Basal Ganglia

• 

  Subject Areas on Research

  • A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease. 
  • A common neural circuit mechanism for internally guided and externally reinforced forms of motor learning. 
  • A neuroanatomic model for depression. 
  • Action, time and the basal ganglia. 
  • Adenosine A2A antagonists in Parkinson's disease: what's next? 
  • Alterations of excitatory amino acid receptors in the brain of manganese-treated mice. 
  • Anhedonia is associated with reduced incentive cue related activation in the basal ganglia. 
  • Anti-brain autoantibodies and altered excitatory neurotransmitters in obsessive-compulsive disorder. 
  • Arteriosclerotic depression. 
  • Association of silent lacunar infarct with brain atrophy and cognitive impairment. 
  • Attention and the frontal cortex as examined by simultaneous temporal processing. 
  • Auditory plasticity in a basal ganglia-forebrain pathway during decrystallization of adult birdsong. 
  • Basal ganglia function, stuttering, sequencing, and repair in adult songbirds. 
  • Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder. 
  • Basal ganglia outputs map instantaneous position coordinates during behavior. 
  • Behavioral and neurochemical consequences of ibotenic acid lesion in the subthalamic nucleus of the common marmoset. 
  • Beliefs, mental health, and evolutionary threat assessment systems in the brain. 
  • Bidirectional modulation of substantia nigra activity by motivational state. 
  • Brain imaging correlates. 
  • Brain magnetic resonance imaging findings in ECT-induced delirium. 
  • Brain regions differentially involved in remembering what and when: a PET study. 
  • Calcification of basal ganglia and cerebellar roof nuclei in mentally defective patient with hidrotic ectodermal dysplasia. Analysis of intracranial concretions by electon microprobe. 
  • Candidate neuroanatomic substrates of psychosis in old-aged depression. 
  • Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis). Report of a case incorporating both purely degenerative and intense inflammatory changes, with special prominence of the latter in the putamen. 
  • Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. 
  • Clinical correlates of cognitive decline in vascular dementia. 
  • Comprehensive in vivo mapping of the human basal ganglia and thalamic connectome in individuals using 7T MRI. 
  • Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction. 
  • Cortico-striatal circuits and interval timing: coincidence detection of oscillatory processes. 
  • Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity. 
  • Deep brain stimulation that abolishes Parkinsonian activity in basal ganglia improves thalamic relay fidelity in a computational circuit. 
  • Different subthreshold mechanisms underlie song selectivity in identified HVc neurons of the zebra finch. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Discrete Evaluative and Premotor Circuits Enable Vocal Learning in Songbirds. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. 
  • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. 
  • Early onset of deafening-induced song deterioration and differential requirements of the pallial-basal ganglia vocal pathway. 
  • Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns. 
  • Error associated with the choice of an aortic cannula in measuring regional cerebral blood flow with microspheres during pulsatile CPB in a neonatal piglet model. 
  • Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences. 
  • Frequency, risk factors, anatomy, and course of unilateral neglect in an acute stroke cohort. 
  • From actions to habits: neuroadaptations leading to dependence. 
  • Functional comparison of RGS9 splice isoforms in a living cell. 
  • Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. 
  • Hierarchically Organized Medial Frontal Cortex-Basal Ganglia Loops Selectively Control Task- and Response-Selection. 
  • Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction. 
  • Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease. 
  • Impulse-control disorders in Parkinson's disease. 
  • In vivo quantitation of basal ganglia and thalamic degenerative changes in two temporal lobectomy patients with affective disorder. 
  • Insights into seeing and grasping: distinguishing the neural correlates of perception and action. 
  • Layer I of striate cortex of Tupaia glis and Galago senegalensis: projections from thalamus and claustrum revealed by retrograde transport of horseradish peroxidase. 
  • Learning is bitter and sweet in ventral striatum. 
  • Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission. 
  • MR diagnosis of Creutzfeldt-Jakob disease: significance of high signal intensity of the basal ganglia. 
  • MRI signal hyperintensities in geriatric depression. 
  • Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction. 
  • Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects. 
  • Magnetic resonance spectroscopy in social phobia: preliminary findings. 
  • Magnetic susceptibility of brain iron is associated with childhood spatial IQ. 
  • Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. 
  • Mid-gestation right basal ganglia lesion: clinical observations in two children. 
  • Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. 
  • Neuroanatomical substrates of depression in the elderly. 
  • Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia. 
  • Neuroinflammation in HCV-infection - peril or protection? 
  • Neuropharmacology of timing and time perception. 
  • Nigrotectal Stimulation Stops Interval Timing in Mice. 
  • Non-ketotic hyperglycemic chorea-hemiballismus mimicking basal ganglia hemorrhage. 
  • Not "just" a coincidence: frontal-striatal interactions in working memory and interval timing. 
  • Optimized temporal pattern of brain stimulation designed by computational evolution. 
  • Pathology of inherited manganese transporter deficiency. 
  • Pathway-Specific Striatal Substrates for Habitual Behavior. 
  • Perceiving patterns in random series: dynamic processing of sequence in prefrontal cortex. 
  • Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. 
  • Physiology and pathophysiology of cortico-basal ganglia-thalamocortical loops: theoretical and practical aspects. 
  • Postasphyxial encephalopathy in term infants. Sonographic demonstration of increased echogenicity of the thalamus and basal ganglia. 
  • Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain. 
  • Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. 
  • Prodynorphin storage and processing in axon terminals and dendrites. 
  • Properties of the pathways from the lateral amygdal nucleus to basolateral nucleus and amygdalostriatal transition area. 
  • Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents. 
  • Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions. 
  • Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. 
  • Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study. 
  • Restoration of locomotive function in Parkinson's disease by spinal cord stimulation: mechanistic approach. 
  • Reward-related ventral striatum reactivity mediates gender-specific effects of a galanin remote enhancer haplotype on problem drinking. 
  • Semiautomatic segmentation of brain subcortical structures from high-field MRI. 
  • Seq-ing the Circuit Logic of the Basal Ganglia. 
  • Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression. 
  • Social context-dependent singing-regulated dopamine. 
  • Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late age onset and early onset elderly depressed subjects. 
  • Subcortical structural changes in ECT-induced delirium. 
  • Sustained release of nerve growth factor from biodegradable polymer microspheres. 
  • Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis. 
  • The Basal Ganglia in Action. 
  • The HVC microcircuit: the synaptic basis for interactions between song motor and vocal plasticity pathways. 
  • The cerebellum influences vocal timing. 
  • The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. 
  • The role of the basal ganglia in habit formation. 
  • Trajectories of early brain volume development in fragile X syndrome and autism. 
  • White Matter Tract Changes Associated with Clinical Improvement in an Open-Label Trial Assessing Autologous Umbilical Cord Blood for Treatment of Young Children with Autism. 
  • [Dopamine autoreceptors subtype D3 predominantly regulate the liberation of dopamine in rat brain basal ganglia]. 
  • l-DOPA changes ventral striatum recruitment during motor sequence learning in Parkinson's disease. 
• 

  Keywords of People

  • Cabeza, Roberto, Professor of Psychology and Neuroscience, Duke Science & Society
  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society
  • Hughes, Ryan, Student, Psychology and Neuroscience
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering