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Subject Areas on Research
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2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor.
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5' exon replacement and repair by spliceosome-mediated RNA trans-splicing.
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A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.
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A calorimetric and equilibrium investigation of the hydrolysis of lactose.
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A new helper phospholipid for gene delivery.
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A pressure-mediated nonviral method for efficient arterial gene and oligonucleotide transfer.
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AMH induces mesonephric cell migration in XX gonads.
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Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway.
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Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis.
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Adenovirus-mediated gene transfer into rat cardiac allografts. Comparison of direct injection and perfusion.
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Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver.
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Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts.
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Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors.
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Antigenicity of a recombinant Ro (SS-A) fusion protein.
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Appearance of protease activities coincides with p10 and polyhedrin-driven protein production in the baculovirus expression system: effects on yield.
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Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.
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Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice.
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Atomic Resolution Cryo-EM Structure of β-Galactosidase.
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Bioelectronic measurement and feedback control of molecules in living cells.
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Bleomycin induces the hsp 70 heat shock promoter in cultured cells.
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Carbohydrate on human factor VIII/von Willebrand factor. Impairment of function by removal of specific galactose residues.
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Cardiac gene delivery with cardiopulmonary bypass.
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Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation.
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Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate.
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Catheter-mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method.
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Cell-mediated cytotoxicity of murine cytomegalovirus-infected target cells allows for release of residual infectious virus.
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Cellular senescence in the glaucomatous outflow pathway.
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Charge-reversal amphiphiles for gene delivery.
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Classification and genetic characterization of pattern-forming Bacilli.
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
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Cytosine deamination in mismatched base pairs.
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Delivery of primary autologous skeletal myoblasts into rabbit heart by coronary infusion: a potential approach to myocardial repair.
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Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis.
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Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases.
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Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.
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Does thalidomide affect IL-2 response and production?
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Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells.
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Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer.
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Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli.
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Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.
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Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes.
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Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model.
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Efficient adenoviral gene transfer to early venous bypass grafts: comparison with native vessels.
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Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method.
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Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation.
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Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone.
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Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries.
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Enhancer blocking by the Drosophila gypsy insulator depends upon insulator anatomy and enhancer strength.
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Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus.
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Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay.
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Ex vivo adenovirus-mediated gene transfer to the adult rat heart.
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Experimental and numerical studies of adenovirus delivery to outflow tissues of perfused human anterior segments.
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Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway.
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Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.
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Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting.
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Fusigenic liposome-mediated DNA transfer into cardiac myocytes.
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GRP94-associated enzymatic activities. Resolution by chromatographic fractionation.
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Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits.
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Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus.
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Glomerular beta-galactosidase expression following transduction with microsphere-adenoviral complexes.
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Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing.
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High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae.
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Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
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Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery.
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Identification of a negative regulatory function for steroid receptors.
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Identifying a transcription factor interaction site on RNA polymerase II.
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In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.
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Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle.
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Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE.
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Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
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Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy.
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Isolation of retinal proteins that interact with retinitis pigmentosa GTPase regulator by interaction trap screen in yeast.
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Kinetics of bisulfite-induced cytosine deamination in single-stranded DNA.
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LexA protein of Escherichia coli represses expression of the Tn5 transposase gene.
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Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development.
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Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis.
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Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
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Messenger RNA repair and restoration of protein function by spliceosome-mediated RNA trans-splicing.
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Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.
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Naked DNA delivered intraportally expresses efficiently in hepatocytes.
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Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.
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Odorant receptors govern the formation of a precise topographic map.
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Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers.
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Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice.
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Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis.
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Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation.
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Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence.
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Polyspecific binding of Escherichia coli beta-galactosidase by murine antibodies to DNA.
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Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus.
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Production of recombinant adeno-associated viral vectors and use for in vitro and in vivo administration.
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Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen.
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Role for hedgehog signaling in hepatic stellate cell activation and viability.
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SOS induction as an in vivo assay of enzyme-DNA interactions.
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Screening for nitric oxide-dependent protein-protein interactions.
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Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry.
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Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition.
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Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.
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Spliceosome-mediated RNA trans-splicing as a tool for gene therapy.
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Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy.
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Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.
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Systemic production of human granulocyte colony-stimulating factor in nonhuman primates by transplantation of genetically modified myoblasts.
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Targeted gene transfer to Schlemm's canal by retroperfusion.
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Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
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The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.
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The SV40 core sequence functions as a repressor element in yeast.
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The end of the beginning. Gene transfer into the vessel wall.
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The epsilon subunit of DNA polymerase III Is involved in the nalidixic acid-induced SOS response in Escherichia coli.
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The human plasminogen activator inhibitor type I gene promoter targets to kidney.
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The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.
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The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites.
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Transgenic indicator mice for studying activated retinoic acid receptors during development.
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Transmyocardial laser revascularization limits in vivo adenoviral-mediated gene transfer in porcine myocardium.
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Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types.
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Transplantation of multipotent progenitors from the adult olfactory epithelium.
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Transrectal gene therapy of the prostate in the canine model.
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Tumor-dendritic cell fusion as a basis for cancer immunotherapy.
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Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning.
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beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy.
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bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis.
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Keywords of People
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Liton, Paloma Borrajo,
Associate Professor in Ophthalmology,
Pathology
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Milano, Carmelo Alessio,
Professor of Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Stinnett, Sandra Sue,
Associate Professor of Biostatistics and Bioinformatics,
Biostatistics & Bioinformatics