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Subject Areas on Research
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A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.
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A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma.
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A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.
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A common duplication in the lysyl hydroxylase gene of patients with Ehlers Danlos syndrome type VI results in preferential stimulation of lysyl hydroxylase activity and mRNA by hydralazine.
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A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma.
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A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium.
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A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene.
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A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D.
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A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.
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ALSUntangled #62: vitamin C.
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Age-related thymic atrophy in the guinea pig.
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Anticancer therapeutic potential of Mn porphyrin/ascorbate system.
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Antioxidant intake and cognitive function of elderly men and women: the Cache County Study.
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Antioxidant nutrients protect against cyclosporine A nephrotoxicity.
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Apoptosis and P53 induction in human lung fibroblasts exposed to chromium (VI): effect of ascorbate and tocopherol.
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Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions.
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Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes.
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Ascorbic acid accumulates in cartilage in vivo.
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Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model.
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Ascorbic acid modulates collagen type I gene expression by cells from an eye tissue--trabecular meshwork.
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Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells.
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Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds.
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Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.
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Ascorbic acid status in postmenopausal women with hormone replacement therapy.
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Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress.
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Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
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Base-specific arrest of in vitro DNA replication by carcinogenic chromium: relationship to DNA interstrand crosslinking.
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Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study.
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Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.
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Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.
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Blood pressure effects of vitamin C: what's the key question?
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Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.
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Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.
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Clinical trials using ascorbic acid aerosol to aid smoking cessation.
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Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.
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Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions.
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Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth.
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Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications.
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Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical.
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Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.
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Deficient dietary iron intakes among women and children in Russia: evidence from the Russian Longitudinal Monitoring Survey.
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Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint.
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Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.
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Diagnosing Rhodococcus equi infections in a setting where tuberculosis is highly endemic: a double challenge.
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Different roles of radical scavengers--ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients.
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Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.
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Effect of feeding excess of vitamin A and vitamin C on liver, plasma and adrenal lipids of rats.
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Effectiveness of Prevention Strategies for Contrast-Induced Nephropathy: A Systematic Review and Meta-analysis.
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Effects of Manganese Porphyrins on Cellular Sulfur Metabolism.
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Effects of combined supplementation with antioxidants on low-density lipoprotein oxidation.
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Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness.
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Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys.
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Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.
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Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions.
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GLOBAL REACH 2018: intra-arterial vitamin C improves endothelial-dependent vasodilatory function in humans at high altitude.
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Hepatotoxic effects of CCl4 on English sole (Parophrys vetulus): possible indicators of liver dysfunction.
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Homeopathic pathogenetic trials and the constitutional type questionnaire.
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Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic Guinea pigs.
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Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart.
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In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria.
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Induction of apoptotic cell death by particulate lead chromate: differential effects of vitamins C and E on genotoxicity and survival.
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Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E.
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Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells.
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Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake.
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Inhibition of lysyl hydroxylase by catechol analogs.
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Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: a placebo-controlled pilot study.
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Iron deficiency in young Lebanese children: association with elevated blood lead levels.
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Is antioxidant use protective of cognitive function in the community-dwelling elderly?
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Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression.
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Lasers and microdermabrasion enhance and control topical delivery of vitamin C.
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Low leucocyte ascorbic acid levels and corneal ulceration.
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Mapping oxidative DNA damage and mechanisms of repair.
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Mapping oxidative DNA damage at nucleotide level.
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Metal ion-dependent hydrogen peroxide-induced DNA damage is more sequence specific than metal specific.
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Metalloporphyrins are potent inhibitors of lipid peroxidation.
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Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
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Mitochondrial respiration after sepsis and prolonged hypoxia.
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Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.
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Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants.
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Nano-C60 cytotoxicity is due to lipid peroxidation.
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Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model.
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Nitrofurantoin-stimulated proteolysis in human erythrocytes: a novel index of toxic insult by nitroaromatics.
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Nitrosylation of manganese(II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: a simple and sensitive spectrophotometric assay for nitric oxide.
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Nutrition and hearing loss: a neglected cause and global health burden.
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Nutritional support in critically ill patients.
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Ortho Isomeric Mn(III) N-Alkyl- and Alkoxyalkylpyridylporphyrins-Enhancers of Hyaluronan Degradation Induced by Ascorbate and Cupric Ions.
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Oxalate deposition on asbestos bodies.
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Oxaluria--the neglected stepchild of nephrolithiasis?
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Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss.
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Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19.
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Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C.
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Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia.
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Production of Cardiomyocytes by microRNA-Mediated Reprogramming in Optimized Reprogramming Media.
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Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults.
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Race differences in the relation of vitamins A, C, E, and β-carotene to metabolic and inflammatory biomarkers.
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Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.
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Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.
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Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study.
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Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders.
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Retinal oxalosis in two diabetic patients.
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Scurvy mimicking osteomyelitis: case report and review of the literature.
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Scurvy presenting with limp and weakness: a case report.
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Scurvy with manifestations limited to a previously injured extremity.
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Scurvy: more than historical relevance.
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Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2.
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Sociodemographic and Kidney Disease Correlates of Nutrient Intakes Among Urban African Americans With Uncontrolled Hypertension.
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Stimulation of cholesterogenesis by ascorbic acid in adrenal of rats fed vitamin A.
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Structure and Affinity of Cu(I) Bound to Human Serum Albumin.
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Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy.
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Ternary complex formation facilitates a redox mechanism for iron release from a siderophore.
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The cardiovascular patient's perceptions of complementary and alternative medicine.
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The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants.
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The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI.
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The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation.
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UV photoprotection by combination topical antioxidants vitamin C and vitamin E.
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Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid.
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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
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Vitamin C supplementation in pregnancy--does it decrease rates of preterm birth? A systematic review.
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Vitamin E, vitamin C, and exercise.
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Vitamin supplement use and breast cancer in a North Carolina population.
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What if cell culture media do not mimic in vivo redox settings?