Autoantigens

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  Subject Areas on Research

  • 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity. 
  • 60-kDa Ro protein autoepitopes identified using recombinant polypeptides. 
  • A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study. 
  • A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. 
  • A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. 
  • A physical interaction network of dengue virus and human proteins. 
  • A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element. 
  • A threshold for central T cell tolerance to an inducible serum protein. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. 
  • Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. 
  • Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. 
  • An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. 
  • Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins. 
  • Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease. 
  • Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. 
  • Anti-La antibodies. 
  • Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. 
  • Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency. 
  • Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. 
  • Antibodies against retroviral proteins and nuclear antigens in a subset of idiopathic CD4+ T lymphocytopenia patients. 
  • Antibodies to endometrial transferrin and alpha 2-Heremans Schmidt (HS) glycoprotein in patients with endometriosis. 
  • Antigenicity of a recombinant Ro (SS-A) fusion protein. 
  • Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. 
  • Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification. 
  • Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus. 
  • Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. 
  • Are Neuropeptide-Reactive T Cells behind Narcolepsy? 
  • Association between the 7 S RNA and the lupus La protein varies among cell types. 
  • Autoantibodies to DEK oncoprotein in human inflammatory disease. 
  • Autoantibody biomarkers identified by proteomics methods distinguish ovarian cancer from non-ovarian cancer with various CA-125 levels. 
  • Autoantibody levels in myositis patients correlate with clinical response during B cell depletion with rituximab. 
  • Autoimmune hepatitis. 
  • Autoimmune retinopathy and antiretinal antibodies: a review. 
  • Autoimmunity to munc-18 in Rasmussen's encephalitis. 
  • Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. 
  • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. 
  • BAFF-ling autoantibodies. 
  • Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: a differential diagnostic challenge in a patient with unexplained visual loss. 
  • Binding of polyreactive antibodies to self versus foreign antigens. 
  • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. 
  • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. 
  • CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation. 
  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. 
  • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. 
  • Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. 
  • Centromere round-up at the heterochromatin corral. 
  • Centromeres of human chromosomes. 
  • Characterization and idiotypic analysis of an anti-RNP monoclonal antibody. 
  • Characterization of a monoclonal antibody, RTE-21, that binds to keratohyalin granule-associated proteins in epithelial cells of human skin and thymus. 
  • Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. 
  • Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA. 
  • Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy. 
  • Chromosome manipulation: a systematic approach toward understanding human chromosome structure and function. 
  • Chronic cicatrizing conjunctivitis in a patient with epidermolysis bullosa acquisita. 
  • Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. 
  • Clinical aspects of MuSK antibody positive seronegative MG. 
  • Clonal Evolution of Autoreactive Germinal Centers. 
  • Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1. 
  • Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity. 
  • Conserved organization of centromeric chromatin in flies and humans. 
  • Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens. 
  • Cytokeratin 12 in human ocular surface epithelia is the antigen reactive with a commercial anti-Galpha q antibody. 
  • Deconstructing B cell tolerance to basement membranes. 
  • Development of autoantibodies before the clinical onset of systemic lupus erythematosus. 
  • Developments in the scientific understanding of lupus. 
  • Dicentric chromosomes: unique models to study centromere function and inactivation. 
  • Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates. 
  • Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. 
  • Direct interactions between autoantigen La and human immunodeficiency virus leader RNA. 
  • Direct interactions between autoantigen La and human immunodeficiency virus leader RNA. 
  • Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • Early detection and prognosis of ovarian cancer using serum YKL-40. 
  • Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid. 
  • Epigenomics of centromere assembly and function. 
  • Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome. 
  • Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. 
  • Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III. 
  • Evaluation of microarray surfaces and arraying parameters for autoantibody profiling. 
  • Expression of IgM and IgG autoantibodies in pediatric and adult systemic lupus erythematosus. 
  • Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. 
  • Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. 
  • Foreword: the centromere and kinetochore in creatures great and small. 
  • Functional epialleles at an endogenous human centromere. 
  • Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. 
  • Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells. 
  • Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. 
  • Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region. 
  • Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells. 
  • Genomic structure and amino acid sequence domains of the human La autoantigen. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. 
  • HIT and run: heparin's unusual immune response. 
  • HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies. 
  • Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. 
  • Hfq structure, function and ligand binding. 
  • Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. 
  • Histone H3K4 methylation keeps centromeres open for business. 
  • How the gut inflames the joints. 
  • Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C. 
  • Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation. 
  • Human centromere repositioning within euchromatin after partial chromosome deletion. 
  • Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA. 
  • Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. 
  • Identification of a common epitope between enterovirus 71 and human MED25 proteins which may explain virus-associated neurological disease. 
  • Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. 
  • Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression. 
  • Idiotypic cross-reaction between MRL autoantibodies and a BALB/c myeloma. 
  • Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity. 
  • IgG antibodies from patients with bullous pemphigoid bind to localized epitopes on synthetic peptides encoded by bullous pemphigoid antigen cDNA. 
  • IgG antinuclear antibodies with cross-reactive rheumatoid factor activity. 
  • Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice. 
  • Immunohistochemical analysis of the pathogenesis of posterior polymorphous dystrophy. 
  • Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. 
  • In vitro RNA selection of an autoimmune epitope on stem-loop II of U1 RNA. 
  • In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains. 
  • Increased leptin levels correlate with thyroid autoantibodies in nonobese males. 
  • Independent expression of autoantibodies in systemic lupus erythematosus. 
  • Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. 
  • Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1. 
  • Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. 
  • Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein. 
  • Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas. 
  • Isolation and analysis of cDNA clones expressing human lupus La antigen. 
  • Isolation of monoclonal antibodies with predetermined conformational epitope specificity. 
  • Juvenile arthritis and autoimmunity to type II collagen. 
  • La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. 
  • La gets its wings. 
  • Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions. 
  • Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'. 
  • Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. 
  • Management of dermatitis herpetiformis. 
  • Mechanisms of antinuclear antibody production in the rheumatic diseases. 
  • Microparticles as a source of extracellular DNA. 
  • Microparticles as autoadjuvants in the pathogenesis of SLE. 
  • Microparticles as autoantigens in systemic lupus erythematosus. 
  • Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. 
  • Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations. 
  • Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. 
  • Molecular analysis of the 60-kDa human Ro ribonucleoprotein. 
  • Molecular biology of nuclear autoantigens. 
  • Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins. 
  • Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics. 
  • Multiplexed protein array platforms for analysis of autoimmune diseases. 
  • Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. 
  • Muscle autoantibodies in myasthenia gravis: beyond diagnosis? 
  • Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. 
  • Nucleotide sequence and host La protein interactions of rabies virus leader RNA. 
  • Organization and molecular evolution of CENP-A--associated satellite DNA families in a basal primate genome. 
  • Outer dense fiber proteins are dominant postobstruction autoantigens in adult Lewis rats. 
  • Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement. 
  • Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome. 
  • Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading. 
  • Pathogenesis of autoimmunity in pemphigus. 
  • Pathogenesis of two axonopathies does not require axonal neurofilaments. 
  • Periconceptional changes in thyroid function: a longitudinal study. 
  • Peripheral blood mononuclear cells from patients with bullous pemphigoid have an increased frequency of response to synthetic peptides encoded by BPAG1. 
  • Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients. 
  • Polyspecific reactivity of a murine monoclonal antibody that binds to nuclear matrix-associated, chromatin-bound autoantigens. 
  • Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta. 
  • Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen. 
  • RNA recognition by autoantigens and autoantibodies. 
  • Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid. 
  • Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays. 
  • Rare coding variants and X-linked loci associated with age at menarche. 
  • Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. 
  • Rasmussen's encephalitis: an autoimmune disorder? 
  • Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. 
  • Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration. 
  • Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides. 
  • Rituximab decreases without preference all subclasses of IgG anti-BP180 autoantibodies in refractory bullous pemphigoid (BP). 
  • SD-OCT and autofluorescence characteristics of autoimmune retinopathy. 
  • Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE. 
  • Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. 
  • Sequences associated with centromere competency in the human genome. 
  • Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity. 
  • Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies. 
  • Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. 
  • Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens. 
  • Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. 
  • Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages. 
  • Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity. 
  • Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies. 
  • Systemic lupus erythematosus. 
  • TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway. 
  • Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B? 
  • Temporal correlation of antibody responses to different epitopes of the human La autoantigen. 
  • The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis. 
  • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. 
  • The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage. 
  • The antigenic properties of bacterial DNA in normal and aberrant immunity. 
  • The author replies. 
  • The disappearance of a cyclin-like protein and the appearance of statin is correlated with the onset of differentiation during myogenesis in vitro. 
  • The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen. 
  • The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients. 
  • The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. 
  • The genetics of autoantibody production in MRL/lpr lupus mice. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The human olfactory transcriptome. 
  • The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. 
  • The nephritogenic immune response. 
  • The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity. 
  • The role of bacterial DNA in autoantibody induction. 
  • The role of innate immunity in the induction of autoimmunity. 
  • Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice. 
  • Transcription and ncRNAs: at the cent(rome)re of kinetochore assembly and maintenance. 
  • Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen. 
  • Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen. 
  • V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice. 
  • Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen. 
  • Visualization of Immune Responses in the Cornea. 
  • ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6. 
  • [A severe course of bullous pemphigoid in a young man]. 
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  Keywords of People

  • Arepally, Gowthami Morey, Professor of Medicine, Pathology
  • Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Sanchez-Perez, Luis Ariel, Assistant Professor of Neurosurgery, Neurosurgery
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Yang, Yiping, Professor of Medicine, Immunology