Biological Clocks

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  Subject Areas on Research

  • After hours keeps clock researchers CRYing Overtime. 
  • Amplitude- and frequency-dependent changes in neuronal regularity parallel changes in tremor With thalamic deep brain stimulation. 
  • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 
  • Attentional bias between modalities: effect on the internal clock, memory, and decision stages used in animal time discrimination. 
  • Behavioral detection of tactile stimuli during 7-12 Hz cortical oscillations in awake rats. 
  • Casein kinase I in the mammalian circadian clock. 
  • Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates. 
  • Chronic treatment with haloperidol induces deficits in working memory and feedback effects of interval timing. 
  • Circadian clocks in daily and seasonal control of development. 
  • Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. 
  • Closed-loop control of deep brain stimulation: a simulation study. 
  • Condition for alternans and its control in a two-dimensional mapping model of paced cardiac dynamics. 
  • Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. 
  • Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. 
  • Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. 
  • Decoding biological principles using gene circuits. 
  • Dedicated clock/timing-circuit theories of time perception and timed performance. 
  • Differential modulation of clock speed by the administration of intermittent versus continuous cocaine. 
  • Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons. 
  • Efficient analysis of stochastic gene dynamics in the non-adiabatic regime using piecewise deterministic Markov processes. 
  • Elements of biological oscillations in time and space. 
  • Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? 
  • Encoding of naturalistic stimuli by local field potential spectra in networks of excitatory and inhibitory neurons. 
  • Epigenetic Clocks. 
  • Frequency-dependent response of the vascular endothelium to pulsatile shear stress. 
  • Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing. 
  • Gating of human theta oscillations by a working memory task. 
  • Global control of cell-cycle transcription by coupled CDK and network oscillators. 
  • Good times for multisensory integration: Effects of the precision of temporal synchrony as revealed by gamma-band oscillations. 
  • High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. 
  • Hippocampal function is required for feedback control of an internal clock's criterion. 
  • How emotions colour our perception of time. 
  • How noise affects the synchronization properties of recurrent networks of inhibitory neurons. 
  • Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking. 
  • Identification of c-kit-positive cells in the mouse ureter: the interstitial cells of Cajal of the urinary tract. 
  • Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania. 
  • Inhibition, Not Excitation, Drives Rhythmic Whisking. 
  • Intercellular communication during plant development. 
  • Keeping the beat in the rising heat. 
  • Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception. 
  • LUX ARRHYTHMO encodes a novel Myb-like transcription factor essential for circadian rhythms 
  • Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania. 
  • Localized high gamma motor oscillations respond to perceived biologic motion. 
  • Molecular clock and recombination in primate Mhc genes. 
  • Multistable dynamics mediated by tubuloglomerular feedback in a model of coupled nephrons. 
  • Neurofeedback learning modifies the incidence rate of alpha spindles, but not their duration and amplitude. 
  • Noise-limited frequency signal transmission in gene circuits. 
  • Non-linear dynamic analysis of the cardiac rhythm during transient myocardial ischemia. 
  • Nonlinear dynamics of the CAM circadian rhythm in response to environmental forcing. 
  • Nutrients and the microenvironment to feed a T cell army. 
  • Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation. 
  • Potential landscape and flux framework of nonequilibrium networks: robustness, dissipation, and coherence of biochemical oscillations. 
  • Processing Oscillatory Signals by Incoherent Feedforward Loops. 
  • Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. 
  • Rate-dependent propagation of cardiac action potentials in a one-dimensional fiber. 
  • Recognition and assessment of shift work disorder. 
  • Relativity theory and time perception: single or multiple clocks? 
  • Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Somatosensory cortical neuronal population activity across states of anaesthesia. 
  • Sparsely synchronized neuronal oscillations. 
  • Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. 
  • Stability of rotors and focal sources for human atrial fibrillation: focal impulse and rotor mapping (FIRM) of AF sources and fibrillatory conduction. 
  • Stable propagation of a burst through a one-dimensional homogeneous excitatory chain model of songbird nucleus HVC. 
  • Systems approaches to identifying gene regulatory networks in plants. 
  • Temporal organization of sleep-wake states in preterm infants. 
  • The 'internal clocks' of circadian and interval timing. 
  • The Brainstem Oscillator for Whisking and the Case for Breathing as the Master Clock for Orofacial Motor Actions. 
  • The Socio-Temporal Brain: Connecting People in Time. 
  • The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle. 
  • The effect of electrical coupling on the frequency of model neuronal oscillators. 
  • The role of intrinsic and induced vulnerability in electrically induced cardiac arrhythmias. 
  • The variability of the electrical properties of the pulmonary veins. 
  • Theta oscillations in human cortex during a working-memory task: evidence for local generators. 
  • Time and memory: towards a pacemaker-free theory of interval timing. 
  • Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators. 
  • Tubular fluid flow and distal NaCl delivery mediated by tubuloglomerular feedback in the rat kidney. 
  • Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation. 
  • ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. 
  • alpha7 Nicotinic acetylcholine receptors and temporal memory: synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock. 
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  Keywords of People

  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology