Bacterial Infections

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  Subject Areas on Research

  • A Genoproteomic Approach to Detect Peptide Markers of Bacterial Respiratory Pathogens. 
  • A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. 
  • A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV. 
  • A comparison of neonatal Gram-negative rod and Gram-positive cocci meningitis. 
  • A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. 
  • A power-law dependence of bacterial invasion on mammalian host receptors. 
  • A retrospective analysis of the long-term effect of splenectomy on late infections, graft-versus-host disease, relapse, and survival after allogeneic marrow transplantation for chronic myelogenous leukemia. 
  • Acute bacterial sinusitis. 
  • Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease. 
  • Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase. 
  • Adoption of a national antimicrobial guide (SWAB-ID) in the Netherlands. 
  • Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group. 
  • Adverse consequences of neonatal antibiotic exposure. 
  • An approach to monoclonal gammopathies in the elderly. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • Anaerobic antimicrobial therapy after necrotizing enterocolitis in VLBW infants. 
  • Antibacterial resistance leadership group: open for business. 
  • Antibacterial susceptibility testing in the clinical laboratory. 
  • Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis. 
  • Antibiotic prophylaxis for hemodialysis access placement. 
  • Antibiotic resistance—the need for global solutions 
  • Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. 
  • Antibiotics for acute bronchitis. 
  • Antimicrobial resistance trends and outbreak frequency in United States hospitals. 
  • Antimicrobial stewardship and infection prevention-leveraging the synergy: A position paper update. 
  • Antimicrobial stewardship programs: how to start and steer a successful program. 
  • Antimicrobial stewardship: a matter of process or outcome? 
  • Appropriate use of antibiotics in serious obstetric and gynecologic infections. 
  • Association of excessive duration of antibiotic therapy for intra-abdominal infection with subsequent extra-abdominal infection and death: a study of 2,552 consecutive infections. 
  • Bacteremia in sickle hemoglobinopathies. 
  • Bacterial colonization of amniotic fluid from intact fetal membranes. 
  • Bacterial colonization of amniotic fluid in the presence of ruptured membranes. 
  • Bacterial gastroenteritis. 
  • Bacterial indicators of risk of diarrhoeal disease from drinking-water in the Philippines. 
  • Bacterial infection remains a leading cause of death in both Western and developing world. Preface. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Bacterial vaginosis: diagnostic and pathogenetic findings during topical clindamycin therapy. 
  • Bacterial vaginosis: treatment with topical intravaginal clindamycin phosphate. 
  • Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. 
  • Behavioral influences on preterm birth: integrated analysis of the pregnancy, infection, and nutrition study. 
  • Caenorhabditis elegans as a host for the study of host-pathogen interactions. 
  • Catheter access for hemodialysis: an overview. 
  • Causes of death in renal transplant recipients. A review of autopsy findings from 1966 through 1985. 
  • Caveolae as portals of entry for microbes. 
  • Cefazolin in the treatment of bacterial pneumonia. 
  • Changing epidemiology of serious bacterial infections in febrile infants without localizing signs. 
  • Children with deep space neck infections: our experience with 178 children. 
  • Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections. 
  • Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection. 
  • Clinical diagnosis of endophthalmitis. 
  • Clinical impact of bacteria and fungi recovered only from broth cultures. 
  • Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. 
  • Clinical practice guideline: management of sinusitis. 
  • Clinical practice. Acute infectious diarrhea. 
  • Collective antibiotic tolerance: mechanisms, dynamics and intervention. 
  • Combating antimicrobial resistance: policy recommendations to save lives. 
  • Community analysis of chronic wound bacteria using 16S rRNA gene-based pyrosequencing: impact of diabetes and antibiotics on chronic wound microbiota. 
  • Comparison of the safety and efficacy of intravenous ciprofloxacin and intravenous ceftazidime in the treatment of selected infections. 
  • Complex bacterial infections pre- and posttransplant. 
  • Complications associated with indwelling catheters. 
  • Complications of implantable venous access devices in patients with sickle cell disease. 
  • Con: Computerized tomographic aspiration of infected pancreatic necrosis: the opinion against its routine use. 
  • Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). 
  • Controlled clinical comparison of bioMérieux VITAL and BACTEC NR-660 blood culture systems for detection of bacteremia and fungemia in adults. 
  • Copper at the front line of the host-pathogen battle. 
  • Critical care perspective on immunotherapy in lung transplantation. 
  • Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes. 
  • Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age. 
  • De-Escalation of Antibiotics Does Not Increase Mortality in Critically Ill Surgical Patients. 
  • Delayed apoptosis of circulating neutrophils in Kawasaki disease. 
  • Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR). 
  • Detection of culture-resistant bacterial pathogens by amplification and sequencing of ribosomal DNA. 
  • Development, implementation, and impact of acceptability criteria for serologic tests for infectious diseases. 
  • Diagnosis and outcome of early pleural space infection following lung transplantation. 
  • Diagnosis of anaerobic infections--communication between the laboratory and the clinic. 
  • Dialysis access infections. 
  • Does this patient have sinusitis? Diagnosing acute sinusitis by history and physical examination. 
  • Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. 
  • Economic issues and antibiotic resistance in the community. 
  • Effective cohorting and "superisolation" in a single intensive care unit in response to an outbreak of diverse multi-drug-resistant organisms. 
  • Efficacy and tolerability of 16% subcutaneous immunoglobulin compared with 20% subcutaneous immunoglobulin in primary antibody deficiency. 
  • Endophthalmitis following Nd:YAG laser posterior capsulotomy. 
  • Endophthalmitis: current approaches. 
  • Engineering of obligate intracellular bacteria: progress, challenges and paradigms. 
  • Epidemiology and outcome of major postoperative infections following cardiac surgery: risk factors and impact of pathogen type. 
  • Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy. 
  • Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study. 
  • Evaluation of cefazolin, a new cephalosporin antibiotic. 
  • Evidence for the diagnosis and treatment of acute uncomplicated sinusitis in children: a systematic review. 
  • Exogenous Moraxella liquefaciens endophthalmitis. 
  • Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. 
  • Factors affecting the incidence of infectious morbidity after radical hysterectomy. 
  • Factors associated with invasive lung aspergillosis and the significance of positive Aspergillus culture after liver transplantation. 
  • Flebogamma(®) 5 % DIF Intravenous Immunoglobulin for Replacement Therapy in Children with Primary Immunodeficiency Diseases. 
  • Flow cytometry and bacterial pathogenesis. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Fungal infection following renal transplantation. 
  • Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. 
  • General guidelines for clinical bacteriology. Infectious Diseases Society of America and the Food and Drug Administration. 
  • Hilar and mediastinal adenopathy caused by bacterial abscess of the lung. 
  • Hormonal, environmental, and infectious risk factors for developing systemic lupus erythematosus. 
  • Host lifestyle affects human microbiota on daily timescales. 
  • Hyperbaric oxygen exposures for intrahepatic abscesses produced in mice by nonsporeforming anaerobic bacteria. 
  • IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens. 
  • Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. 
  • Immune pathogenesis of heparin-induced thrombocytopenia. 
  • Immunodeficiencies. 
  • Immunotherapy for refractory pulmonary infection after adult cardiac surgery: immune dysregulation syndrome. 
  • Impact of central venous catheter type and methods on catheter-related colonization and bacteraemia. 
  • Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. 
  • In vivo models for studying mast cell-dependent responses to bacterial infection. 
  • In-vitro susceptibility of nosocomial gram-negative bloodstream pathogens to quinolones and other antibiotics--a statistical approach. 
  • Infections caused by multidrug resistant organisms are not associated with overall, all-cause mortality in the surgical intensive care unit: the 20,000 foot view. 
  • Infections diagnosed in the first year after pediatric stem cell transplantation. 
  • Infections during a randomized trial comparing cyclosporine to FK 506 immunosuppression in liver transplantation. 
  • Infectious complications after cardiac surgery: lack of association with fresh frozen plasma or platelet transfusions. 
  • Infectious complications after small bowel transplantation in adults. 
  • Infectious complications after small bowel transplantation in adults: an update. 
  • Infectious complications of lung transplantation. 
  • Infectious complications of modern cataract surgery and intraocular lens implantation. 
  • Inherited deficiencies of complement and complement-related proteins. 
  • Innate Immune Responses to Bladder Infection. 
  • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. 
  • Innate immunity and antimicrobial defense systems in psoriasis. 
  • Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. 
  • Intestinal and hepatic complications of human bone marrow transplantation. Part II. 
  • Introduction. 
  • Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected adults and adolescents in northern Tanzania. 
  • Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern Tanzania. 
  • Iron deficiency anemia: its relationship to infection susceptibility and host defense. 
  • Is computerized tomographic fine needle aspiration helpful in the management of infected pancreatic necrosis? 
  • Key references in infectious diseases pharmacotherapy. 
  • Knowledge, beliefs, and confidence regarding infections and antimicrobial stewardship: a survey of Veterans Affairs providers who care for older adults. 
  • Late hematogenous infection of penile prostheses. 
  • Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. 
  • Low-shear modeled microgravity: a global environmental regulatory signal affecting bacterial gene expression, physiology, and pathogenesis. 
  • Lung transplantation at Duke University Medical Center. 
  • Managing the complications of plasma cell myeloma. 
  • Marine mammal zoonoses: a review of disease manifestations. 
  • Mast cell mediator responses and their suppression by pathogenic and commensal microorganisms. 
  • Mast cell modulation of immune responses to bacteria. 
  • Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. 
  • Mast cells and basophils in innate immunity. 
  • Mast cells in infection and immunity. 
  • Mechanisms of immune stimulation by bacterial DNA. 
  • Microbial entry through caveolae: variations on a theme. 
  • Microglia and memory: modulation by early-life infection. 
  • Models to study ancient host-pathogen interactions: lessons from Crete. 
  • Molecular microbiology: new dimensions for cutaneous biology and wound healing. 
  • Mucosal immunity to infection with implications for vaccine development. 
  • Multicenter collaborative evaluation of a standardized serum bactericidal test as a predictor of therapeutic efficacy in acute and chronic osteomyelitis. 
  • Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes. 
  • Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. 
  • Multivariate analysis for predicting the presence of bacteria in bile in patients with acute cholecystitis. 
  • Neglected tropical diseases. 
  • Neurosurgical Device-Related Infections. 
  • Neutropenia Precautions for Children Receiving Chemotherapy or Stem Cell Transplantation for Cancer. 
  • New antibiotic dosing in infants. 
  • Newborn care training of midwives and neonatal and perinatal mortality rates in a developing country. 
  • Nosocomial infection in the NICU: a medical complication or unavoidable problem? 
  • Ofloxacin: its pharmacology, pharmacokinetics, and potential for clinical application. 
  • Once-daily aminoglycoside dosing. 
  • Opsonic requirements for intravascular clearance after splenectomy. 
  • Osteomyelitis: approaching the 1990s. 
  • Pain regulation by non-neuronal cells and inflammation. 
  • Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED). 
  • Pharmacist-managed antimicrobial stewardship program for patients discharged from the emergency department. 
  • Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. 
  • Plasticity in mast cell responses during bacterial infections. 
  • Pleural space infections: microbiology and antimicrobial therapy. 
  • Polymicrobial acute respiratory infections in a hospital-based pediatric population. 
  • Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia. 
  • Predictors of extraventricular drain-associated bacterial ventriculitis. 
  • Predictors of successful clinical and laboratory outcomes in patients with primary sclerosing cholangitis undergoing endoscopic retrograde cholangiopancreatography. 
  • Preliminary experience with FK 506 in pancreas transplant recipients. 
  • Prevalence of mastitis in imported Friesian cows in Sudan. 
  • Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. 
  • Procalcitonin-based indication of bacterial infection identifies high risk acute heart failure patients. 
  • Profound reduction of invariant natural killer T cells in the peripheral blood of a patient with interleukin-1 receptor-associated kinase 4 deficiency. 
  • Programmed necrosis in the cross talk of cell death and inflammation. 
  • Propionibacterium acnes endophthalmitis seven months after extracapsular cataract extraction and intraocular lens implantation. 
  • Propionibacterium shunt nephritis in two adolescents with medulloblastoma. 
  • Prostatitis. Sorting out the different causes. 
  • Pulmonary coin lesion caused by Neisseria mucosa in a child with chronic granulomatous disease. 
  • Pyogenic arthritis: emphasis on the need for surgical drainage of the infected joint. 
  • Quinolone safety and efficacy more important than potency. 
  • Rapid bacterial antigen detection is not clinically useful. 
  • Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial. 
  • Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections--needs, advances, and future prospects. 
  • Rates of and factors associated with infection in 200 909 Medicare implantable cardioverter-defibrillator implants: results from the National Cardiovascular Data Registry. 
  • Real-time PCR assays compared to culture-based approaches for identification of aerobic bacteria in chronic wounds. 
  • Recent changes in the NHSN definition for UTI: for better AND worse. 
  • Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. 
  • Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases). 
  • Reducing the risk of hemodialysis access. 
  • Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis elegans. 
  • Regulation of T-helper-cell lineage development by osteopontin: the inside story. 
  • Rejection criteria for endotracheal aspirates from adults. 
  • Repairing the broken market for antibiotic innovation. 
  • Resistance diagnosis and the changing economics of antibiotic discovery. 
  • Resistance diagnosis and the changing epidemiology of antibiotic resistance. 
  • Response to letter regarding article, "Rates of and factors associated with infection in 200 909 Medicare implantable cardioverter-defibrillator implants: results from the National Cardiovascular Data Registry". 
  • Rhythmic bacterial susceptibility to antibiotics at a large hospital. 
  • Role of the nervous system in the control of proteostasis during innate immune activation: insights from C. elegans. 
  • Selective antimicrobial modulation of human microbial flora. 
  • Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. 
  • Septic arthritis due to Micrococcus luteus. 
  • Sequential prophylactic oral and empiric once-daily parenteral antibiotics for neutropenia and fever after high-dose chemotherapy and autologous bone marrow support. 
  • Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes. 
  • Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention. 
  • Single and multiple pyogenic liver abscesses. Natural history, diagnosis and treatment, with emphasis on percutaneous drainage. 
  • Soft tissue abscess caused by Torulopsis glabrata and Lactobacillus. 
  • Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents. 
  • Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis. 
  • Spontaneous tonsillar hemorrhage. 
  • Studies of antibody and complement function in host defense against bacterial infection. 
  • Studies of the multifaceted mast cell response to bacteria. 
  • Studies on phagocytosis in patients with acute bacterial infections. 
  • Study of host-microbe interactions in zebrafish. 
  • Subcutaneous fat necrosis after paracentesis: Report of a case in a patient with acute pancreatitis. 
  • Subcutaneous immunoglobulin replacement therapy with Hizentra, the first 20% SCIG preparation: a practical approach. 
  • Successful prophylaxis against Pneumocystis carinii pneumonia in HIV-infected children using smaller than recommended dosages of trimethoprim-sulfamethoxazole. 
  • Surgical site infections following bariatric surgery in community hospitals: a weighty concern? 
  • Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998. 
  • TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. 
  • Target Product Profile for a Diagnostic Assay to Differentiate between Bacterial and Non-Bacterial Infections and Reduce Antimicrobial Overuse in Resource-Limited Settings: An Expert Consensus. 
  • The Role of Stewardship in Addressing Antibacterial Resistance: Stewardship and Infection Control Committee of the Antibacterial Resistance Leadership Group. 
  • The Use of Systemic and Topical Fluoroquinolones. 
  • The association between immunodeficiency and the development of autoimmune disease. 
  • The changing pattern of bacterial sepsis since the introduction of antibiotic therapy. 
  • The etiology of febrile illness in adults presenting to Patan hospital in Kathmandu, Nepal. 
  • The impact of antimicrobial resistance on empiric antibiotic selection and antimicrobial use in clinical practice. 
  • The incidence of fluoroquinolone resistant infections after prostate biopsy--are fluoroquinolones still effective prophylaxis? 
  • The management of fractures with soft-tissue disruptions. 
  • The nature of immune responses to urinary tract infections. 
  • The role of complement in host resistance to bacteria. 
  • The role of lipid rafts in the pathogenesis of bacterial infections. 
  • The role of mast cells in host defense and their subversion by bacterial pathogens. 
  • The role of the surface environment in healthcare-associated infections. 
  • The safety of eating shellfish. 
  • The use of once-daily dosing of gentamicin in obstetrics and gynecology. 
  • Toll-like receptors in the pathogenesis of human disease. 
  • Transparent polyurethane film as an intravenous catheter dressing. A meta-analysis of the infection risks. 
  • Treatment of bacterial prostatitis. Comparison of cephalexin and minocycline. 
  • Treatment of non-Hodgkin's lymphoma with chemoradiotherapy and allogenic marrow transplantation. 
  • Trimethoprium-sulfamethoxazole and minocycline- hydrochloride in the treatment of culture-proved bacterial prostatitis. 
  • Twice daily intramuscular imipenem/cilastatin in the treatment of skin and soft tissue infections. 
  • USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: disease-specific recommendations. USPHS/IDSA Prevention of Opportunistic Infections Working Group. 
  • Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells. 
  • Ureaplasma urealyticum septic arthritis in hypogammaglobulinemia. 
  • Use of a new chemically modified intravenous IgG preparation in severe primary humoral immunodeficiency: clinical efficacy and attempts to individualize dosage. 
  • Use of intravenous gamma-globulin in antibody immunodeficiency: results of a multicenter controlled trial. 
  • Use of silver in the prevention and treatment of infections: silver review. 
  • Use of the microvascular free fibula transfer as a salvage reconstruction for failed anterior spine surgery due to chronic osteomyelitis. 
  • Use of triple-lumen subclavian catheters for administration of total parenteral nutrition. 
  • Validity of cultures of fluid collected through drainage catheters versus those obtained by direct aspiration. 
  • Vascular access infections in patients undergoing dialysis with special emphasis on the role and treatment of Staphylococcus aureus. 
  • Very late onset infections in the neonatal intensive care unit. 
  • Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. 
  • White paper: recommendations on the conduct of superiority and organism-specific clinical trials of antibacterial agents for the treatment of infections caused by drug-resistant bacterial pathogens. 
  • Whole-animal chemical screen identifies colistin as a new immunomodulator that targets conserved pathways. 
  • Zidovudine-induced neutropenia: are we too cautious? 
  • p47 GTPases: regulators of immunity to intracellular pathogens. 
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  Keywords of People

  • Aballay, Alejandro, Adjunct Professor in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • Cohen-Wolkowiez, Michael, Professor of Pediatrics, Pediatrics, Infectious Diseases
  • Cunningham, Coleen Kathryn, Professor of Pediatrics, Pathology
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia
  • Jowell, Paul Simon, Professor of Medicine, Medicine, Gastroenterology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • Reed, Shelby Derene, Professor in Population Health Sciences, Duke Science & Society
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology