Bacillus subtilis

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  Subject Areas on Research

  • A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA. 
  • Antibacterial activity of fullerene water suspensions (nC60) is not due to ROS-mediated damage. 
  • Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. 
  • Appearance of a ribonucleic acid polymerase-binding protein in asporogenous mutants of Bacillus subtilis. 
  • Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. 
  • Bimodal activation of SMC ATPase by intra- and inter-molecular interactions. 
  • Cell-directed assembly of lipid-silica nanostructures providing extended cell viability. 
  • Chromosomal organization of rRNA operons in Bacillus subtilis. 
  • Circular ribozymes generated in Escherichia coli using group I self-splicing permuted intron-exon sequences. 
  • Classification and genetic characterization of pattern-forming Bacilli. 
  • Co-orientation of replication and transcription preserves genome integrity. 
  • Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation. 
  • Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR. 
  • Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase. 
  • Crystallization and preliminary X-ray crystallographic investigations on several thermostable forms of a Bacillus subtilis lipase. 
  • Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis. 
  • Cytoskeleton. Evolution in bacteria. 
  • Dimer recognition and secretion by the ESX secretion system in Bacillus subtilis. 
  • Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide. 
  • Dynamics of backbone conformational heterogeneity in Bacillus subtilis ribonuclease P protein. 
  • Effect of a fullerene water suspension on bacterial phospholipids and membrane phase behavior. 
  • Electrostatic Energetics of Bacillus subtilis Ribonuclease P Protein Determined by Nuclear Magnetic Resonance-Based Histidine pKa Measurements. 
  • Endocarditis caused by Bacillus subtilis. 
  • FtsZ filament capping by MciZ, a developmental regulator of bacterial division. 
  • FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli. 
  • Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein. 
  • Genetic composition of the Bacillus subtilis SOS system. 
  • Genetic structure and DNA sequences at junctions involved in the rearrangements of Bacillus subtilis strains carrying the trpE26 mutation. 
  • Instability of rRNA operons in Bacillus subtilis. 
  • Isolation of a new RNA polymerase-binding protein from sporulating Bacillus subtilis. 
  • Ligand concentration regulates the pathways of coupled protein folding and binding. 
  • Ligation-state hydrogen exchange: coupled binding and folding equilibria in ribonuclease P protein. 
  • Linked domain architectures allow for specialization of function in the FtsK/SpoIIIE ATPases of ESX secretion systems. 
  • Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. 
  • Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation. 
  • Mapping of rRNA genes with integrable plasmids in Bacillus subtilis. 
  • Molecular insights into DNA binding and anchoring by the Bacillus subtilis sporulation kinetochore-like RacA protein. 
  • Multiplex-PCR-based recombination as a novel high-fidelity method for directed evolution. 
  • NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. 
  • Novel mutations that alter the regulation of sporulation in Bacillus subtilis. Evidence that phosphorylation of regulatory protein SpoOA controls the initiation of sporulation. 
  • Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand. 
  • Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. 
  • Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis. 
  • Probing the folding intermediate of Bacillus subtilis RNase P protein by nuclear magnetic resonance. 
  • Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit. 
  • Purification and characterization of a fibrinolytic enzyme of Bacillus subtilis DC33, isolated from Chinese traditional Douchi. 
  • RNA polymerase from sporulating Bacillus subtilis. Purification and properties of a modified form of the enzyme containing two sporulation polypeptides. 
  • Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. 
  • Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. 
  • Stability studies on a lipase from Bacillus subtilis in guanidinium chloride. 
  • Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis. 
  • Structural basis for the remarkable stability of Bacillus subtilis lipase (Lip A) at low pH. 
  • Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. 
  • Structural basis of selection and thermostability of laboratory evolved Bacillus subtilis lipase. 
  • Structural characterization of the late competence protein ComFB from Bacillus subtilis. 
  • Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. 
  • Structure and DNA-binding traits of the transition state regulator AbrB. 
  • Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex. 
  • Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. 
  • Structure of the endonuclease domain of MutL: unlicensed to cut. 
  • Structure of the manganese-bound manganese transport regulator of Bacillus subtilis. 
  • Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. 
  • Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. 
  • Structures of partition protein ParA with nonspecific DNA and ParB effector reveal molecular insights into principles governing Walker-box DNA segregation. 
  • Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. 
  • Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism. 
  • Sustained release of antibiotics from injectable and thermally responsive polypeptide depots. 
  • Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents. 
  • The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system. 
  • The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state. 
  • The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions. 
  • The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus. 
  • Thermodynamic characterization of the osmolyte- and ligand-folded states of Bacillus subtilis ribonuclease P protein. 
  • Trait-to-gene: a computational method for predicting the function of uncharacterized genes. 
  • Two tRNA gene clusters associated with rRNA operons rrnD and rrnE in Bacillus subtilis. 
  • Use of poly-l-aspartic acid to inhibit aminoglycoside cochlear ototoxicity. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering