Aromatase
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Subject Areas on Research
- A highly complex organization of the regulatory region of the human CYP19 (aromatase) gene revealed by the Human Genome Project.
- A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.
- Apoptosis in atretic ovarian follicles is associated with selective decreases in messenger ribonucleic acid transcripts for gonadotropin receptors and cytochrome P450 aromatase.
- Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.
- Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
- Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.
- Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification.
- Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification.
- Effect of type 1 transforming growth factor-beta on the level of aromatase cytochrome P-450 in human fetal hepatocytes.
- Embryonic expression and steroid regulation of brain aromatase cyp19a1b in zebrafish (Danio rerio).
- Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene.
- Estrogen production and metabolism in endometriosis.
- Estrogenic modulation of CYP3A38, CYP3A40, and CYP19 in mature male medaka (Oryzias latipes).
- Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.
- Granulosa cell differentiation in vitro: effect of insulin on growth and functional integrity.
- Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta.
- Interactions between hormones and growth factors in the regulation of granulosa cell differentiation in vitro.
- Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
- Mechanisms of excessive estrogen formation in endometriosis.
- Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.
- Organization of the human aromatase p450 (CYP19) gene.
- Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.
- Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue.
- Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification.
- Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy.
- Role of aromatase in endometrial disease.
- Steroidogenesis in porcine atretic follicles: loss of aromatase activity in isolated granulosa and theca.
- The aromatase enzyme: from cloning to cancer.
- The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters.
- WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells.
- WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells.
- Whole-genome analysis informs breast cancer response to aromatase inhibition.
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Keywords of People
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology