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Subject Areas on Research
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase.
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A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models.
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A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.
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A genetically tractable model of human glioma formation.
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A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.
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A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia.
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A vasoactive peptide, endothelin-3, is produced by and specifically binds to primary astrocytes.
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Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
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An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells.
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Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
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Association between cell-mediated demyelination and astrocyte stimulation.
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Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene.
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Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
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Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
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Astrocytes "Chordinate" Synapse Maturation and Plasticity.
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Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.
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Astrocytes Control Synapse Formation, Function, and Elimination.
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Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development.
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Astrocytes in chronic pain and itch.
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Astrocytes refine cortical connectivity at dendritic spines.
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Astrocytes: Orchestrating synaptic plasticity?
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Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury.
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Astrocytic activation as evidence for brain damage.
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Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis.
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Astroglial acid-base dynamics in hyperglycemic and normoglycemic global ischemia.
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Atypical retinal astrocytic hamartoma diagnosed by fine-needle biopsy.
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Bioimpedance modeling to monitor astrocytic response to chronically implanted electrodes.
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Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration.
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CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.
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Cell Biology of Astrocyte-Synapse Interactions.
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Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.
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Cellular niches for endogenous neural stem cells in the adult brain.
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Characterization and immunotherapeutic potential of gammadelta T-cells in patients with glioblastoma.
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Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase.
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Characterization of interleukin-1 production by microglia in culture.
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Chemico-genetic discovery of astrocytic control of inhibition in vivo.
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Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2.
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Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons.
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Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.
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Clinicopathologic correlation of surgically removed macular hole opercula.
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Clinicopathologic correlations in the oligodendroglioma.
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Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA.
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Complement activation contributes to perioperative neurocognitive disorders in mice.
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Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.
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Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.
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Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis.
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Creatine kinase brain isoenzyme: relationship of cerebrospinal fluid concentration to the neurologic condition of newborns and cellular localization in the human brain.
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Cytoskeletal actin gates a Cl- channel in neocortical astrocytes.
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Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice.
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Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes.
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Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells.
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Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection.
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Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes.
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ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model.
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Editorial: Turning fluorescence into black and white.
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Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia.
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Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.
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Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth.
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Enhanced production of superoxide anion by microglia from trisomy 16 mice.
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Evans blue nanocarriers visually demarcate margins of invasive gliomas.
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Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain.
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Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage.
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Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack.
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Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.
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Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells.
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Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.
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GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins.
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Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.
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Hyperammonemia in the ICU.
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Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation.
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Hypothalamic astrocytes respond to transforming growth factor-alpha with the secretion of neuroactive substances that stimulate the release of luteinizing hormone-releasing hormone.
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Identification of viral infection by confocal microscopy.
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Immunohistochemistry of the glial fibrillary acidic protein: basic and applied considerations.
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In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury.
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In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain.
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In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
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Increased brain-type creatine phosphokinase in marathon runners.
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Increased expression of p130 in Alzheimer disease.
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Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors.
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Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro.
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Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes.
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Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons.
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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke.
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Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture.
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Insulin-like growth factor-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma.
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Interaction between TRPV1-expressing neurons in the hypothalamus.
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Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord.
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Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.
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Ion regulation in the brain: implications for pathophysiology.
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JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.
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JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.
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Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression.
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Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.
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Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia.
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Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells.
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Met and hepatocyte growth factor/scatter factor expression in human gliomas.
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Microtubule-associated protein 1B (MAP1B) is present in glial cells phosphorylated different than in neurones.
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Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.
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Molecular mechanisms of astrocyte-induced synaptogenesis.
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Molecular signaling mechanisms underlying epileptogenesis.
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Monoclonal antibodies reactive with epitopes restricted to glial fibrillary acidic proteins of several species.
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Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome.
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NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro.
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Nano-C60 cytotoxicity is due to lipid peroxidation.
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Ncm-D-aspartate: a novel caged D-aspartate suitable for activation of glutamate transporters and N-methyl-D-aspartate (NMDA) receptors in brain tissue.
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Neuroinflammation in Alzheimer's disease.
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Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism.
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Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
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Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1.
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Nrf2-mediated protection against 6-hydroxydopamine.
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Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation.
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Optical coherence tomography of retinal astrocytic hamartoma in 15 cases.
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Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis.
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Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta.
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Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.
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Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation.
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Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.
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Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.
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Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.
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Protective role of fructose in the metabolism of astroglial C6 cells exposed to hydrogen peroxide.
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Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice.
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Purification of hexabrachion (tenascin) from cell culture conditioned medium, and separation from a cell adhesion factor.
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Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain.
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Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors.
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Reactive astrocytes express the embryonic intermediate neurofilament nestin.
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Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.
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Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice.
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Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development.
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S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents.
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Selective autoregulation of endothelins in primary astrocyte cultures: endothelin receptor-mediated potentiation of endothelin-1 secretion.
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Selective neocortical and thalamic cell death in the gerbil after transient ischemia.
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Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes.
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Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults.
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Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity.
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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.
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Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires.
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Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1.
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Structural analysis of a human glial variant laminin.
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Synthesis and characterization of 4-methoxy-7-nitroindolinyl-D-aspartate, a caged compound for selective activation of glutamate transporters and N-methyl-D-aspartate receptors in brain tissue.
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TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone.
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TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling.
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TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.
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Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition.
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Targeting astrocyte signaling for chronic pain.
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Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.
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The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration.
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The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition.
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The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures.
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The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.
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The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury.
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The regulation of quinolinic acid in human immunodeficiency virus-infected monocytes.
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The relationship of expression of statin, the nuclear protein of nonproliferating cells, to the differentiation and cell cycle of astroglia in cultures and in situ.
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The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion.
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Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1.
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Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.
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Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.
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Thrombospondins as key regulators of synaptogenesis in the central nervous system.
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Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice.
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Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice.
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
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Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
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Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice.
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Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects.
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Uptake and internalization of exogenous apolipoprotein E3 by cultured human central nervous system neurons.
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Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease.
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Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology.
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miR-21 improves the neurological outcome after traumatic brain injury in rats.
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Keywords of People
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Erickson, Harold Paul,
James B. Duke Distinguished Professor of Cell Biology,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Nackley, Andrea Gail,
Associate Professor in Anesthesiology,
Pharmacology & Cancer Biology
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Savage, Justin,
Student,
Neurobiology
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Shinohara, Mari L.,
Associate Professor of Immunology,
Immunology
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Turner, Dennis Alan,
Professor of Neurosurgery,
Biomedical Engineering
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Warner, David Samuel,
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine,
Neurobiology
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Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology