Benzhydryl Compounds

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  Subject Areas on Research

  • A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression. 
  • A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate. 
  • Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. 
  • An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. 
  • Analysis of bisphenol A diglycidyl ether (BADGE) and its hydrolytic metabolites in biological specimens by high-performance liquid chromatography and tandem mass spectrometry. 
  • Applications and societal benefits of plastics. 
  • Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study. 
  • Assessment of brain activity during memory encoding in a narcolepsy patient on and off modafinil using normative fMRI data. 
  • Augmentation of dopaminergic agents for major depressive disorder. 
  • Biological assessment of bisphenol A degradation in water following direct photolysis and UV advanced oxidation. 
  • Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation. 
  • Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. 
  • Bisphenol A affects androgen receptor function via multiple mechanisms. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. 
  • Comparisons of polychromatic and monochromatic UV-based treatments of bisphenol-A in water via toxicity assessments. 
  • Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia. 
  • Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. 
  • Elucidating the links between endocrine disruptors and neurodevelopment. 
  • From the editor: A run of success in treating atherosclerotic vascular disease. 
  • Gene expression in oogenesis and implications for transgenerational effects of environmental toxicants. 
  • Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. 
  • Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics. 
  • Investigation of maternal environmental exposures in association with self-reported preterm birth. 
  • Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study. 
  • Modafinil and cocaine interactions. 
  • Modafinil for atypical depression: effects of open-label and double-blind discontinuation treatment. 
  • Modafinil for the treatment of attention-deficit/hyperactivity disorder: A meta-analysis. 
  • Multicenter, double-blind, placebo-controlled trial of terfenadine suspension in the treatment of fall-allergic rhinitis in children. 
  • On chronic fatigue syndrome. 
  • Oral Debio1143 (AT406), an antagonist of inhibitor of apoptosis proteins, combined with daunorubicin and cytarabine in patients with poor-risk acute myeloid leukemia--results of a phase I dose-escalation study. 
  • Palladium-catalyzed asymmetric diene cyclization/hydrosilylation employing functionalized silanes and disiloxanes. 
  • Pediatric narcolepsy. 
  • Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group. 
  • Recommendations for high-priority research on cancer-related fatigue in children and adults. 
  • Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL. 
  • Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study. 
  • Synthesis of human CCK26-33 and CCK-33 related analogues on 2,4-DMBHA and TMBHA. 
  • The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. 
  • The potential role and rationale for treatment of heart failure with sodium-glucose co-transporter 2 inhibitors. 
  • The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat. 
  • Toxicology of environmental estrogens. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship