Aspergillus fumigatus

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  Subject Areas on Research

  • 15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus. 
  • A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. 
  • A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states. 
  • Advances against aspergillosis. 
  • Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis. 
  • Aspergillus fumigatus and related species. 
  • Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. 
  • Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole. 
  • Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. 
  • Balancing iron and calcium: Flavin carrier family proteins in Aspergillus fumigatus virulence. 
  • Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. 
  • Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. 
  • Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. 
  • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. 
  • Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. 
  • Calcineurin-dependent galactomannan release in Aspergillus fumigatus. 
  • Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus. 
  • Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus. 
  • Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. 
  • Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization. 
  • Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. 
  • Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. 
  • Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. 
  • Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus. 
  • Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions. 
  • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. 
  • Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis. 
  • Endogenous ocular aspergillosis. 
  • Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. 
  • Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. 
  • FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. 
  • Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. 
  • Fungal meningitis. 
  • Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft. 
  • Genomic characterization of recurrent mold infections in thoracic transplant recipients. 
  • Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. 
  • Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus. 
  • Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. 
  • Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus. 
  • Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus. 
  • In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates. 
  • In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. 
  • In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients. 
  • In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. 
  • Infections in patients with cystic fibrosis following lung transplantation. 
  • Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. 
  • Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. 
  • Low genetic variation and no detectable population structure in aspergillus fumigatus compared to closely related Neosartorya species. 
  • Malignant otitis externa caused by Aspergillus fumigatus: a case report. 
  • Misidentification of Neosartorya pseudofischeri as Aspergillus fumigatus in a lung transplant patient. 
  • Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. 
  • Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. 
  • Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus. 
  • Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus. 
  • Plasminogen alleles influence susceptibility to invasive aspergillosis. 
  • Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis. 
  • Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus. 
  • Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. 
  • Sex and virulence of human pathogenic fungi. 
  • Sexual reproduction and the evolution of microbial pathogens. 
  • Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. 
  • Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. 
  • Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. 
  • Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive. 
  • Synthesis and antifungal activities of miltefosine analogs. 
  • The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. 
  • The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. 
  • The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus. 
  • The class V myosin interactome of the human pathogen Aspergillus fumigatus reveals novel interactions with COPII vesicle transport proteins. 
  • The index case for the fungal meningitis outbreak in the United States. 
  • The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. 
  • Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus. 
  • Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. 
  • Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population. 
  • Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus. 
  • Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantation. 
  • Value of an inhalational model of invasive aspergillosis. 
  • Wild-type MIC distribution and epidemiological cutoff values for Aspergillus fumigatus and three triazoles as determined by the Clinical and Laboratory Standards Institute broth microdilution methods. 
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  Keywords of People

  • Juvvadi, Praveen Rao, Associate Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Steinbach, William J., Samuel L. Katz Distinguished Professor of Pediatrics, Duke Innovation & Entrepreneurship