Aspartic Acid

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  Subject Areas on Research

  • 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. 
  • A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia. 
  • A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A kinetic investigation of the interaction of alpha-methylaspartic acid with aspartate aminotransferase. 
  • A kinetic investigation of the interaction of erythro-beta-hydroxyaspartic acid with aspartate aminotransferase. 
  • A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. 
  • A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. 
  • A new syndrome: ascites, hyperbilirubinemia, and hypoalbuminemia after biochemical modulation of fluorouracil with N-phosphonacetyl-L-aspartate (PALA). 
  • A phase II pilot study of high-dose 24-hour continuous infusion of 5-FU and leucovorin and low-dose PALA for patients with colorectal cancer: a Southwest Oncology Group study. 
  • A phase II study of high-dose 24 hour continuous infusion 5-FU and leucovorin and low-dose PALA for patients with advanced pancreatic adenocarcinoma: a Southwest Oncology Group Study. 
  • A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain. 
  • A repeat proton magnetic resonance spectroscopy study in social phobia. 
  • A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein. 
  • A temperature jump study of aspartate aminotransferase. a reinvestigation. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. 
  • Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles. 
  • Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel. 
  • Altered development of the dorsolateral prefrontal cortex in chromosome 22q11.2 deletion syndrome: an in vivo proton spectroscopy study. 
  • An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. 
  • Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents. 
  • Aspartate release and signalling in the hippocampus. 
  • Aspartate release from rat hippocampal synaptosomes. 
  • Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage. 
  • Automated spectral analysis I: formation of a priori information by spectral simulation. 
  • Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals. 
  • Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. 
  • Automated whole-brain N-acetylaspartate proton MRS quantification. 
  • Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area. 
  • Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators. 
  • Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression. 
  • Biochemical correlates of transmission mediated by glutamate and aspartate. 
  • Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats. 
  • Biochemical modulation of bolus fluorouracil by PALA in patients with advanced colorectal cancer. 
  • Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. 
  • Brain metabolite profiles of T1-hypointense lesions in relapsing-remitting multiple sclerosis. 
  • Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder. 
  • Capillary electrophoresis with electrochemiluminescence detection for measurement of aspartate aminotransferase and alanine aminotransferase activities in biofluids. 
  • Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro. 
  • Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: a critical role for Asp-280 in substrate binding and subunit interactions. 
  • Characterization of putative amino acid transmitter release from slices of rat dentate gyrus. 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Collision-induced dissociative chemical cross-linking reagents and methodology: Applications to protein structural characterization using tandem mass spectrometry analysis. 
  • Colocalization of excitatory and inhibitory neurotransmitter markers in striatal projection neurons in the rat. 
  • Depression of glutamate-mediated synaptic transmission by benzyl alcohol. 
  • Determination of the number of regulatory and catalytic sites on aspartate transcarbamylase. 
  • Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. 
  • Dual response of lobster muscle fibers to L-glutamate. 
  • Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. 
  • Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia. 
  • Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia. 
  • Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro. 
  • Effects of sodium fluoroacetate on the metabolism of N-acetylaspartate and aspartate in mouse brain. 
  • Effects of therapy on the 1H NMR spectrum of a human glioma line. 
  • Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. 
  • Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1. 
  • Evaluation of variable line-shape models and prior information in automated 1H spectroscopic imaging analysis. 
  • Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures. 
  • FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation. 
  • Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study. 
  • Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man†. 
  • Global brain metabolic quantification with whole-head proton MRS at 3 T. 
  • Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging. 
  • Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes. 
  • Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes. 
  • Gray and white matter brain chemistry in young children with autism. 
  • Heat induces gene amplification in cancer cells. 
  • Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82. 
  • High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6. 
  • Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. 
  • Human brain-structure resolved T(2) relaxation times of proton metabolites at 3 Tesla. 
  • Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. 
  • Inhibition of muscarinic-coupled phosphoinositide hydrolysis by N-methyl-D-aspartate is dependent on depolarization via channel activation. 
  • Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. 
  • Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. 
  • Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate. 
  • Magnetic resonance spectroscopy in social phobia: preliminary findings. 
  • Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. 
  • Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy. 
  • Metabolism of the aspartyl moiety of N-acetyl-L-aspartic acid in the rat brain. 
  • Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates. 
  • Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. 
  • Method of lesioning brainstem determines seizure probability. 
  • Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists. 
  • Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism. 
  • Multisection proton MR spectroscopy for mesial temporal lobe epilepsy. 
  • N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues. 
  • N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis. 
  • NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. 
  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 
  • Nitric oxide amplifies the excitatory to inhibitory neurotransmitter imbalance accelerating oxygen seizures. 
  • Non-N-methyl-D-aspartate Autoimmune Encephalopathy and Catatonia Treated With Electroconvulsive Therapy: A Pediatric Case Series and Treatment Guidelines. 
  • Noninvasive differentiation of tumors with use of localized H-1 spectroscopy in vivo: initial experience in patients with cerebral tumors. 
  • Numerical simulation of PRESS localized MR spectroscopy. 
  • Observation of coupled 1H metabolite resonances at long TE. 
  • Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. 
  • Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate. 
  • Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release. 
  • Prediction of cognitive decline in early Alzheimer's disease. 
  • Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate. 
  • Protein modification by deamidation indicates variations in joint extracellular matrix turnover. 
  • Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination. 
  • Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions. 
  • Proton spectroscopy of human brain: effects of age and sex. 
  • Protonation state of Glu142 differs in the green- and blue-absorbing variants of proteorhodopsin. 
  • Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T. 
  • Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. 
  • Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease. 
  • Quantitative proton MR spectroscopic imaging of the human brain. 
  • Quantitative proton spectroscopy and histology of a canine brain tumor model. 
  • Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations. 
  • Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. 
  • Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism. 
  • Regional brain chemical alterations in young children with autism spectrum disorder. 
  • Regional metabolite T2 in the healthy rhesus macaque brain at 7T. 
  • Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen. 
  • Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells. 
  • Relaxation spectra of aspartate transcarbamylase. I. Interaction of 5-bromocytidine triphosphate with native enzyme and regulatory subunit. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with aspartate analogs. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate. 
  • Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands. 
  • Reproducibility of 3D proton spectroscopy in the human brain. 
  • Role of Increased n-acetylaspartate Levels in Cancer. 
  • Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. 
  • Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Role of the substantia nigra in the kindling model of limbic epilepsy. 
  • Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. 
  • Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis. 
  • Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. 
  • Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial. 
  • Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle. 
  • Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities. 
  • Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position. 
  • Stimulation of substantia nigra pars reticulata enhances dentate granule cell excitability. 
  • Structure of macromolecular aggregates. I. Aggregation-induced conformational changes in polypeptides. 
  • Studies of the regulatory mechanism of Ca2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate. 
  • Synaptic activation of presynaptic glutamate transporter currents in nerve terminals. 
  • TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling. 
  • Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. 
  • The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. 
  • The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. 
  • The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro. 
  • The interaction of aspartate aminotransferase with alpha-methylaspartic acid. 
  • The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. 
  • The role of substantia nigra in the development of kindling: pharmacologic and lesion studies. 
  • The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding. 
  • Thermodynamic parameters of the alpha-methyl aspartate-aspartate aminotransferase interaction. 
  • Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate. 
  • Use of poly-l-aspartic acid to inhibit aminoglycoside cochlear ototoxicity. 
  • Whole brain neuronal abnormalities in focal epilepsy quantified with proton MR spectroscopy. 
  • Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge. 
  • d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution. 
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  Keywords of People

  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry