanisms. 
  • Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer. 
  • Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans. 
  • Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma. 
  • Precocious osteoarthritis in a family with recurrent COL2A1 mutation. 
  • Preoperative immunonutrition prior to radical cystectomy: a pilot study. 
  • Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction. 
  • Protection of perfused lung from oxidant injury by inhibitors of anion exchange. 
  • Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. 
  • Pulmonary vasodilator response to vagal stimulation is blocked by N omega-nitro-L-arginine methyl ester in the cat. 
  • R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. 
  • RNA dynamics by design: biasing ensembles towards the ligand-bound state. 
  • Rapid detection of argininosuccinic aciduria and citrullinuria by fast atom bombardment and tandem mass spectrometry. 
  • Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). 
  • Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. 
  • Recurrent nonsense mutations at arginine residues cause severe hemophilia B in unrelated hemophiliacs. 
  • Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan. 
  • Resolving the motional modes that code for RNA adaptation. 
  • Retinal phenotype of an X-linked pseudo-Usher syndrome in association with the G173R mutation in the RPGR gene. 
  • Reversal Agents for the New Generation of Oral Anticoagulants: Implications for the Perioperative Physician. 
  • Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. 
  • Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes. 
  • Role of nitric oxide in human esophageal circular smooth muscle in vitro. 
  • Role of nitric oxide in the development of distant metastasis from squamous cell carcinoma. 
  • S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets. 
  • Safety profile of L-arginine infusion in moderately severe falciparum malaria. 
  • Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. 
  • Silencing of the constitutive activity of the dopamine D1B receptor. Reciprocal mutations between D1 receptor subtypes delineate residues underlying activation properties. 
  • Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban. 
  • Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. 
  • Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. 
  • Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells. 
  • Structural and functional studies of hemoglobin Suresnes (arg 141 alpha 2 replaced by His beta 2). Consequences of disrupting an oxygen-linked anion-binding site. 
  • Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta. 
  • Studies on the function of the non-primer tRNAs associated with the 70 S RNA of avian myeloblastosis virus. 
  • Substituting ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. 
  • The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. 
  • The LargPAD Trial: Phase IIA evaluation of l-arginine infusion in patients with peripheral arterial disease. 
  • The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. 
  • The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. 
  • The dose-related effects of nitric oxide synthase inhibition on cerebral blood flow during isoflurane and pentobarbital anesthesia. 
  • The effect of ethyl alcohol on isolated human myometrium. 
  • The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. 
  • The high concentration of Arg213-->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities. 
  • The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment. 
  • The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. 
  • Thrombin-catalyzed activation of recombinant human factor V. 
  • Transgenic manipulation of the metabolism of polyamines in poplar cells. 
  • Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules. 
  • Treatment outcome of creatine transporter deficiency: international retrospective cohort study. 
  • Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • Use of an electrochemical nitric oxide sensor to detect neuronal nitric oxide production in conscious, unrestrained rats. 
  • When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH. 
  • Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase. 
  • beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. 
  • l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology