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Subject Areas on Research
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15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus.
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A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.
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A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states.
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Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.
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Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole.
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Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry.
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Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.
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Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
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Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development.
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Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.
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Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.
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Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus.
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Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus.
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Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.
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Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
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Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.
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Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.
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Endogenous ocular aspergillosis.
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Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus.
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Extrapulmonary Aspergillus infection in patients with CARD9 deficiency.
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FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
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Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus.
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Functional heterogeneity of alveolar macrophage population based on expression of CXCL2.
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Fungal meningitis.
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Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft.
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Genomic characterization of recurrent mold infections in thoracic transplant recipients.
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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
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Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus.
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Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.
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In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates.
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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
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Infections in patients with cystic fibrosis following lung transplantation.
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Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.
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Low genetic variation and no detectable population structure in aspergillus fumigatus compared to closely related Neosartorya species.
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Malignant otitis externa caused by Aspergillus fumigatus: a case report.
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Misidentification of Neosartorya pseudofischeri as Aspergillus fumigatus in a lung transplant patient.
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Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.
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Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus.
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Plasminogen alleles influence susceptibility to invasive aspergillosis.
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Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.
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Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.
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Sex and virulence of human pathogenic fungi.
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Sexual reproduction and the evolution of microbial pathogens.
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Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from Sphaerostilbella toxica.
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Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
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Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
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Successful management of a simultaneous Aspergillus fumigatus and Absidia corymbifera invasive fungal infection.
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Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive.
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Synthesis and antifungal activities of miltefosine analogs.
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The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence.
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The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets.
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The index case for the fungal meningitis outbreak in the United States.
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The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.
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Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.
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Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.
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Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantation.
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Value of an inhalational model of invasive aspergillosis.
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Wild-type MIC distribution and epidemiological cutoff values for Aspergillus fumigatus and three triazoles as determined by the Clinical and Laboratory Standards Institute broth microdilution methods.