Ascorbic Acid

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  Subject Areas on Research

  • A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination. 
  • A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma. 
  • A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon. 
  • A common duplication in the lysyl hydroxylase gene of patients with Ehlers Danlos syndrome type VI results in preferential stimulation of lysyl hydroxylase activity and mRNA by hydralazine. 
  • A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. 
  • A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium. 
  • A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. 
  • Age-related thymic atrophy in the guinea pig. 
  • Anemia due to inadequate iron sources or poor iron utilization. 
  • Anticancer therapeutic potential of Mn porphyrin/ascorbate system. 
  • Antioxidant intake and cognitive function of elderly men and women: the Cache County Study. 
  • Apoptosis and P53 induction in human lung fibroblasts exposed to chromium (VI): effect of ascorbate and tocopherol. 
  • Apple pectin-derived oligosaccharides produce carbon dioxide radical anion in Fenton reaction and prevent growth of Escherichia coli and Staphylococcus aureus. 
  • Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions. 
  • Arsenic trioxide with ascorbic acid and high-dose melphalan: results of a phase II randomized trial. 
  • Ascorbic acid accumulates in cartilage in vivo. 
  • Ascorbic acid effects on lens 86 rubidium transport. 
  • Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. 
  • Ascorbic acid modulates collagen type I gene expression by cells from an eye tissue--trabecular meshwork. 
  • Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. 
  • Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds. 
  • Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. 
  • Ascorbic acid status in postmenopausal women with hormone replacement therapy. 
  • Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. 
  • Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. 
  • Base-specific arrest of in vitro DNA replication by carcinogenic chromium: relationship to DNA interstrand crosslinking. 
  • Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin. 
  • Blood pressure effects of vitamin C: what's the key question? 
  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Clinical trials using ascorbic acid aerosol to aid smoking cessation. 
  • Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions. 
  • Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. 
  • Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. 
  • Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors. 
  • Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate. 
  • Deficient dietary iron intakes among women and children in Russia: evidence from the Russian Longitudinal Monitoring Survey. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. 
  • Diagnosing Rhodococcus equi infections in a setting where tuberculosis is highly endemic: a double challenge. 
  • Different roles of radical scavengers--ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. 
  • Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells. 
  • Editorial: Thalassemia major: a problem of iron overload. 
  • Effect of diet and vitamin C on DNA strand breakage in freshly-isolated human white blood cells. 
  • Effect of feeding excess of vitamin A and vitamin C on liver, plasma and adrenal lipids of rats. 
  • Effects of combined supplementation with antioxidants on low-density lipoprotein oxidation. 
  • Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness. 
  • Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. 
  • Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study. 
  • Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. 
  • Hepatotoxic effects of CCl4 on English sole (Parophrys vetulus): possible indicators of liver dysfunction. 
  • Homeopathic pathogenetic trials and the constitutional type questionnaire. 
  • Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic Guinea pigs. 
  • Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. 
  • In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria. 
  • Induction of apoptotic cell death by particulate lead chromate: differential effects of vitamins C and E on genotoxicity and survival. 
  • Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. 
  • Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake. 
  • Inhibition of lysyl hydroxylase by catechol analogs. 
  • Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: a placebo-controlled pilot study. 
  • Iron deficiency in young Lebanese children: association with elevated blood lead levels. 
  • Is antioxidant use protective of cognitive function in the community-dwelling elderly? 
  • Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. 
  • Metalloporphyrins are potent inhibitors of lipid peroxidation. 
  • Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins. 
  • Mitochondrial respiration after sepsis and prolonged hypoxia. 
  • Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death. 
  • Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants. 
  • Nano-C60 cytotoxicity is due to lipid peroxidation. 
  • Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model. 
  • Nitrosylation of manganese(II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: a simple and sensitive spectrophotometric assay for nitric oxide. 
  • Nutrition and hearing loss: a neglected cause and global health burden. 
  • Nutritional support in critically ill patients. 
  • Oxalate deposition on asbestos bodies. 
  • Oxaluria--the neglected stepchild of nephrolithiasis? 
  • Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. 
  • Phase II trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases. 
  • Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C. 
  • Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia. 
  • Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. 
  • Race differences in the relation of vitamins A, C, E, and β-carotene to metabolic and inflammatory biomarkers. 
  • Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate. 
  • Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. 
  • Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. 
  • Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders. 
  • Retinal oxalosis in two diabetic patients. 
  • Reversal of P-glycoprotein expressed in Escherichia coli leaky mutant by ascorbic acid. 
  • Scurvy with manifestations limited to a previously injured extremity. 
  • Scurvy: more than historical relevance. 
  • Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2. 
  • Stimulation of cholesterogenesis by ascorbic acid in adrenal of rats fed vitamin A. 
  • Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy. 
  • Ternary complex formation facilitates a redox mechanism for iron release from a siderophore. 
  • The cardiovascular patient's perceptions of complementary and alternative medicine. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • Topical L-ascorbic acid: percutaneous absorption studies. 
  • UV photoprotection by combination topical antioxidants vitamin C and vitamin E. 
  • Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. 
  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. 
  • Vitamin E, vitamin C, and exercise. 
  • Vitamin supplement use and breast cancer in a North Carolina population. 
  • What if cell culture media do not mimic in vivo redox settings? 
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  Keywords of People

  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology