Biological Transport

• 

  Subject Areas on Research

  • 22Na+ and 86Rb+ transport in vascular smooth muscle of SHR, Wistar Kyoto, and Wistar rats. 
  • 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes. 
  • 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. 
  • A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination. 
  • A Monte Carlo model reveals independent signaling at central glutamatergic synapses. 
  • A WNK in the kidney controls blood pressure. 
  • A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors. 
  • A computational model for simulating solute transport and oxygen consumption along the nephrons. 
  • A computational model of epithelial solute and water transport along a human nephron. 
  • A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. 
  • A fine line between molecular umbrella transport and ionophoric activity. 
  • A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic. 
  • A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. 
  • A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. 
  • A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. 
  • A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. 
  • A novel relaxase homologue is involved in chromosomal DNA processing for type IV secretion in Neisseria gonorrhoeae. 
  • A nuclear role for the Fragile X mental retardation protein. 
  • A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. 
  • A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity. 
  • A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB). 
  • A review of three-dimensional in vitro tissue models for drug discovery and transport studies. 
  • A widespread transposable element masks expression of a yeast copper transport gene. 
  • ABCs of erythroid mitochondrial iron uptake. 
  • Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components. 
  • Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. 
  • Albumin influences sulfobromophthalein transport by hepatocytes of each acinar zone. 
  • Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles. 
  • Alterations in activity at auditory nuclei of the rat induced by exposure to microwave radiation: autoradiographic evidence using [14C]2-deoxy-D-glucose. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • An Escherichia coli mutant defective in lipid export. 
  • An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. 
  • An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. 
  • An investigation of hemopexin redox properties by spectroelectrochemistry: biological relevance for heme uptake. 
  • An optimization algorithm for a distributed-loop model of an avian urine concentrating mechanism. 
  • An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. 
  • An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. 
  • Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element. 
  • Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue. 
  • Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue. 
  • Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor. 
  • Analytical and biological methods for probing the blood-brain barrier. 
  • Anastral spindle assembly: a mathematical model. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Apolipoprotein E uptake and low-density lipoprotein receptor-related protein expression by the NTera2/D1 cell line: a cell culture model of relevance for late-onset Alzheimer's disease. 
  • Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. 
  • Aquaporin-4-dependent glymphatic solute transport in the rodent brain. 
  • Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. 
  • Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells. 
  • Assaying nuclear messenger RNA export in human cells. 
  • Assessment of the CFTR and ENaC association. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Astringent-tasting compounds alter ion transport across isolated canine lingual epithelia. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Autoradiographic localization of proline uptake in excitatory hippocampal pathways. 
  • Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root. 
  • Balancing acts: molecular control of mammalian iron metabolism. 
  • Barriers, pathways and processes for uptake, translocation and accumulation of nanomaterials in plants--Critical review. 
  • Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. 
  • Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants. 
  • Biotic and abiotic factors act in coordination to amplify hydraulic redistribution and lift. 
  • Bole girdling affects metabolic properties and root, trunk and branch hydraulics of young ponderosa pine trees. 
  • Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • Broadening of the RF power-density window for calcium-ion efflux from brain tissue. 
  • COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. 
  • Calcium- and zinc-binding proteins in intracellular transport. 
  • Calmodulin: a prototypical calcium sensor. 
  • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. 
  • Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse. 
  • Cell biology and physiology of the uroepithelium. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells. 
  • Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung. 
  • Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). 
  • Characteristics of lysine transport by isolated rat renal cortical tubule fragments. 
  • Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. 
  • Characterization of neutral and cationic amino acid transport in Xenopus oocytes. 
  • Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells. 
  • Charting the travels of copper in eukaryotes from yeast to mammals. 
  • Chemical carcinogenesis and toxicity models: matching complexity to objectives. 
  • Chemistry and biology of copper-chelatin. 
  • Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. 
  • Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. 
  • Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. 
  • Co-culture of primary pulmonary cells to model alveolar injury and translocation of proteins. 
  • Co-option of endocytic functions of cellular caveolae by pathogens. 
  • Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk. 
  • Common variants associated with plasma triglycerides and risk for coronary artery disease. 
  • Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models. 
  • Compartmental analysis of amine storage in bovine adrenal medullary granules. 
  • Composition and transport properties of human ankle and knee cartilage. 
  • Concerted nitric oxide/oxygen delivery by hemoglobin. 
  • Connections between the processing and nuclear export of mRNA: evidence for an export license? 
  • Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. 
  • Contrasting hydraulic architecture and function in deep and shallow roots of tree species from a semi-arid habitat. 
  • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Copper signaling axis as a target for prostate cancer therapeutics. 
  • Copper-induced synthesis of copper-chelatin in rat liver. 
  • Copper: an essential metal in biology. 
  • Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. 
  • Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å. 
  • Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. 
  • Cyclosporine augments receptor-mediated cellular Ca2+ fluxes in isolated hepatocytes. 
  • Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells. 
  • Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole. 
  • Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia. 
  • D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination. 
  • Definition of a consensus transportin-specific nucleocytoplasmic transport signal. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement. 
  • Determination of the functional domain organization of the importin alpha nuclear import factor. 
  • Developmental aspects of cystine transport in the dog. 
  • Developmental changes of glycine transport in the dog. 
  • Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells. 
  • Dexamethasone suppression test identifies a subset of elderly depressed patients with reduced platelet serotonin transport and resistance to imipramine inhibition of transport. 
  • Differential Translocation of Host Cellular Materials into the Chlamydia trachomatis Inclusion Lumen during Chemical Fixation. 
  • Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. 
  • Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. 
  • Direct ribosomal binding by a cellular inhibitor of translation. 
  • Discs of mammalian rod photoreceptors form through the membrane evagination mechanism. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection. 
  • Divalent metal transporter-1 decreases metal-related injury in the lung. 
  • Does dopamine contribute to striatal damage caused by impaired mitochondrial function? 
  • Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. 
  • Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations. 
  • Drosophila Ctr1A functions as a copper transporter essential for development. 
  • Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. 
  • Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress. 
  • Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain. 
  • Dynamics of HIV neutralization by a microbicide formulation layer: biophysical fundamentals and transport theory. 
  • Dynamics of water transport and storage in conifers studied with deuterium and heat tracing techniques. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • Effect of AQP1 expression level on Co(2) permeability in bovine corneal endothelium. 
  • Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein-Enriched Serum in Rheumatoid Arthritis. 
  • Effect of FSH on protein biosynthesis in testes of the immature rat. 
  • Effect of acidosis on glutamine transport by isolated rat renal brush-border and basolateral-membrane vesicles. 
  • Effect of cystine loading and cystine dimethylester on renal brushborder membrane transport. 
  • Effect of dietary protein manipulation on translocation of protein kinase C activity in various tissues of rats. 
  • Effect of exercise on cation transport in human red cells. 
  • Effect of fluid shear stress on the permeability of the arterial endothelium. 
  • Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins. 
  • Effect of the shape and configuration of smooth muscle cells on the diffusion of ATP through the arterial wall. 
  • Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study. 
  • Effects of endocytosis on receptor-mediated signaling. 
  • Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer. 
  • Effects of iron depletion on CALM-AF10 leukemias. 
  • Effects of mRNA untranslated regions on translational efficiency of NMDA receptor subunits. 
  • Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. 
  • Effects of specific activity on meta-[(131)I]iodobenzylguanidine kinetics in isolated rat heart. 
  • Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts. 
  • Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization. 
  • Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis. 
  • Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. 
  • Enhancement of transport selectivity through nano-channels by non-specific competition. 
  • Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. 
  • Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. 
  • Evidence for a low Km transporter for non-transferrin-bound iron in isolated rat hepatocytes. 
  • Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport. 
  • Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion. 
  • Evidence that ribavirin is transported in Aedes albopictus cells by the nucleoside transport system. 
  • Excretory role of the midgut in larvae of the tobacco hornworm, Manduca sexta (L.). 
  • Expanding the scope of quantitative FRAP analysis. 
  • Export by red blood cells of nitric oxide bioactivity. 
  • Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage. 
  • Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium. 
  • Extracellular Vesicles: A Brief Overview and Its Role in Precision Medicine. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. 
  • Factors that influence the uptake and turnover of glucocerebrosidase and alpha-galactosidase in mammalian liver. 
  • Fe3+ coordination and redox properties of a bacterial transferrin. 
  • Field distribution and DNA transport in solid tumors during electric field-mediated gene delivery. 
  • Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. 
  • Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. 
  • Functional advantages conferred by extracellular prokaryotic membrane vesicles. 
  • Functional and structural characterization of endosomes from toad bladder epithelial cells. 
  • Functional coordination between leaf gas exchange and vulnerability to xylem cavitation in temperate forest trees. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex. 
  • G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. 
  • GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. 
  • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. 
  • GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability. 
  • Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect. 
  • Generation of a novel antibody probe to the apical sodium-dependent bile acid transporter that inhibits ileal bile acid absorption. 
  • Generation of high curvature membranes mediated by direct endophilin bilayer interactions. 
  • Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport. 
  • Glucagon stimulation of ruthenium red-insensitive calcium ion transport in developing rat liver. 
  • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. 
  • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. 
  • Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain. 
  • HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes. 
  • HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. 
  • Hemodynamic parameters and early intimal thickening in branching blood vessels. 
  • Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport. 
  • Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. 
  • High-level production of recombinant human lysosomal acid alpha-glucosidase in Chinese hamster ovary cells which targets to heart muscle and corrects glycogen accumulation in fibroblasts from patients with Pompe disease. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Hormonal regulation of androgen-binding protein in hypophysectomized rats. 
  • Hydraulic lift and tolerance to salinity of semiarid species: consequences for species interactions. 
  • Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation. 
  • Hypochlorous acid modifies calcium release channel function from skeletal muscle sarcoplasmic reticulum. 
  • Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. 
  • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. 
  • Identification and characterization of rns4/vps32 mutation in the RNase T1 expression-sensitive strain of Saccharomyces cerevisiae: Evidence for altered ambient response resulting in transportation of the secretory protein to vacuoles. 
  • Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. 
  • Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. 
  • Identification of a novel high affinity copper transport complex in the fission yeast Schizosaccharomyces pombe. 
  • Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18. 
  • Impact of renal medullary three-dimensional architecture on oxygen transport. 
  • Impacts of nitric oxide and superoxide on renal medullary oxygen transport and urine concentration. 
  • Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues. 
  • In vitro electrophoresis and in vivo electrophysiology of peripheral nerve using DC field stimulation. 
  • In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. 
  • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. 
  • Increased wedge pressure facilitates decreased lung vascular resistance during upright exercise. 
  • Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. 
  • Increases in nitrogen uptake rather than nitrogen-use efficiency support higher rates of temperate forest productivity under elevated CO2. 
  • Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. 
  • Inhalation exposures to barium aerosols: physical, chemical and mathematical analysis. 
  • Inhibition of 125I-chemotactic peptide uptake by protease inhibitors. 
  • Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin. 
  • Integrating trace element metabolism from the cell to the whole organism. 
  • Interactions of VirB9, -10, and -11 with the membrane fraction of Agrobacterium tumefaciens: solubility studies provide evidence for tight associations. 
  • Intercellular communication during plant development. 
  • Internalization of carcinogenic lead chromate particles by cultured normal human lung epithelial cells: formation of intracellular lead-inclusion bodies and induction of apoptosis. 
  • Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. 
  • Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. 
  • Intrinsic connections of macaque striate cortex: afferent and efferent connections of lamina 4C. 
  • Ion channels under the sun. 
  • Ion transport across lingual epithelium is modulated by chorda tympani nerve fibers. 
  • Iron deficiency: lessons from anemic mice. 
  • Iron metabolism and cell membranes. I. Relation between ferritin and hemosiderin in bile and biliary excretion of lysosome contents. 
  • Iron transport across biologic membranes. 
  • Iron-dependent regulation of the divalent metal ion transporter. 
  • Kinesins at a glance. 
  • Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. 
  • Large-scale profiling of Rab GTPase trafficking networks: the membrome. 
  • Leaf-level gas-exchange uniformity and photosynthetic capacity among loblolly pine (Pinus taeda L.) genotypes of contrasting inherent genetic variation. 
  • Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions. 
  • Life without myoglobin. 
  • Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. 
  • Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT. 
  • Liposome reconstitution and transport assay for recombinant transporters. 
  • Localization of LRRK2 to membranous and vesicular structures in mammalian brain. 
  • Localization of aquaporin CHIP in the human eye: implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance. 
  • Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. 
  • Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. 
  • Low temperature reversibly inhibits transport from tubular endosomes to a perinuclear, acidic compartment in African trypanosomes. 
  • Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation. 
  • Lysolipid exchange with lipid vesicle membranes. 
  • Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. 
  • Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier. 
  • Mast cell-derived particles deliver peripheral signals to remote lymph nodes. 
  • Mathematical modeling of kidney transport. 
  • Mathematical modeling of urea transport in the kidney. 
  • Mechanisms for copper acquisition, distribution and regulation. 
  • Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation. 
  • Mechanisms of immune stimulation by bacterial DNA. 
  • Mechanistic analysis of electroporation-induced cellular uptake of macromolecules. 
  • Membrane Trafficking in Plant Immunity. 
  • Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines. 
  • Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent. 
  • Metabolic profiling of muscle contraction in lean compared with obese rodents. 
  • Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. 
  • Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. 
  • Metabolism and vascular fatty acid transport. 
  • Metal transporters and disease. 
  • Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. 
  • Methionine-enkephalin and morphine: amount ejected microiontophoretically. 
  • Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. 
  • Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. 
  • Microtubule transport defects in neurological and ciliary disease. 
  • Mining copper transport genes. 
  • Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. 
  • Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. 
  • Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition. 
  • Modeling the relative impact of capsular tissue effects on implanted glucose sensor time lag and signal attenuation. 
  • Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ. 
  • Molecular control of iron metabolism. 
  • Molecular mechanisms of copper uptake and distribution. 
  • Motor proteins 1: kinesins. 
  • Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. 
  • Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. 
  • Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. 
  • Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. 
  • NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis. 
  • Nitric oxide and superoxide transport in a cross section of the rat outer medulla. I. Effects of low medullary oxygen tension. 
  • Nitric oxide and superoxide transport in a cross section of the rat outer medulla. II. Reciprocal interactions and tubulovascular cross talk. 
  • Nitric oxide in RBCs. 
  • Non-neoplastic and neoplastic pleural endpoints following fiber exposure. 
  • Nonlinear dependence of hydraulic conductivity on tissue deformation during intratumoral infusion. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Nuclear RNA export pathways. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta. 
  • Nucleocytoplasmic shuttling by protein nuclear import factors. 
  • Nucleotide interactions with the dicyclohexylcarbodiimide-sensitive adenosinetriphosphatase from spinach chloroplasts. 
  • Nucleotide receptors regulate membrane ion transport in renal epithelial cells. 
  • Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork. 
  • Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. 
  • On the structure of the hemocyanin channel in lipid bilayers. 
  • Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. 
  • Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate. 
  • Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. 
  • Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. 
  • Parc-ing p53 in the cytoplasm. 
  • Perinatal dietary supplementation with a soy lecithin preparation: effects on development of central catecholaminergic neurotransmitter systems. 
  • Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma. 
  • Phase-lifetime spectrophotometry of membranes from ion flux mutants of Halobacterium halobium. 
  • Phasic ion channel blockade. A kinetic model and parameter estimation procedure. 
  • Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. 
  • Placental transport of free palmitic and linoleic acids in the guinea pig. 
  • Platelet glutathione transport: characteristics and evidence for regulation by intraplatelet thiol status. 
  • Polarographic cerebral oxygen availability, fluorocarbon blood levels and efficacy of oxygen transport by emulsions. 
  • Potassium channels regulate cholecystokinin secretion in STC-1 cells. 
  • Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus. 
  • Predicting glucose sensor behavior in blood using transport modeling: relative impacts of protein biofouling and cellular metabolic effects. 
  • Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. 
  • Preservation of brush border transport systems for proline and alpha-methyl-D glucoside from rat, dog, and human kidney. 
  • Prognostic significance of amino acid transport imaging in patients with brain tumors. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Protein biosynthesis in the testis. 3. Dual effect of glucose. 
  • Protein kinase C mediates cholinergically regulated protein phosphorylation in a Cl(-)-secreting epithelium. 
  • Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. 
  • Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases. 
  • Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter. 
  • Pulsating tandem microbubble for localized and directional single-cell membrane poration. 
  • Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. 
  • Quantitative analysis of intratumoral infusion of color molecules. 
  • Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs. 
  • Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic. 
  • Raphael Valdivia: how Chlamydia settles in. 
  • Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. 
  • Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. 
  • Recognition of multiple drugs by a single protein: a trivial solution of an old paradox. 
  • Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein. 
  • Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates. 
  • Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. 
  • Regulation of complement activity by immunoglobulin. I. Effect of immunoglobulin isotype on C4 uptake on antibody-sensitized sheep erythrocytes and solid phase immune complexes. 
  • Regulation of microfilaments and microtubules by calcium and cyclic AMP. 
  • Regulation of the renal Na+-H+ exchanger. 
  • Requirement of Ca2+ for aflatoxin production: inhibitory effect of Ca2+ channel blockers on aflatoxin production by Aspergillus parasiticus NRRL 2999. 
  • Retinol & membrane functions: phospholipid exchange between liver microsomes & mitochondria in rats fed retinol. 
  • Review of methods used to study oxygen transport at the microcirculatory level. 
  • Rheology and the regulation of oxygen delivery. 
  • RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. 
  • Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo. 
  • Role of the microvillus in the absorption of disaccharides. 
  • S-Nitrosohemoglobin: an allosteric mediator of NO group function in mammalian vasculature. 
  • S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets. 
  • S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. 
  • SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. 
  • Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis. 
  • Scara5 is a ferritin receptor mediating non-transferrin iron delivery. 
  • Secretion and movement of wingless protein in the epidermis of the Drosophila embryo. 
  • Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17 beta (E2) on the renal handling of urate. 
  • Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Simultaneous measurements of blood flow and blood-to-tissue transport in xenotransplanted medulloblastomas. 
  • Small molecule intervention in microtubule-associated human disease. 
  • Speciation Matters: Bioavailability of Silver and Silver Sulfide Nanoparticles to Alfalfa (Medicago sativa). 
  • Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Stage- and ribosome-specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane. 
  • Stem compression reversibly reduces phloem transport in Pinus sylvestris trees. 
  • Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. 
  • Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. 
  • Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport. 
  • Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. 
  • Structural determinants for signal sequence function in the mammalian endoplasmic reticulum. 
  • Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum. 
  • Structure of the Ctr1 copper trans'PORE'ter reveals novel architecture. 
  • Studies on the zinc content of Cd-induced thionein. 
  • Sulfate activation and transport in mammals: system components and mechanisms. 
  • Superoxide-dependent iron uptake: a new role for anion exchange protein 2. 
  • Synaptic vesicles isolated from rat heart: l-[3H]norepinephrine uptake properties. 
  • T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. 
  • Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. 
  • Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. 
  • The ABCDs of periplasmic copper trafficking. 
  • The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. 
  • The Drosophila copper transporter Ctr1C functions in male fertility. 
  • The Fanconi syndrome and mechanisms of tubular transport dysfunction. 
  • The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. 
  • The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain. 
  • The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. 
  • The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. 
  • The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling. 
  • The absorption of oleic acid from emulsion and micellar solution. 
  • The anion in salt taste: a possible role for paracellular pathways. 
  • The centrosome in human genetic disease. 
  • The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment. 
  • The concurrence of hypoparathyroidism provides new insights to the pathophysiology of X-linked hypophosphatemic rickets. 
  • The consequences of enhanced cell-autonomous glucose metabolism. 
  • The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain. 
  • The effect of aldosterone on water and electrolyte composition of incubated rat diaphragms. 
  • The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma. 
  • The effect of ionophore A23187 on calcium ion fluxes and alpha-adrenergic-agonist action in perfused rat liver. 
  • The filamentous bacteriophage assembly proteins require the bacterial SecA protein for correct localization to the membrane. 
  • The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. 
  • The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. 
  • The intestinal glucose-apelin cycle controls carbohydrate absorption in mice. 
  • The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. 
  • The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. 
  • The redox hypothesis in siderophore-mediated iron uptake. 
  • The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy. 
  • The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. 
  • The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. 
  • The role of blood-brain barrier permeability in brain tumor imaging and therapeutics. 
  • The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells. 
  • The specialized junctions of the lens. 
  • The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. 
  • The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. 
  • Theoretical analysis of lipid transport in sciatic nerve. 
  • Time and pressure dependence of transvascular Clara cell protein, albumin, and IgG transport during ventilator-induced lung injury in mice. 
  • Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin. 
  • Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. 
  • Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery. 
  • Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules. 
  • Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. 
  • Transport of drugs from blood vessels to tumour tissue. 
  • Transport of free fatty acid and triglyceride in anhepatic rats. 
  • Transport properties of the calcium ionophore ETH-129. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Transport studies and enzyme assays in mice infected with human Giardia lamblia. 
  • Transscleral diffusion of ethacrynic acid and sodium fluorescein. 
  • Transvascular drug delivery in solid tumors. 
  • Trigeminal nerve responses in the rat elicited by chemical stimulation of the tongue. 
  • Trimeric autotransporters: a distinct subfamily of autotransporter proteins. 
  • Tubular fluid flow and distal NaCl delivery mediated by tubuloglomerular feedback in the rat kidney. 
  • Tubuloglomerular feedback signal transduction in a short loop of henle. 
  • Ultrastructural Analysis of Vesicular Transport in Electrotransfection. 
  • Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. 
  • Understanding cargo specificity in intraflagellar transport. 
  • Underwater life support based on immobilized oxygen carriers. 
  • Unusual Synergism of Transferrin and Citrate in the Regulation of Ti(IV) Speciation, Transport, and Toxicity. 
  • Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dot mediated Förster resonance energy transfer. 
  • Uptake of catecholamines by storage vesicles. 
  • Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. 
  • Urea as a passive transport marker for arthritis biomarker studies. 
  • Urea transport in a distributed loop model of the urine-concentrating mechanism. 
  • Validation of the mIBG skeletal SIOPEN scoring method in two independent high-risk neuroblastoma populations: the SIOPEN/HR-NBL1 and COG-A3973 trials. 
  • Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. 
  • Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae. 
  • Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. 
  • WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. 
  • What's new in diuretic therapy. 
  • Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. 
  • X-ray structures of the high-affinity copper transporter Ctr1. 
  • Xylem functioning, dysfunction and repair: a physical perspective and implications for phloem transport. 
  • Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase. 
  • beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Katz, David F., Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Molecular Genetics and Microbiology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Middleton, John Paul, Associate Professor of Medicine, Medicine, Nephrology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Turi, Jennifer Lilly, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine