Biocompatible Materials

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  Subject Areas on Research

  • 10-year follow-up wear analysis of first-generation highly crosslinked polyethylene in primary total hip arthroplasty. 
  • 2010 Panel on the biomaterials grand challenges. 
  • 2011 panel on developing a biomaterials curriculum. 
  • 3D biofabrication strategies for tissue engineering and regenerative medicine. 
  • A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. 
  • A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. 
  • A perspective on immunomodulation and tissue repair. 
  • A preliminary study of the fixation mechanism of collagen reaction with a polyepoxy fixative. 
  • Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. 
  • Adhesion/cementation to zirconia and other non-silicate ceramics: where are we now? 
  • Adult adipose-derived stem cell attachment to biomaterials. 
  • Advances in bioengineered conduits for peripheral nerve regeneration. 
  • Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures. 
  • Al-Cu-Fe quasicrystal/ultra-high molecular weight polyethylene composites as biomaterials for acetabular cup prosthetics. 
  • An arthroscopic technique for anterior stabilization of the shoulder with a bioabsorbable tack. 
  • Analysis of biomedical polymer surfaces: polyurethanes and plasma-deposited thin films. 
  • Analysis, design, and performance of a capacitive pressure sensor IC. 
  • Analyte flux through chronically implanted subcutaneous polyamide membranes differs in humans and rats. 
  • Antibodies to prothrombin, factor V, and beta2-glycoprotein I and vascular access thrombosis. 
  • Application of magnetic resonance microscopy to tissue engineering: a polylactide model. 
  • Application of total internal reflection fluorescence microscopy to study cell adhesion to biomaterials. 
  • Assessments of thrombogenicity by three in vitro techniques. Student Research Award in the Undergraduate, Master Candidate, or Health Science Degree Candidate Category, 21st annual meeting of the Society for Biomaterials, San Francisco, CA, March 18-22, 1995. 
  • Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies. 
  • Biocompatibility response to modified Baerveldt glaucoma drains. 
  • Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. 
  • Biocompatible hydrogels by oxime Click chemistry. 
  • Biomaterial strategies for generating therapeutic immune responses. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells. 
  • Biomaterials for the central nervous system. 
  • Biomaterials use in Mulago National Referral Hospital in Kampala, Uganda: Access and affordability. 
  • Biomimetic strategies based on viruses and bacteria for the development of immune evasive biomaterials. 
  • Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. 
  • Cardiac transplantation following ACORN CorCap device implantation. 
  • Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds. 
  • Change in surface roughness by dynamic shape-memory acrylate networks enhances osteoblast differentiation. 
  • Characterization of implantable biosensor membrane biofouling. 
  • Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Comparison of 10-0 polypropylene and 10-0 nylon sutures in rat arterial anastomosis. 
  • Comparison of sutures and dendritic polymer adhesives for corneal laceration repair in an in vivo chicken model. 
  • Compressive cyclic ratcheting and fatigue of synthetic, soft biomedical polymers in solution. 
  • Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis. 
  • Controlled differentiation of stem cells. 
  • Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Culture of hepatocytes on fructose-modified chitosan scaffolds. 
  • Culture of primary rat hepatocytes within porous chitosan scaffolds. 
  • Current status of biodegradable stents. 
  • Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries. 
  • Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. 
  • Cytotoxicity and thermomechanical behavior of biomedical shape-memory polymer networks post-sterilization. 
  • Decellularized native and engineered arterial scaffolds for transplantation. 
  • Decreased analyte transport through implanted membranes: differentiation of biofouling from tissue effects. 
  • Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window. 
  • Defensins impair phagocytic killing by neutrophils in biomaterial-related infection. 
  • Dendritic macromers as in situ polymerizing biomaterials for securing cataract incisions. 
  • Development of coronary collateral circulation in left circumflex Ameroid-occluded swine myocardium. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Dynamic fatigue and strength characterization of three ceramic materials. 
  • Early mechanical failure of highly cross-linked porcine dermal matrix for abdominal wall reconstruction. 
  • Effect of fibronectin amount and conformation on the strength of endothelial cell adhesion to HEMA/EMA copolymers. 
  • Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks. 
  • Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. 
  • Effectiveness of Glycerol Mono-oleate as a Biosealant. 
  • Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells. 
  • Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. 
  • Engineered skeletal muscle tissue networks with controllable architecture. 
  • Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. 
  • Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. 
  • Epitope tagging for tracking elastin-like polypeptides. 
  • Evaluation of poly(L-lactic acid) as a material for intravascular polymeric stents. 
  • Evolving the use of peptides as components of biomaterials. 
  • Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve. 
  • Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering. 
  • Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. 
  • Facial Filler Complications. 
  • Fibrillar peptide gels in biotechnology and biomedicine. 
  • Gene therapy and genomic strategies for cardiovascular surgery: The emerging field of surgiomics. 
  • Getting there is half the battle: recent advances in delivering therapeutics. 
  • Glycophase glass revisited: protein adsorption and cell growth on glass surfaces bearing immobilized glycerol monosaccharides. 
  • Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging. 
  • Gradated assembly of multiple proteins into supramolecular nanomaterials. 
  • High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. 
  • Hydrogels for brain repair after stroke: an emerging treatment option. 
  • Hydrogels muscle their way into new territory. 
  • Iloprost in alginate decreases the thrombogenicity of expanded polytetrafluoroethylene. 
  • Imaging Biomaterial-Tissue Interactions. 
  • Imaging the distribution of magnetic nanoparticles with ultrasound. 
  • Immune responses to coiled coil supramolecular biomaterials. 
  • Impact of surface porosity and topography on the mechanical behavior of high strength biomedical polymers. 
  • Impaction durability of porous polyether-ether-ketone (PEEK) and titanium-coated PEEK interbody fusion devices. 
  • Implantable, multifunctional, bioresorbable optics. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive. 
  • In vivo assessment of an absorbable and nonabsorbable knotless barbed suture for laparoscopic single-layer enterotomy closure: a clinical and biomechanical comparison against nonbarbed suture. 
  • In vivo cytokine-associated responses to biomaterials. 
  • Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. 
  • Influence of physical properties of biomaterials on cellular behavior. 
  • Inhibition of epidural scar formation after lumbar laminectomy in the rat. 
  • Inhibition of implant-associated infections via nitric oxide release. 
  • Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats. 
  • Long-term outcome after biologic versus mechanical aortic valve replacement in 841 patients. 
  • Long-term stability of electroenzymatic glucose sensors implanted in mice. An update. 
  • Macrophage embedded fibrin gels: an in vitro platform for assessing inflammation effects on implantable glucose sensors. 
  • Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel. 
  • Mammographic appearance of calcium hydroxylapatite (RadiesseTM) injected into the breast for nipple reconstruction. 
  • Meniscal fixation with an absorbable staple. An experimental study in dogs. 
  • Metamaterial silk composites at terahertz frequencies. 
  • Microdroplet dissolution into a second-phase solvent using a micropipet technique: test of the Epstein-Plesset model for an aniline-water system. 
  • Microparticle Drug Delivery in Ophthalmology. 
  • Middle ear packing: comparison of materials in an animal model of mucosal trauma. 
  • Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells. 
  • Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold. 
  • Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates. 
  • Multi-component extracellular matrices based on peptide self-assembly. 
  • Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration. 
  • Mylar and Teflon-AF as cell culture substrates for studying endothelial cell adhesion. 
  • Myocardial tolerance to mechanical actuation is affected by biomaterial characteristics. 
  • Nanomechanics of streptavidin hubs for molecular materials. 
  • Nanopatterned polymer brushes: conformation, fabrication and applications. 
  • Nanoscale neuro-integrative coatings for neural implants. 
  • New dendritic adhesives for sutureless ophthalmic surgical procedures: in vitro studies of corneal laceration repair. 
  • Nitinol intravascular stent: results of preclinical evaluation. 
  • Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. 
  • Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. 
  • Noncanonical self-assembly of highly asymmetric genetically encoded polypeptide amphiphiles into cylindrical micelles. 
  • Orbital surgery: state of the art. 
  • Patency and blood flow in gas denucleated arterial prostheses. 
  • Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression. 
  • Periosteum-guided prefabrication of vascularized bone of clinical shape and volume. 
  • Peripheral nerve regeneration: an opinion on channels, scaffolds and anisotropy. 
  • Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions. 
  • Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties. 
  • Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering. 
  • Photopolymerizable hydrogels for tissue engineering applications. 
  • Platelet adhesion on a bioresorbable poly(propylene fumarate-co-ethylene glycol) copolymer. 
  • Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. 
  • Polyethylene wear characteristics in vivo and in a knee stimulator. 
  • Polyimides as biomaterials: preliminary biocompatibility testing. 
  • Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. 
  • Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture. 
  • Porous hyaluronic acid hydrogels for localized nonviral DNA delivery in a diabetic wound healing model. 
  • Porous polyethylene implant for cranioplasty and skull base reconstruction. 
  • Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption. 
  • Progress in orthopedic biomaterials and drug delivery. 
  • Prospective trial of gross-total resection with Gliadel wafers followed by early postoperative Gamma Knife radiosurgery and conformal fractionated radiotherapy as the initial treatment for patients with radiographically suspected, newly diagnosed glioblastoma multiforme. 
  • Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2- and 3-dimensions. 
  • Protein array method for assessing in vitro biomaterial-induced cytokine expression. 
  • Quantification of in vitro endothelial cell adhesion to vascular graft material. 
  • Quantitative biological surface science: challenges and recent advances. 
  • Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. 
  • Rapid nanoimprinting of silk fibroin films for biophotonic applications. 
  • Rate of vascularization of coralline hydroxyapatite spherical implants pretreated with saline/gentamicin, rTGF-beta 2, and autogenous plasma. 
  • Rationale and design of the Japan-USA harmonized assessment by randomized, multicenter study of OrbusNEich's combo StEnt (Japan-USA HARMONEE): Assessment of a novel DES platform for percutaneous coronary revascularization in patients with ischemic coronary disease and non-ST-elevation acute coronary syndrome. 
  • Readily available tissue-engineered vascular grafts. 
  • Recombinant human platelet-derived growth factor-BB and beta-tricalcium phosphate (rhPDGF-BB/β-TCP): an alternative to autogenous bone graft. 
  • Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement. 
  • Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling. 
  • Response of brain tissue to chronically implanted neural electrodes. 
  • Rigid and flexible thin-film multielectrode arrays for transmural cardiac recording. 
  • Role of endothelial cell-substrate contact area and fibronectin-receptor affinity in cell adhesion to HEMA/EMA copolymers. 
  • Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model. 
  • Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis. 
  • Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. 
  • Self-healing biomaterials. 
  • Semi-degradable poly(β-amino ester) networks with temporally controlled enhancement of mechanical properties. 
  • Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing. 
  • Small intestinal submucosa for anular defect closure: long-term response in an in vivo sheep model. 
  • Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. 
  • Spectral analysis of induced color change on periodically nanopatterned silk films. 
  • Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. 
  • Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials. 
  • Structure and thermomechanical behavior of NiTiPt shape memory alloy wires. 
  • Studies on the preparation of chitosan microcarriers cross-linked by oxidized lactose and culture of primary hepatocytes. 
  • Surface tension-assisted additive manufacturing. 
  • Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. 
  • Sustained release of antibiotics from injectable and thermally responsive polypeptide depots. 
  • Sustained release of antibiotics from injectable and thermally responsive polypeptide depots. 
  • Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. 
  • Synthesis, characterization, and cyclic stress-influenced degradation of a poly(ethylene glycol)-based poly(beta-amino ester). 
  • Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery. 
  • Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity. 
  • Tensile deformation of NiTi wires. 
  • The "ideal" replacement heart valve. 
  • The Effect of Microporous Polysaccharide Hemospheres on Wound Healing and Scarring in Wild-Type and db/db Mice. 
  • The Potential Role of Graphene in Developing the Next Generation of Endomaterials. 
  • The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants. 
  • The design of an industry-sponsored randomized controlled trial to compare synthetic mesh versus biologic mesh for inguinal hernia repair. 
  • The effect of interstitial air on the in vitro thrombogenicity of ePTFE vascular grafts. 
  • The future of spinal arthroplasty: a biomaterial perspective. 
  • The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs. 
  • The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps. 
  • The role of biomaterials in stem cell differentiation: applications in the musculoskeletal system. 
  • The use of constrained components in total hip arthroplasty. 
  • The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation. 
  • Thermomechanics of the shape memory effect in polymers for biomedical applications. 
  • Thin-film enhanced nerve guidance channels for peripheral nerve repair. 
  • This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts. 
  • Three-dimensional direct writing of B35 neuronal cells. 
  • Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart. 
  • Tissue engineering of bone: a primer for the practicing hand surgeon. 
  • Tissue-engineered scaffolds are effective alternatives to autografts for bridging peripheral nerve gaps. 
  • Ultrafast excited-state dynamics of nanoscale near-infrared emissive polymersomes. 
  • Ultrathin coating by plasma polymerization applied to corneal contact lens. 
  • Unconstrained recovery characterization of shape-memory polymer networks for cardiovascular applications. 
  • Urinary tract erosions after synthetic pubovaginal slings: diagnosis and management strategy. 
  • VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. 
  • [BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit]. 
  • α-Helical coiled-coil peptide materials for biomedical applications. 
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  Keywords of People

  • Allori, Alexander C, Assistant Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Cohen, Seth Morris, Associate Professor of Surgery, Surgery, Head and Neck Surgery and Communication Sciences
  • Craciunescu, Oana, Associate Professor of Radiation Oncology, Radiation Oncology
  • Craig, Stephen L, William T. Miller Professor of Chemistry, Duke University Energy Initiative
  • Gall, Ken, Professor in the Department of Mechanical Engineering and Materials Science, Duke Innovation & Entrepreneurship
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Nightingale, Roger W, Adjunct Associate Professor of Biomedical Engineering, Biomedical Engineering
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics