Autophagy

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  Subject Areas on Research

  • A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia. 
  • A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A new role for ATM: regulating mitochondrial function and mitophagy. 
  • A role for Rac3 GTPase in the regulation of autophagy. 
  • A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. 
  • A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. 
  • A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. 
  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. 
  • Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. 
  • An Animal Trial on the Optimal Time and Intensity of Exercise after Stroke. 
  • An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. 
  • An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. 
  • Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. 
  • Androgens promote prostate cancer cell growth through induction of autophagy. 
  • Apoptosis and autophagy in the regulation of T lymphocyte function. 
  • Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Autophagic dysregulation in glaucomatous trabecular meshwork cells. 
  • Autophagic protein ULK1 regulates FOXM1 signalling in human hepatoma cells. 
  • Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria. 
  • Autophagy and lymphocyte homeostasis. 
  • Autophagy and mechanotransduction in outflow pathway cells. 
  • Autophagy and mitophagy in ALS. 
  • Autophagy and mitophagy participate in ocular lens organelle degradation. 
  • Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration. 
  • Autophagy as a mechanism of antiviral defense at the maternal-fetal interface. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Autophagy in age-related macular degeneration. 
  • Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model. 
  • Autophagy inhibitor Vacuolin-1 interferes with lipid-based small interference RNA delivery. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Autophagy is essential for mitochondrial clearance in mature T lymphocytes. 
  • Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Autophagy links inflammasomes to atherosclerotic progression. 
  • Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. 
  • Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line. 
  • Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Autophagy: not good OR bad, but good AND bad. 
  • BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. 
  • BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication. 
  • BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection. 
  • BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery. 
  • BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. 
  • Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. 
  • BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. 
  • CFLAR/c-FLIPL: a star in the autophagy, apoptosis and necroptosis alliance. 
  • CLT1 targets bladder cancer through integrin α5β1 and CLIC3. 
  • Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy. 
  • Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. 
  • Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. 
  • Catch me if you can: the link between autophagy and viruses. 
  • Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy. 
  • Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. 
  • Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy. 
  • Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. 
  • Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. 
  • Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. 
  • Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease. 
  • Connecting copper and cancer: from transition metal signalling to metalloplasia. 
  • Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. 
  • Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues. 
  • Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 
  • Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress. 
  • Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas. 
  • De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics. 
  • Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand.. 
  • Decreased autophagy and fuel switching occur in a senescent hepatic cell model system. 
  • Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. 
  • Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons. 
  • Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B. 
  • Dengue virus and autophagy. 
  • Dengue virus-induced autophagy regulates lipid metabolism. 
  • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. 
  • E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I. 
  • ER stress modulates cellular metabolism. 
  • Editorial: TRPV1: how thymocytes sense stress and respond with autophagy. 
  • Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. 
  • Electrophysiological findings in X-linked myopathy with excessive autophagy. 
  • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. 
  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. 
  • Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype. 
  • Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. 
  • Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. 
  • From the editor: Considering less carbohydrate. 
  • Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. 
  • GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. 
  • Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. 
  • Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. 
  • Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons. 
  • Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. 
  • Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing. 
  • Host-Directed Therapies for Tuberculosis. 
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria. 
  • Human placental trophoblasts confer viral resistance to recipient cells. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells. 
  • Identification of transcription factors that regulate ATG8 expression and autophagy in Arabidopsis . 
  • Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. 
  • Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. 
  • In desmoid-type fibromatosis cells sorafenib induces ferroptosis and apoptosis, which are enhanced by autophagy inhibition. 
  • Increases in miR-124-3p in Microglial Exosomes Confer Neuroprotective Effects by Targeting FIP200-Mediated Neuronal Autophagy Following Traumatic Brain Injury. 
  • Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy. 
  • Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. 
  • Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. 
  • Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth. 
  • Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. 
  • Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection. 
  • Introduction: tumor as an organ. 
  • Involvement of autophagy and mitochondrial dynamics in determining the fate and effects of irreparable mitochondrial DNA damage. 
  • Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. 
  • Irgm1 regulates metabolism and function in T cell subsets. 
  • Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation. 
  • Links between autophagy and disorders of glycogen metabolism - Perspectives on pathogenesis and possible treatments. 
  • Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. 
  • Lysine modifications and autophagy. 
  • Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. 
  • Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy. 
  • MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. 
  • MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. 
  • MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. 
  • MTORC1 inhibition drives crinophagic degradation of glucagon. 
  • MTORC1-dependent crinophagy regulates glucagon content in pancreatic α-cells. 
  • MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. 
  • Maintaining T lymphocyte homeostasis: another duty of autophagy. 
  • Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity. 
  • Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. 
  • Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. 
  • Metabolic stress in autophagy and cell death pathways. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. 
  • Metabolism and autophagy in the immune system: immunometabolism comes of age. 
  • Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. 
  • Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine. 
  • Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver. 
  • Mitochondrial DNA damage induced autophagy, cell death, and disease. 
  • Mitochondrial Dysfunction in Critical Illness: Implications for Nutritional Therapy. 
  • Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. 
  • Mitochondrial dynamics and Parkinson's disease: focus on parkin. 
  • Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Mitophagy in the little lymphocytes: an essential role for autophagy in mitochondrial clearance in T lymphocytes. 
  • NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. 
  • Narrowing in on the causative defect of an intriguing X-linked myopathy with excessive autophagy. 
  • Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. 
  • Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy. 
  • Neurospora crassa female development requires the PACC and other signal transduction pathways, transcription factors, chromatin remodeling, cell-to-cell fusion, and autophagy. 
  • Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy. 
  • Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure. 
  • Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. 
  • Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. 
  • PAMPs and DAMPs: signal 0s that spur autophagy and immunity. 
  • PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice. 
  • Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro. 
  • Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells. 
  • Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. 
  • Proteinuria causes dysfunctional autophagy in the proximal tubule. 
  • Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. 
  • Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms. 
  • Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. 
  • Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. 
  • Recycling to discover something new: the role of autophagy in kidney disease. 
  • Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis. 
  • Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy. 
  • Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. 
  • Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice. 
  • Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. 
  • Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. 
  • Role of autophagy genetic variants for the risk of Candida infections. 
  • Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. 
  • Roles of autophagy in lymphocytes: reflections and directions. 
  • Roles of autophagy in orthodontic tooth movement. 
  • Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux. 
  • STING'ing Zika virus in neurons. 
  • Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. 
  • Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • T cell stemness and dysfunction in tumors are triggered by a common mechanism. 
  • TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities. 
  • TGF-β Family Signaling in the Control of Cell Proliferation and Survival. 
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. 
  • Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. 
  • The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells. 
  • The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells. 
  • The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. 
  • The F-box E3 ubiquitin ligase BAF1 mediates the degradation of the brassinosteroid-activated transcription factor BES1 through selective autophagy in Arabidopsis. 
  • The TP53 tumor suppressor and autophagy in malignant lymphoma. 
  • The autophagic lysosomal system in outflow pathway physiology and pathophysiology. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The autophagy gene ATG5 plays an essential role in B lymphocyte development. 
  • The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The contribution of autophagy to lymphocyte survival and homeostasis. 
  • The crosstalk between autophagy and apoptosis: where does this lead? 
  • The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. 
  • The lung is protected from spontaneous inflammation by autophagy in myeloid cells. 
  • The new era of Pompe disease: advances in the detection, understanding of the phenotypic spectrum, pathophysiology, and management. 
  • The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up. 
  • The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy. 
  • The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia. 
  • The value of muscle biopsies in Pompe disease: identifying lipofuscin inclusions in juvenile- and adult-onset patients. 
  • Therapeutic Benefit of Autophagy Modulation in Pompe Disease. 
  • Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle. 
  • Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. 
  • Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. 
  • Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. 
  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. 
  • Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. 
  • Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells. 
  • Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. 
  • Transcriptomic profiles of aging in purified human immune cells. 
  • Transport of lysosomes decreases in the perinuclear region: Insights from changepoint analysis. 
  • Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. 
  • UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation. 
  • UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. 
  • Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model. 
  • Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. 
  • Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. 
  • WIPI1 is a conserved mediator of right ventricular failure. 
  • mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. 
  • β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology