Binding Sites, Antibody

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  Subject Areas on Research

  • A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. 
  • A serologic approach to the definition of human prostatic carcinoma antigens. 
  • A visual assay to monitor purification of cell surface antigens reacting with monoclonal antibodies. 
  • Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis. 
  • Alteration of human erythrocyte membrane properties by complement fixation. 
  • Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins. 
  • Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals. 
  • Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. 
  • Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin. 
  • Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antibody-induced proteinase activation: a proposed mechanism for pemphigus. 
  • Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. 
  • C-terminal region of human T cell lymphotropic virus type I (HTLVI) p19 core protein is immunogenic in humans and contains an HTLVI-specific epitope. 
  • CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells. 
  • Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop. 
  • Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of the serum In(Lu)-related antigen: identification of a serum protein related to erythrocyte p80. 
  • Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. 
  • Clinical and immunologic features of selective IgA deficiency. 
  • Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. 
  • Combination therapy with anti-HIV-1 antibodies maintains viral suppression. 
  • Comparison of glycoproteins isolated by phenol-water partition of human erythrocyte membranes. 
  • Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope. 
  • Cutaneous T cell lymphoma. Lymphocyte phenotype analysis after anti-thymocyte globulin therapy. 
  • Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction. 
  • Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. 
  • Development and validation of a cell-based fluorescent method for measuring antibody affinity. 
  • Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4. 
  • Diverse humoral and cell-mediated effects of antisperm antibodies on reproduction. 
  • Effect of radioiodination on the binding of monoclonal antibody DF3 to breast carcinoma cells. 
  • Embryo dissociation, cell isolation, and cell reassociation. 
  • Epstein Barr virus binding induces internalization of the C3d receptor: a novel immunotoxin delivery system. 
  • Evidence for a novel hybrid immunotoxin recognizing ricin A-chain by one antigen-combining site and a prostate-restricted antigen by the remaining antigen-combining site: potential for immunotherapy. 
  • Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. 
  • Expression of antigens by cultured epithelial cells: comparison of epidermis and thymic epithelium. 
  • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. 
  • Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration. 
  • GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody. 
  • Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H2-linked genes in the control of the anti-nuclease antibody response. 
  • Heparin-induced decrease in circulating antithrombin-III. 
  • High-throughput affinity ranking of antibodies using surface plasmon resonance microarrays. 
  • Human red cell antigens. IV. The abnormal sialoglycoprotein of Gerbich-negative red cells. 
  • Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. 
  • Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression. 
  • Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R). 
  • Immunocytochemical binding to neurons of serum from spinocerebellar degeneration patients. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. IV. Characterization of the protective antibody in hyperimmune serum. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. V. Antibody-directed macrophages mediate tumor cell destruction. 
  • Immunopathological and clinical studies in herpes gestationis. 
  • Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. 
  • Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. 
  • Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. 
  • Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage. 
  • Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. 
  • Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor). 
  • Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody. 
  • Mapping of immunogenic regions of human T cell leukemia virus type I (HTLV-I) gp46 and gp21 envelope glycoproteins with env-encoded synthetic peptides and a monoclonal antibody to gp46. 
  • Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency. 
  • Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV. 
  • Monoclonal antibodies binding renal renin. 
  • Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny. 
  • Passive transfer of human myasthenia gravis to rats: 1. Electrophysiology of the developing neuromuscular block. 
  • Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data. 
  • Phenotypic characterization of human bone marrow granulocyte-macrophage forming progenitor cells. 
  • Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers. 
  • Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. 
  • Polyspecific binding of Escherichia coli beta-galactosidase by murine antibodies to DNA. 
  • Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. 
  • Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens. 
  • Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. 
  • Proteinase activation: a mechanism for cellular dyshesion in pemphigus. 
  • Rationale for immunotoxin therapy of metastatic prostate carcinoma formatted as a multi-stage delivery system. 
  • Reactivity of avian RNA tumor viruses with lectins. 
  • Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial. 
  • Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45. 
  • Separation of the acetylcholinesterase-deficient red cells in paroxysmal nocturnal hemoglobinuria. 
  • Shapes of antibody binding sites: qualitative and quantitative analyses based on a geomorphic classification scheme. 
  • Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells. 
  • Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. 
  • Specificity analysis of monoclonal anti-DNA antibodies from B6-lpr/lpr mice. 
  • Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. 
  • Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus. 
  • Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. 
  • Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies. 
  • Structural mechanism of trimeric HIV-1 envelope glycoprotein activation. 
  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. 
  • Structure of the major peanut allergen Ara h 1 may protect IgE-binding epitopes from degradation. 
  • The binding of anti-DNA antibodies to phosphorothioate oligonucleotides in a solid phase immunoassay. 
  • The binding of sera of patients with SLE to bacterial and mammalian DNA. 
  • The development of CD4 binding site antibodies during HIV-1 infection. 
  • The immune response to staphylococcal nuclease: a probe of cellular and humoral antigen-specific receptors. 
  • The pathogenesis of dermatitis herpetiformis. 
  • The primary antibody repertoire: the somatic genotype and paratopic phenotype of B-cell populations. 
  • The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes. 
  • Two biochemical markers in lymphocyte subpopulations. 
  • Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology