Baclofen

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  Subject Areas on Research

  • 3-amino-2-(4-chlorophenyl)-nitropropane is a new GABAB receptor agonist, more active peripherally. 
  • A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics. 
  • A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature. 
  • A pilot study assessing pharmacokinetics and tolerability of oral and intravenous baclofen in healthy adult volunteers. 
  • Anticonvulsant-like actions of baclofen in the rat hippocampal slice. 
  • Attenuation of epileptiform bursting by baclofen: reduced potency in elevated potassium. 
  • Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms. 
  • Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors. 
  • Baclofen disrupts passive avoidance retention in rats. 
  • Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus. 
  • Baclofen has a proepileptic effect in the rat dentate gyrus. 
  • Baclofen in the treatment of post-amputation autonomous stump movements. 
  • Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. 
  • Baclofen interactions with nicotine in rats: effects on memory. 
  • Baclofen selectively inhibits transmission at synapses made by axons of CA3 pyramidal cells in the hippocampal slice. 
  • Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments. 
  • Baclofen suppresses hippocampal epileptiform activity at low concentrations without suppressing synaptic transmission. 
  • Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump function. 
  • Defining the role of baclofen for the treatment of alcohol dependence: a systematic review of the evidence. 
  • Discrimination of post- and presynaptic GABAB receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus. 
  • Drug-induced dystonia in neuronal ceroid-lipofuscinosis. 
  • Effects of baclofen on synaptically-induced cell firing in the rat hippocampal slice. 
  • Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome. 
  • Electroacupuncture improves restraint stress-induced delay of gastric emptying via central glutaminergic pathways in conscious rats. 
  • Facilitation of the induction of long-term potentiation by GABAB receptors. 
  • GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus. 
  • GABAB receptors modulate synaptically-evoked responses in the rat dentate gyrus, in vivo. 
  • GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. 
  • GABAB-activated gK+ in thalamic neurons in the lethargic (lh/lh) mouse model of generalized absence seizures. 
  • GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. 
  • Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons. 
  • Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management. 
  • Increased number of GABAB receptors in the lethargic (lh/lh) mouse model of absence epilepsy. 
  • Intracranial hypotension from intrathecal baclofen pump insertion. A case report and review of the literature. 
  • Involuntary movements of the lower extremity following dorsal root entry zone lesions in a man treated for phantom limb pain 
  • Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs. 
  • Neural network of structures in which GABAB receptors regulate absence seizures in the lethargic (lh/lh) mouse model. 
  • Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus. 
  • Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze. 
  • Prevention of intrathecal baclofen withdrawal syndrome: successful use of a temporary intrathecal catheter. 
  • Psychotic disorder in a patient with central and extrapontine myelinolysis. 
  • Regenerative, all-or-none electrographic seizures in the rat hippocampal slice in Mg-free and physiological medium. 
  • Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen. 
  • Seizure-like events in brain slices: suppression by interictal activity. 
  • The (S)-enantiomer of 2-hydroxysaclofen is the active GABAB receptor antagonist in central and peripheral preparations. 
  • The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion. 
  • The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. 
  • The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT(2C) receptor. 
  • Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review.