Binding Sites

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  Subject Areas on Research

  • "Active" conformation of an inactive semi-synthetic ribonuclease-S. 
  • (3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors. 
  • (3H)norepinephrine binding and lipolysis by isolated fat cells. 
  • (3H)norepinephrine binding: unrelated to catechol-O-methyl transferase. 
  • (Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen. 
  • 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant. 
  • 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. 
  • 29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome. 
  • 3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. 
  • 3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells. 
  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. 
  • 5alpha-Dihydrotestosterone binding to androgen binding protein. Effects of testosterone and other compounds in vivo and in vitro on the number of binding sites measured. 
  • Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy. 
  • A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. 
  • A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. 
  • A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer. 
  • A bacteriophage model system for studying topoisomerase inhibitors. 
  • A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. 
  • A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. 
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A catalog of neutral and deleterious polymorphism in yeast. 
  • A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst. 
  • A combinatorial mechanism for determining the specificity of E2F activation and repression. 
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. 
  • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. 
  • A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A conserved domain of the viviparous-1 gene product enhances the DNA binding activity of the bZIP protein EmBP-1 and other transcription factors. 
  • A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation. 
  • A crystal clear view of the beta2-adrenergic receptor. 
  • A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. 
  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. 
  • A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. 
  • A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. 
  • A functional variant at miRNA-122 binding site in IL-1a 3' UTR predicts risk of recurrence in patients with oropharyngeal cancer. 
  • A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and HPV-positive tumours of oropharyngeal cancer. 
  • A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck. 
  • A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer. 
  • A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease. 
  • A genetic variant within MDM4 3'UTR miRNA binding site is associated with HPV16-positive tumors and survival of oropharyngeal cancer. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A human gamma globin gene variant binds SP1. 
  • A kinesin motor in a force-producing conformation. 
  • A kinetic study of protein-protein interactions. 
  • A kinetic study of the binding of an ADP fluorescent analog to mitochondrial ATPase. 
  • A linking function for the cellulose-binding protein SP85 in the spore coat of Dictyostelium discoideum. 
  • A long-range flexible billboard model of gene activation. 
  • A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases. 
  • A model for fast axonal transport. 
  • A molecular analysis of hyalin--a substrate for cell adhesion in the hyaline layer of the sea urchin embryo. 
  • A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin. 
  • A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T). 
  • A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model. 
  • A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation. 
  • A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. 
  • A naturally occurring gamma globin gene mutation enhances SP1 binding activity. 
  • A negative coregulator for the human ER. 
  • A new irreversibly inhibited form of xanthine oxidase from ethylisonitrile. 
  • A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. 
  • A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. 
  • A nucleosome-guided map of transcription factor binding sites in yeast. 
  • A peptide sequence on carcinoembryonic antigen binds to a 80kD protein on Kupffer cells. 
  • A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity. 
  • A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. 
  • A potentially abundant junctional RNA motif stabilized by m6A and Mg2. 
  • A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. 
  • A requirement for ankyrin binding to clathrin during coated pit budding. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus. 
  • A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. 
  • A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability. 
  • A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. 
  • A specific internal RNA polymerase recognition site of VSV RNA is involved in the generation of DI particles. 
  • A structural pathway for activation of the kinesin motor ATPase. 
  • A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. 
  • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. 
  • A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. 
  • A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin. 
  • A toggle duplex in hepatitis delta virus self-cleaving RNA that stabilizes an inactive and a salt-dependent pro-active ribozyme conformation. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents. 
  • A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck. 
  • A20 modulates lipid metabolism and energy production to promote liver regeneration. 
  • ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. 
  • ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. 
  • ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. 
  • ATP-regulated activity of the plasmin-streptokinase complex: a novel mechanism involving phosphorylation of streptokinase. 
  • Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. 
  • Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. 
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. 
  • Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. 
  • Absence of a simple code: how transcription factors read the genome. 
  • Absence of effect of cardiac denervation and induced right ventricular failure on canine myocardial norepinephrine binding sites. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. 
  • Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. 
  • Activation of human B lymphocytes. X. Heterogeneity of concanavalin A-generated suppressor cells of the pokeweed mitogen-induced plaque-forming cell response of human peripheral blood lymphocytes. 
  • Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Activation of phenylalanine hydroxylase by phenylalanine. 
  • Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. 
  • Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • Activation-dependent conformational changes in {beta}-arrestin 2. 
  • Active learning for computational chemogenomics. 
  • Active-site heterogeneity in Limulus hemocyanin as revealed by reaction with peroxides. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Activity of a Py-Im polyamide targeted to the estrogen response element. 
  • Adapting the nudged elastic band method for determining minimum-energy paths of chemical reactions in enzymes. 
  • Adaptive evolution drives the diversification of zinc-finger binding domains. 
  • Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. 
  • Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Adherence of streptococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa to fibronectin-coated and uncoated epithelial cells. 
  • Adhesion mediated by bonds in series. 
  • Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding. 
  • Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs. 
  • Affinity chromatography of adrenergic receptors and binding proteins. 
  • Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains. 
  • Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids. 
  • Allele-specific distribution of RNA polymerase II on female X chromosomes. 
  • Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms. 
  • Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. 
  • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. 
  • Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding. 
  • Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation. 
  • Altered ligand rebinding kinetics due to distal-side effects in hemoglobin chico (Lysbeta66(E10) --> thr). 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • Amino acid residues in thrombin-sensitive region and first epidermal growth factor domain of vitamin K-dependent protein S determining specificity of the activated protein C cofactor function. 
  • Amino acid sequence of the nucleotide binding region of chloroplast coupling factor 1. 
  • Amino acid sequences of pyridoxal 5'-phosphate binding sites and fluorescence resonance energy transfer in chicken liver fatty acid synthase. 
  • Amino acid sequences of substrate-binding sites in chicken liver fatty acid synthase. 
  • Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality. 
  • Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. 
  • An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation. 
  • An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. 
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor. 
  • An amphipathic helix enables septins to sense micrometer-scale membrane curvature. 
  • An antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage T4 replication fork in vivo. 
  • An automated decision-tree approach to predicting protein interaction hot spots. 
  • An electron spin resonance study of cholestane spin label in aqueous mixtures of biliary lipids. 
  • An ensemble model of competitive multi-factor binding of the genome. 
  • An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1. 
  • An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate. 
  • An equilibrium binding study of the interaction of fructose 6-phosphate and fructose 1,6-bisphosphate with rabbit muscle phosphofructokinase. 
  • An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with alpha 2-antiplasmin. 
  • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 
  • An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. 
  • An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor. 
  • An integrated encyclopedia of DNA elements in the human genome. 
  • An integrated map of genetic variation from 1,092 human genomes. 
  • An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • An iron tetrahydroporphyrin prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • An x-ray study of the condensed and separated states of sciatic nerve myelin. 
  • Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. 
  • Analysis of autoantibodies to plasminogen in the serum of patients with rheumatoid arthritis. 
  • Analysis of cleavage complexes using reactive inhibitor derivatives. 
  • Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase. 
  • Analysis of the binding specificities of oligomannoside-binding proteins using methylated monosaccharides. 
  • Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. 
  • Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB. 
  • Analysis of thiolester bond cleavage-dependent conformational changes in binary alpha 2-macroglobulin-proteinase complexes. 
  • Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region. 
  • Androgen receptor-cofactor interactions as targets for new drug discovery. 
  • Anion binding of short, flexible aryl triazole oligomers. 
  • Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. 
  • Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain. 
  • Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Antidepressant effects of nicotine in an animal model of depression. 
  • Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein. 
  • Antigenicity and immunogenicity of a trimeric envelope protein from an Indian clade C HIV-1 isolate. 
  • Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel. 
  • Aquaporin 6 binds calmodulin in a calcium-dependent manner. 
  • Argininamide binding arrests global motions in HIV-1 TAR RNA: comparison with Mg2+-induced conformational stabilization. 
  • Artificial receptors for the recognition of phosphorylated molecules. 
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. 
  • Assembly and molecular activities of the MutS tetramer. 
  • Assembly of proteolytically cleaved tubulin. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Assessing transcription factor motif drift from noisy decoy sequences. 
  • Assessment of the number of nucleotide binding sites on chloroplast coupling factor 1 by the continuous variation method. 
  • Association between miRNA-binding site polymorphisms in double-strand break repair genes and risk of recurrence in patients with squamous cell carcinomas of the non-oropharynx. 
  • Association of brain ankyrin with brain membranes and isolation of active proteolytic fragments of membrane-associated ankyrin-binding protein(s). 
  • Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin. 
  • Atomic Resolution Cryo-EM Structure of β-Galactosidase. 
  • Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore. 
  • Augmentation of human monocyte chemotactic response by levamisole. 
  • Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. 
  • Autoradiographic localization of benzomorphan binding sites in rat brain. 
  • Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions. 
  • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. 
  • BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. 
  • Bacterial Transcription Factors Bind to Coding Regions and Regulate Internal Cryptic Promoters. 
  • Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies. 
  • Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors. 
  • Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. 
  • Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels. 
  • Being there: cellular targeting of voltage-gated sodium channels in the heart. 
  • Beta adrenergic receptors in lymphocyte subpopulations. 
  • Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes. 
  • Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. 
  • Beta-adrenergic receptors: evidence for negative cooperativity. 
  • Beta-adrenoceptor modulation of transiently overexpressed alpha 2-adrenoceptors in brain and peripheral tissues: cellular mechanisms underlying the developmental toxicity of terbutaline. 
  • BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics. 
  • Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding. 
  • Binding of catecholamines to receptors in cultured myocardial cells. 
  • Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding. 
  • Binding of placental lactogen and growth hormone to fetal sheep fibroblasts. 
  • Binding of progesterone to cell surfaces of human granulosa-lutein cells. 
  • Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. 
  • Binding of the global response regulator protein CovR to the sag promoter of Streptococcus pyogenes reveals a new mode of CovR-DNA interaction. 
  • Binding of warfarin influences the acid-base equilibrium of H242 in sudlow site I of human serum albumin. 
  • Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance. 
  • Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain. 
  • Binding site graphs: a new graph theoretical framework for prediction of transcription factor binding sites. 
  • Binding site on human immunoglobulin G for the affinity ligand HWRGWV. 
  • Binding sites for L-[3H]glutamate on hippocampal synaptic membranes: three populations differentially affected by chloride and calcium ions. 
  • Binding sites on microtubules of kinesin motors of the same or opposite polarity. 
  • Binding stoichiometry and structural mapping of the epsilon polypeptide of chloroplast coupling factor 1. 
  • Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF). 
  • Biochemistry of protein prenylation. 
  • Biological activity of agarose-immobilized catecholamines. 
  • Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin. Evidence for two use-dependent binding sites. 
  • Bone marrow-derived lymphoid cells (B cells): functional depletion with cobra factor and fresh serum. 
  • Boron-containing aptamers to ATP. 
  • Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel. 
  • Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. 
  • Bridged peptide macrocycles as ligands for PDZ domain proteins. 
  • Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody. 
  • Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. 
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. 
  • Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide. 
  • C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • CO binding by hemocyanins of Limulus polyphemus, Busycon carica, and Callinectes sapidus. 
  • COUGER--co-factors associated with uniquely-bound genomic regions. 
  • COUP-TFII regulates human endometrial stromal genes involved in inflammation. 
  • Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin. 
  • Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. 
  • Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini. 
  • Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. 
  • Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy. 
  • Calcium binding by monosulfate esters of taurochenodeoxycholate. 
  • Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. 
  • Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle. 
  • Calmodulin limits pathogenic Na+ channel persistent current. 
  • Calmodulin supports both inactivation and facilitation of L-type calcium channels. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM. 
  • Carbon chain shape selectivity by the mouse olfactory receptor OR-I7. 
  • Carbon monoxide binding by simple heme proteins under photodissociating conditions. 
  • Carcinoembryonic antigen binding to Kupffer cells is via a peptide located at the junction of the N-terminal and first loop domains. 
  • Carcinogenesis in urogenital sites. 
  • Casein kinase I: another cog in the circadian clockworks. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Catalytic properties of the HhaII restriction endonuclease. 
  • Catalytic strategies of the hepatitis delta virus ribozymes. 
  • Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. 
  • Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase. 
  • Characteristics of norepinephrine and clonidine displacement of [3H]yohimbine binding to platelet alpha2-adrenoreceptors in healthy volunteers. 
  • Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure. 
  • Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain. 
  • Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase. 
  • Characterization of RanBP2-associated molecular components in neuroretina. 
  • Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. 
  • Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand. 
  • Characterization of elongating T7 and SP6 RNA polymerases and their response to a roadblock generated by a site-specific DNA binding protein. 
  • Characterization of fragment E from fibrinogen and cross-linked fibrin. 
  • Characterization of functional human alpha 2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol. 
  • Characterization of glomerular thromboxane receptors in murine lupus nephritis. 
  • Characterization of human alpha 2-macroglobulin monomers obtained by reduction with dithiothreitol. 
  • Characterization of nucleotide binding sites on chloroplast coupling factor 1. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. 
  • Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation. 
  • Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site. 
  • Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. 
  • Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B. DNA sequences of cysI and cysH and a model for the siroheme-Fe4S4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase. 
  • Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. 
  • Characterization of three-subunit chloroplast coupling factor. 
  • Chemical logic of MraY inhibition by antibacterial nucleoside natural products. 
  • Chemical modification of alpha 2-adrenoceptors. Possible role for tyrosine in the ligand binding site. 
  • Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase. 
  • Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn-->Lys) that can modulate cooperativity as well as oxygen affinity. 
  • Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. 
  • Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. 
  • Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations. 
  • Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. 
  • Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. 
  • Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis delta virus RNA sequence. 
  • Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro. 
  • Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer. 
  • Clonazepam-induced up-regulation of serotonin1 and serotonin2 binding sites in rat frontal cortex. 
  • Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. 
  • Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. 
  • Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. 
  • Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis. 
  • Coarse-grained modeling of allosteric regulation in protein receptors. 
  • Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate. 
  • Codon bias and plasticity in immunoglobulins. 
  • Cofractionation of the 17-kD PK 14105 binding site protein with solubilized peripheral-type benzodiazepine binding sites. 
  • Combinatorial mutagenesis of the reactive site region in plasminogen activator inhibitor I. 
  • Commentary. Molecular pharmacology of beta-adrenergic receptors--a status report. 
  • Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. 
  • Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site. 
  • Comparative genomics and regulatory evolution: conservation and function of the Chs and Apetala3 promoters. 
  • Comparison of the functional differences for the homologous residues within the carboxy phosphate and carbamate domains of carbamoyl phosphate synthetase. 
  • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. 
  • Compartmental analysis of amine storage in bovine adrenal medullary granules. 
  • Complement factor H variant increases the risk of age-related macular degeneration. 
  • Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. 
  • Compromised HOXA5 function can limit p53 expression in human breast tumours. 
  • Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors. 
  • Computational design of a biologically active enzyme. 
  • Computational design of receptor and sensor proteins with novel functions. 
  • Computational design of receptors for an organophosphate surrogate of the nerve agent soman. 
  • Concentration-dependent effects of anions on the anaerobic oxidation of hemoglobin and myoglobin. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Conformation change of horseradish peroxidase in lipid membrane. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase. 
  • Conformational changes of purine repressor DNA-binding domain upon complexation with DNA. 
  • Conformational fluctuations in deoxy hemoglobin revealed as a major contributor to anionic modulation of function through studies of the oxygenation and oxidation of hemoglobins A0 and Deer Lodge beta2(NA2)His --> Arg. 
  • Conformational kinetics reveals affinities of protein conformational states. 
  • Conformational plasticity in the selectivity filter of the TRPV2 ion channel. 
  • Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriaceae. 
  • Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays. 
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. 
  • Construction of a catalytically active iron superoxide dismutase by rational protein design. 
  • Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design. 
  • Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center. 
  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. 
  • Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin. 
  • Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding. 
  • Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs. 
  • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. 
  • Controlling the SARS-CoV-2 spike glycoprotein conformation. 
  • Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. 
  • Conversion of a maltose receptor into a zinc biosensor by computational design. 
  • Conversion of protein farnesyltransferase to a geranylgeranyltransferase. 
  • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. 
  • Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. 
  • Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function. 
  • Copper-chelatin: purification and properties of a copper-binding protein from rat liver. 
  • Coronary artery disease and the thrombospondin single nucleotide polymorphisms. 
  • Correlated x-ray diffraction and freeze-fracture studies on membrane model systems. Perturbations induced by freeze-fracture preparative procedures. 
  • Correlating notch signaling with thymocyte maturation. 
  • Correlations of test skin grafts and renal allograft function in human subjects genotyped for HL-A. 
  • Covalent labelling of ligand binding sites of human placental S-adenosylhomocysteine hydrolase with 8-azido derivatives of adenosine and cyclic AMP. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Creatine kinase: essential arginine residues at the nucleotide binding site identified by chemical modification and high-resolution tandem mass spectrometry. 
  • Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions. 
  • Crucial role for the VWF A1 domain in binding to type IV collagen. 
  • Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. 
  • Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. 
  • Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. 
  • Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae. 
  • Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. 
  • Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization. 
  • Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å. 
  • Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. 
  • Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. 
  • Crystal structure of activated CheY. Comparison with other activated receiver domains. 
  • Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5. 
  • Crystal structure of an Escherichia coli Hfq Core (residues 2-69)-DNA complex reveals multifunctional nucleic acid binding sites. 
  • Crystal structure of an RNA aptamer bound to thrombin. 
  • Crystal structure of an activated response regulator bound to its target. 
  • Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands. 
  • Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. 
  • Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. 
  • Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation. 
  • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. 
  • Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase. 
  • Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. 
  • Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. 
  • Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. 
  • Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. 
  • Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. 
  • Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. 
  • Crystal structures of the membrane-binding C2 domain of human coagulation factor V. 
  • Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor. 
  • Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. 
  • Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences. 
  • Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. 
  • Cyclic adenosine 3':5'-monophosphate-dependent protein kinase. 
  • Cyclin-binding motifs are essential for the function of p21CIP1. 
  • Cyclophilin active site mutants have native prolyl isomerase activity with a protein substrate. 
  • Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. 
  • Cytochemistry of sex steroid receptors: a critique. 
  • D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization. 
  • DNA CpG methylation inhibits binding of NF-kappa B proteins to the HIV-1 long terminal repeat cognate DNA motifs. 
  • DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. 
  • DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling. 
  • DNA damage induces phosphorylation of the amino terminus of p53. 
  • DNA mismatches reveal conformational penalties in protein-DNA recognition. 
  • DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA. 
  • DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast. 
  • DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis. 
  • DNase-seq predicts regions of rotational nucleosome stability across diverse human cell types. 
  • DO-RIP-seq to quantify RNA binding sites transcriptome-wide. 
  • DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. 
  • Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 
  • Deciphering the molecular basis of multidrug recognition: crystal structures of the Staphylococcus aureus multidrug binding transcription regulator QacR. 
  • Decrease in myometrial beta-adrenergic receptors with prenatal cocaine use. 
  • Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels. 
  • Decreased hyperthermic effect of MK-801 in selectively bred hypercholinergic rats. 
  • Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer. 
  • Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. 
  • Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics. 
  • Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. 
  • Deletion analysis of recombinant human factor V. Evidence for a phosphatidylserine binding site in the second C-type domain. 
  • Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. 
  • Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. 
  • Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets. 
  • Demonstration of a chemotactic factor receptor on macrophages. 
  • Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study. 
  • Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus. 
  • Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium. 
  • Design considerations for analyzing protein translation regulation by condensates. 
  • Design of a calcium-binding protein with desired structure in a cell adhesion molecule. 
  • Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies. 
  • Design of protease-resistant peptide ligands for the purification of antibodies from human plasma. 
  • Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy. 
  • Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity. 
  • Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. 
  • Determination of separate inhibitor and substrate binding sites in the dehaloperoxidase-hemoglobin from Amphitrite ornata. 
  • Determination of the number of regulatory and catalytic sites on aspartate transcarbamylase. 
  • Development of adrenergic receptor binding sites in brain regions of the neonatal rat: effects of prenatal or postnatal exposure to methylmercury. 
  • Development of peptide antagonists that target estrogen receptor-cofactor interactions. 
  • Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. 
  • Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines. 
  • Different structural changes occur in blue- and green-proteorhodopsins during the primary photoreaction. 
  • Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. 
  • Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. 
  • Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis. 
  • Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle. 
  • Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor. 
  • Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome. 
  • Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Direct identification and characterisation of beta-adrenergic receptors in rat brain. 
  • Direct in vivo measurement of targeted binding in a human tumor xenograft. 
  • Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. 
  • Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail. 
  • Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B. 
  • Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. 
  • Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. 
  • Discovering sequences with potential regulatory characteristics. 
  • Discovery of Thermostable, Fluorescently Responsive Glucose Biosensors by Structure-Assisted Function Extrapolation. 
  • Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor. 
  • Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. 
  • Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome. 
  • Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH). 
  • Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations. 
  • Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. 
  • Dissection of the protein G B1 domain binding site for human IgG Fc fragment. 
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 
  • Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs. 
  • Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. 
  • Distinct DNA targets for trans-activation by HTLV-1 tax and adenovirus E1A. 
  • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. 
  • Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. 
  • Distinct patterns of glycosylation of colligin, a collagen-binding glycoprotein, and SPARC (osteonectin), a secreted Ca2+-binding glycoprotein. Evidence for the localisation of colligin in the endoplasmic reticulum. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Distinguishing direct versus indirect transcription factor-DNA interactions. 
  • Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. 
  • Distribution of anionic sites on surfaces of retinal cells: a study using cationized ferritin. 
  • Distribution of binding sites for thromboxane A2 in the mouse kidney. 
  • Distribution of lead-203 in human peripheral blood in vitro. 
  • Disulfide-mediated dimerization of L1 Ig domains. 
  • Divergence in DNA Specificity among Paralogous Transcription Factors Contributes to Their Differential In Vivo Binding. 
  • Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
  • Diversity of ankyrins in the brain. 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex. 
  • Dose-dependent glucocorticoid effects on noradrenergic synaptogenesis in rat brain: ontogeny of [3H]desmethylimipramine binding sites after fetal exposure to dexamethasone. 
  • Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures. 
  • Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells. 
  • Downhill kinetics of biomolecular interface binding: globally connected scenario. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a. 
  • Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. 
  • Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site. 
  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. 
  • Effect of Mts1 on the structure and activity of nonmuscle myosin II. 
  • Effect of genetic circular permutation near the active site on the activity and stability of an enzyme inhibitor. 
  • Effect of steady illumination on the binding of carbon monoxide by carboxymethylated cytochrome c. 
  • Effect of temperature, pH, and metals on the stability and activity of phenylalanine hydroxylase from Chromobacterium violaceum. 
  • Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome. 
  • Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. 
  • Effects of chemical group specific reagents on sodium entry and the amiloride binding site in frog skin: evidence for separate sites. 
  • Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest. 
  • Effects of glycine receptor antagonism on spreading depression in the rat. 
  • Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line. 
  • Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels. 
  • Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat. 
  • Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. 
  • Electron microscope study of native and crosslinked rabbit muscle phosphofructokinase. 
  • Electron paramagnetic resonance of the tungsten derivative of rat liver sulfite oxidase. 
  • Electron paramagnetic resonance properties and oxidation-reduction potentials of the molybdenum, flavin, and iron-sulfur centers of chicken liver xanthine dehydrogenase. 
  • Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry. 
  • Electrostatic recognition between superoxide and copper, zinc superoxide dismutase. 
  • Elementary steps in the reaction mechanism of chicken liver fatty acid synthase. Acylation of specific binding sites. 
  • Elementary steps in the reaction mechanism of chicken liver fatty acid synthase: reduced nicotinamide adenine dinucleotide phosphate binding and formation and reduction of acetoacetyl-enzyme. 
  • Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel. 
  • Emergence of SARS-CoV-2 through recombination and strong purifying selection. 
  • Endoplasmic reticulum chaperone GRP94 subunit assembly is regulated through a defined oligomerization domain. 
  • Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB. 
  • Energetic contribution of non-essential 5' sequence to catalysis in a hepatitis delta virus ribozyme. 
  • Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia. 
  • Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. 
  • Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein. 
  • Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA. 
  • Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes. 
  • Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. 
  • Epigenome characterization at single base-pair resolution. 
  • Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function. 
  • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. 
  • Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase. 
  • Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. 
  • Erythroid transcription factor NF-E2 coordinates hemoglobin synthesis. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. 
  • Essential role of an active-site guanine in glmS ribozyme catalysis. 
  • Estrogen modulation of nuclear matrix-associated steroid hormone binding. 
  • Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. 
  • Estrogen receptor-cofactor interactions as targets for novel drug discovery. 
  • Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping. 
  • Ethanol consumption by Fawn-Hooded rats following abstinence: effect of naltrexone and changes in mu-opioid receptor density. 
  • Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. 
  • Evaluation of ligand-dependent changes in AR structure using peptide probes. 
  • Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. 
  • Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate. 
  • Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata. 
  • Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. 
  • Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport. 
  • Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. 
  • Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis. 
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. 
  • Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites. 
  • Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates. 
  • Evolutionary rate variation in anthocyanin pathway genes. 
  • Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate. 
  • Explicit DNase sequence bias modeling enables high-resolution transcription factor footprint detection. 
  • Exploring steric constraints on protein mutations using MAGE/PROBE. 
  • Exposing Hidden High-Affinity RNA Conformational States. 
  • Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. 
  • Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146. 
  • Expression of SV40 and polyoma T antigens in E. coli. 
  • Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli. 
  • Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. 
  • Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. 
  • Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. 
  • Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite. 
  • Extrinsic pathway proteolytic activity. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. 
  • FMRP targets distinct mRNA sequence elements to regulate protein expression. 
  • Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. 
  • Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. 
  • Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysis. 
  • Factor IXa as a target for pharmacologic inhibition in acute coronary syndrome. 
  • Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. 
  • Female steroid hormones and target cell nuclei. 
  • Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. 
  • Fibronectin molecule visualized in electron microscopy: a long, thin, flexible strand. 
  • Finding regulatory DNA motifs using alignment-free evolutionary conservation information. 
  • Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. 
  • Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding. 
  • Flavonoids. 8. Synthesis and antifertility and estrogen receptor binding activities of coumarins and delta3-isoflavenes. 
  • Flexible histone tails in a new mesoscopic oligonucleosome model. 
  • Fluorescence energy transfer between ligand binding sites on aspartate transcarbamylase. 
  • Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. 
  • Fluorescence energy transfer between the thiamine diphosphate and flavine adenine dinucleotide binding sites on the pyruvate dehydrogenase multienzyme complex. 
  • Fluorescence energy transfer measurements between ligand binding sites of the pyruvate dehydrogenase multienzyme complex. 
  • Fluorescence studies of benzo-[a]-pyrene in liposome membrane systems. 
  • Fluorescence studies on the binding of reduced nicotinamide adenine dinucleotide phosphate to human hemoglobin A and its variant hemoglobin Providence. 
  • Fluorescent properties of pyrene bound at specific acylation sites of chicken liver fatty acid synthase. 
  • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. 
  • Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase. 
  • Formation of planar bilayer membranes from lipid monolayers. A critique. 
  • Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site. 
  • FoxO-dependent regulation of diacylglycerol kinase α gene expression. 
  • Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. 
  • Fretting about FRET: correlation between kappa and R. 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • Functional association of the parkin gene promoter with idiopathic Parkinson's disease. 
  • Functional characterization of a unique liver gene promoter. 
  • Functional consequences of ligand-linked dissociation in hemoglobin from the sea cucumber Molpadia arenicola. 
  • Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene. 
  • Functional domains of the ubiquitous chromatin protein DEK. 
  • Functional heterogeneity of type 1 fimbriae of Escherichia coli. 
  • Functional organization of polytene chromosomes. 
  • Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue. 
  • Functional roles of the two domains of phosducin and phosducin-like protein. 
  • Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators. 
  • Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. 
  • Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)? 
  • Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae. 
  • Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. 
  • Further characterization of nucleotide binding sites on chloroplast coupling factor one. 
  • Further characterization of the cellular plasminogen binding site: evidence that plasminogen 2 and lipoprotein a compete for the same site. 
  • Further characterization of the platinum-reactive component of the alpha 2-macroglobulin-receptor recognition site. 
  • G Protein-coupled Receptor Biased Agonism. 
  • G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. 
  • G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. 
  • GC sequence specific recognition by an N-formamido, C-terminus-modified and imidazole-containing analogue of netropsin. 
  • GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. 
  • GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Gamma-phosphate-linked ATP-sepharose for the affinity purification of protein kinases. Rapid purification to homogeneity of skeletal muscle mitogen-activated protein kinase kinase. 
  • Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples. 
  • Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C42 sites. 
  • Generation of species cross-reactive aptamers using "toggle" SELEX. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies. 
  • Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. 
  • Genetic composition of the Bacillus subtilis SOS system. 
  • Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break. 
  • Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer. 
  • Genetic variability of the U5 and downstream sequence of major HIV-1 subtypes and circulating recombinant forms. 
  • Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ≤ 55 years. 
  • Genetic variants in microRNA-binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx. 
  • Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy. 
  • Genetically engineered calmodulins differentially activate target enzymes. 
  • Genetics. Enhancing gene regulation. 
  • Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genome-wide identification of regulatory elements in Sertoli cells. 
  • Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. 
  • Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes. 
  • Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. 
  • Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity. 
  • Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape. 
  • Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 
  • Global analysis of the relationship between the binding of the Bas1p transcription factor and meiosis-specific double-strand DNA breaks in Saccharomyces cerevisiae. 
  • Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage. 
  • Group I intron self-splicing with adenosine: evidence for a single nucleoside-binding site. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • Guanosine triphosphate binding sites in solubilized myocardium. Relation to adenylate cyclase activity. 
  • HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. 
  • HDV ribozyme activity in monovalent cations. 
  • HDV ribozymes. 
  • HEPATIC ALDEHYDE OXIDASE. 3. THE SUBSTRATE-BINDING SITE. 
  • HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172. 
  • HIV transmitted/founder vaccines elicit autologous tier 2 neutralizing antibodies for the CD4 binding site. 
  • HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies. 
  • Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. 
  • Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. 
  • Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites. 
  • Heavy metal ion interactions with Callinectes sapidus hemocyanin: structural and functional changes induced by a variety of heavy metal ions. 
  • Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. 
  • Hemoglobin Deer Lodge (beta 2 His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site. 
  • Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. 
  • Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82. 
  • Hemoglobins and hemocyanins: comparative aspects of structure and function. 
  • Hepatic sulfite oxidase. Identification of the molybdenum center as the site of irreversible inactivation by ferricyanide. 
  • Hepatitis C virus NS5B polymerase: QM/MM calculations show the important role of the internal energy in ligand binding. 
  • Hepatitis delta virus ribozymes fold to generate a solvent-inaccessible core with essential nucleotides near the cleavage site phosphate. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • Heritable individual-specific and allele-specific chromatin signatures in humans. 
  • Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. 
  • Hfq structure, function and ligand binding. 
  • High level expression of a truncated chicken progesterone receptor in Escherichia coli. 
  • High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. 
  • High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A. 
  • High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. 
  • High-resolution mapping and characterization of open chromatin across the genome. 
  • High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain. 
  • High-throughput affinity ranking of antibodies using surface plasmon resonance microarrays. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. 
  • Histone modifications at human enhancers reflect global cell-type-specific gene expression. 
  • Homer: a protein that selectively binds metabotropic glutamate receptors. 
  • Hormone receptor complexes and their modulation of membrane function. 
  • Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. 
  • How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1. 
  • How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts? 
  • How the EcoRI endonuclease recognizes and cleaves DNA. 
  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Human lymphocyte complement receptors. Stimulation of lymphocyte RNA synthesis by complement-coated human red cells. 
  • Human nucleotide excision repair protein XPA: NMR spectroscopic studies of an XPA fragment containing the ERCC1-binding region and the minimal DNA-binding domain (M59-F219). 
  • Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. 
  • Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. 
  • IAP proteins: blocking the road to death's door. 
  • IP7 guards the CDK gate. 
  • Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. 
  • Identification and characterization of the sodium-binding site of activated protein C. 
  • Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. 
  • Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene. 
  • Identification and inhibitory properties of a novel Ca(2+)/calmodulin antagonist. 
  • Identification and regulation of alpha- and beta-adrenergic receptors. 
  • Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. 
  • Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. 
  • Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein. 
  • Identification of N⁶ -methyladenosine reader proteins. 
  • Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel. 
  • Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-1alpha. 
  • Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. 
  • Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. 
  • Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. 
  • Identification of a novel stage of ribosome/nascent chain association with the endoplasmic reticulum membrane. 
  • Identification of a third autonomous activation domain within the human estrogen receptor. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. 
  • Identification of amino acid residues involved in structural and ubiquinone-binding functions of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides. 
  • Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase. 
  • Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. 
  • Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene. 
  • Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. 
  • Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. 
  • Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding. 
  • Identification of cell cycle-regulated, putative hyphal genes in Candida albicans. 
  • Identification of chloride-binding sites in hemoglobin by nuclear-magnetic-resonance quadrupole-relaxation studies of hemoglobin digests. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites. 
  • Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. 
  • Identification of liver cancer-specific aptamers using whole live cells. 
  • Identification of monomeric alpha-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric alpha-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbeiana. 
  • Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif. 
  • Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor. 
  • Identification of self-lipids presented by CD1c and CD1d proteins. 
  • Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. 
  • Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. 
  • Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets. 
  • Identification of the TBX5 transactivating domain and the nuclear localization signal. 
  • Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. 
  • Identification of the components controlling inactivation of voltage-gated Ca2+ channels. 
  • Identification of the functionally relevant calmodulin binding site in smooth muscle caldesmon. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection. 
  • Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. 
  • Identification of troponin C antagonists from a phage-displayed random peptide library. 
  • Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes. 
  • Identifying a transcription factor interaction site on RNA polymerase II. 
  • IgA-binding structures in dermatitis herpetiformis skin are independent of elastic-microfibrillar bundles. 
  • Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme. 
  • Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. 
  • Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site. 
  • Impact of intracellular hemin on N-type inactivation of voltage-gated K+ channels. 
  • Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. 
  • Importance of a c-Myb binding site for lymphomagenesis by the retrovirus SL3-3. 
  • Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates. 
  • In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s). 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription. 
  • In vivo catabolism of alpha 1-antichymotrypsin is mediated by the Serpin receptor which binds alpha 1-proteinase inhibitor, antithrombin III and heparin cofactor II. 
  • In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction. 
  • In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer. 
  • Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate. 
  • Incorporation of low molecular weight molecules into alpha(2)-macroglobulin by nucleophilic exchange. 
  • Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus. 
  • Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers. 
  • Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice. 
  • Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. 
  • Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach. 
  • Influence of allosteric ligands on the activity and aggregation of rabbit muscle phosphofructokinase. 
  • Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses. 
  • Informative priors based on transcription factor structural class improve de novo motif discovery. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch. 
  • Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain. 
  • Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. 
  • Inhibition of thermolysin by phosphonamidate transition-state analogues: measurement of 31P-15N bond lengths and chemical shifts in two enzyme-inhibitor complexes by solid-state nuclear magnetic resonance. 
  • Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics. 
  • Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. 
  • Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes. 
  • Insights into the nature of DNA binding of AbrB-like transcription factors. 
  • Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C. 
  • Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF. 
  • Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. 
  • Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. 
  • Integrative annotation of variants from 1092 humans: application to cancer genomics. 
  • Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. 
  • Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels. 
  • Inter- and intra-molecular electron transfer in the cytochrome bc(1) complex. 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Interaction between residues in the Mg2+-binding site regulates BK channel activation. 
  • Interaction of aspartate transcarbamylase with 5-bromocytidine 5'-tri-, di-, and monophosphates. 
  • Interaction of calcium and lead in human erythrocytes. 
  • Interaction of reduced nicotinamide adenine dinucleotide with beef heart s-malate dehydrogenase. 
  • Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT). 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Interactions between nucleotide binding sites on chloroplast coupling factor during ATP hydrolysis. 
  • Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Interactions of nicotinamide adenine dinucleotides with varied states and forms of hemoglobin. 
  • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. 
  • Interferon regulatory factors are transcriptional regulators of adipogenesis. 
  • Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. 
  • Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. 
  • Internal triplication in the structure of human ceruloplasmin. 
  • Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. 
  • Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. 
  • Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site. 
  • Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor. 
  • Intrinsic disorder within and flanking the DNA-binding domains of human transcription factors. 
  • Invertebrate hemoglobins and nitric oxide: how heme pocket structure controls reactivity. 
  • Investigation of nucleotide binding sites on chloroplast coupling factor 1 with 3'O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. 
  • Investigation of quercetin binding sites on chloroplast coupling factor 1. 
  • Investigation of reduced nicotinamide adenine dinucleotide phosphate and acyl-binding sites on avian fatty acid synthase. 
  • Investigation of the complexes of EcoRI endonuclease with decanucleotides containing canonical and modified recognition sequences using fluorescence and optical detection of magnetic resonance spectroscopy. 
  • Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. 
  • Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association. 
  • Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. 
  • Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. 
  • Isolated hormone receptors: physiologic and clinical implications. 
  • Isolation and initial characterization of the BRCA2 promoter. 
  • Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. 
  • Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. 
  • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. 
  • JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes. 
  • Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. 
  • KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. 
  • Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus. 
  • Kinesin: switch I & II and the motor mechanism. 
  • Kinetic and structural investigation of acyl-binding sites on avian fatty acid synthase. 
  • Kinetic mechanism of RGS9-1 potentiation by R9AP. 
  • Kinetic properties of iodinated ribonuclease A. 
  • Kinetic scheme for intermolecular RNA cleavage by a ribozyme derived from hepatitis delta virus RNA. 
  • Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. 
  • Kinetic studies of tryptophan synthetase. Interaction of L-serine, indole, and tryptophan with the native enzyme. 
  • Kinetics and mechanism of exogenous anion exchange in FeFbpA-NTA: significance of periplasmic anion lability and anion binding activity of ferric binding protein A. 
  • Kinetics of allosteric enzymes. 
  • LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. 
  • LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids. 
  • Lanthanide-binding tags as versatile protein coexpression probes. 
  • Large conformational changes in a kinesin motor catalyzed by interaction with microtubules. 
  • Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes. 
  • Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor. 
  • Ligand binding to transiently accessible sites: mechanisms for varying apparent binding rates. 
  • Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding. 
  • Ligand-binding residues integrate affinity and efficacy in the NMDA receptor. 
  • Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. 
  • Ligand-induced conformational changes in a thermophilic ribose-binding protein. 
  • Ligatin binds phosphohexose residues on acidic hydrolases. 
  • Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. 
  • Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. 
  • Lipid molecules induce p38α activation via a novel molecular switch. 
  • Lipid specificity of beta-hydroxybutyrate dehydrogenase activation. 
  • Lipopolysaccharide 3-deoxy-D-manno-octulosonic acid (Kdo) core determines bacterial association of secreted toxins. 
  • Localization and characterization of 35S-t-butylbicyclophosphorothionate binding in rat brain: an autoradiographic study. 
  • Localization and characterization of neuropeptide Y/peptide YY receptors in the brain of the smooth dogfish (Mustelis canis). 
  • Localization and characterization of secretin binding sites expressed by rat bile duct epithelium. 
  • Localization and structure of the ankyrin-binding site on beta2-spectrin. 
  • Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex. 
  • Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. 
  • Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human. 
  • Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human. 
  • Localization of specific binding sites for bombesin in the canine gastrointestinal tract. 
  • Location of the PH-20 protein on acrosome-intact and acrosome-reacted spermatozoa of cynomolgus macaques. 
  • Long- and short-range interactions between phospholipid/ganglioside GM1 bilayers. 
  • Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor). 
  • Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis. 
  • MHC class I-peptide interactions and TCR recognition. 
  • MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. 
  • MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. 
  • Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody. 
  • Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta. 
  • Mammalian class I odorant receptors exhibit a conserved vestibular-binding pocket. 
  • Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. 
  • Manganese superoxide dismutases from Escherichia coli and from yeast mitochondria: preliminary x-ray crystallographic studies. 
  • Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. 
  • Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. 
  • Mapping individual cosmid DNAs by direct AFM imaging. 
  • Mapping nucleosome positions using DNase-seq. 
  • Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. 
  • Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain. 
  • Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras. 
  • Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. 
  • Mapping the interaction surface of scorpion β-toxins with an insect sodium channel. 
  • Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. 
  • Mass Spectrometry and Ion Mobility Characterization of Bioactive Peptide-Synthetic Polymer Conjugates. 
  • Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening. 
  • Measuring spatial preferences at fine-scale resolution identifies known and novel cis-regulatory element candidates and functional motif-pair relationships. 
  • Mechanism and function of synaptotagmin-mediated membrane apposition. 
  • Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchanger. 
  • Mechanism for catalysis and regulation of adenosine 5'-triphosphate hydrolysis by chloroplast coupling factor 1. 
  • Mechanism of Cdc25B phosphatase with the small molecule substrate p-nitrophenyl phosphate from QM/MM-MFEP calculations. 
  • Mechanism of ancrod anticoagulation. A direct proteolytic effect on fibrin. 
  • Mechanism of corepressor-mediated specific DNA binding by the purine repressor. 
  • Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding. 
  • Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01. 
  • Mechanism of nicotinamide-adenine dinucleotide binding to rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. 
  • Mechanism of specific site location and DNA cleavage by EcoR I endonuclease. 
  • Mechanism of the Class I KDPG aldolase. 
  • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies. 
  • Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. 
  • Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286. 
  • Mechanisms of apparent affinity variation of guarded receptors. 
  • Mechanisms of beta-adrenergic receptor desensitization and resensitization. 
  • Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. 
  • Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis. 
  • Megalin mediates renal uptake of heavy metal metallothionein complexes. 
  • Membrane topology and biogenesis of eukaryotic signal peptidase. 
  • Membrane-protein structural mapping of chloroplast coupling factor in asolectin vesicles. 
  • Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. 
  • Metalloprotein design. 
  • Metastatic behavior and cell surface properties of HT-29 human colon carcinoma variant cells selected for their differential expression of sialyl-dimeric Le(x)-antigen. 
  • Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I). 
  • Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors. 
  • Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases. 
  • Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues. 
  • MicroRNA binding-site polymorphisms as potential biomarkers of cancer risk. 
  • MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium. 
  • Microsomal membranes contain a high affinity binding site for prenylated peptides. 
  • Mimosine targets serine hydroxymethyltransferase. 
  • Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. 
  • Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region. 
  • Mitogenic and adhesive effects of tenascin-C on human hematopoietic cells are mediated by various functional domains. 
  • Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1. 
  • Modeling ion channel blockade at guarded binding sites: application to tertiary drugs. 
  • Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. 
  • Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II). 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. 
  • Modulation of thromboxane receptor activation in rat glomerular mesangial cells. 
  • Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin. 
  • Molecular abnormalities of human plasminogen isolated from synovial fluid of rheumatoid arthritis patients. 
  • Molecular basis for interactions of G protein betagamma subunits with effectors. 
  • Molecular basis for species-specific sensitivity to "hot" chili peppers. 
  • Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A. 
  • Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels. 
  • Molecular basis of selective resistance of the bumblebee BiNa_v 1 sodium channel to tau-fluvalinate. 
  • Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. 
  • Molecular basis of the biological function of molybdenum. Molybdenum-free sulfite oxidase from livers of tungsten-treated rats. 
  • Molecular basis of the biological function of molybdenum. Molybdenum-free xanthine oxidase from livers of tungsten-treated rats. 
  • Molecular biology. Versatility of self-cleaving ribozymes. 
  • Molecular cloning and functional expression of a recombinant 72.5 kDa fragment of the 110 kDa regulatory subunit of smooth muscle protein phosphatase 1M. 
  • Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells. 
  • Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. 
  • Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions. 
  • Molecular interactions and residues involved in force generation in the T4 viral DNA packaging motor. 
  • Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. 
  • Molecular mechanisms of BK channel activation. 
  • Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors. 
  • Molecular structure of a 9-MDa icosahedral pyruvate dehydrogenase subcomplex containing the E2 and E3 enzymes using cryoelectron microscopy. 
  • Molecular studies of human renin structure and synthesis using monoclonal antibodies. 
  • Monocyte chemoattractant activity of Ser195-->Ala active site mutant recombinant alpha-thrombin. 
  • Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. 
  • Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. 
  • Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test. 
  • Motor proteins. 1: kinesins. 
  • Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. 
  • Multiple Functional Variants in cis Modulate PDYN Expression. 
  • Multiple Modes of Zinc Binding to Histatin 5 Revealed by Buffer-Independent Thermodynamics. 
  • Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport. 
  • Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. 
  • Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. 
  • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. 
  • Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors. 
  • Muscarinic cholinergic receptors participate in the kindling model of epilepsy. 
  • MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. 
  • Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates. 
  • Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus. 
  • Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding. 
  • Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. 
  • Mutational analysis of a type II topoisomerase cleavage site: distinct requirements for enzyme and inhibitors. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. 
  • Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the β3-β4 loop to favor a low-affinity drug-binding state. 
  • Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma. 
  • Mutations in the active site of Escherichia coli phosphofructokinase. 
  • Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. 
  • Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a. 
  • Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains. 
  • Myeloma light chains are ligands for cubilin (gp280). 
  • Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. 
  • N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. 
  • N-myc regulates parkin expression. 
  • N-terminal PDZ domain is required for NHERF dimerization. 
  • NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. 
  • NMR assignment of the SRI domain of human Set2/HYPB. 
  • NMR structure of activated CheY. 
  • NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. 
  • Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1. 
  • Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor. 
  • Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes. 
  • Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. 
  • Network calisthenics: control of E2F dynamics in cell cycle entry. 
  • Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. 
  • Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy. 
  • Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. 
  • Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled. 
  • Neutralization of genetically diverse HIV-1 strains by IgA antibodies to the gp120-CD4-binding site from long-term survivors of HIV infection. 
  • Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. 
  • New roles for pyruvate kinase M2: working out the Warburg effect. 
  • Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations. 
  • Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. 
  • Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse. 
  • Nonconsensus Protein Binding to Repetitive DNA Sequence Elements Significantly Affects Eukaryotic Genomes. 
  • Nonequivalence of the flavin adenine dinucleotide moieties of chicken liver xanthine dehydrogenase. 
  • Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of alpha 2-macroglobulin. 
  • Norepinephrine: dissociation of -receptor binding from adenylate cyclase activation in solubilized myocardium. 
  • Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo. 
  • Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. 
  • Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells. 
  • Novel function of clathrin light chain in promoting endocytic vesicle formation. 
  • Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. 
  • Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. 
  • Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • Nuclear magnetic resonance study of ligand binding to Mn-aspartate transcarbamylase. 
  • Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. 
  • Nuclear protein CBP is a coactivator for the transcription factor CREB. 
  • Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. 
  • OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding. 
  • ORChestrating the human DNA replication program. 
  • Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. 
  • Observation of dually decoded regions of the human genome using ribosome profiling data. 
  • On the definition and the construction of pockets in macromolecules. 
  • On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. 
  • Oncogenic mutations in ras create HLA-A2.1 binding peptides but affect their extracellular antigen processing. 
  • One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. 
  • Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation. 
  • Ontogeny of rat hepatic adrenoceptors. 
  • Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits. 
  • Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. 
  • Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. 
  • Optimal self-cleavage activity of the hepatitis delta virus RNA is dependent on a homopurine base pair in the ribozyme core. 
  • Optimal specificity and function for flexible biomolecular recognition. 
  • Optimization of a Noncanonical Anti-infective: Interrogation of the Target Binding Pocket for a Small-Molecule Inhibitor of Escherichia coli Polysaccharide Capsule Expression. 
  • Optimized mixed Markov models for motif identification. 
  • Optimized production and analysis of the staphylococcal multidrug efflux protein QacA. 
  • Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms. 
  • Oxalate decarboxylase uses electron hole hopping for catalysis. 
  • Oxygen affinity and amino acid sequence of myoglobins from endothermic and ectothermic fish. 
  • Oxygen binding by Limulus polyphemus hemocyanin: allosteric modulation by chloride ions. 
  • Oxygen binding domains of Helisoma trivolvis hemoglobin. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. 
  • PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data. 
  • PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. 
  • PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes. 
  • PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer. 
  • POWRS: position-sensitive motif discovery. 
  • PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. 
  • Paired-end analysis of transcription start sites in Arabidopsis reveals plant-specific promoter signatures. 
  • Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. 
  • Patterns of internal and external tetraethylammonium block in four homologous K+ channels. 
  • Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. 
  • Peptide antagonists of the human estrogen receptor. 
  • Peptide hormone "receptors": specific binding of 3 H-FSH to testis. 
  • Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. 
  • Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter. 
  • Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. 
  • Phase changes induced by cyclopropane of phosphatidylserine bilayers in the presence and absence of calcium. 
  • Phasic ion channel blockade. A kinetic model and parameter estimation procedure. 
  • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. 
  • Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. 
  • Phosphoproteome analysis in yeast. 
  • Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor. 
  • Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. 
  • Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. 
  • Phosphorylation of Nox1 regulates association with NoxA1 activation domain. 
  • Phosphorylation of Ser136 is critical for potent bone sialoprotein-mediated nucleation of hydroxyapatite crystals. 
  • Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2. 
  • Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments. 
  • Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits. 
  • Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools. 
  • Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate. 
  • Physical parameters of the anesthetic site. 
  • Physiological receptors as physicochemical entities. 
  • Placental lactogen-binding sites in isolated fetal fibroblasts: characterization, processing, and regulation. 
  • Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Polymorphisms in microRNA targets: a gold mine for molecular epidemiology. 
  • Positional clustering improves computational binding site detection and identifies novel cis-regulatory sites in mammalian GABAA receptor subunit genes. 
  • Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. 
  • Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids. 
  • Precise arrangement of factor-binding sites is required for murine CD4 promoter function. 
  • Predicting cell-type-specific gene expression from regions of open chromatin. 
  • Predicting protein-ligand interactions based on bow-pharmacological space and Bayesian additive regression trees. 
  • Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features. 
  • Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain? 
  • Preliminary X-ray diffraction studies of acyl carrier protein from Escherichia coli. 
  • Prenatal exposure to methylmercury alters development of adrenergic receptor binding sites in peripheral sympathetic target tissues. 
  • Primary structure of hemoglobins from trout (Salmo irideus).partial determination of amino acid sequence of HB trout IV. 
  • Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. 
  • Probing the DNA sequence specificity of Escherichia coli RECA protein. 
  • Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage. 
  • Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. 
  • Probing the folding intermediate of Bacillus subtilis RNase P protein by nuclear magnetic resonance. 
  • Probing the renin active site by collisional quenching of endogenous fluorescence. 
  • Processing of intermediates in multienzyme complexes. 
  • Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. 
  • Profiling the quantitative occupancy of myriad transcription factors across conditions by modeling chromatin accessibility data. 
  • Programming of brainstem serotonin transporter development by prenatal glucocorticoids. 
  • Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. 
  • Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains. 
  • Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning. 
  • Prostate. III--A structural feature characteristic of the rat prostate 5 alpha-reductase active site. 
  • Protein engineering and the development of generic biosensors. 
  • Protein farnesyltransferase. 
  • Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. 
  • Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. 
  • Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. 
  • Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. 
  • Protein-DNA binding in the absence of specific base-pair recognition. 
  • Protein-protein docking: overview and performance analysis. 
  • Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. 
  • Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. 
  • Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. 
  • Proteomic analysis of arginine adducts on glyoxal-modified ribonuclease. 
  • Proton NMR of Escherichia coli sulfite reductase: the unligated hemeprotein subunit. 
  • Pulsed EPR studies of nonexchangeable protons near the Mo(V) center of sulfite oxidase: direct detection of the alpha-proton of the coordinated cysteinyl residue and structural implications for the active site. 
  • Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase. 
  • Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris. 
  • Purification and properties of chicken liver xanthine dehydrogenase. 
  • Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. 
  • Purification of an active proteolytic fragment of the membrane attachment site for human erythrocyte spectrin. 
  • Purification of serine-specific transfer ribonucleic acid from bakers' yeast. 
  • Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. 
  • Puzzle pieces defined: locating common packing units in tertiary protein contacts. 
  • QBiC-Pred: quantitative predictions of transcription factor binding changes due to sequence variants. 
  • QM/MM model of the mouse olfactory receptor MOR244-3 validated by site-directed mutagenesis experiments. 
  • QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization. 
  • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. 
  • Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. 
  • Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation. 
  • Quantifying RNA binding sites transcriptome-wide using DO-RIP-seq. 
  • Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity. 
  • Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. 
  • Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. 
  • Quantitative modeling of transcription factor binding specificities using DNA shape. 
  • Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. 
  • Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa. 
  • R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. 
  • RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. 
  • RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins. 
  • RNA editing generates tissue-specific sodium channels with distinct gating properties. 
  • RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus. 
  • RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. 
  • RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. 
  • Rabbit plasma, unlike its human counterpart, contains no complex between protein S and C4b-binding protein. 
  • Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex. 
  • Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies. 
  • Rapid evolution of cis-regulatory sequences via local point mutations. 
  • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. 
  • Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis. 
  • Rational design of a calcium-binding protein. 
  • Reaction of human alpha 2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure. 
  • Reaction path determination for quantum mechanical/molecular mechanical modeling of enzyme reactions by combining first order and second order "chain-of-replicas" methods. 
  • Reaction path potential for complex systems derived from combined ab initio quantum mechanical and molecular mechanical calculations. 
  • Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin. 
  • Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. 
  • Recently Designed Multivalent Spike Binders Cannot Bind Multivalently─How Do They Achieve Enhanced Avidity to SARS-CoV-2? 
  • Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. 
  • Receptor biophysics and biochemistry. Enzymes. 
  • Receptors on hepatocytes that bind ligands containing fucosyl alpha 1,3 N-acetylglucosamine linkages. 
  • Recognition of multiple drugs by a single protein: a trivial solution of an old paradox. 
  • Reconstitution of the beta-adrenergic receptor. 
  • Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections. 
  • Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. 
  • Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. 
  • Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. 
  • Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization. 
  • Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. 
  • Regulation of Co-transcriptional Pre-mRNA Splicing by m⁶ A through the Low-Complexity Protein hnRNPG. 
  • Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2. 
  • Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene. 
  • Regulation of beta-adrenergic receptors by steroid hormones. 
  • Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. 
  • Regulation of enzyme activity. The activity of enzymes can be controlled by a multiplicity of conformational equilibria. 
  • Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. 
  • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. 
  • Regulation of postnatal beta-adrenergic receptor/adenylate cyclase development by prenatal agonist stimulation and steroids: alterations in rat kidney and lung after exposure to terbutaline or dexamethasone. 
  • Regulation of streptokinase expression by CovR/S in Streptococcus pyogenes: CovR acts through a single high-affinity binding site. 
  • Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors. 
  • Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. 
  • Regulation of the human interleukin-3 gene. 
  • Regulation of transducin GTPase activity in bovine rod outer segments. 
  • Regulatory domains of erythrocyte ankyrin. 
  • Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase. 
  • Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence. 
  • Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with aspartate analogs. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate. 
  • Relaxation spectrometry of biological systems. 
  • Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. 
  • Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. 
  • Research and clinical potential of receptor based radiopharmaceuticals. 
  • Residual dipolar coupling derived orientational constraints on ligand geometry in a 53 kDa protein-ligand complex. 
  • Residues of heat-labile enterotoxin involved in bacterial cell surface binding. 
  • Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. 
  • Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. 
  • Resolving Heart Regeneration by Replacement Histone Profiling. 
  • Resolving fast and slow motions in the internal loop containing stem-loop 1 of HIV-1 that are modulated by Mg2+ binding: role in the kissing-duplex structural transition. 
  • Resonance Raman spectroscopic characterization of the molybdopterin active site of DMSO reductase. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes. 
  • Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA. 
  • Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation. 
  • Ribozyme cleavage of a 2,5-phosphodiester linkage: mechanism and a restricted divalent metal-ion requirement. 
  • Rivaroxaban, an oral direct factor Xa inhibitor. 
  • Robust IR-based detection of stable and fractionally populated G-C+ and A-T Hoogsteen base pairs in duplex DNA. 
  • Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. 
  • Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase. 
  • Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase. 
  • Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase. 
  • Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. 
  • Role of myosin-II phosphorylation in V12Cdc42-mediated disruption of Drosophila cellularization. 
  • Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae. 
  • Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin. 
  • Rotation of nucleotide sites is not required for the enzymatic activity of chloroplast coupling factor 1. 
  • Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel. 
  • SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo. 
  • Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants. 
  • Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. 
  • Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis. 
  • Secondary structure of ovalbumin messenger RNA. 
  • Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence. 
  • Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes. Quantitative determination with purified (32P)spectrin. 
  • Sensing of molecules using quantum dynamics. 
  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. 
  • Sequence features of DNA binding sites reveal structural class of associated transcription factor. 
  • Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2. 
  • Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes. 
  • Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. 
  • Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains. 
  • Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120. 
  • Signatures of protein-DNA recognition in free DNA binding sites. 
  • Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit. 
  • Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor. 
  • Siroheme and sirohydrochlorin. The basis for a new type of porphyrin-related prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Siroheme: a prosthetic group of the Neurospora crassa assimilatory nitrite reductase. 
  • Site of Tc-99m binding to the red blood cell: concise communication. 
  • Site of carcinoembryonic antigen binding to Kupffer cells. 
  • Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress. 
  • Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase. 
  • Site-directed mutagenesis of recombinant sulfite oxidase: identification of cysteine 207 as a ligand of molybdenum. 
  • Site-directed mutagenesis of the inhibitory subunit of retinal rod cyclic GMP phosphodiesterase. 
  • Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. 
  • Site-specific conjugation of a temperature-sensitive polymer to a genetically-engineered protein. 
  • Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. 
  • Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle. 
  • Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. 
  • Sites of interaction between kinase-related protein and smooth muscle myosin. 
  • Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism. 
  • SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. 
  • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. 
  • Sodium binding site of factor Xa: role of sodium in the prothrombinase complex. 
  • Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop. 
  • Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes. 
  • Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs. 
  • SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila . 
  • Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells. 
  • Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites. 
  • Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53. 
  • Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger. 
  • Specific association of retroviral envelope protein, p15E, with human cell surfaces. 
  • Specific binding at the cellulose binding module-cellulose interface observed by force spectroscopy. 
  • Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity. 
  • Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells. 
  • Specific binding sites for atrial natriuretic factor in the human kidney. 
  • Specific interaction of 3H-FSH with rat testis binding sites. 
  • Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. 
  • Specific receptors for phorbol diesters on freshly isolated human myeloid and lymphoid leukemia cells: comparable binding characteristics despite different cellular responses. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Specificity of alpha 2-macroglobulin covalent cross-linking for the active domain of proteinases. 
  • Spinach siroheme enzymes: Isolation and characterization of ferredoxin-sulfite reductase and comparison of properties with ferredoxin-nitrite reductase. 
  • Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. 
  • Spot hemoglobin. Studies on the Root effect hemoglobin of a marine teleost. 
  • Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. 
  • Stability selection for regression-based models of transcription factor-DNA binding specificity. 
  • Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein. 
  • Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. 
  • Steady-state kinetic study of rabbit muscle phosphofructokinase. 
  • Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP). 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. 
  • Streptavidin binding and endothelial cell adhesion to biotinylated fibronectin. 
  • Streptavidin-biotin binding energetics. 
  • Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth. 
  • Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins. 
  • Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein. 
  • Structural analysis, identification, and design of calcium-binding sites in proteins. 
  • Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA). 
  • Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. 
  • Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase. 
  • Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. 
  • Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin. 
  • Structural and functional studies of cyclic GMP phosphodiesterase. 
  • Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA. 
  • Structural and mechanistic studies of the alpha-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli. 
  • Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. 
  • Structural basis for SH2D1A mutations in X-linked lymphoproliferative disease. 
  • Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. 
  • Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism. 
  • Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis. 
  • Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. 
  • Structural basis for the remarkable stability of Bacillus subtilis lipase (Lip A) at low pH. 
  • Structural basis for μ-opioid receptor binding and activation. 
  • Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. 
  • Structural basis of core promoter recognition in a primitive eukaryote. 
  • Structural basis of diverse membrane target recognitions by ankyrins. 
  • Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. 
  • Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex. 
  • Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. 
  • Structural basis of odorant recognition by a human odorant receptor. 
  • Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. 
  • Structural basis of the intrasteric regulation of myosin light chain kinases. 
  • Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction. 
  • Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain. 
  • Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin. 
  • Structural mapping of aspartate transcarbamoylase by fluorescence energy-transfer measurements: determination of the distance between catalytic sites of different subunits. 
  • Structural mapping of chloroplast coupling factor. 
  • Structural mapping of nucleotide binding sites on chloroplast coupling factor. 
  • Structural mapping of rabbit muscle phosphofructokinase. Distance between the adenosine cyclic 3',5'-phosphate binding site and a reactive sulfhydryl group. 
  • Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation. 
  • Structural mechanism of glutamate receptor activation and desensitization. 
  • Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein. 
  • Structural mechanism of trimeric HIV-1 envelope glycoprotein activation. 
  • Structural mechanisms of QacR induction and multidrug recognition. 
  • Structural model of human ceruloplasmin based on internal triplication, hydrophilic/hydrophobic character, and secondary structure of domains. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide. 
  • Structural requirements for association of neurofascin with ankyrin. 
  • Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. 
  • Structural studies of Klenow fragment: an enzyme with two active sites. 
  • Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. 
  • Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. 
  • Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94. 
  • Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae. 
  • Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants. 
  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. 
  • Structure and Affinity of Cu(I) Bound to Human Serum Albumin. 
  • Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. 
  • Structure and DNA-binding traits of the transition state regulator AbrB. 
  • Structure and function of cholera toxin and hormone receptors. 
  • Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta. 
  • Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant. 
  • Structure and mechanism of copper, zinc superoxide dismutase. 
  • Structure and sequence of the mouse Bmp6 gene. 
  • Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage. 
  • Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength. 
  • Structure of DNA polymerase I Klenow fragment bound to duplex DNA. 
  • Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. 
  • Structure of a Z-DNA with two different backbone chain conformations. Stabilization of the decadeoxyoligonucleotide d(CGTACGTACG) by [Co(NH3)6]3+ binding to the guanine. 
  • Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication. 
  • Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. 
  • Structure of mammalian protein geranylgeranyltransferase type-I. 
  • Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate. 
  • Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. 
  • Structure of the cold- and menthol-sensing ion channel TRPM8. 
  • Structure of the endonuclease domain of MutL: unlicensed to cut. 
  • Structure of the human MutSalpha DNA lesion recognition complex. 
  • Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. 
  • Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K). 
  • Structure-Function Analysis of Interallelic Complementation in ROOTY Transheterozygotes. 
  • Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo. 
  • Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies. 
  • Structure-based classification of 45 FK506-binding proteins. 
  • Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. 
  • Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. 
  • Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations. 
  • Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. 
  • Structures of human Patched and its complex with native palmitoylated sonic hedgehog. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding. 
  • Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. 
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. 
  • Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy. 
  • Studies on the adapter molecule LAT. 
  • Studies on the regulation and specificity of the DNA-untwisting enzyme. 
  • Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants. 
  • Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. 
  • Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. 
  • Subtype specificity of alpha-adrenergic receptors in rat heart. 
  • Subunit IV of cytochrome bc1 complex from Rhodobacter sphaeroides. Localization of regions essential for interaction with the three-subunit core complex. 
  • Subunit dissociation and unfolding of rabbit muscle phosphofructokinase by guanidine by hydrochloride. 
  • SulA inhibits assembly of FtsZ by a simple sequestration mechanism. 
  • Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. 
  • Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis. 
  • Suppression of conformational heterogeneity at a protein-protein interface. 
  • Suppressor analysis of temperature-sensitive RNA polymerase I mutations in Saccharomyces cerevisiae: suppression of mutations in a zinc-binding motif by transposed mutant genes. 
  • Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation. 
  • Survey of variation in human transcription factors reveals prevalent DNA binding changes. 
  • Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. 
  • Synergistic and tunable human gene activation by combinations of synthetic transcription factors. 
  • Synergistic cofactor function of factor V and protein S to activated protein C in the inactivation of the factor VIIIa - factor IXa complex -- species specific interactions of components of the protein C anticoagulant system. 
  • Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. 
  • Syntheses, X-ray crystal structures, and solution behavior of monomeric, cationic, two-coordinate gold(I) pi-alkene complexes. 
  • Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. 
  • Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity. 
  • Synthesis of programmable integrases. 
  • Synthesis, characterization, and in vitro transfection activity of charge-reversal amphiphiles for DNA delivery. 
  • Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition. 
  • TAMC: A deep-learning approach to predict motif-centric transcriptional factor binding activity based on ATAC-seq profile. 
  • TFBSshape: a motif database for DNA shape features of transcription factor binding sites. 
  • TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. 
  • Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. 
  • Targeted Mass Spectrometry-Based Approach for Protein-Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy. 
  • Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins. 
  • Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. 
  • Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. 
  • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. 
  • Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. 
  • Techniques for the study of the biochemical basis of drug action. 
  • Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. 
  • Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization. 
  • Tenascin supports lymphocyte rolling. 
  • Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin. 
  • Testicular adenosine 3':5'-monophosphate-dependent protein kinase. Regulation by follicle-stimulating hormone. 
  • The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. 
  • The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX). 
  • The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger. 
  • The ATP binding site of the yeast plasma membrane proton-translocating ATPase. 
  • The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. 
  • The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. 
  • The CD28 signaling pathway regulates glucose metabolism. 
  • The CovR response regulator of group A streptococcus (GAS) acts directly to repress its own promoter. 
  • The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. 
  • The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. 
  • The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. 
  • The DPE, a conserved downstream core promoter element that is functionally analogous to the TATA box. 
  • The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. 
  • The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim. 
  • The Haemophilus influenzae Hap autotransporter binds to fibronectin, laminin, and collagen IV. 
  • The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. 
  • The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. 
  • The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor. 
  • The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The SAF-box domain of chromatin protein DEK. 
  • The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. 
  • The Tetrahymena ribozyme acts like an RNA restriction endonuclease. 
  • The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs. 
  • The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain. 
  • The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. 
  • The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. 
  • The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays. 
  • The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. 
  • The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription. 
  • The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog. 
  • The beta-adrenergic receptor and adenylate cyclase. 
  • The beta-adrenergic receptor in heart failure. 
  • The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. 
  • The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation. 
  • The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. 
  • The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency. 
  • The bleeding diathesis in human glycogen storage disease type I: in vitro identification of a naturally occurring inhibitor of ristocetin-induced platelet aggregation. 
  • The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin. 
  • The catalytic subunit of yeast telomerase. 
  • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. 
  • The cis-Pro touch-turn: a rare motif preferred at functional sites. 
  • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. 
  • The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin. 
  • The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. 
  • The crystal structure of bovine Cu2+,Zn2+ superoxide dismutase at 5.5-A resolution. 
  • The crystal structure of the UvsW helicase from bacteriophage T4. 
  • The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome. 
  • The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression. 
  • The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain. 
  • The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. 
  • The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro. 
  • The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration. 
  • The effect of zinc and other divalent cations on the structure and function of human alpha 2-macroglobulin. 
  • The effects of selection against spurious transcription factor binding sites. 
  • The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. 
  • The energetics of binding of a signal peptide to lipid bilayers: the role of bilayer properties. 
  • The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein. 
  • The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. 
  • The force-driven conformations of heparin studied with single molecule force microscopy. 
  • The gamma2 late glycoprotein K promoter of equine herpesvirus 1 is differentially regulated by the IE and EICP0 proteins. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. 
  • The hemoglobin of the crossopterygian fish, Latimeria chalumnae (Smith). Subunit structure and oxygen equilibria. 
  • The hemoglobin system of the primitive fish, Amia calva: isolation and functional characterization of the individual hemoglobin components. 
  • The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. 
  • The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. 
  • The identification of a second actin-binding region in spinophilin/neurabin II. 
  • The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation. 
  • The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. 
  • The interleukin 1 receptor. 
  • The kinetic mechanism of xanthine dehydrogenase and related enzymes. 
  • The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. 
  • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. 
  • The mechanism of action of angiostatin: can you teach an old dog new tricks? 
  • The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O). 
  • The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. 
  • The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. 
  • The molecular basis for membrane - cytoskeleton association in human erythrocytes. 
  • The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain. 
  • The molecular elasticity of the extracellular matrix protein tenascin. 
  • The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus. 
  • The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades. 
  • The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms. 
  • The new biology of drug receptors. 
  • The nuclear DEK interactome supports multi-functionality. 
  • The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus. 
  • The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA. 
  • The preparation and properties of an antiserum for the radioimmunoassay of serum conjugated cholic acid. 
  • The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. 
  • The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment. 
  • The purinome, a complex mix of drug and toxicity targets. 
  • The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy. 
  • The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides. 
  • The role of ligand-ligand interactions in competition by fibrinogen and fibrin degradation products for fibrinogen binding to human platelets. 
  • The role of molybdenum in xanthine oxidase and related enzymes. Reactivity with cyanide, arsenite, and methanol. 
  • The role of transmethylation reactions in regulating the binding of BCG-activated murine macrophages to neoplastic target cells. 
  • The role of tyrosine 343 in substrate binding and catalysis by human sulfite oxidase. 
  • The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain. 
  • The spectrin skeleton: from red cells to brain. 
  • The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II. 
  • The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers. 
  • The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. 
  • The structural basis for the mutagenicity of O(6)-methyl-guanine lesions. 
  • The structural basis for the selectivity of benzotriazole inhibitors of PTP1B. 
  • The structural basis of repertoire shift in an immune response to phosphocholine. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The structure and function of pyruvate kinase. 
  • The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding. 
  • The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes. 
  • The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins. 
  • The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway. 
  • The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. 
  • The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. 
  • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. 
  • The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers. 
  • The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells. 
  • The winged-helix DNA-binding motif: another helix-turn-helix takeoff. 
  • The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. 
  • The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. 
  • Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. 
  • Therapeutic applications of transcription factor decoy oligonucleotides. 
  • Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands. 
  • Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry. 
  • Thermodynamic evaluation of binding interactions in the methionine repressor system of Escherichia coli using isothermal titration calorimetry. 
  • Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain. 
  • Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase. 
  • Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants. 
  • Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid. 
  • Three-dimensional structure of calmodulin. 
  • Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Thrombomodulin increases the rate of thrombin inhibition by BPTI. 
  • Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection. 
  • Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. 
  • Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells. 
  • Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. 
  • Topology of an amiloride-binding protein. 
  • Toward deciphering the mechanistic role of variations in the Rep1 repeat site in the transcription regulation of SNCA gene. 
  • Transcription Factor-DNA Binding Motifs in Saccharomyces cerevisiae: Tools and Resources. 
  • Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation. 
  • Transcription factor AP-2 regulates human immunodeficiency virus type 1 gene expression. 
  • Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. 
  • Transcription of the terminal loop region of vaccinia virus DNA is initiated from the telomere sequences directing DNA resolution. 
  • Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. 
  • Transcriptional regulation and the evolution of development. 
  • Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. 
  • Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. 
  • Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice. 
  • Transfer of radioiodine from iodinated oncornavirus proteins to unlabeled protein carrier during routine procedures for peptide mapping. 
  • Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. 
  • Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. 
  • Transforming growth factors beta 1, beta 2, and beta 3 messenger RNA and protein expression in mouse uterus and vagina during estrogen-induced growth: a comparison to other estrogen-regulated genes. 
  • Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length. 
  • Transient expression of a winged-helix protein, MNF-beta, during myogenesis. 
  • Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin. 
  • Translating antibody-binding peptides into peptoid ligands with improved affinity and stability. 
  • Translation of phage f1 gene VII occurs from an inherently defective initiation site made functional by coupling. 
  • Transmission coefficient calculation for proton transfer in triosephosphate isomerase based on the reaction path potential method. 
  • Treatment of HCV infection by targeting microRNA. 
  • Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli. 
  • TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus. 
  • Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes IGF-II binding. 
  • Tryptic cleavage of rat liver sulfite oxidase. Isolation and characterization of molybdenum and heme domains. 
  • Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. 
  • Tuning magnesium sensitivity of BK channels by mutations. 
  • Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I. 
  • Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. 
  • Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. 
  • Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro 
  • Two oligomeric forms of plasma ficolin have differential lectin activity. 
  • Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon. 
  • Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines. 
  • Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex. 
  • Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. 
  • Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. 
  • U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts. 
  • UV irradiation remodels the specificity landscape of transcription factors. 
  • Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. 
  • Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. 
  • Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1). 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
  • Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
  • Uptake of catecholamines by storage vesicles. 
  • Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1. 
  • Using DNA duplex stability information for transcription factor binding site discovery. 
  • Using DNase digestion data to accurately identify transcription factor binding sites. 
  • Using N-Terminal Coordination of Cu(II) and Ni(II) to Isolate the Coordination Environment of Cu(I) and Cu(II) Bound to His13 and His14 in Amyloid-β(4-16). 
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. 
  • V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120. NIH-NIAID AIDS Vaccine Clinical Trials Network. 
  • Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates. 
  • Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site. 
  • Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide. 
  • Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor. 
  • Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Visualization of carbohydrate-binding molecules expressed by myelomono- and erythropoietic cells derived from human bone marrow: an immunoenzymatic double-staining study. 
  • Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. 
  • Visualizing multistep elevator-like transitions of a nucleoside transporter. 
  • Vitamin A in liposomes. Inhibition of complement binding and alteration of membrane structure. 
  • Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase. 
  • When is a transcription factor a NAP? 
  • Whole-genome comparison of Leu3 binding in vitro and in vivo reveals the importance of nucleosome occupancy in target site selection. 
  • X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. 
  • X-ray crystallographic studies of streptavidin mutants binding to biotin. 
  • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. 
  • YbiV from Escherichia coli K12 is a HAD phosphatase. 
  • Yin yang 1 modulates taxane response in epithelial ovarian cancer. 
  • ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. 
  • Zinc finger protein binding to DNA: an energy perspective using molecular dynamics simulation and free energy calculations on mutants of both zinc finger domains and their specific DNA bases. 
  • [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. 
  • [Endogenous inhibitors of specific benzodiazepine binding in the cerebral cortex of the bull]. 
  • [Identification and evaluation of properties of benzodiazepine receptors of glial and neuronal fractions of human cerebral cortex]. 
  • [Localization of binding sites of E. coli DNA-dependent RNA-polymerase with photosensitive template analogs]. 
  • [New type of specific binding sites for gamma-aminobutyric acid (GABA) found in a mouse glioblastoma]. 
  • beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. 
  • c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells. 
  • c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor. 
  • cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction. 
  • cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin. 
  • gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. 
  • hSnm1B is a novel telomere-associated protein. 
  • iPABP, an inducible poly(A)-binding protein detected in activated human T cells. 
  • lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. 
  • p-Amidino esters as irreversible inhibitors of factors IXa and Xa and thrombin. 
  • pH-dependent conformational change of gastric mucin leads to sol-gel transition. 
  • ¹H, ¹³C and ¹⁵N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology
  • Schmid, Amy K., David M. Goodner Associate Professor, Duke Science & Society
  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology