Arthritis, Experimental

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  Subject Areas on Research

  • 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility. 
  • An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. 
  • Antigen-induced arthritis. Decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage. 
  • Antigen-induced arthritis. Studies on the inhibition of proteoglycan synthesis observed in articular cartilage during short-term joint inflammation. 
  • B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. 
  • Basic methods in histopathology of joint tissues. 
  • Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. 
  • Cortical stimulation in conscious rats controls joint inflammation. 
  • Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model. 
  • Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis. 
  • Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. 
  • Evaluation of indium-111 chloride as a radiopharmaceutical for joint imaging in a rabbit model of arthritis. 
  • Evidence for polymorphonuclear-leucocyte-derived proteinases in arthritic cartilage. 
  • G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. 
  • Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). 
  • High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. 
  • Histopathology atlas of animal model systems - overview of guiding principles. 
  • IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection. 
  • In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis. 
  • Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation. 
  • Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints. 
  • Introduction: Regulatory B Cell Special Issue-making all the pieces fit. 
  • Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. 
  • Modulation of experimental arthritis by vagal sensory and central brain stimulation. 
  • Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis. 
  • Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. 
  • Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice. 
  • Platelet-derived growth factor receptor-β (PDGFRβ) lineage tracing highlights perivascular cell to myofibroblast transdifferentiation during post-traumatic osteoarthritis. 
  • Regulation of murine arthritis by systemic, spinal, and intra-articular adrenoceptors. 
  • Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. 
  • Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis. 
  • Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177). 
  • Substituted 1,3-Dihydro-2H-pyrrolo-[2,3-b]pyridin-2-ones as Potential Antiinflammatory Agents 
  • Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis. 
  • Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. 
  • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig. 
  • The azaspirane SKF 105685 ameliorates renal allograft rejection in rats. 
  • Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. 
  • Uveitis and arthritis: experimental models and clinical correlates.