Biological Availability

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  Subject Areas on Research

  • 2,4,6-Tribromophenol Disposition and Kinetics in Rodents: Effects of Dose, Route, Sex, and Species. 
  • A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics. 
  • A new era in pharmacotherapy: the need to understand the principles of therapeutic drug monitoring. 
  • A phase I/II study of the protease inhibitor indinavir in children with HIV infection. 
  • A pilot study assessing pharmacokinetics and tolerability of oral and intravenous baclofen in healthy adult volunteers. 
  • A pilot study assessing the bioavailability and pharmacokinetics of diazepam after intranasal and intravenous administration in healthy volunteers. 
  • A prospective, open-label study of single-dose ciprofloxacin absorption after chemotherapy in patients with malignancy. 
  • A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258). 
  • Accumulation of atmospheric and sedimentary PCBs and toxaphene in a Lake Michigan food web. 
  • Adjustment of iron intake for dietary enhancers and inhibitors in population studies: bioavailable iron in rural and urban residing Russian women and children. 
  • Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. 
  • Antifungal pharmacodynamics: review of the literature and clinical applications. 
  • Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents. 
  • Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. 
  • Assessing bioequivalence using genomic data. 
  • Assessment of bioequivalence using a multiplicative model. 
  • Associations between dopamine D2 receptor availability and BMI depend on age. 
  • Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics. 
  • Bioaccessibility of metals in human health risk assessment: evaluating risk from exposure to cobalt compounds. 
  • Bioaccessibility testing of cobalt compounds. 
  • Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid. 
  • Bioavailability of IgG administered by the subcutaneous route. 
  • Bioavailability of estradiol as a marker for breast cancer risk assessment. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Bioavailability of slowly cycling soil phosphorus: major restructuring of soil P fractions over four decades in an aggrading forest. 
  • Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives. 
  • CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. 
  • Caspofungin: first approved agent in a new class of antifungals. 
  • Characterization and solubilization of pyrrole-imidazole polyamide aggregates. 
  • Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products. 
  • Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension. 
  • Comparison of 50- and 100-g L -tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood states. 
  • Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs. 
  • DNA-polycation nanospheres as non-viral gene delivery vehicles. 
  • Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure. 
  • Deficient dietary iron intakes among women and children in Russia: evidence from the Russian Longitudinal Monitoring Survey. 
  • Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. 
  • Dietary CdSe/ZnS quantum dot exposure in estuarine fish: bioavailability, oxidative stress responses, reproduction, and maternal transfer. 
  • Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. 
  • Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. 
  • Ecdysone-inducible gene expression in mammalian cells and transgenic mice. 
  • Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation. 
  • Effect of ketoconazole on the pharmacokinetics and safety of telithromycin and clarithromycin in older subjects with renal impairment. 
  • Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death. 
  • Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations. 
  • Effects of single-walled carbon nanotubes on the bioavailability of PCBs in field-contaminated sediments. 
  • Environmental occurrences, behavior, fate, and ecological effects of nanomaterials: an introduction to the special series. 
  • Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP). 
  • Evaluating the bioaccessibility of flame retardants in house dust using an in vitro Tenax bead-assisted sorptive physiologically based method. 
  • Evaluation of a delivery system providing long-term release of cyclosporine. 
  • Examining outlying subjects and outlying records in bioequivalence trials. 
  • External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models. 
  • Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. 
  • Factors that influence siderophoremediated iron bioavailability: catalysis of interligand iron (III) transfer from ferrioxamine B to EDTA by hydroxamic acids. 
  • Fluid availability of sports drinks differing in carbohydrate type and concentration. 
  • Four-decade responses of soil trace elements to an aggrading old-field forest: B, Mn, Zn, Cu, and Fe. 
  • Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. 
  • Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. 
  • Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. 
  • In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics. 
  • In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia. 
  • In vitro and in vivo models for the study of oral delivery of nanoparticles. 
  • In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors. 
  • Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. 
  • Influence of skin site on bioavailability of nitroglycerin ointment in congestive heart failure. 
  • Influence of the Gastrointestinal Environment on the Bioavailability of Ethinyl Estradiol Sorbed to Single-Walled Carbon Nanotubes. 
  • Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells. 
  • Interferon in the treatment of cutaneous T-cell lymphoma. 
  • Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. 
  • Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. 
  • Interspecies comparison of pharmacokinetic profile and bioavailability of (+/-)-gossypol in male Fischer-344 rats and male B6C3F mice. 
  • Intravenous busulfan in pretransplant chemotherapy: bioavailability and patient benefit. 
  • Latanoprost systemic exposure in pediatric and adult patients with glaucoma: a phase 1, open-label study. 
  • Letrozole in the treatment of breast cancer. 
  • Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries. 
  • Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. 
  • Mean difference vs. variability reduction: tradeoffs in aggregate measures for individual bioequivalence. FDA Individual Bioequivalence Working Group. 
  • Microscale oral delivery devices incorporating nanoparticles. 
  • Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation. 
  • Nanoparticle- and biomaterials-mediated oral delivery for drug, gene, and immunotherapy. 
  • Nasogastric administration of garenoxacin as crushed tablets with and without concomitant enteral feeding in healthy subjects. 
  • Net methylation of mercury in estuarine sediment microcosms amended with dissolved, nanoparticulate, and microparticulate mercuric sulfides. 
  • Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease. 
  • Ocular penetration and pharmacokinetics of topical gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions after keratoplasty. 
  • On assessment of bioequivalence under a higher-order crossover design. 
  • Oral ondansetron pharmacokinetics: the effect of chemotherapy. 
  • Outlier detection in bioavailability/bioequivalence studies. 
  • PA tablets: investigational compounds combining aspirin and omeprazole for cardioprotection. 
  • Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. 
  • Pharmacokinetic-hemodynamic studies of nitroglycerin ointment in congestive heart failure. 
  • Pharmacokinetic-hemodynamic studies of transdermal nitroglycerin in congestive heart failure. 
  • Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. 
  • Pharmacokinetics of Clindamycin in Obese and Nonobese Children. 
  • Pharmacokinetics of amlodipine and olmesartan after administration of amlodipine besylate and olmesartan medoxomil in separate dosage forms and as a fixed-dose combination. 
  • Pharmacokinetics of intraperitoneal, intravenous, and subcutaneous recombinant human erythropoietin in patients on continuous ambulatory peritoneal dialysis. 
  • Pharmacokinetics of levetiracetam. 
  • Pharmacokinetics of oral treprostinil sustained release tablets during chronic administration to patients with pulmonary arterial hypertension. 
  • Pharmacokinetics of the fluocinolone/5-fluorouracil codrug in the gas-filled eye. 
  • Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice. 
  • Pharmacokinetics of zidovudine administered intravenously and orally in children with human immunodeficiency virus infection. 
  • Pharmacological activity of metal binding agents that alter copper bioavailability. 
  • Pharmacology of riluzole in acute spinal cord injury. 
  • Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma. 
  • Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships. 
  • Preclinical differentiation of low molecular weight heparins. 
  • Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions. 
  • Quantification of Mercury Bioavailability for Methylation Using Diffusive Gradient in Thin-Film Samplers. 
  • Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression. 
  • Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. 
  • Regulatable aptamers in medicine: focus on antithrombotic strategies. 
  • Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis. 
  • Relative Reactivity and Bioavailability of Mercury Sorbed to or Coprecipitated with Aged Iron Sulfides. 
  • Revisiting the distribution of oceanic N2 fixation and estimating diazotrophic contribution to marine production. 
  • Sample size determination for the two one-sided tests procedure in bioequivalence. 
  • Schedule dependency of 21-day oral versus 3-day intravenous etoposide in combination with intravenous cisplatin in extensive-stage small-cell lung cancer: a randomized phase III study of the Cancer and Leukemia Group B. 
  • Sex-related difference in the metabolism of isosorbide dinitrate following incubation in human blood. 
  • Short-chain alkyl esters of L-dopa as prodrugs for rectal absorption. 
  • Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177). 
  • Speciation Matters: Bioavailability of Silver and Silver Sulfide Nanoparticles to Alfalfa (Medicago sativa). 
  • Speciation and bioaccessibility of mercury in adobe bricks and dirt floors in Huancavelica, Peru. 
  • Steady-state bioavailability of extended-release methylphenidate (MPH-MLR) capsule vs. immediate-release methylphenidate tablets in healthy adult volunteers. 
  • Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells. 
  • Subcutaneous administration of nimodipine improves bioavailability in rabbits. 
  • Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists. 
  • Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. 
  • Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors. 
  • Synthesis, characterization, and bioavailability of mannosylated shell cross-linked nanoparticles. 
  • The bioavailability of isoniazid, rifampin, and pyrazinamide in two commercially available combined formulations designed for use in the short-course treatment of tuberculosis. 
  • The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine. 
  • The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. 
  • The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor. 
  • The effect of formulation and food consumption on the bioavailability of dovitinib (TKI258) in patients with advanced solid tumors. 
  • The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug. 
  • The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. 
  • The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress. 
  • The role of oral beclometasone dipropionate in the treatment of gastrointestinal Graft-versus-Host Disease. 
  • Time course of fenretinide-induced modulation of circulating insulin-like growth factor (IGF)-i, IGF-II and IGFBP-3 in a bladder cancer chemoprevention trial. 
  • Topical fibronectin and corneal epithelial wound healing in the rabbit. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Use of short-term assays to evaluate the potential toxicity of two new biosoluble glasswool fibers. 
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  Keywords of People

  • Deshusses, Marc, Professor of Civil and Environmental Engineering, Duke University Energy Initiative
  • Ferguson, P. Lee, Associate Professor of Civil and Environmental Engineering, Civil and Environmental Engineering
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine