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Subject Areas on Research
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3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
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An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models.
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Antigen-induced arthritis. Decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage.
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Antigen-induced arthritis. Studies on the inhibition of proteoglycan synthesis observed in articular cartilage during short-term joint inflammation.
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B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity.
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Basic methods in histopathology of joint tissues.
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Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.
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Cortical stimulation in conscious rats controls joint inflammation.
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Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model.
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Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.
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Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.
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Evaluation of indium-111 chloride as a radiopharmaceutical for joint imaging in a rabbit model of arthritis.
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Evidence for polymorphonuclear-leucocyte-derived proteinases in arthritic cartilage.
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G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.
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Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).
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High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis.
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Histopathology atlas of animal model systems - overview of guiding principles.
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IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection.
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In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.
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Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation.
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Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints.
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Introduction: Regulatory B Cell Special Issue-making all the pieces fit.
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Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model.
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Modulation of experimental arthritis by vagal sensory and central brain stimulation.
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Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis.
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Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.
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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.
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Platelet-derived growth factor receptor-β (PDGFRβ) lineage tracing highlights perivascular cell to myofibroblast transdifferentiation during post-traumatic osteoarthritis.
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Regulation of murine arthritis by systemic, spinal, and intra-articular adrenoceptors.
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
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Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis.
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Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).
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Substituted 1,3-Dihydro-2H-pyrrolo-[2,3-b]pyridin-2-ones as Potential Antiinflammatory Agents
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Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis.
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Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.
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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig.
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The azaspirane SKF 105685 ameliorates renal allograft rejection in rats.
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Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.
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Uveitis and arthritis: experimental models and clinical correlates.