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Subject Areas on Research
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A new era in pharmacotherapy: the need to understand the principles of therapeutic drug monitoring.
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A phase I/II study of the protease inhibitor indinavir in children with HIV infection.
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A prospective, open-label study of single-dose ciprofloxacin absorption after chemotherapy in patients with malignancy.
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A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258).
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Accumulation of atmospheric and sedimentary PCBs and toxaphene in a Lake Michigan food web.
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Acute reductions in haematocrit increase flow-mediated dilatation independent of resting nitric oxide bioavailability in humans.
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Adjustment of iron intake for dietary enhancers and inhibitors in population studies: bioavailable iron in rural and urban residing Russian women and children.
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Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia.
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Antifungal pharmacodynamics: review of the literature and clinical applications.
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Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents.
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Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria.
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Assessing bioequivalence using genomic data.
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Assessment of bioequivalence using a multiplicative model.
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Associations between dopamine D2 receptor availability and BMI depend on age.
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Bedside thromboelastography to rapidly assess the pharmacodynamic response of anticoagulants and aspirin in COVID-19: evidence of inadequate therapy in a predominantly minority population.
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Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics.
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Bioavailabilities of rectal and oral methadone in healthy subjects.
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Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid.
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Bioavailability of IgG administered by the subcutaneous route.
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Bioavailability of estradiol as a marker for breast cancer risk assessment.
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Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.
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Bioavailability of phosphorus and kidney function in the Jackson Heart Study.
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Bioavailability of slowly cycling soil phosphorus: major restructuring of soil P fractions over four decades in an aggrading forest.
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Bioavailability of terfenadine in man.
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Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives.
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CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.
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Caspofungin: first approved agent in a new class of antifungals.
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Characterization and solubilization of pyrrole-imidazole polyamide aggregates.
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Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension.
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Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking.
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Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs.
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Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir.
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Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure.
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Deficient dietary iron intakes among women and children in Russia: evidence from the Russian Longitudinal Monitoring Survey.
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Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.
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Dietary CdSe/ZnS quantum dot exposure in estuarine fish: bioavailability, oxidative stress responses, reproduction, and maternal transfer.
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Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.
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Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
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Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.
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Ecdysone-inducible gene expression in mammalian cells and transgenic mice.
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Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation.
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Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.
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Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations.
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Effects of single-walled carbon nanotubes on the bioavailability of PCBs in field-contaminated sediments.
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Endotracheal lidocaine administration via an esophageal combitube.
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Environmental occurrences, behavior, fate, and ecological effects of nanomaterials: an introduction to the special series.
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Evaluating the bioaccessibility of flame retardants in house dust using an in vitro Tenax bead-assisted sorptive physiologically based method.
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Evaluation of a delivery system providing long-term release of cyclosporine.
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Evaluation of fluoride release from commercially available fluoride varnishes.
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Examining outlying subjects and outlying records in bioequivalence trials.
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Extended Oral Antibiotics and Infection Prophylaxis after a Primary or Revision Total Knee Arthroplasty.
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External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models.
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Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.
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Factors that influence siderophoremediated iron bioavailability: catalysis of interligand iron (III) transfer from ferrioxamine B to EDTA by hydroxamic acids.
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Four-decade responses of soil trace elements to an aggrading old-field forest: B, Mn, Zn, Cu, and Fe.
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Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.
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H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways.
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Heavy metal distribution and uptake by maize in a mudflat soil amended by vermicompost derived from sewage sludge.
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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
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Impact of organic amendments on the bioavailability of heavy metals in mudflat soil and their uptake by maize.
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Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria.
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In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics.
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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.
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In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors.
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Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome.
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Influence of skin site on bioavailability of nitroglycerin ointment in congestive heart failure.
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Influence of the Gastrointestinal Environment on the Bioavailability of Ethinyl Estradiol Sorbed to Single-Walled Carbon Nanotubes.
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Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells.
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Interferon in the treatment of cutaneous T-cell lymphoma.
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Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.
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Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content.
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Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
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Investigating and Modeling the Regulation of Extracellular Antibiotic Resistance Gene Bioavailability by Naturally Occurring Nanoparticles.
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Latanoprost systemic exposure in pediatric and adult patients with glaucoma: a phase 1, open-label study.
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Letrozole in the treatment of breast cancer.
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Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.
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Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men.
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Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.
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Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
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Net methylation of mercury in estuarine sediment microcosms amended with dissolved, nanoparticulate, and microparticulate mercuric sulfides.
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Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease.
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Ocular penetration and pharmacokinetics of topical gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions after keratoplasty.
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On assessment of bioequivalence under a higher-order crossover design.
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Oral ondansetron pharmacokinetics: the effect of chemotherapy.
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Outlier detection in bioavailability/bioequivalence studies.
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PA tablets: investigational compounds combining aspirin and omeprazole for cardioprotection.
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Pathophysiologic and therapeutic importance of tissue ACE: a consensus report.
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Pharmacokinetic-hemodynamic studies of nitroglycerin ointment in congestive heart failure.
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Pharmacokinetic-hemodynamic studies of transdermal nitroglycerin in congestive heart failure.
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Pharmacokinetics of Clindamycin in Obese and Nonobese Children.
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Pharmacokinetics of intraperitoneal, intravenous, and subcutaneous recombinant human erythropoietin in patients on continuous ambulatory peritoneal dialysis.
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Pharmacokinetics of levetiracetam.
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Pharmacokinetics of oral triazolam in children.
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Pharmacokinetics of the fluocinolone/5-fluorouracil codrug in the gas-filled eye.
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Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice.
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Pharmacokinetics of zidovudine administered intravenously and orally in children with human immunodeficiency virus infection.
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Pharmacological activity of metal binding agents that alter copper bioavailability.
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Pharmacology of riluzole in acute spinal cord injury.
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Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma.
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Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor.
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Population pharmacokinetics of NNZ-2566 in healthy subjects.
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Preclinical differentiation of low molecular weight heparins.
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Preliminary analysis of a randomized comparison of 5-fluorouracil versus 5-fluorouracil and high-dose continuous-infusion folinic acid in disseminated colorectal cancer.
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Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions.
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Pyrolytic characteristics, pharmacokinetics, and bioavailability of smoked heroin, cocaine, phencyclidine, and methamphetamine.
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Pyrolytic degradation of heroin, phencyclidine, and cocaine: identification of products and some observations on their metabolism.
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Quantification of Mercury Bioavailability for Methylation Using Diffusive Gradient in Thin-Film Samplers.
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Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression.
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Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations.
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Regulatable aptamers in medicine: focus on antithrombotic strategies.
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Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis.
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Relative Reactivity and Bioavailability of Mercury Sorbed to or Coprecipitated with Aged Iron Sulfides.
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Revisiting the distribution of oceanic N2
fixation and estimating diazotrophic contribution to marine production.
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Sample size determination for the two one-sided tests procedure in bioequivalence.
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Schedule dependency of 21-day oral versus 3-day intravenous etoposide in combination with intravenous cisplatin in extensive-stage small-cell lung cancer: a randomized phase III study of the Cancer and Leukemia Group B.
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Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
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Sex-related difference in the metabolism of isosorbide dinitrate following incubation in human blood.
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Short-chain alkyl esters of L-dopa as prodrugs for rectal absorption.
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Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).
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Speciation Matters: Bioavailability of Silver and Silver Sulfide Nanoparticles to Alfalfa (Medicago sativa).
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Speciation and bioaccessibility of mercury in adobe bricks and dirt floors in Huancavelica, Peru.
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Steady-state bioavailability of extended-release methylphenidate (MPH-MLR) capsule vs. immediate-release methylphenidate tablets in healthy adult volunteers.
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Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.
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Subcutaneous administration of nimodipine improves bioavailability in rabbits.
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Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists.
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Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.
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Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
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Synthesis, characterization, and bioavailability of mannosylated shell cross-linked nanoparticles.
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The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine.
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
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The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
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The effect of formulation and food consumption on the bioavailability of dovitinib (TKI258) in patients with advanced solid tumors.
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The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug.
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The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.
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The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections.
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The role of oral beclometasone dipropionate in the treatment of gastrointestinal Graft-versus-Host Disease.
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Topical fibronectin and corneal epithelial wound healing in the rabbit.
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Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans.
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Use of short-term assays to evaluate the potential toxicity of two new biosoluble glasswool fibers.
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Keywords of People
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Deshusses, Marc,
Professor of Civil and Environmental Engineering,
Nicholas Institute-Energy Initiative
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Ferguson, P. Lee,
Associate Professor of Civil and Environmental Engineering,
Civil and Environmental Engineering
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O'Connor, Christopher Michael,
Richard Sean Stack, M.D. Distinguished Professor,
Medicine, Clinical Pharmacology
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Wu, Li-Tzy,
Professor in Psychiatry and Behavioral Sciences,
Medicine, General Internal Medicine