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Subject Areas on Research
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60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.
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60-kDa Ro protein autoepitopes identified using recombinant polypeptides.
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A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking.
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A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study.
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A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus.
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A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen.
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A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.
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A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.
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A physical interaction network of dengue virus and human proteins.
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A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element.
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A threshold for central T cell tolerance to an inducible serum protein
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ATM binds to beta-adaptin in cytoplasmic vesicles.
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Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A.
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Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins.
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Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis.
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Anti-La antibodies.
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Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity.
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Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency.
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Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens.
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Antibodies against retroviral proteins and nuclear antigens in a subset of idiopathic CD4+ T lymphocytopenia patients.
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Antigenicity of a recombinant Ro (SS-A) fusion protein.
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Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids.
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Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification.
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Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.
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Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection.
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Are Neuropeptide-Reactive T Cells behind Narcolepsy?
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Association between the 7 S RNA and the lupus La protein varies among cell types.
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Autoantibodies to DEK oncoprotein in human inflammatory disease.
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Autoantibody biomarkers identified by proteomics methods distinguish ovarian cancer from non-ovarian cancer with various CA-125 levels.
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Autoantibody levels in myositis patients correlate with clinical response during B cell depletion with rituximab.
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Autoimmune Encephalitis: NMDA Receptor Encephalitis as an Example of Translational Neuroscience.
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Autoimmune retinopathy and antiretinal antibodies: a review.
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Autoimmunity to munc-18 in Rasmussen's encephalitis.
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Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance.
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Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies.
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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies.
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BAFF-ling autoantibodies.
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Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: a differential diagnostic challenge in a patient with unexplained visual loss.
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Binding of polyreactive antibodies to self versus foreign antigens.
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CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes.
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CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells.
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CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation.
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Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.
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Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen.
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Centromere round-up at the heterochromatin corral.
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Centromeres of human chromosomes.
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Characterization and idiotypic analysis of an anti-RNP monoclonal antibody.
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Characterization of a monoclonal antibody, RTE-21, that binds to keratohyalin granule-associated proteins in epithelial cells of human skin and thymus.
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Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.
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Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA.
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Characterization of the human Snrpn minimal promoter and cis elements within it.
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Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy.
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Chronic cicatrizing conjunctivitis in a patient with epidermolysis bullosa acquisita.
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Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis.
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Clinical aspects of MuSK antibody positive seronegative MG.
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Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1.
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Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity.
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Conserved organization of centromeric chromatin in flies and humans.
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Correlation of IgG autoantibodies against acetylcholine receptors and desmogleins in patients with pemphigus treated with steroid sparing agents or rituximab.
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Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens.
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Cytokeratin 12 in human ocular surface epithelia is the antigen reactive with a commercial anti-Galpha q antibody.
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Deconstructing B cell tolerance to basement membranes.
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Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia.
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Development of autoantibodies before the clinical onset of systemic lupus erythematosus.
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Developments in the scientific understanding of lupus.
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Dicentric chromosomes: unique models to study centromere function and inactivation.
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Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates.
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Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.
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Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
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Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
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Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain.
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Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.
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Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid.
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Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii.
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Epigenomics of centromere assembly and function.
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Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.
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Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model.
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Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
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Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.
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Evaluation of microarray surfaces and arraying parameters for autoantibody profiling.
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Evolving story of autoantibodies in systemic lupus erythematosus.
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Expression of IgM and IgG autoantibodies in pediatric and adult systemic lupus erythematosus.
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Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.
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Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.
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Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease.
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Foreword: the centromere and kinetochore in creatures great and small.
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Functional epialleles at an endogenous human centromere.
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Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy.
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Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells.
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Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway genes are independent predictors of cutaneous melanoma-specific survival.
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Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.
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Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells.
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Genomic structure and amino acid sequence domains of the human La autoantigen.
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Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.
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Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.
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Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.
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HIT and run: heparin's unusual immune response.
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HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies.
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Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly.
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Hfq structure, function and ligand binding.
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Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.
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Histone H3K4 methylation keeps centromeres open for business.
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How the gut inflames the joints.
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Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.
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Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation.
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Human centromere repositioning within euchromatin after partial chromosome deletion.
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Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA.
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Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.
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Identification of a common epitope between enterovirus 71 and human MED25 proteins which may explain virus-associated neurological disease.
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Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.
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Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres.
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Idiotypic analysis of a monoclonal anti-Sm antibody.
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Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression.
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Idiotypic cross-reaction between MRL autoantibodies and a BALB/c myeloma.
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Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity.
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IgG antibodies from patients with bullous pemphigoid bind to localized epitopes on synthetic peptides encoded by bullous pemphigoid antigen cDNA.
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IgG antinuclear antibodies with cross-reactive rheumatoid factor activity.
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Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice.
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Immunohistochemical analysis of the pathogenesis of posterior polymorphous dystrophy.
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Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres.
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In vitro RNA selection of an autoimmune epitope on stem-loop II of U1 RNA.
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In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains.
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Increased leptin levels correlate with thyroid autoantibodies in nonobese males.
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Independent expression of autoantibodies in systemic lupus erythematosus.
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Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis.
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Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1.
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Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production.
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Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.
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Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein.
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Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas.
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Isolation and analysis of cDNA clones expressing human lupus La antigen.
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Isolation of monoclonal antibodies with predetermined conformational epitope specificity.
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Juvenile arthritis and autoimmunity to type II collagen.
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La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.
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La gets its wings.
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Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions.
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Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'.
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Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
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Management of dermatitis herpetiformis.
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Mechanisms of antinuclear antibody production in the rheumatic diseases.
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Microparticles as a source of extracellular DNA.
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Microparticles as autoadjuvants in the pathogenesis of SLE.
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Microparticles as autoantigens in systemic lupus erythematosus.
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Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.
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Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations.
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Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading.
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Molecular analysis of the 60-kDa human Ro ribonucleoprotein.
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Molecular biology of nuclear autoantigens.
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Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins.
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Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics.
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Multiplexed protein array platforms for analysis of autoimmune diseases.
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Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.
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Muscle autoantibodies in myasthenia gravis: beyond diagnosis?
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Non-Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice.
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Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens.
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Nucleotide sequence and host La protein interactions of rabies virus leader RNA.
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Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis.
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Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
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Outer dense fiber proteins are dominant postobstruction autoantigens in adult Lewis rats.
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Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading.
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Pathogenesis of autoimmunity in pemphigus.
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Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5.
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Peripheral blood mononuclear cells from patients with bullous pemphigoid have an increased frequency of response to synthetic peptides encoded by BPAG1.
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Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients.
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Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases.
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Polyspecific reactivity of a murine monoclonal antibody that binds to nuclear matrix-associated, chromatin-bound autoantigens.
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Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen.
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RNA recognition by autoantigens and autoantibodies.
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Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid.
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Rare coding variants and X-linked loci associated with age at menarche.
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Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.
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Rasmussen's encephalitis: an autoimmune disorder?
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Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides.
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Rituximab decreases without preference all subclasses of IgG anti-BP180 autoantibodies in refractory bullous pemphigoid (BP).
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Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.
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Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons.
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Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE.
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Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.
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Self-tolerance curtails the B cell repertoire to microbial epitopes.
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Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox.
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Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.
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Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies.
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Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity.
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Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.
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Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.
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Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages.
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Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity.
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Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.
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Systemic lupus erythematosus.
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TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway.
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Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B?
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Temporal correlation of antibody responses to different epitopes of the human La autoantigen.
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The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis.
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The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage.
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The antigenic properties of bacterial DNA in normal and aberrant immunity.
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The author replies.
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The binding of SLE autoantibodies to mitochondria.
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The disappearance of a cyclin-like protein and the appearance of statin is correlated with the onset of differentiation during myogenesis in vitro.
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The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen.
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The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients.
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The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA.
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The genetics of autoantibody production in MRL/lpr lupus mice.
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The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.
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The human olfactory transcriptome.
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The interaction of anti-DNA antibodies with DNA antigen: Evidence for hysteresis for high avidity binding.
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The mechanism of autoantibody production in an autoimmune MRL/lpr mouse.
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The mouse Snrpn minimal promoter and its human orthologue: activity and imprinting.
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The nephritogenic immune response.
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The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity.
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The role of bacterial DNA in autoantibody induction.
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The role of innate immunity in the induction of autoimmunity.
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Tracing Self-Reactive B Cells in Normal Mice.
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Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen.
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V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.
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Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen.
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Visualization of Immune Responses in the Cornea.
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[A severe course of bullous pemphigoid in a young man].
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Keywords of People
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Arepally, Gowthami Morey,
Professor of Medicine,
Pathology
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Kelsoe, Garnett H.,
James B. Duke Distinguished Professor of Immunology,
Immunology
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Mruthyunjaya, Prithvi,
Adjunct Associate Professor in the Department of Ophthalmology,
Ophthalmology, Vitreoretinal Diseases & Surgery
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Tsalik, Ephraim,
Adjunct Associate Professor in the Department of Medicine,
Medicine, Infectious Diseases