Arteriosclerosis

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  Subject Areas on Research

  • A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. 
  • A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. 
  • A focal stress gradient-dependent mass transfer mechanism for atherogenesis in branching arteries. 
  • A pressure-mediated nonviral method for efficient arterial gene and oligonucleotide transfer. 
  • AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Science Advisory and Coordinating Committee. 
  • Accelerated atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Advanced lipoprotein testing does not improve identification of subclinical atherosclerosis in young adults: the Bogalusa Heart Study. 
  • Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators. 
  • Altered ultrastructural morphology of self-aggregated low density lipoproteins: coalescence of lipid domains forming droplets and vesicles. 
  • Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. 
  • Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. 
  • Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. 
  • Antioxidant therapy for atherosclerotic vascular disease: the promise and the pitfalls. 
  • Antisense technology to block autocrine growth factors. 
  • Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery. 
  • Apo E structure determines VLDL clearance and atherosclerosis risk in mice. 
  • Apolipoprotein E polymorphism and the risk of acute nephropathy after cardiac surgery. 
  • Apolipoprotein E polymorphisms and age at first coronary artery bypass graft. 
  • Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. 
  • Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients. 
  • Arteriosclerotic depression. 
  • Associations between findings on cranial magnetic resonance imaging and retinal photography in the elderly: the Cardiovascular Health Study. 
  • Atheroembolic involvement of renal allografts. 
  • Atherosclerosis and cancer: common molecular pathways of disease development and progression. 
  • Atherosclerosis and hypertension: mechanisms and interrelationships. 
  • Atherosclerosis and restenosis: an inflammatory issue. 
  • Atherosclerosis: a cancer of the blood vessels? 
  • Atherosclerotic Vascular Disease Conference: Writing Group IV: imaging. 
  • Atherosclerotic disease in non-insulin-dependent diabetes mellitus: role of abnormal lipids and the place for lipid-altering therapies. 
  • Atherothrombosis at a distance: contributing role of existing large-burden vascular disease, circulating biosignals and modulating extravascular tissues. 
  • Atherothrombotic disorders: new insights from hematology. 
  • Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression. 
  • C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis. 
  • COX-2-derived prostacyclin modulates vascular remodeling. 
  • Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta. 
  • Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts. 
  • Cerebral embolization during cardiac surgery: impact of aortic atheroma burden. 
  • Chemical shift imaging of atherosclerosis at 7.0 Tesla. 
  • Cholesterol atheroembolic renal disease. Report of 3 cases with emphasis on diagnosis by skin biopsy and extended survival. 
  • Cholesterol controversy--where do we go from here? 'Toward healthful diets' reevaluated. 
  • Cholesterol-fed and casein-fed rabbit models of atherosclerosis. Part 2: Differing morphological severity of atherogenesis despite matched plasma cholesterol levels. 
  • Clinical and angiographic efficacy of a self-expanding nitinol stent in saphenous vein graft atherosclerotic disease: the Stent Comparative Restenosis (SCORES) Saphenous Vein Graft Registry. 
  • Clinical assessment of atherosclerotic lesions: emerging from angiographic shadows. 
  • Clinical review: irradiation for lower extremity arterial occlusive disease. 
  • Combination drug therapy for combined hyperlipidemia. 
  • Comparison of PET oxygen extraction fraction methods for the prediction of stroke risk. 
  • Comparison of intravascular ultrasound, external ultrasound and digital angiography for evaluation of peripheral artery dimensions and morphology. 
  • Comparison of thickness and distensibility in the carotid artery and descending thoracic aorta: in vivo ultrasound assessment. 
  • Complete and incomplete revascularization at aortocoronary bypass surgery: experience with 392 consecutive patients. 
  • Concomitant aortic and renal artery reconstruction in patients on an intensive antihypertensive medical regimen: long-term outcome. 
  • Development of the atherosclerotic core region. Chemical and ultrastructural analysis of microdissected atherosclerotic lesions from human aorta. 
  • Development of the lipid-rich core in human atherosclerosis. 
  • Dietary fish oil. Influence on lesion regression in the porcine model of atherosclerosis. 
  • Differential effects of antihypertensive agents in experimental and human atherosclerosis. 
  • Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. 
  • Does hypertension potentiate atherosclerosis via vascular hypertrophy? 
  • Dyslipoproteinemia and premature atherosclerosis in pediatric systemic lupus erythematosus. 
  • Early carotid artery stenting and angioplasty in patients with acute ischemic stroke. 
  • Effect of fluid shear stress on the permeability of the arterial endothelium. 
  • Effect of uniaxial, cyclic stretch on the morphology of monocytes/macrophages in culture. 
  • Embolic stroke from mural thrombi, a fatal complication of axillary artery catheterization. 
  • Emerging paradigms in arterial thrombosis. 
  • Empirical reconstruction of the renal artery: long-term outcome. 
  • Estimates of U.S. multiple cause life tables. 
  • Extracellular lipid deposition in atherosclerosis. 
  • Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. 
  • Factors influencing the nonuniform localization of monocytes in the arterial wall. 
  • False aneurysm of the aortic root: mimic of malignancy, mediator of myocardial ischemia. 
  • Finite-element analysis of balloon angioplasty. 
  • Fixing the heart: must the brain pay the price? 
  • Florida's response to the Physician's National Cholesterol Education Program. 
  • Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding. 
  • Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. 
  • Focusing on inflammation in the treatment of atherosclerosis. 
  • Future horizons in cardiovascular molecular therapeutics. 
  • Gene expression phenotypes of atherosclerosis. 
  • Genetic engineering of vein grafts resistant to atherosclerosis. 
  • Genomics and the circulation. 
  • Heat shock protein 47 : a chaperone for the fibrous cap? 
  • Hemodynamic parameters and early intimal thickening in branching blood vessels. 
  • Hemodynamic stress and experimental aortoiliac atherosclerosis. 
  • Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries. 
  • Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. 
  • Human aortic fibrolipid lesions. Immunochemical localization of apolipoprotein B and apolipoprotein A. 
  • Human aortic fibrolipid lesions. Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core. 
  • Hyperlipidemia in children and adolescents. 
  • Impact of aortoiliac tortuosity on endovascular repair of abdominal aortic aneurysms: evaluation of 3D computer-based assessment. 
  • Increased subclinical atherosclerosis in young adults with metabolic syndrome: the Bogalusa Heart Study. 
  • Interaction of low density lipoproteins with human aortic elastin. 
  • Intracranial atherosclerosis following radiotherapy. 
  • Intravascular radiation therapy after balloon angioplasty of narrowed femoropopliteal arteries to prevent restenosis: results of the PARIS feasibility clinical trial. 
  • Intravascular ultrasonography versus digital subtraction angiography: a human in vivo comparison of vessel size and morphology. 
  • Irradiation for intimal hyperplasia: implications for peripheral arterial bypass. 
  • Ischemic disease of the kidney: how and why to consider revascularization. 
  • Ischemic nephropathy and concomitant aortic disease: a ten-year experience. 
  • Large conduit arteries in hypertension: role of the vascular renin-angiotensin system. 
  • Lipids and stroke: a paradox resolved. 
  • Lipoprotein (a) in the regulation of fibrinolysis. 
  • Lipoprotein (a) regulates plasmin generation and inhibition. 
  • Lipoprotein(A) and effective renal plasma flow rate in older patients with arteriosclerotic diseases. 
  • Lipoprotein(a) and its role in atherothrombotic disease. 
  • Long-term pancreatic function: potential benefits. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • Low yield in the diagnostic evaluation of transient ischemic attacks. 
  • Magnetic resonance microscopy of the rat carotid artery at 300 megahertz. 
  • Mast cell tryptase: a new biomarker in patients with stable coronary artery disease. 
  • Mechanism of the interaction of hypertension and hypercholesterolemia in atherogenesis: the effects of antihypertensive agents. 
  • Metabolic syndrome: evaluation of pathological and therapeutic outcomes. 
  • Modeling the adaptive permeability response of porcine iliac arteries to acute changes in mural shear 
  • Molecular approaches for the treatment of atherosclerosis. 
  • Molecular therapies for vascular diseases. 
  • Mortality of the chronically impaired. 
  • NSAID use and association with cardiovascular outcomes in outpatients with stable atherothrombotic disease. 
  • New interventional technology for the management of multivessel coronary artery disease. 
  • Nitric oxide synthase: role in the genesis of vascular disease. 
  • Noninvasive carotid artery testing. 
  • Numerical investigation and prediction of atherogenic sites in branching arteries. 
  • Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology. 
  • Pathobiology of atherosclerosis and plaque complications. 
  • Penetrating atherosclerotic ulcer of the aortic arch resulting in extensive and fatal dissection. 
  • Percutaneous and open renal revascularizations have equivalent long-term functional outcomes. 
  • Percutaneous angioplasty and stenting of the superficial femoral artery. 
  • Peripheral artery atherectomy: description of technique and report of initial results. 
  • Peripheral atherectomy: experimental results with a new device. 
  • Phospholipid hydrolytic enzymes in a 'cesspool' of arterial intimal lipoproteins: a mechanism for atherogenic lipid accumulation. 
  • Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness. 
  • Plaque modification with tetracycline: enhanced tissue ablation with the excimer laser. 
  • Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG. 
  • Preoperative vascular imaging for the fibular osteocutaneous flap. 
  • Primary aortoduodenal fistula caused by severe atherosclerosis, not by aneurysm. 
  • Primary renal artery stenting: characteristics and outcomes after 363 procedures. 
  • Progesterone inhibits human infragenicular arterial smooth muscle cell proliferation induced by high glucose and insulin concentrations. 
  • Prospects for cardiovascular research. 
  • Reduction of atherogenic risk factors by short-term weight reduction. Evidence of the efficacy of National Cholesterol Education Program guidelines for the obese. 
  • Regression of atherosclerosis in monkeys reduces vascular superoxide levels. 
  • Relation between near-wall residence times of monocytes and early lesion growth in the rabbit aorto-celiac junction. 
  • Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction. 
  • Relationship between carotid artery stiffness and retinal arteriolar narrowing in healthy middle-aged persons. 
  • Relationship of plasma lipoprotein Lp(a) levels to race and to apolipoprotein B. 
  • Relative importance of systemic determinants of retinal arteriolar and venular caliber: the atherosclerosis risk in communities study. 
  • Reliability of retinal photography in the assessment of retinal microvascular characteristics: the Atherosclerosis Risk in Communities Study. 
  • Restriction fragment length polymorphism of the apoprotein A-I-C-III gene cluster in control and stroke-prone white and black subjects: racial differences. 
  • Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. 
  • Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study. 
  • Retinal vascular imaging: a new tool in microvascular disease research. 
  • Revascularization of the solitary kidney: a challenging problem in a high risk population. 
  • Risk of ischemic heart disease in patients with TIA. 
  • Role of Doppler US in screening for carotid atherosclerotic disease. 
  • Role of fibrinopeptide B in early atherosclerotic lesion formation. 
  • Role of the distal balloon protection technique in the prevention of cerebral embolic events during carotid stent placement. 
  • Role of transforming growth factor beta in human disease. 
  • Scintigraphic detection of platelet deposition in atherosclerotic macaques: a new technique for investigation of antithrombotic drugs. 
  • Smooth muscle growth and cholesterol accumulation in atherogenesis. 
  • Soluble P-selectin levels are associated with cardiovascular mortality and sudden cardiac death in male dialysis patients. 
  • Stress fibers in endothelial cells overlying atherosclerotic lesions in rabbit aorta. 
  • Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. 
  • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. 
  • Temporal trends in U. S. multiple cause of death mortality data: 1968 to 1977. 
  • The arterial wall and the atherosclerotic lesion. 
  • The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes : the atherosclerosis risk in communities study. 
  • The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus. 
  • The distribution of intimal white blood cells in the normal rabbit aorta. 
  • The dynamics of dimensions of age-related disability 1982 to 1994 in the U.S. elderly population. 
  • The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B. 
  • The impact of coronary artery disease on carotid endarterectomy. 
  • The lipid-rich core region of human atherosclerotic fibrous plaques. Prevalence of small lipid droplets and vesicles by electron microscopy. 
  • The nonhuman primate model of the relationship between gonadal steroids and coronary heart disease. 
  • The physiologic consequences of vas ligation. 
  • The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men. 
  • The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. 
  • The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. 
  • The role of apoptosis in the initiation of vascular calcification. 
  • The role of lipoproteins in atherogenesis. 
  • The vasculopathy of aging. 
  • Three-dimensional CT evaluation for endovascular abdominal aortic aneurysm repair. Quantitative assessment of the infrarenal aortic neck. 
  • Thrombus imaging with indium-111 platelets. 
  • Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. 
  • Toll-like receptors in the pathogenesis of human disease. 
  • Transcriptional regulation of matrix gla protein. 
  • Transesophageal echocardiography: useful tool or expensive toy? 
  • Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. 
  • Transitional features in human atherosclerosis. Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks. 
  • Transluminal angioplasty for atherosclerotic disease of the vertebral and basilar arteries. 
  • Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. 
  • Ultrastructural discrimination of lipid droplets and vesicles in atherosclerosis: value of osmium-thiocarbohydrazide-osmium and tannic acid-paraphenylenediamine techniques. 
  • Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core. 
  • Using imaging for cardiovascular risk prediction: an overview. 
  • Vascular biology: the past 50 years. 
  • Vascular disease in the antiphospholipid syndrome: a comparison with the patient population with atherosclerosis. 
  • Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. 
  • Venous leg ulcers: an analysis of underlying venous disease. 
  • What have we learned from the calcium channel blocker controversy? 
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  Keywords of People

  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology