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Subject Areas on Research
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A comparison of non-toxin vaccine adjuvants for their ability to enhance the immunogenicity of nasally-administered anthrax recombinant protective antigen.
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Antagonism of toxigenic Clostridium difficile by nontoxigenic C. difficile.
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Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis.
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Bacterial surface association of heat-labile enterotoxin through lipopolysaccharide after secretion via the general secretory pathway.
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Biogenesis, cellular localization, and functional activation of the heat-stable enterotoxin receptor (guanylyl cyclase C).
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Cell biology. Caveolae--not just craters in the cellular landscape.
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Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases.
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Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.
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Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
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Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes.
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Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins.
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Clostridial toxins: sensing a target in a hostile gut environment.
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Clostridium difficile associated with pseudomembranous colitis. Occurrence in a 12-week-old infant without prior antibiotic therapy.
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Clostridium difficile infection in obstetric and gynecologic patients.
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Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing.
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Comparison of two rapid assays for Clostridium difficile Common antigen and a C difficile toxin A/B assay with the cell culture neutralization assay.
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Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.
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Context-dependent activation kinetics elicited by soluble versus outer membrane vesicle-associated heat-labile enterotoxin.
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Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension.
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Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1.
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Cytokines: the future of intranasal vaccine adjuvants.
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Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system.
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Detection of Escherichia coli enterotoxins in stools.
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Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity.
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Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms.
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Diarrhea, demography and cell signaling: lessons from microbial toxins.
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Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases.
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Effect of particulate adjuvant on the anthrax protective antigen dose required for effective nasal vaccination.
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Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists.
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Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.
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Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis.
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Efficacy of telavancin in patients with specific types of complicated skin and skin structure infections.
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Engineering of obligate intracellular bacteria: progress, challenges and paradigms.
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Enterotoxigenic Escherichia coli secretes active heat-labile enterotoxin via outer membrane vesicles.
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Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells.
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Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
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Evaluation of repeat Clostridium difficile enzyme immunoassay testing.
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Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats.
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Fecal leukocytes in stool specimens submitted for Clostridium difficile toxin assay.
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Heat-labile enterotoxin: beyond G(m1) binding.
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Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins.
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Host target modification as a strategy to counter pathogen hijacking of the jasmonate hormone receptor.
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Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome.
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Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.
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Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.
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In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity.
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Increased in vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus.
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Inhibition of Clostridium difficile toxin A-induced colitis in rats by APAZA.
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Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor.
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Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.
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Lipid diversity among botulinum neurotoxin-producing clostridia.
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Lipopolysaccharide 3-deoxy-D-manno-octulosonic acid (Kdo) core determines bacterial association of secreted toxins.
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Mast cell activators: a new class of highly effective vaccine adjuvants.
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Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.
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Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus.
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Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations.
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Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy.
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Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: evaluation from the CANVAS studies.
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Part III. Analysis of data gaps pertaining to enterotoxigenic Escherichia coli infections in low and medium human development index countries, 1984-2005.
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Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators.
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Phenylalanine 30 plays an important role in receptor binding of verotoxin-1.
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Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
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Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus.
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Presence of genes encoding the panton-valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational trial.
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Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial.
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Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.
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Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein.
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Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors.
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Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
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Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.
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Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis.
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Relationship between enterotoxin production and serotype in enterotoxigenic Escherichia coli.
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Residues of heat-labile enterotoxin involved in bacterial cell surface binding.
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Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.
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Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia.
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Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA.
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Role of platelet activating factor in the inflammatory and secretory effects of Clostridium difficile toxin A.
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Serologic differentiation between antitoxin responses to infection with Vibrio cholerae and enterotoxin-producing Escherichia coli.
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Specificity of the type II secretion systems of enterotoxigenic Escherichia coli and Vibrio cholerae for heat-labile enterotoxin and cholera toxin.
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Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
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Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum.
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Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.
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The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.
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The complete nucleotide sequence of the Vibrio harveyi bacteriophage VHML.
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The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen.
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Yield of stool culture with isolate toxin testing versus a two-step algorithm including stool toxin testing for detection of toxigenic Clostridium difficile.
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Keywords of People